Publications by authors named "Norihito Iida"

5 Publications

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Contact-free unconstraint respiratory measurements with load cells under the bed in awake healthy volunteers: breath-by-breath comparison with pneumotachography.

J Appl Physiol (1985) 2019 05 14;126(5):1432-1441. Epub 2019 Feb 14.

Department of Preventive Medicine and Public Health, Keio University School of Medicine , Tokyo , Japan.

Rate of respiration is a fundamental vital sign. Accuracy and precision of respiratory rate measurements with contact-free load cell sensors under the bed legs were assessed by breath-by-breath comparison with the pneumotachography technique during two different dynamic breathing tasks in 16 awake human adults resting on the bed. The subject voluntarily increased and decreased the respiratory rate between 4 and 16 breaths/min ( = 8) and 10 and 40 breaths/min ( = 8) at every 2 breaths in 6 different lying postures such as supine, left lateral, right lateral, and 30, 45, and 60° sitting postures. Reciprocal phase changes of the upper and lower load cell signals accorded with the respiratory phases indicating respiratory-related shifts of the centroid along the long axis of the bed. Bland-Altman analyses revealed 0.66 and 1.59 breaths/min standard deviation differences between the techniques (limits of agreement: -1.22 to 1.36 and -2.96 to 3.30) and 0.07 and 0.17 breaths/min fixed bias differences (accuracy) (confidence interval: 0.04 to 0.10 and 0.12 to 0.22) for the mean respiratory rates of 10.5 ± 3.7 and 24.6 ± 8.9 breaths/min, respectively, regardless of the body postures on the bed. Proportional underestimation by this technique was evident for respiratory rates >40 breaths/min. Sample breath increase up to 10 breaths improved the precision from 1.59 to 0.26 breaths/min. Abnormally faster and slower respirations were accurately detected. We conclude that contact-free unconstraint respiratory rate measurements with load cells under the bed legs are accurate and may serve as a new clinical and investigational tool. Four load cells placed under the bed legs successfully captured a centroid shift during respiration in human subjects lying on a bed. Breath-by-breath comparison of the breaths covering a wide respiratory rate range by pneumotachography confirmed reliability of the contact-free unconstraint respiratory rate measurements by small standard deviations and biases regardless of body postures. Abnormally faster and slower respirations were accurately detected. This technique should be an asset as a new clinical and investigational tool.
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http://dx.doi.org/10.1152/japplphysiol.00730.2018DOI Listing
May 2019

Synthesis of Phthalocyanines with a Pentafluorosulfanyl Substituent at Peripheral Positions.

ChemistryOpen 2015 12 24;4(6):698-702. Epub 2015 Jul 24.

Department of Frontier Materials Nagoya Institute of Technology Gokiso, Showa-ku Nagoya 466-8555 Japan; Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Gokiso, Showa-ku Nagoya 466-8555 Japan.

The pentafluorosulfanyl (SF5) group is more electronegative, lipophilic and sterically bulky relative to the well-explored trifluoromethyl (CF3) group. As such, the SF5 group could offer access to pharmaceuticals, agrochemicals and optoelectronic materials with novel properties. Here, the first synthesis of phthalocyanines (Pcs), a class of compounds used as dyes and with potential as photodynamic therapeutics, with a SF5 group directly attached on their peripheral positions is disclosed. The key for this work is the preparation of a series of SF5-containing phthalonitriles, which was beautifully regio-controlled by a stepwise cyanation via ortho-lithiation/iodination from commercially available pentafluorosulfanyl arenes. The macrocyclization of the SF5-containing phthalonitriles to SF5-substituted Pcs required harsh conditions with the exception of the synthesis of β-SF5-substituted Pc. The regiospecificity of the newly developed SF5-substituted Pcs observed by UV/Vis spectra and fluorescence quantum yields depend on the peripheral positon of the SF5 group.
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http://dx.doi.org/10.1002/open.201500165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906510PMC
December 2015

Regioisomer-Free C 4h β-Tetrakis(tert-butyl)metallo-phthalocyanines: Regioselective Synthesis and Spectral Investigations.

ChemistryOpen 2015 Apr 21;4(2):102-6. Epub 2014 Nov 21.

Department of Frontier Materials, Nagoya Institute of Technology Gokiso, Showa-ku, Nagoya, 466-8555, Japan ; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology Gokiso, Showa-ku, Nagoya, 466-8555, (Japan).

Metal β-tetrakis(tert-butyl)phthalocyanines are the most commonly used phthalocyanines due to their high solubility, stability, and accessibility. They are commonly used as a mixture of four regioisomers, which arise due to the tert-butyl substituent on the β-position, and to the best of our knowledge, their regioselective synthesis has yet to be reported. Herein, the C 4h -selective synthesis of β-tetrakis(tert-butyl)metallophthalocyanines is disclosed. Using tetramerization of α-trialkylsilyl phthalonitriles with metal salts following acid-mediated desilylation, the desired metallophthalocyanines were obtained in good yields. Upon investigation of regioisomer-free zinc β-tetrakis(tert-butyl)phthalocyanine using spectroscopy, the C 4h single isomer described here was found to be distinct in the solid state to zinc β-tetrakis(tert-butyl)phthalocyanine obtained by a conventional method.
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http://dx.doi.org/10.1002/open.201402093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420579PMC
April 2015

Cinchona alkaloid/Ti(IV)-catalyzed enantioselective enamine-trifluoropyruvate condensation-cyclization reaction and its application to drug-like heterocycles.

Chemistry 2010 Jun;16(24):7090-5

Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, 466-8555 Japan.

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http://dx.doi.org/10.1002/chem.201000911DOI Listing
June 2010