Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma.
Biochem Biophys Res Commun 2017 Mar 20;484(2):269-277. Epub 2017 Jan 20.
Department of Molecular Pathology, Tokyo Medical University, Tokyo, Japan; Biomedical Research Institute, Kyungpook National University Hospital, Daegu, Republic of Korea; Physician, Student and Researcher Support Center, Tokyo Medical University, Tokyo, Japan. Electronic address:

Randomized Phase III Study Comparing Gefitinib With Erlotinib in Patients With Previously Treated Advanced Lung Adenocarcinoma: WJOG 5108L.
J Clin Oncol 2016 Sep 28;34(27):3248-57. Epub 2016 Mar 28.
Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and Masashi Kanehara, Hiroshima City Hospital, Hiroshima; Norihiko Ikeda, Tokyo Medical University, Tokyo; Haruyasu Murakami, Shizuoka Cancer Center, Shizuoka; Haruko Daga, Osaka City General Hospital; Fumio Imamura, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka; Isao Goto, Osaka Medical College, Takatsuki; Hideo Saka, National Hospital Organization Nagoya Medical Center; Tetsuya Oguri, Nagoya City University Graduate School of Medical Sciences, Nagoya; Shunichi Sugawara, Sendai Kousei Hospital, Sendai; Naoyuki Nogami, National Hospital Organization Shikoku Cancer Center, Matsuyama; and Kazuhiko Nakagawa, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.

Severity of lung fibrosis affects early surgical outcomes of lung cancer among patients with combined pulmonary fibrosis and emphysema.
Medicine (Baltimore) 2016 Jul;95(29):e4314
aDepartment of Surgical Oncology, Hiroshima University, Hiroshima bDepartment of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo cDivision of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa dDepartment of Surgery, Tokyo Medical University, Tokyo, Japan.

Drastic morphological and molecular differences between lymph node micrometastatic tumors and macrometastatic tumors of lung adenocarcinoma.
J Cancer Res Clin Oncol 2016 Jan 18;142(1):37-46. Epub 2015 Jun 18.
Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Three-dimensional multidetector computed tomography may aid preoperative planning of the transmanubrial osteomuscular-sparing approach to completely resect superior sulcus tumor.
Gen Thorac Cardiovasc Surg 2015 Nov 25;63(11):627-31. Epub 2014 Jan 25.
Department of Thoracic Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Cost-Benefit Performance of Robotic Surgery Compared with Video-Assisted Thoracoscopic Surgery under the Japanese National Health Insurance System.
Ann Thorac Cardiovasc Surg 2015 16;21(2):95-101. Epub 2014 May 16.
Department of Surgery, Tokyo Medical University, Tokyo, Japan; Department of Health Science and Social Welfare, Waseda University School of Human Sciences, Tokyo, Japan.

Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank Repositories.
Clin Transl Med 2014 Dec 22;3(1):61. Epub 2014 Nov 22.
First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, 160-0023 Japan ; Clinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC D13, 221 84 Lund, Sweden ; Center of Excellence in Biological and Medical mass spectrometry (CEBMMS), 221 84 Lund, Sweden.

Insulin-like growth factor-1 receptor (IGF-1R) as a biomarker for resistance to the tyrosine kinase inhibitor gefitinib in non-small cell lung cancer.
Cell Oncol (Dordr) 2013 Jul 26;36(4):277-88. Epub 2013 Apr 26.
Department of Medicine/Medical Oncology, University of Colorado Cancer Center, UC Denver, 12801 E 17th Ave, Mail Stop 8177, Aurora, CO 80045, USA.

Klotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgery.
Lung Cancer 2011 Nov 6;74(2):332-7. Epub 2011 May 6.
Division of Thoracic Surgery, Department of Surgery 1, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Randomized phase II study of two schedules of carboplatin and gemcitabine for stage IIIB and IV advanced non-small cell lung cancer (JACCRO LC-01 study).
Chemotherapy 2011 6;57(4):357-62. Epub 2011 Sep 6.
Department of Thoracic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan. imamura-fu @