Publications by authors named "Norhayati Yahaya"

4 Publications

  • Page 1 of 1

Prevalence of Vitamin B12 Deficiency and its Associated Factors among Patients with Type 2 Diabetes Mellitus on Metformin from a District in Malaysia.

J ASEAN Fed Endocr Soc 2020 25;35(2):163-168. Epub 2020 Aug 25.

Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia.

Introduction: Vitamin B12 deficiency is more common among metformin-treated subjects although the prevalence is variable. Many factors have been associated with this. The aim of this study is to determine the prevalence of vitamin B12 deficiency and its associated factors among patients with type 2 diabetes mellitus (DM) who are on metformin.

Methodology: A total of 205 patients who fit eligibility criteria were included in the study. A questionnaire was completed, and blood was drawn to study vitamin B12 levels. Vitamin B12 deficiency was defined as serum B12 level of ≤300 pg/mL (221 pmol/L).

Results: The prevalence of vitamin B12 deficiency among metformin-treated patients with type 2 DM patients was 28.3% (n=58). The median vitamin B12 level was 419 (±257) pg/mL. The non-Malay population was at a higher risk for metformin-associated vitamin B12 deficiency [adjusted odds ratio (OR) 3.86, 95% CI: 1.836 to 8.104, p<0.001]. Duration of metformin use of more than five years showed increased risk for metformin-associated vitamin B12 deficiency (adjusted OR 2.06, 95% CI: 1.003 to 4.227, =0.049).

Conclusion: Our study suggests that the prevalence of vitamin B12 deficiency among patients with type 2 diabetes mellitus on metformin in our population is substantial. This is more frequent among the non-Malay population and those who have been on metformin for more than five years.
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http://dx.doi.org/10.15605/jafes.035.02.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784158PMC
August 2020

Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study.

Diagnostics (Basel) 2020 Dec 11;10(12). Epub 2020 Dec 11.

Endocrine Unit, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases ( = 64, hyperthyroid; = 53 euthyroid; = 18, hypothyroid) and healthy controls ( = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.
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http://dx.doi.org/10.3390/diagnostics10121075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763871PMC
December 2020

Hyperthyroidism presenting as ST Elevation Myocardial Infarction with Normal Coronaries - A Case Report.

J ASEAN Fed Endocr Soc 2019 3;34(1):92-94. Epub 2019 Apr 3.

Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia.

A 31-year-old male, apparently well, presented with typical chest pain. His ECG showed ST-elevation from V1-V4 and echocardiogram revealed anteroseptal wall hypokinesia with ejection fraction of 45%. Normal coronary arteries were seen on coronary angiogram. A thyroid function test showed elevated free T4 levels with suppressed thyroid stimulating hormone (TSH). Treatment with thionamides and beta-blockers improved symptoms. Upon review 4 months later he was well. Repeat echocardiogram showed good ejection fraction with no hypokinetic area.
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http://dx.doi.org/10.15605/jafes.034.01.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784089PMC
April 2019

Case Report of an Adult Female with Neglected Congenital Adrenal Hyperplasia (CAH).

J ASEAN Fed Endocr Soc 2018 9;33(2):199-201. Epub 2018 Oct 9.

Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia.

An apparently well 27-year-old phenotypically male adult was seen at the endocrine clinic for gender assignment. Patient had been raised as a male and identifies as such. Abdominal CT scan showed a unilateral left adrenal mass and karyotyping revealed 46 XX female karyotype. She was diagnosed to have simple virilizing CAH and needed thorough counselling with subsequent management by a multidisciplinary team.
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http://dx.doi.org/10.15605/jafes.033.02.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784164PMC
October 2018