Publications by authors named "Norbert Krug"

87Publications

Blood eosinophils predict therapeutic effects of a GATA3-specific DNAzyme in asthma patients.

J Allergy Clin Immunol 2017 08 22;140(2):625-628.e5. Epub 2017 Mar 22.

Institute of Laboratory Medicine, Philipps University Marburg, Marburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749173042
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http://dx.doi.org/10.1016/j.jaci.2017.02.024DOI Listing
August 2017

Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure.

Ann Allergy Asthma Immunol 2017 03;118(3):290-297

Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Research, Hannover, Germany.

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http://dx.doi.org/10.1016/j.anai.2017.01.018DOI Listing
March 2017

Efficacy and safety of a novel nasal steroid, S0597, in patients with seasonal allergic rhinitis.

Ann Allergy Asthma Immunol 2015 Oct 11;115(4):325-329.e1. Epub 2015 Aug 11.

Clinical Research Department, Sun Pharma Advanced Research Company Ltd, Mumbai, India.

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http://dx.doi.org/10.1016/j.anai.2015.07.016DOI Listing
October 2015

Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber.

J Allergy Clin Immunol 2015 Jul 1;136(1):96-103.e9. Epub 2015 Jun 1.

Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Research (BREATH), Member of the German Center for Lung Research, Hannover, Germany.

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http://dx.doi.org/10.1016/j.jaci.2015.04.015DOI Listing
July 2015

Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme.

N Engl J Med 2015 May 17;372(21):1987-95. Epub 2015 May 17.

From the Fraunhofer Institute for Toxicology and Experimental Medicine (N.K., J.M.H.) and the Department of Dermatology and Allergy, Hannover Medical School (J.Z., T.W.), Hannover, Pulmonary Research Institute at Lung Clinic Grosshansdorf, Grosshansdorf (A.-M.K.), Institut für klinische Forschung Pneumologie, Clinical Research Center Respiratory Medicine, Frankfurt (O.K.), Insaf Respiratory Research Institute, Wiesbaden (K.M.B.), Inamed, Gauting (D.K., W.T.), Pulmonary Department, Medical Clinic, University Hospital Mainz, Mainz (S.K., R.B.), Charité Research Organization, Berlin (S.I.), FGK Clinical Research, Munich (C.R.), Sterna Biologicals (J.B., U.H., A.T., J.R.) and Institute of Laboratory Medicine, Philipps University Marburg, a member of Universities Giessen and Marburg Lung Center (H.G., H.R.), Marburg - all in Germany; Upper Airways Research Laboratory, University Hospital Ghent, Ghent, Belgium (N.Z., C.B.); and the Division of Ear, Nose, and Throat Diseases, Clintec, Karolinska Institute, Stockholm (N.Z., C.B.).

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http://ssom.luc.edu/media/stritchschoolofmedicine/publicheal
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http://www.nejm.org/doi/abs/10.1056/NEJMoa1411776
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http://dx.doi.org/10.1056/NEJMoa1411776DOI Listing
May 2015

Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma.

J Allergy Clin Immunol 2015 Sep 2;136(3):797-800. Epub 2015 Apr 2.

Institute of Laboratory Medicine and Pathobiochemistry-Molecular Diagnostics, Medical Faculty, Philipps University Marburg, Universities of Giessen and Marburg Lung Center (UGMLC), Marburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.02.018DOI Listing
September 2015

Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging: a proof of concept study.

Radiology 2015 Jan 8;274(1):267-75. Epub 2014 Sep 8.

From the Department of Diagnostic and Interventional Radiology (J.R., J.H., C.S., M.G., F.W., J.V.), Fraunhofer Institute for Toxicology and Experimental Medicine (C.W., C.F., F.S., N.K., J.M.H.), and Department of Pneumology (C.W., J.M.H.), Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, OE 8220, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Department of Experimental Physics (Biophysics), University of Würzburg, Würzburg, Germany (P.J.).

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http://dx.doi.org/10.1148/radiol.14132607DOI Listing
January 2015

Phase-contrast MRI for detection of mild systemic hemodynamic response after segmental allergen challenge in asthmatic patients.

Acad Radiol 2014 Aug;21(8):994-1001

Institute of Interventional Radiology, Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, OE 8220, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1016/j.acra.2014.03.003DOI Listing
August 2014

Identification and quantification of basophils in the airways of asthmatics following segmental allergen challenge.

Cytometry A 2014 Jul 14;85(7):580-7. Epub 2014 Apr 14.

Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, D-30625, Hannover, Germany; Department of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, D-30625, Hannover, Germany.

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http://dx.doi.org/10.1002/cyto.a.22472DOI Listing
July 2014

Cell counting in human endobronchial biopsies--disagreement of 2D versus 3D morphometry.

PLoS One 2014 24;9(3):e92510. Epub 2014 Mar 24.

Department of Pneumology, Philipps-University Marburg, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Marburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092510PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963904PMC
January 2015

Omalizumab in patients with allergic (IgE-mediated) asthma and IgE/bodyweight combinations above those in the initially approved dosing table.

Pulm Pharmacol Ther 2014 Aug 18;28(2):149-53. Epub 2014 Mar 18.

Novartis Pharma AG, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2014.03.003DOI Listing
August 2014

Pollen starch granules in bronchial inflammation.

Ann Allergy Asthma Immunol 2012 Sep 18;109(3):208-214.e6. Epub 2012 Jul 18.

Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.

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http://dx.doi.org/10.1016/j.anai.2012.06.019DOI Listing
September 2012

Anti-allergic drug testing in an environmental challenge chamber is suitable both in and out of the relevant pollen season.

Ann Allergy Asthma Immunol 2011 Apr 5;106(4):336-41. Epub 2011 Feb 5.

Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S108112061001254
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http://dx.doi.org/10.1016/j.anai.2010.12.018DOI Listing
April 2011

Breath profiles by electronic nose correlate with systemic markers but not ozone response.

Respir Med 2011 Sep 24;105(9):1352-63. Epub 2011 Mar 24.

Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Nikolai-Fuchs-Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1016/j.rmed.2011.03.002DOI Listing
September 2011

Surfactant protein D modulates pulmonary clearance of pollen starch granules.

Exp Lung Res 2010 Nov;36(9):522-30

Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.

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http://dx.doi.org/10.3109/01902141003790148DOI Listing
November 2010

A Toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to Timothy grass pollen antigens.

Int Arch Allergy Immunol 2010 16;152(2):131-9. Epub 2009 Dec 16.

Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.

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http://dx.doi.org/10.1159/000265534DOI Listing
June 2010

Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2010 Mar 10;181(5):438-45. Epub 2009 Dec 10.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200909-1415O
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http://dx.doi.org/10.1164/rccm.200909-1415OCDOI Listing
March 2010

The effect of titanium dioxide nanoparticles on pulmonary surfactant function and ultrastructure.

Respir Res 2009 Sep 30;10:90. Epub 2009 Sep 30.

Fraunhofer Institute of Toxicology and Experimental Medicine, Division of Immunology, Allergology and Airway Research, Nikolai-Fuchs-Str, 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1186/1465-9921-10-90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765946PMC
September 2009

Therapeutic surfactants modulate the viability of eosinophils and induce inflammatory mediator release.

Int Arch Allergy Immunol 2009 17;149(4):333-42. Epub 2009 Mar 17.

Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.

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https://www.karger.com/Article/FullText/205579
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http://dx.doi.org/10.1159/000205579DOI Listing
August 2009

Dendritic cell-nerve clusters are sites of T cell proliferation in allergic airway inflammation.

Am J Pathol 2009 Mar 29;174(3):808-17. Epub 2009 Jan 29.

Dept. of Immunology, Allergology, and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs-Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.2353/ajpath.2009.080800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665742PMC
March 2009

Effects of the phosphodiesterase type 4 inhibitor roflumilast on early and late allergic response and airway hyperresponsiveness in Aspergillus-fumigatus-sensitized mice.

Pharmacology 2009 29;83(3):188-95. Epub 2009 Jan 29.

Fraunhofer Institute of Toxicology and Experimental Medicine (Fraunhofer ITEM), Hannover, Germany.

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http://dx.doi.org/10.1159/000196814DOI Listing
March 2009

Therapeutic use of surfactant components in allergic asthma.

Naunyn Schmiedebergs Arch Pharmacol 2009 Mar 15;379(3):217-24. Epub 2008 Oct 15.

Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.

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http://dx.doi.org/10.1007/s00210-008-0354-zDOI Listing
March 2009

Animal models for human asthma: the perspective of a clinician.

Curr Drug Targets 2008 Jun;9(6):438-42

Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Nikolai-Fuchs-Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.2174/138945008784533598DOI Listing
June 2008

Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma.

Am J Respir Crit Care Med 2008 Jun 3;177(12):1307-13. Epub 2008 Apr 3.

Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs-Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1164/rccm.200706-870OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427055PMC
June 2008

Pneumococcal vaccines: mechanism of action, impact on epidemiology and adaption of the species.

Int J Antimicrob Agents 2008 Sep 18;32(3):199-206. Epub 2008 Apr 18.

Department of Pulmonary Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S092485790800053
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http://dx.doi.org/10.1016/j.ijantimicag.2008.01.021DOI Listing
September 2008

Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: a randomized placebo-controlled trial.

Pulm Pharmacol Ther 2008 Aug 21;21(4):616-23. Epub 2008 Feb 21.

Department of Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Nikolai-Fuchs-Street 1A, D-30625 Hannover, Germany.

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http://dx.doi.org/10.1016/j.pupt.2008.02.002DOI Listing
August 2008

Neuroimmune crosstalk in asthma: dual role of the neurotrophin receptor p75NTR.

J Allergy Clin Immunol 2007 Nov 22;120(5):1089-96. Epub 2007 Aug 22.

Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.

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http://dx.doi.org/10.1016/j.jaci.2007.07.007DOI Listing
November 2007

Safety and tolerability of indacaterol in asthma: a randomized, placebo-controlled 28-day study.

Respir Med 2007 Oct 20;101(10):2065-75. Epub 2007 Jul 20.

Pulmonology Research Institute, Parkovaya Street, 32/61, 105077 Moscow, Russian Federation.

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http://dx.doi.org/10.1016/j.rmed.2007.06.002DOI Listing
October 2007

Spatial interactions between dendritic cells and sensory nerves in allergic airway inflammation.

Am J Respir Cell Mol Biol 2007 Nov 28;37(5):553-61. Epub 2007 Jun 28.

Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.

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http://dx.doi.org/10.1165/rcmb.2007-0087OCDOI Listing
November 2007

Effects of keratinocyte growth factor on intra-alveolar surfactant fixed in situ: Quantitative ultrastructural and immunoelectron microscopic analysis.

Anat Rec (Hoboken) 2007 Aug;290(8):974-80

Clinical Research Group "Chronic Airway Diseases", Clinic of Internal Medicine (Respiratory Medicine), Philipps-University Marburg, Baldingerstrasse, Marburg Germany.

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http://doi.wiley.com/10.1002/ar.20549
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http://dx.doi.org/10.1002/ar.20549DOI Listing
August 2007

Usefulness of pollen chamber in the evaluation of clinical trials with allergen products.

Authors:
Norbert Krug

Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M 2006 (95):167-70; discussion 170-1

Fraunhofer Institut, Hannover.

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April 2007

[Pathomechanisms in chronic obstructive pulmonary disease (COPD)].

Med Klin (Munich) 2006 Dec;101(12):951-6

Abteilung Pneumologie, Medizinische Hochschule Hannover, Hannover, Deutschland.

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http://dx.doi.org/10.1007/s00063-006-1126-5DOI Listing
December 2006

Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers.

Environ Health Perspect 2006 Nov;114(11):1655-61

Drug Research and Medical Biotechnology, Fraunhofer Instituteof technology and Experimental Medicien, Hannover, Germany.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.8861
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665420PMC
http://dx.doi.org/10.1289/ehp.8861DOI Listing
November 2006

Induced trefoil factor family 1 expression by trans-differentiating Clara cells in a murine asthma model.

Am J Respir Cell Mol Biol 2007 Mar 21;36(3):286-95. Epub 2006 Sep 21.

Institut für Molekularbiologie und Medizinische Chemie, Otto-von-Guericke-Universität, Magdeburg; and Fraunhofer-Institut für Toxikologie und Experimentelle Medizin, Hannover, Germany.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2006-0008OC
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http://dx.doi.org/10.1165/rcmb.2006-0008OCDOI Listing
March 2007

Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma.

J Allergy Clin Immunol 2006 Sep 3;118(3):597-605. Epub 2006 Jul 3.

Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S009167490600948
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http://dx.doi.org/10.1016/j.jaci.2006.04.052DOI Listing
September 2006

Regulation of GATA-3, c-maf and T-bet mRNA expression in bronchoalveolar lavage cells and bronchial biopsies after segmental allergen challenge.

Int Arch Allergy Immunol 2006 22;139(4):306-16. Epub 2006 Feb 22.

Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.

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http://dx.doi.org/10.1159/000091602DOI Listing
June 2006

Invasive versus noninvasive measurement of allergic and cholinergic airway responsiveness in mice.

Respir Res 2005 Nov 25;6:139. Epub 2005 Nov 25.

Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1186/1465-9921-6-139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1316879PMC
November 2005

Efficacy of macrophage-activating lipopeptide-2 combined with interferon-gamma in a murine asthma model.

Am J Respir Crit Care Med 2005 Sep 18;172(5):566-72. Epub 2005 May 18.

Department of Immunology, Allergology, and Clinical Inhalation, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs-Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1164/rccm.200411-1490OCDOI Listing
September 2005

Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules.

Am J Physiol Lung Cell Mol Physiol 2005 Apr 10;288(4):L692-8. Epub 2004 Dec 10.

Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs-Str. 1a, 30625 Hannover, Germany.

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http://dx.doi.org/10.1152/ajplung.00362.2004DOI Listing
April 2005

Influence of plasma and inflammatory proteins on the ultrastructure of exogenous surfactant.

J Electron Microsc (Tokyo) 2004 ;53(4):407-16

Centre of Anatomy, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1093/jmicro/dfh056DOI Listing
January 2005

Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects.

Am J Respir Crit Care Med 2004 Oct 30;170(8):898-903. Epub 2004 Jun 30.

Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, Hannover 30625, Germany.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200403-423OC
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http://dx.doi.org/10.1164/rccm.200403-423OCDOI Listing
October 2004

The Toll-like receptor-2/6 agonist macrophage-activating lipopeptide-2 cooperates with IFN-gamma to reverse the Th2 skew in an in vitro allergy model.

J Immunol 2004 May;172(10):6080-6

Fraunhofer Institute of Toxicology and Experimental Medicine, Department of Immunology, Allergology, and Clinical Inhalation, Hannover, Germany.

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http://dx.doi.org/10.4049/jimmunol.172.10.6080DOI Listing
May 2004

Repetitive measurements of pulmonary mechanics to inhaled cholinergic challenge in spontaneously breathing mice.

J Appl Physiol (1985) 2004 Sep 30;97(3):1104-11. Epub 2004 Apr 30.

Fraunhofer Institute of Technology and Experimental Medicine, D-30625 Hannover, Germany.

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http://dx.doi.org/10.1152/japplphysiol.01182.2003DOI Listing
September 2004

Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma.

J Allergy Clin Immunol 2004 Mar;113(3):496-502

Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.jaci.2003.12.008DOI Listing
March 2004

Keratinocyte growth factor transiently alters pulmonary function in rats.

J Appl Physiol (1985) 2004 Feb 17;96(2):704-10. Epub 2003 Oct 17.

Department of Respiratory Medicine, Hannover Medical School, D-30625 Hannover, Germany.

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http://dx.doi.org/10.1152/japplphysiol.00783.2003DOI Listing
February 2004

Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes.

J Allergy Clin Immunol 2003 Jun;111(6):1319-27

Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover Medical School, Nikolai-Fuchs-Strasse 1a, 30625 Hannover, Germany.

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http://dx.doi.org/10.1067/mai.2003.1485DOI Listing
June 2003

Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells.

Immunobiology 2003 ;207(3):223-33

Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.

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http://dx.doi.org/10.1078/0171-2985-00234DOI Listing
January 2004

Increased expression of interleukin-9 messenger RNA after segmental allergen challenge in allergic asthmatics.

Chest 2003 Mar;123(3 Suppl):370S

Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany.

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March 2003

Increased messenger RNA expression of c-maf and GATA-3 after segmental allergen challenge in allergic asthmatics.

Chest 2003 Mar;123(3 Suppl):370S-1S

Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany.

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March 2003

Surfactant homeostasis is maintained in vivo during keratinocyte growth factor-induced rat lung type II cell hyperplasia.

Am J Respir Crit Care Med 2003 May 5;167(9):1264-70. Epub 2003 Feb 5.

Division of Electron Microscopy, Center of Anatomy, University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1164/rccm.200112-132OCDOI Listing
May 2003

Noninvasive measurement of midexpiratory flow indicates bronchoconstriction in allergic rats.

J Appl Physiol (1985) 2002 Oct;93(4):1208-14

Department of Respiratory Medicine, Hannover Medical School, 30625 Hannover, Germany.

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http://dx.doi.org/10.1152/japplphysiol.01121.2001DOI Listing
October 2002