Publications by authors named "Nora A Barrett"

31Publications

Leukotriene D paradoxically limits LTC-driven platelet activation and lung immunopathology.

J Allergy Clin Immunol 2020 Dec 4. Epub 2020 Dec 4.

Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Boston, Mass; Jeff and Penny Vinik Center for Allergic Disease Research, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass. Electronic address:

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December 2020

Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation.

J Exp Med 2021 Jan;218(1)

Jeff and Penny Vinik Center for Allergic Disease Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA.

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January 2021

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

Cell 2020 05 27;181(5):1016-1035.e19. Epub 2020 Apr 27.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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May 2020

IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease.

J Allergy Clin Immunol 2020 Jun 19;145(6):1574-1584. Epub 2020 Mar 19.

Department of Medicine, Harvard Medical School, Boston, Mass; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass. Electronic address:

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June 2020

Epithelial cell function and remodeling in nasal polyposis.

Ann Allergy Asthma Immunol 2020 04 30;124(4):333-341. Epub 2020 Jan 30.

Division of Allergy and Clinical Immunology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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April 2020

Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2.

Sci Immunol 2020 01 17;5(43). Epub 2020 Jan 17.

Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA.

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January 2020

Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia.

J Allergy Clin Immunol 2019 11 7;144(5):1158-1160. Epub 2019 Oct 7.

Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, MIT, Cambridge; Broad Institute of MIT and Harvard, Cambridge; Ragon Institute of MGH, MIT, and Harvard, Cambridge.

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November 2019

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas.

J Vis Exp 2019 06 12(148). Epub 2019 Jun 12.

Division of Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School;

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June 2019

The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation.

Sci Immunol 2018 10;3(28)

Division of Rheumatology, Immunology and Allergy, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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October 2018

Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity.

J Immunol 2018 02 27;200(3):915-927. Epub 2017 Dec 27.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115;

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February 2018

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s.

J Exp Med 2017 01 23;214(1):27-37. Epub 2016 Dec 23.

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143

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January 2017

Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity.

J Immunol 2016 07 18;197(1):278-87. Epub 2016 May 18.

Department of Medicine, Harvard Medical School, Boston, MA 02115; Jeff and Penny Vinik Center for Allergic Disease Research, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115;

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July 2016

Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99.

Proc Natl Acad Sci U S A 2016 May 16;113(22):6242-7. Epub 2016 May 16.

Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Boston, MA 02115; Department of Medicine, Harvard Medical School, Boston, MA 02115

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May 2016

Expression profiling of constitutive mast cells reveals a unique identity within the immune system.

Nat Immunol 2016 Jul 2;17(7):878-87. Epub 2016 May 2.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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July 2016

Licensed to Ill: IL-9 Generation in Immature Mast Cells Permits Food-Elicited Anaphylaxis.

Immunity 2015 Oct;43(4):626-8

Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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October 2015

Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway.

J Immunol 2015 Oct 4;195(8):3537-45. Epub 2015 Sep 4.

Department of Medicine, Harvard Medical School, Boston, MA 02115; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115; Jeff and Penny Vinik Center for Allergic Disease Research, Boston, MA 02115; Department of Pediatrics, Harvard Medical School, Boston, MA 02115

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October 2015

Signaling through FcRγ-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses.

J Allergy Clin Immunol 2014 Sep 31;134(3):706-713.e8. Epub 2014 Jul 31.

Committee on Immunology, University of Chicago, Chicago, Ill; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Ill; Committee on Molecular Pathogenesis and Molecular Medicine, University of Chicago, Chicago, Ill. Electronic address:

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September 2014

Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease.

J Allergy Clin Immunol Pract 2014 Mar-Apr;2(2):208-13.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass. Electronic address:

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May 2014

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes.

J Exp Med 2011 Mar 28;208(3):593-604. Epub 2011 Feb 28.

Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

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March 2011

Inhibition of Th2 adaptive immune responses and pulmonary inflammation by leukocyte Ig-like receptor B4 on dendritic cells.

J Immunol 2010 Jan 4;184(2):1003-13. Epub 2009 Dec 4.

Department of Medicine, Harvard Medical School and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

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January 2010

Innate cells and T helper 2 cell immunity in airway inflammation.

Immunity 2009 Sep;31(3):425-37

Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

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September 2009

Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.

J Immunol 2009 Jan;182(2):1119-28

Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

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January 2009