Noelle S Williams

Noelle S Williams

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Noelle S Williams

Noelle S Williams

Publications by authors named "Noelle S Williams"

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55Publications

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Benzothiourea Derivatives Target the Secretory Pathway of the Human Fungal Pathogen .

ACS Infect Dis 2020 Feb 26. Epub 2020 Feb 26.

Department of Pediatrics, Carver College of Medicine , University of Iowa , 25 South Grand Avenue , Iowa City , Iowa 52245 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.9b00478DOI Listing
February 2020

NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers.

Clin Cancer Res 2019 04 7;25(8):2601-2609. Epub 2019 Jan 7.

Department of Biochemistry and Molecular Biology, Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-2560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788754PMC
April 2019

Targeting NAD Metabolism to Enhance Radiation Therapy Responses.

Semin Radiat Oncol 2019 01;29(1):6-15

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN.

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http://dx.doi.org/10.1016/j.semradonc.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310039PMC
January 2019

(-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia.

Biol Psychiatry 2018 10 6;84(7):488-498. Epub 2017 Nov 6.

Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Department of Neurology, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Free Radical and Radiation Biology Program, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Department of Radiation Oncology, Holden Comprehensive Cancer Center, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Pappajohn Biomedical Institute, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Interdisciplinary Graduate Program in Human Toxicology, Department of Occupational and Environmental Health, University of Iowa College of Public Health, Iowa City, Iowa; Iowa City VA Health Care System, Iowa City, Iowa; Weill Cornell Autism Research Program, Weill Cornell Medical College New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415524PMC
October 2018

Neuroprotective efficacy of P7C3 compounds in primate hippocampus.

Transl Psychiatry 2018 09 26;8(1):202. Epub 2018 Sep 26.

University Hospital Case Medical Center; Department of Psychiatry Case Western Reserve University; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland VAMC, Harrington Discovery Institute, Cleveland, OH, 44106, USA.

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http://dx.doi.org/10.1038/s41398-018-0244-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158178PMC
September 2018

Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells.

Sci Rep 2018 01 17;8(1):967. Epub 2018 Jan 17.

The Center for Drug Discovery, Design and Delivery, the Center for Scientific Computing, Southern Methodist University, Dallas, TX, 75275-0376, USA.

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http://dx.doi.org/10.1038/s41598-018-19325-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772368PMC
January 2018

Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.

J Med Chem 2017 05 25;60(9):3979-4001. Epub 2017 Apr 25.

Department of Biochemistry, UT Southwestern Medical Center , 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580352PMC
May 2017

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

Science 2017 04 16;356(6336). Epub 2017 Mar 16.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/science.aal3755DOI Listing
April 2017

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.

Proc Natl Acad Sci U S A 2017 02 31;114(7):1649-1654. Epub 2017 Jan 31.

Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.1621346114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320972PMC
February 2017

Development of a triazole class of highly potent Porcn inhibitors.

Bioorg Med Chem Lett 2016 12 11;26(24):5891-5895. Epub 2016 Nov 11.

Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142825PMC
December 2016

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.

Sci Transl Med 2016 10;8(361):361ra140

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf8127DOI Listing
October 2016

Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma.

Mol Cancer Ther 2016 05 28;15(5):866-76. Epub 2016 Jan 28.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern, Dallas, Texas. Department of Internal Medicine, University of Texas Southwestern, Dallas, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0729-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873341PMC
May 2016

Identification of CREB3L1 as a Biomarker Predicting Doxorubicin Treatment Outcome.

PLoS One 2015 25;10(6):e0129233. Epub 2015 Jun 25.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129233PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482141PMC
April 2016

Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease.

NPJ Parkinsons Dis 2015;1. Epub 2015 May 21.

Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Department of Free Radical and Radiation Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA; The Iowa City Department of Veterans Affairs, Iowa City, IA, USA.

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http://dx.doi.org/10.1038/npjparkd.2015.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859442PMC
May 2015

Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy.

J Control Release 2015 Feb 24;200:201-11. Epub 2014 Dec 24.

Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659140082
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http://dx.doi.org/10.1016/j.jconrel.2014.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803448PMC
February 2015

Diet-induced unresolved ER stress hinders KRAS-driven lung tumorigenesis.

Cell Metab 2015 Jan 18;21(1):117-25. Epub 2014 Dec 18.

Department of Cell Physiology and Metabolism, University of Geneva, 1211 Geneva 4, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305190PMC
January 2015

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.

Chem Biol 2014 Dec 4;21(12):1680-9. Epub 2014 Dec 4.

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272670PMC
December 2014

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.

Elife 2014 Jul 29;3:e03206. Epub 2014 Jul 29.

Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States

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http://dx.doi.org/10.7554/eLife.03206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129439PMC
July 2014

Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.

J Med Chem 2014 May 16;57(9):3746-54. Epub 2014 Apr 16.

Departments of †Biochemistry and ‡Neuroscience, University of Texas Southwestern Medical Center , 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States.

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http://dx.doi.org/10.1021/jm401919sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206694PMC
May 2014

Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors.

Cancer Res 2014 Jan 27;74(2):586-97. Epub 2013 Nov 27.

Authors' Affiliations: Departments of Dermatology, Developmental Biology, and Biochemistry, and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947005PMC
January 2014

Identification of DNMT1 selective antagonists using a novel scintillation proximity assay.

J Biol Chem 2013 Jul 13;288(27):19673-84. Epub 2013 May 13.

Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1074/jbc.M112.443895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707673PMC
July 2013

A mass balance approach for calculation of recovery and binding enables the use of ultrafiltration as a rapid method for measurement of plasma protein binding for even highly lipophilic compounds.

J Pharm Biomed Anal 2013 Mar 21;75:112-7. Epub 2012 Nov 21.

Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S07317085120063
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http://dx.doi.org/10.1016/j.jpba.2012.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545278PMC
March 2013

The development of highly potent inhibitors for porcupine.

J Med Chem 2013 Mar 19;56(6):2700-4. Epub 2013 Mar 19.

Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1021/jm400159cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631274PMC
March 2013

Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model.

Am J Physiol Heart Circ Physiol 2012 May 9;302(9):H1847-59. Epub 2012 Mar 9.

Department of Surgery, University of Texas Southwestern Medical center, Dallas, Texas 75390-9160, USA.

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http://dx.doi.org/10.1152/ajpheart.00203.2011DOI Listing
May 2012

Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species.

Am J Physiol Cell Physiol 2011 Sep 8;301(3):C695-704. Epub 2011 Jun 8.

Dept. of Surgery, The Univ. of Texas Southwestern Medical Cente at Dallas, 75390-9156, USA.

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http://dx.doi.org/10.1152/ajpcell.00322.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174570PMC
September 2011

Development of proneurogenic, neuroprotective small molecules.

J Am Chem Soc 2011 Feb 6;133(5):1428-37. Epub 2011 Jan 6.

Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States.

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http://dx.doi.org/10.1021/ja108211mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033481PMC
February 2011

Structure-activity relationship studies of small-molecule inhibitors of Wnt response.

Bioorg Med Chem Lett 2009 Jul 18;19(14):3825-7. Epub 2009 Apr 18.

Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709695PMC
July 2009

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

Nat Chem Biol 2009 Feb 4;5(2):100-7. Epub 2009 Jan 4.

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/nchembio.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628455PMC
February 2009

Phase I dose escalation study with irinotecan, capecitabine, epirubicin, and granulocyte colony-stimulating factor support for patients with solid malignancies.

Am J Clin Oncol 2008 Jun;31(3):219-25

Translational Oncology Program-Phase I unit, Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA.

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http://dx.doi.org/10.1097/COC.0b013e31815a438fDOI Listing
June 2008

Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity.

Proc Natl Acad Sci U S A 2007 Feb 7;104(7):2074-9. Epub 2007 Feb 7.

Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.0611340104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794345PMC
February 2007