Noelia Nebot

Noelia Nebot

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Noelia Nebot

Noelia Nebot

Publications by authors named "Noelia Nebot"

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Metabolism and disposition of oral dabrafenib in cancer patients: proposed participation of aryl nitrogen in carbon-carbon bond cleavage via decarboxylation following enzymatic oxidation.

Drug Metab Dispos 2013 Dec 4;41(12):2215-24. Epub 2013 Oct 4.

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M).

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http://dx.doi.org/10.1124/dmd.113.053785DOI Listing
December 2013

Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites.

Drug Metab Dispos 2013 Jun 12;41(6):1179-86. Epub 2013 Mar 12.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1124/dmd.112.048181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657095PMC
June 2013

Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes.

Br J Pharmacol 2010 Nov;161(5):1059-69

Pharmacogenomics and Drug Development Group, Faculty of Pharmacy, University of Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/j.1476-5381.2010.00946.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998687PMC
November 2010

Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease.

Br J Clin Pharmacol 2010 Sep;70(3):400-8

Pharmacogenomics and Drug Development Group, Faculty of Pharmacy, University of Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.1111/j.1365-2125.2010.03715.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949913PMC
September 2010