Noel Southall

Noel Southall

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Noel Southall

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How to Illuminate the Druggable Genome Using Pharos.

Curr Protoc Bioinformatics 2020 Mar;69(1):e92

Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico.

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http://dx.doi.org/10.1002/cpbi.92DOI Listing
March 2020

Evaluating kratom alkaloids using PHASE.

PLoS One 2020 3;15(3):e0229646. Epub 2020 Mar 3.

Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229646PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053747PMC
March 2020

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding.

Commun Biol 2020 Mar 6;3(1):109. Epub 2020 Mar 6.

Laboratory of Molecular Signaling, National Institute on Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Rockville, MD, 20852, USA.

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http://dx.doi.org/10.1038/s42003-020-0831-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060178PMC
March 2020

Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus.

J Med Chem 2020 Mar 27. Epub 2020 Mar 27.

Department of Pediatrics, Division of Infectious Disease, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01501DOI Listing
March 2020

Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models.

Sci Adv 2020 02 7;6(6):eaaz2736. Epub 2020 Feb 7.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1126/sciadv.aaz2736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032923PMC
February 2020

The NCATS Pharmaceutical Collection: a 10-year update.

Drug Discov Today 2019 Dec 1;24(12):2341-2349. Epub 2019 Oct 1.

Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.drudis.2019.09.019DOI Listing
December 2019

Agonist-specific voltage-dependent gating of lysosomal two-pore Na channels.

Elife 2019 12 11;8. Epub 2019 Dec 11.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.

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http://dx.doi.org/10.7554/eLife.51423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905855PMC
December 2019

Novel Consensus Architecture To Improve Performance of Large-Scale Multitask Deep Learning QSAR Models.

J Chem Inf Model 2019 Nov 25;59(11):4613-4624. Epub 2019 Oct 25.

National Center for Advancing Translational Sciences (NCATS) , National Institutes of Health , 9800 Medical Center Drive , Rockville , Maryland 20850 , United States.

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http://dx.doi.org/10.1021/acs.jcim.9b00526DOI Listing
November 2019

Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists.

Bioorg Med Chem Lett 2019 05 26;29(9):1113-1119. Epub 2019 Feb 26.

Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.02.027DOI Listing
May 2019

Deconstructing the Translational Tower of Babel.

Clin Transl Sci 2019 03 9;12(2):85. Epub 2018 Nov 9.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.

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http://doi.wiley.com/10.1111/cts.12595
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http://dx.doi.org/10.1111/cts.12595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440561PMC
March 2019

A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha.

J Lipid Res 2019 Mar 9;60(3):683-693. Epub 2019 Jan 9.

Section on Molecular Signal Transduction, Program for Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892

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http://dx.doi.org/10.1194/jlr.D090159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399489PMC
March 2019

A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C.

Antiviral Res 2019 03 31;163:149-155. Epub 2019 Jan 31.

Liver Diseases Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2019.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402797PMC
March 2019

Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions.

Cell Chem Biol 2019 02 13;26(2):244-254.e4. Epub 2018 Dec 13.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road BTM 3-016, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405215PMC
February 2019

Advancing precision medicine with personalized drug screening.

Drug Discov Today 2019 01 17;24(1):272-278. Epub 2018 Aug 17.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892-3375, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2018.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372320PMC
January 2019

Identification of Positive Allosteric Modulators of the D Dopamine Receptor That Act at Diverse Binding Sites.

Mol Pharmacol 2018 10 1;94(4):1197-1209. Epub 2018 Aug 1.

Molecular Neuropharmacology Section, National Institute of Neurologic Disorders and Stroke, Intramural Research Program, National Institutes of Health, Bethesda, Maryland (K.D.L., J.L.C., R.B.F., M.S.-S., A.E.M., B.K.A.W., L.A.H., D.R.S.); NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland (N.S., M.F., S.T.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (T.J.F., J.R.L.); KU Specialized Chemistry Center, University of Kansas, Lawrence, Kansas (P.J., J.A., K.J.F.); and Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.A., K.J.F.)

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.118
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http://dx.doi.org/10.1124/mol.118.113175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117505PMC
October 2018

Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro.

J Pharmacol Exp Ther 2018 01 31;364(1):38-45. Epub 2017 Oct 31.

Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (S.N., E.E., A.B., S.J.M., M.C.G.); and Division of Pre-Clinical Innovations, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland (E.B., M.F., N.S., D.K., X.H., J.J.M.).

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http://dx.doi.org/10.1124/jpet.117.244095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729612PMC
January 2018

Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.

Sci Rep 2017 09 15;7(1):11673. Epub 2017 Sep 15.

Laboratory of Molecular Signaling, National Institute of Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Rockville, MD, 20852, USA.

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http://dx.doi.org/10.1038/s41598-017-11870-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601486PMC
September 2017

A High-Throughput Assay for Developing Inhibitors of PhoP, a Virulence Factor of Mycobacterium tuberculosis.

Comb Chem High Throughput Screen 2016 ;19(10):855-864

Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd. Bethesda, MD 20814, USA.. United States.

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http://www.eurekaselect.com/146216/article
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http://dx.doi.org/10.2174/1386207319666161010163249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542402PMC
June 2017

Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing.

Mol Inform 2017 04 21;36(4). Epub 2016 Dec 21.

National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/minf.201600126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382096PMC
April 2017

Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer.

Clin Cancer Res 2016 Dec 7;22(24):6204-6216. Epub 2016 Jun 7.

Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-3059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143224PMC
December 2016

Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria.

Emerg Microbes Infect 2016 Nov 9;5(11):e116. Epub 2016 Nov 9.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/emi.2016.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148025PMC
November 2016

ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice.

JCI Insight 2016 11 17;1(19):e88427. Epub 2016 Nov 17.

Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1172/jci.insight.88427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111506PMC
November 2016

High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1.

Sci Rep 2016 Sep 27;6:34060. Epub 2016 Sep 27.

Therapeutics for Rare and Neglected Diseases, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037430PMC
http://dx.doi.org/10.1038/srep34060DOI Listing
September 2016

Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus.

PLoS Pathog 2016 06 23;12(6):e1005717. Epub 2016 Jun 23.

Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919066PMC
June 2016

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.

Stem Cells Transl Med 2016 May 31;5(5):613-27. Epub 2016 Mar 31.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.5966/sctm.2015-0170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835244PMC
May 2016

Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists.

Biochemistry 2016 Mar 4;55(12):1772-83. Epub 2016 Mar 4.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/acs.biochem.5b01195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137375PMC
March 2016

A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration.

Sci Rep 2016 Mar 9;6:22273. Epub 2016 Mar 9.

Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/srep22273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783656PMC
March 2016

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

J Med Chem 2016 Feb 1;59(3):841-53. Epub 2016 Feb 1.

Division of Pre-Clinical Innovations, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753534PMC
February 2016

Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay.

Antiviral Res 2015 Dec 26;124:20-9. Epub 2015 Oct 26.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01663542153002
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http://dx.doi.org/10.1016/j.antiviral.2015.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684727PMC
December 2015

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.

ACS Comb Sci 2015 Oct 17;17(10):641-52. Epub 2015 Sep 17.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , 10 Center Drive, Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/acscombsci.5b00101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015500PMC
October 2015

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290.

Front Endocrinol (Lausanne) 2015 17;6:128. Epub 2015 Aug 17.

Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University , Miami, FL , USA.

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http://dx.doi.org/10.3389/fendo.2015.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538381PMC
September 2015

High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells.

Stem Cells Transl Med 2015 Jul 21;4(7):800-8. Epub 2015 May 21.

Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA; Therapeutics for Rare and Neglected Diseases, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.

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http://doi.wiley.com/10.5966/sctm.2014-0278
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http://dx.doi.org/10.5966/sctm.2014-0278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479623PMC
July 2015

Mitochondrial DNA damage by bleomycin induces AML cell death.

Apoptosis 2015 Jun;20(6):811-20

Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Room 7-116, 610 University Ave, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s10495-015-1119-zDOI Listing
June 2015

High-throughput viability assay using an autonomously bioluminescent cell line with a bacterial Lux reporter.

J Lab Autom 2015 Apr 1;20(2):164-74. Epub 2014 Dec 1.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA

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http://jla.sagepub.com/content/20/2/164.full.pdf
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http://jla.sagepub.com/lookup/doi/10.1177/2211068214560608
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http://dx.doi.org/10.1177/2211068214560608DOI Listing
April 2015

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.

Proc Natl Acad Sci U S A 2015 Mar 2;112(11):E1373-81. Epub 2015 Mar 2.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109; and

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http://www.pnas.org/lookup/doi/10.1073/pnas.1419669112
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http://dx.doi.org/10.1073/pnas.1419669112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371935PMC
March 2015

A high throughput screening assay system for the identification of small molecule inhibitors of gsp.

PLoS One 2014 25;9(3):e90766. Epub 2014 Mar 25.

Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090766PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965391PMC
January 2015

Discovery of novel antigiardiasis drug candidates.

Antimicrob Agents Chemother 2014 Dec 29;58(12):7303-11. Epub 2014 Sep 29.

Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, USA Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, USA

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http://dx.doi.org/10.1128/AAC.03834-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249522PMC
December 2014

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.

Mol Pharmacol 2014 Jul 22;86(1):96-105. Epub 2014 Apr 22.

Molecular Neuropharmacology Section, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (R.B.F., L.S.C., A.E.M., B.N.M., T.B.D., J.L.C., A.P., J.A.M., D.R.S.); National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland (J.X., X.H., A.E.D., S.T., M.B.-G., E.B., M.F., N.T.S., J.J.M.); Cellular, Molecular, Developmental Biology & Biophysics Program, Johns Hopkins University, Baltimore, Maryland (L.S.C.); Center for Molecular Recognition and Departments of Psychiatry and Pharmacology, Columbia University College of Physicians and Surgeons, and Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York (Y.H., L.D., J.A.J.); Schrödinger Inc., New York, New York (T.B.); and Department of Physiology and Biophysics and Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York (L.S.).

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http://molpharm.aspetjournals.org/content/86/1/96.full.pdf
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.113.09
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http://dx.doi.org/10.1124/mol.113.090563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054005PMC
July 2014

Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.

J Comput Aided Mol Des 2014 Jul 24;28(7):765-78. Epub 2014 Jun 24.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20850, USA,

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http://dx.doi.org/10.1007/s10822-014-9758-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138512PMC
July 2014

Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists.

J Med Chem 2014 Apr 10;57(8):3450-63. Epub 2014 Apr 10.

Discovery Innovation, NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/jm500126sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315423PMC
April 2014

Chemical signatures and new drug targets for gametocytocidal drug development.

Sci Rep 2014 Jan 17;4:3743. Epub 2014 Jan 17.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, United States.

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http://www.nature.com/articles/srep03743
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http://dx.doi.org/10.1038/srep03743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894558PMC
January 2014

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.

Nat Commun 2013 ;4:1953

NIH Chemical Genomics Center, Discovery Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.

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http://dx.doi.org/10.1038/ncomms2953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915074PMC
December 2013

Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor.

J Med Chem 2013 Nov 11;56(22):9045-56. Epub 2013 Nov 11.

National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States .

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http://pubs.acs.org/doi/10.1021/jm400904m
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http://dx.doi.org/10.1021/jm400904mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877059PMC
November 2013

Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins.

PLoS One 2013 16;8(1):e54525. Epub 2013 Jan 16.

Division of Hematology and Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054525PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546986PMC
August 2013

A high-throughput screening assay using Krabbe disease patient cells.

Anal Biochem 2013 Mar 5;434(1):15-25. Epub 2012 Nov 5.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.ab.2012.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975245PMC
March 2013

Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches.

Bioorg Med Chem Lett 2013 Feb 20;23(4):1056-62. Epub 2012 Dec 20.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563096PMC
February 2013

A homogenous luminescence assay reveals novel inhibitors for giardia lamblia carbamate kinase.

Curr Chem Genomics 2012 31;6:93-102. Epub 2012 Dec 31.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.2174/1875397301206010093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565245PMC
February 2013

High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model.

Curr Chem Genomics 2012 28;6:79-86. Epub 2012 Dec 28.

National Center for Advancing Translational Sciences, National Institutes of Health. 9800 Medical Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.2174/1875397301206010079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551243PMC
January 2013

Discovery of a novel noniminosugar acid α glucosidase chaperone series.

J Med Chem 2012 Sep 17;55(17):7546-59. Epub 2012 Aug 17.

NIH Chemical Genomics Center, NIH Center for Translational Therapeutics, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.

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http://dx.doi.org/10.1021/jm3005543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448374PMC
September 2012

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.

Proc Natl Acad Sci U S A 2012 Sep 21;109(36):14592-7. Epub 2012 Aug 21.

Oncogenesis and Development Section, National Institute of Allergy and Infectious Diseases, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1200037109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437880PMC
September 2012

Dealing with the Data Deluge: Handling the Multitude Of Chemical Biology Data Sources.

Curr Protoc Chem Biol 2012 Sep 1;4:193-209. Epub 2012 Sep 1.

NIH Center for Advancing Translational Science, 9800 Medical Center Drive Rockville, MD 20850.

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http://dx.doi.org/10.1002/9780470559277.ch110262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655879PMC
September 2012