Noel G Morgan

Noel G Morgan

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Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns.

Hum Mol Genet 2019 Aug;28(16):2763-2774

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Barrack Road, Exeter EX2 5DW, UK.

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddz094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687954PMC
August 2019

How, When, and Where Do Human β-Cells Regenerate?

Curr Diab Rep 2019 Jun 27;19(8):48. Epub 2019 Jun 27.

Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s11892-019-1176-8DOI Listing
June 2019

The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes.

Diabetologia 2019 01 18;62(1):87-98. Epub 2018 Oct 18.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, RILD Building (Level 4), Barrack Road, Exeter, EX2 5DW, UK.

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http://link.springer.com/10.1007/s00125-018-4750-8
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http://dx.doi.org/10.1007/s00125-018-4750-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290857PMC
January 2019

Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention.

Curr Opin Pharmacol 2018 12 29;43:11-19. Epub 2018 Jul 29.

Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, Devon, UK. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2018.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294842PMC
December 2018

Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made.

Diabetologia 2018 12 25;61(12):2499-2506. Epub 2018 Sep 25.

Islet Biology Exeter (IBEx), Institute of Biomedical and Clinical Science, University of Exeter Medical School, RILD Building (Level 4), Barrack Road, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s00125-018-4731-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223849PMC
December 2018

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells.

Diabetologia 2018 11 3;61(11):2344-2355. Epub 2018 Aug 3.

Islet Biology Exeter (IBEx), Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, RILD Building (Level 4), Barrack Road, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s00125-018-4704-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182664PMC
November 2018

Abnormal islet sphingolipid metabolism in type 1 diabetes.

Diabetologia 2018 07 18;61(7):1650-1661. Epub 2018 Apr 18.

The Bartholin Institute, Department of Pathology, Rigshospitalet, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s00125-018-4614-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445476PMC
July 2018

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes.

Diabetes 2018 04 17;67(4):687-696. Epub 2018 Jan 17.

Department of Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London, U.K.

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http://dx.doi.org/10.2337/db17-0021DOI Listing
April 2018

A novel de novo activating mutation in STAT3 identified in a patient with common variable immunodeficiency (CVID).

Clin Immunol 2018 02 24;187:132-136. Epub 2017 Nov 24.

Institute of Biomedical and Clinical Science, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.1016/j.clim.2017.11.007DOI Listing
February 2018

Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes.

Diabetologia 2017 07 17;60(7):1294-1303. Epub 2017 Feb 17.

Diabetes and Metabolism, Level 2 Learning and Research, University of Bristol, Southmead Hospital, Bristol, BS10 5NB, UK.

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http://dx.doi.org/10.1007/s00125-017-4221-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487689PMC
July 2017

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.

Cell Rep 2017 04;19(2):281-294

Research Programs Unit, Molecular Neurology and Biomedicum Stem Cell Centre, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland; Children's Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.055DOI Listing
April 2017

Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes.

Front Physiol 2016 27;7:633. Epub 2016 Dec 27.

College for Engineering, Mathematics and Physical Sciences, University of ExeterExeter, UK; Engineering and Physical Sciences Research Council Centre for Predictive Modelling in Healthcare, University of ExeterExeter, UK.

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http://dx.doi.org/10.3389/fphys.2016.00633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5186767PMC
December 2016

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.

Diabetologia 2016 11 9;59(11):2448-2458. Epub 2016 Aug 9.

Islet Biology Exeter (IBEx), Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, RILD Building (Level 4), Barrack Road, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s00125-016-4067-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042874PMC
November 2016

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.

J Cell Sci 2016 06 3;129(12):2368-81. Epub 2016 May 3.

Laboratoire Signalisation et Transports Ioniques Membranaires (STIM), CNRS ERL 7368, Université de Poitiers, 1, rue Georges Bonnet, Poitiers Cedex 9 86073, France

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http://dx.doi.org/10.1242/jcs.183590DOI Listing
June 2016

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes.

Diabetes 2016 05 8;65(5):1362-9. Epub 2016 Feb 8.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, U.K.

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http://dx.doi.org/10.2337/db15-1615DOI Listing
May 2016

The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor.

Diabetologia 2015 Sep 9;58(9):2056-63. Epub 2015 Jun 9.

Institute of Biomedical & Clinical Science, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s00125-015-3645-1DOI Listing
September 2015

Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

Trends Endocrinol Metab 2014 Dec 28;25(12):611-9. Epub 2014 Aug 28.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, RILD Building, Barrack Road, Exeter EX2 5DW, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2014.08.002DOI Listing
December 2014

Islet inflammation in human type 1 diabetes mellitus.

IUBMB Life 2014 Nov 11;66(11):723-34. Epub 2014 Dec 11.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.

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http://dx.doi.org/10.1002/iub.1330DOI Listing
November 2014

Pancreatic pathology in type 1 diabetes mellitus.

Endocr Pathol 2014 Mar;25(1):80-92

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, RILD Building Barrack Road, Exeter, EX2 5DW, Devon, UK,

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http://dx.doi.org/10.1007/s12022-014-9297-8DOI Listing
March 2014

Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells.

Islets 2013 Mar-Apr;5(2):95-105. Epub 2013 Mar 1.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Plymouth, Devon, UK.

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http://dx.doi.org/10.4161/isl.24249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204019PMC
January 2014

Induction of an antiviral state and attenuated coxsackievirus replication in type III interferon-treated primary human pancreatic islets.

J Virol 2013 Jul 1;87(13):7646-54. Epub 2013 May 1.

Department of Medicine HS, The Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1128/JVI.03431-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700265PMC
July 2013

The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119.

Br J Pharmacol 2012 Apr;165(8):2758-70

Institute of Biomedical & Clinical Sciences, Peninsula Medical School, University of Exeter, Plymouth, Devon, UK.

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http://dx.doi.org/10.1111/j.1476-5381.2011.01755.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423238PMC
April 2012

Down-regulation of proliferation does not affect the secretory function of transformed β-cell lines regardless of their anatomical configuration.

Islets 2011 May-Jun;3(3):80-8. Epub 2011 May 1.

Diabetes Research Group, Division of Diabetes and Nutrition, King's College, London, UK.

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http://dx.doi.org/10.4161/isl.3.3.15428DOI Listing
September 2011

Expression and functional roles of guanylate cyclase isoforms in BRIN-BD11 β-cells.

Islets 2010 Nov-Dec;2(6):374-82. Epub 2010 Nov 1.

Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth, Devon, UK.

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http://www.tandfonline.com/doi/abs/10.4161/isl.2.6.13917
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http://dx.doi.org/10.4161/isl.2.6.13917DOI Listing
August 2011

Structure-activity relationships influencing lipid-induced changes in eIF2α phosphorylation and cell viability in BRIN-BD11 cells.

FEBS Lett 2011 Jul 31;585(14):2243-8. Epub 2011 May 31.

Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Plymouth, Plymouth, UK.

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http://doi.wiley.com/10.1016/j.febslet.2011.05.045
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http://dx.doi.org/10.1016/j.febslet.2011.05.045DOI Listing
July 2011

Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion.

Clin Sci (Lond) 2011 May;120(9):403-13

Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry (University of Plymouth), Plymouth, Devon PL6 8BU, U.K.

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http://clinsci.org/lookup/doi/10.1042/CS20100416
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http://dx.doi.org/10.1042/CS20100416DOI Listing
May 2011

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line.

Clin Sci (Lond) 2011 Mar;120(5):195-206

UCD School of Biomolecular and Biomedical Science, UCD Conway Institute and UCD Institute of Sport and Health, UCD Dublin, Belfield, Dublin 4, Ireland.

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http://clinsci.org/lookup/doi/10.1042/CS20100282
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http://dx.doi.org/10.1042/CS20100282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990202PMC
March 2011

Pharmacological characterization of the cytoprotective effects of polyunsaturated fatty acids in insulin-secreting BRIN-BD11 cells.

Br J Pharmacol 2011 Mar;162(6):1340-50

Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Plymouth, Plymouth, UK.

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http://dx.doi.org/10.1111/j.1476-5381.2010.01145.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058166PMC
March 2011

Immunopathology of the human pancreas in type-I diabetes.

Semin Immunopathol 2011 Jan 28;33(1):9-21. Epub 2010 Apr 28.

Peninsula Medical School, University of Plymouth, Plymouth, PL6 8BU, UK.

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http://dx.doi.org/10.1007/s00281-010-0205-0DOI Listing
January 2011

Dysregulation of Hnf1b gene expression in cultured beta-cells in response to cytotoxic fatty acid.

JOP 2011 Jan 5;12(1):6-10. Epub 2011 Jan 5.

Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom.

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January 2011

The significance of GPR119 agonists as a future treatment for type 2 diabetes.

Drug News Perspect 2010 Sep;23(7):418-24

Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Plymouth, Plymouth, UK.

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http://dx.doi.org/10.1358/dnp.2010.23.7.1468395DOI Listing
September 2010

Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell.

Prostaglandins Leukot Essent Fatty Acids 2010 Apr-Jun;82(4-6):231-6. Epub 2010 Mar 4.

Institute of Biomedical & Clinical Science, Peninsula Medical School (University of Exeter), Plymouth, UK.

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http://dx.doi.org/10.1016/j.plefa.2010.02.018DOI Listing
August 2010

The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines.

Methods Mol Biol 2009 ;560:53-64

Peninsula Medical School, Institute of Biomedical and Clinical Science, Tamar Science Park, John Bull Building, Plymouth, Devon, PL6 8BU, UK.

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http://dx.doi.org/10.1007/978-1-59745-448-3_5DOI Listing
December 2009

Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways.

Biosci Rep 2009 Dec 15;30(3):169-75. Epub 2009 Dec 15.

Institute of Biomedical and Clinical Science, John Bull Building, Peninsula Medical School, Plymouth, Devon PL6 8BU, UK.

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http://bioscirep.org/cgi/doi/10.1042/BSR20090021
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http://dx.doi.org/10.1042/BSR20090021DOI Listing
December 2009

G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell.

Biochem Pharmacol 2009 Dec 4;78(12):1419-27. Epub 2009 Aug 4.

Institute of Biomedical & Clinical Science, John Bull Building, Peninsula Medical School, Plymouth PL6 8BU, UK.

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http://dx.doi.org/10.1016/j.bcp.2009.07.020DOI Listing
December 2009

Fatty acids and beta-cell toxicity.

Authors:
Noel G Morgan

Curr Opin Clin Nutr Metab Care 2009 Mar;12(2):117-22

Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth, UK.

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https://insights.ovid.com/crossref?an=00075197-200903000-000
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http://dx.doi.org/10.1097/MCO.0b013e328321e423DOI Listing
March 2009

The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells.

Biochem Soc Trans 2008 Oct;36(Pt 5):905-8

Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, UK.

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http://dx.doi.org/10.1042/BST0360905DOI Listing
October 2008

Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell.

Biochem Soc Trans 2008 Oct;36(Pt 5):959-62

Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, UK.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST0360959
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http://dx.doi.org/10.1042/BST0360959DOI Listing
October 2008

The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway.

J Endocrinol 2008 Jun 15;197(3):543-52. Epub 2008 Apr 15.

Institute of Biomedical and Clinical Science, Peninsula Medical School, Universities of Exeter and Plymouth, John Bull Building, Research Way, Plymouth PL6 8BU, UK.

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http://dx.doi.org/10.1677/JOE-07-0262DOI Listing
June 2008

Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids.

J Endocrinol 2008 Jun;197(3):553-63

Peninsula Medical School, Institute of Biomedical and Clinical Science, John Bull Building, Plymouth PL6 8BU, UK.

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http://dx.doi.org/10.1677/JOE-08-0041DOI Listing
June 2008

Life and death decisions of the pancreatic beta-cell: the role of fatty acids.

Clin Sci (Lond) 2007 Jan;112(1):27-42

School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1042/CS20060115DOI Listing
January 2007

Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process.

Biochem Biophys Res Commun 2006 Oct 24;349(2):809-15. Epub 2006 Aug 24.

Institute of Cell Signalling, School of Biomedical Sciences, University of Nottingham, The Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1016/j.bbrc.2006.08.102DOI Listing
October 2006

Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate.

Apoptosis 2006 Jul;11(7):1231-8

Institute of Biomedical and Clinical Science, Peninsula Medical School, Devon, Research Way, Plymouth, PL6 8BU, UK.

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http://dx.doi.org/10.1007/s10495-006-7450-7DOI Listing
July 2006

Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes.

Hum Mol Genet 2006 Jul 7;15(14):2216-24. Epub 2006 Jun 7.

Institute of Biomedical and Clincal Sciences, Peninsula Medical School, Barrack Road, Exeter, Devon, UK.

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http://dx.doi.org/10.1093/hmg/ddl147DOI Listing
July 2006

The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells.

Eur J Pharmacol 2004 Oct;501(1-3):31-9

Molecular Physiology, Biomedical Research Institute, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK.

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http://dx.doi.org/10.1016/j.ejphar.2004.08.018DOI Listing
October 2004

Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors.

Proc Natl Acad Sci U S A 2004 Sep 13;101(37):13677-82. Epub 2004 Sep 13.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1073/pnas.0404846101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC518812PMC
September 2004

Expression and functional activity of PPARgamma in pancreatic beta cells.

Br J Pharmacol 2004 Aug 5;142(7):1162-70. Epub 2004 Jul 5.

Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth, Devon, UK.

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http://dx.doi.org/10.1038/sj.bjp.0705844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575182PMC
August 2004

Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells.

FEBS Lett 2004 Feb;559(1-3):118-24

Endocrine Pharmacology Group, Institute of Biomedical and Clinical Science, Peninsula Medical School, Room N32, ITTC Building, Tamar Science Park, Plymouth, Devon PL6 8BX, UK.

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http://doi.wiley.com/10.1016/S0014-5793%2804%2900048-1
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http://dx.doi.org/10.1016/S0014-5793(04)00048-1DOI Listing
February 2004

Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure.

FEBS Lett 2004 Feb;560(1-3):103-8

Institute of Biomedical and Clinical Science, Peninsula Medical School, Room N32, ITTC Building, Tamar Science Park, Plymouth, PL6 8BX, UK.

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http://dx.doi.org/10.1016/S0014-5793(04)00079-1DOI Listing
February 2004

Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans.

Eur J Pharmacol 2003 Dec;482(1-3):189-96

Cellular Pharmacology Group, School of Life Sciences, Keele University, Staffs ST5 5BG, UK.

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http://dx.doi.org/10.1016/j.ejphar.2003.09.039DOI Listing
December 2003

Comparative effects of efaroxan and beta-carbolines on the secretory activity of rodent and human beta cells.

Ann N Y Acad Sci 2003 Dec;1009:167-74

Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth, Devon PL6 8BX, UK.

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http://dx.doi.org/10.1196/annals.1304.019DOI Listing
December 2003

Functional effects of expression of wolframin-antisense transcripts in BRIN-BD11 beta-cells.

Biochem Biophys Res Commun 2003 Aug;307(3):684-8

School of Life Sciences, Keele University, Staffs ST5 5BG, UK.

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http://dx.doi.org/10.1016/s0006-291x(03)01243-9DOI Listing
August 2003

Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells.

JOP 2003 May;4(3):117-24

Cellular Pharmacology Group, School of Life Sciences, Keele University, Staffs, United Kingdom.

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May 2003

Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell.

Br J Pharmacol 2002 May;136(1):31-6

Institute of Cell Signalling, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1038/sj.bjp.0704680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762110PMC
May 2002

GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell.

Biochem Pharmacol 2002 Mar;63(6):1027-35

Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Wayne State University, 619 Shapero Hall, Detroit, MI 48202, USA.

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http://dx.doi.org/10.1016/s0006-2952(02)00849-3DOI Listing
March 2002