Publications by authors named "Noel G McElvaney"

100Publications

Corrigendum to 'A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19'.

EBioMedicine 2020 Nov 10;62:103116. Epub 2020 Nov 10.

Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Beaumont Hospital, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.103116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654328PMC
November 2020

A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19.

EBioMedicine 2020 Nov 8;61:103026. Epub 2020 Oct 8.

Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Beaumont Hospital, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.103026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543971PMC
November 2020

Reply to: Blot et al. and Inoue et al.

Am J Respir Crit Care Med 2020 Sep 21. Epub 2020 Sep 21.

Royal College of Surgeons in Ireland, 8863, Dublin, Ireland.

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http://dx.doi.org/10.1164/rccm.202008-3169LEDOI Listing
September 2020

SZ alpha-1 antitrypsin deficiency and pulmonary disease: more like MZ, not like ZZ.

Thorax 2020 Sep 11. Epub 2020 Sep 11.

Irish Centre for Genetic Lung Disease, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1136/thoraxjnl-2020-215250DOI Listing
September 2020

Targeting IgG Autoantibodies for Improved Cytotoxicity of Bactericidal Permeability Increasing Protein in Cystic Fibrosis.

Front Pharmacol 2020 17;11:1098. Epub 2020 Jul 17.

Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.3389/fphar.2020.01098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379883PMC
July 2020

Anti-cytokines as a Strategy in Alpha-1 Antitrypsin Deficiency.

Chronic Obstr Pulm Dis 2020 Jul;7(3):203-213

Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.15326/jcopdf.7.3.2019.0171DOI Listing
July 2020

Alpha-Antitrypsin Deficiency.

N Engl J Med 2020 04;382(15):1443-1455

From the Department of Internal Medicine III, University Hospital RWTH (Rheinisch-Westfälisch Technische Hochschule) Aachen, Aachen, Germany (P.S.); the Irish Centre for Genetic Lung Disease, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin (N.G.M.); and UCL Respiratory, Division of Medicine, Rayne Institute, University College London, London (D.A.L.).

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http://dx.doi.org/10.1056/NEJMra1910234DOI Listing
April 2020

α Antitrypsin therapy modulates the neutrophil membrane proteome and secretome.

Eur Respir J 2020 Apr 30;55(4). Epub 2020 Apr 30.

Irish Centre for Genetic Lung Disease, Dept of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1183/13993003.01678-2019DOI Listing
April 2020

Targeting airway inflammation in cystic fibrosis.

Expert Rev Respir Med 2019 11 10;13(11):1041-1055. Epub 2019 Oct 10.

Irish Centre for Genetic Lung Disease, Royal College of Surgeons in Ireland, Beaumont Hospital , Dublin , Ireland.

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http://dx.doi.org/10.1080/17476348.2019.1666715DOI Listing
November 2019

Pitfalls and caveats in α1-antitrypsin deficiency testing: a guide for clinicians.

Lancet Respir Med 2019 12 16;7(12):1059-1067. Epub 2019 Jul 16.

Irish Centre for Genetic Lung Disease, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Medicine, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/S2213-2600(19)30141-9DOI Listing
December 2019

The Estrogen-Induced miR-19 Downregulates Secretory Leucoprotease Inhibitor Expression in Monocytes.

J Innate Immun 2020 2;12(1):90-102. Epub 2019 Jul 2.

Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland,

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http://dx.doi.org/10.1159/000500419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959121PMC
July 2019

Characterisation of the Major Extracellular Proteases of and Their Effects on Pulmonary Antiproteases.

Pathogens 2019 06 28;8(3). Epub 2019 Jun 28.

Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, D02 YN77 Dublin, Ireland.

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http://dx.doi.org/10.3390/pathogens8030092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789491PMC
June 2019

Pneumothorax and lung cysts: a family affair.

Lancet 2019 06 27;393(10191):2635. Epub 2019 Jun 27.

Irish Centre for Genetic Lung Disease, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/S0140-6736(19)31283-8DOI Listing
June 2019

The European Alpha-1 Research Collaboration (EARCO): a new ERS Clinical Research Collaboration to promote research in alpha-1 antitrypsin deficiency.

Eur Respir J 2019 02 14;53(2). Epub 2019 Feb 14.

Dept of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Philipps-University, Member of the German Centre for Lung Research (DZL), Marburg, Germany.

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http://dx.doi.org/10.1183/13993003.00138-2019DOI Listing
February 2019

GDPR: an impediment to research?

Ir J Med Sci 2019 Nov 8;188(4):1129-1135. Epub 2019 Feb 8.

Beaumont Hospital Ethics (Medical Research) Committee, Beaumont Hospital, Dublin, Ireland.

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http://link.springer.com/10.1007/s11845-019-01980-2
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http://dx.doi.org/10.1007/s11845-019-01980-2DOI Listing
November 2019

Author Correction: α1-Antitrypsin deficiency.

Nat Rev Dis Primers 2018 Oct 29;4(1):40. Epub 2018 Oct 29.

Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1038/s41572-018-0043-2DOI Listing
October 2018

Safety of biweekly α-antitrypsin treatment in the RAPID programme.

Eur Respir J 2018 11 29;52(5). Epub 2018 Nov 29.

Irish Centre for Genetic Lung disease, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1183/13993003.00897-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557539PMC
November 2018

Emerging pharmacotherapies in cystic fibrosis.

Expert Rev Respir Med 2018 10 19;12(10):843-855. Epub 2018 Sep 19.

a Irish Centre for Genetic Lung Disease, Royal College of Surgeons in Ireland , Beaumont Hospital , Dublin , Ireland.

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http://dx.doi.org/10.1080/17476348.2018.1512409DOI Listing
October 2018

Hermansky-Pudlak syndrome with a novel genetic variant in and subsequent accelerated pulmonary fibrosis: significance for phenocopy diseases.

Thorax 2018 11 25;73(11):1085-1088. Epub 2018 Jun 25.

Irish Centre for Genetic Lung Disease, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1136/thoraxjnl-2018-211920DOI Listing
November 2018

Targeting IL-8 in Cystic Fibrosis: Enough but Not Too Much.

Am J Respir Cell Mol Biol 2018 10;59(4):401-402

1 Royal College of Surgeons in Ireland Beaumont Hospital Dublin, Ireland.

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http://dx.doi.org/10.1165/rcmb.2018-0145EDDOI Listing
October 2018

The Human Cathelicidin Antimicrobial Peptide LL-37 Promotes the Growth of the Pulmonary Pathogen Aspergillus fumigatus.

Infect Immun 2018 07 21;86(7). Epub 2018 Jun 21.

Medical Mycology Laboratory, Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland

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http://dx.doi.org/10.1128/IAI.00097-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013660PMC
July 2018

The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals.

J Inflamm Res 2018 26;11:123-134. Epub 2018 Mar 26.

Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.2147/JIR.S156405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875399PMC
March 2018

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing.

Cell Rep 2018 03;22(11):2937-2950

Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.062DOI Listing
March 2018

Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95).

J Cyst Fibros 2018 09 2;17(5):616-623. Epub 2018 Mar 2.

Airway Innate Immunity Research Group, Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1016/j.jcf.2018.01.010DOI Listing
September 2018

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications.

Int J Chron Obstruct Pulmon Dis 2018 31;13:419-432. Epub 2018 Jan 31.

Department of Medicine, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland.

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https://www.dovepress.com/alpha-1-antitrypsin-to-treat-lung-
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http://dx.doi.org/10.2147/COPD.S149429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797472PMC
September 2018

European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α-antitrypsin deficiency.

Eur Respir J 2017 11 30;50(5). Epub 2017 Nov 30.

Lung Investigation Unit Medicine - University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham, UK

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http://dx.doi.org/10.1183/13993003.00610-2017DOI Listing
November 2017

Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB.

Sci Rep 2017 10 23;7(1):13803. Epub 2017 Oct 23.

Lung Biology Group, Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1038/s41598-017-14310-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653852PMC
October 2017

Reply.

Arthritis Rheumatol 2017 12 8;69(12):2404-2406. Epub 2017 Nov 8.

Royal College of Surgeons in Ireland, and Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1002/art.40309DOI Listing
December 2017

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease.

EBioMedicine 2017 Sep 16;23:173-184. Epub 2017 Aug 16.

Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605378PMC
September 2017

X Chromosome-encoded MicroRNAs Are Functionally Increased in Cystic Fibrosis Monocytes.

Am J Respir Crit Care Med 2018 03;197(5):668-670

1 Royal College of Surgeons in Ireland Dublin, Ireland.

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http://www.atsjournals.org/doi/10.1164/rccm.201707-1417LE
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http://dx.doi.org/10.1164/rccm.201707-1417LEDOI Listing
March 2018

The Role of Neutrophils in Alpha-1 Antitrypsin Deficiency.

Ann Am Thorac Soc 2016 08;13 Suppl 4:S297-304

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://www.atsjournals.org/doi/10.1513/AnnalsATS.201509-634K
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http://dx.doi.org/10.1513/AnnalsATS.201509-634KVDOI Listing
August 2016

α1-Antitrypsin deficiency.

Nat Rev Dis Primers 2016 07 28;2:16051. Epub 2016 Jul 28.

Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1038/nrdp.2016.51DOI Listing
July 2016

Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences.

Biomed Res Int 2016 1;2016:5258727. Epub 2016 Jun 1.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1155/2016/5258727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908263PMC
January 2017

Alpha-1 Antitrypsin Therapy in Cystic Fibrosis and the Lung Disease Associated with Alpha-1 Antitrypsin Deficiency.

Authors:
Noel G McElvaney

Ann Am Thorac Soc 2016 04;13 Suppl 2:S191-6

Respiratory Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1513/AnnalsATS.201504-245KVDOI Listing
April 2016

Reply.

J Allergy Clin Immunol 2016 Mar 9;137(3):969-70. Epub 2016 Jan 9.

Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.jaci.2015.11.013DOI Listing
March 2016

Tumor necrosis factor-α driven inflammation in alpha-1 antitrypsin deficiency: a new model of pathogenesis and treatment.

Expert Rev Respir Med 2016 Feb 18;10(2):207-22. Epub 2015 Dec 18.

a Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre , Beaumont Hospital , Dublin , Ireland.

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http://dx.doi.org/10.1586/17476348.2016.1127759DOI Listing
February 2016

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6.

Mol Cell Pediatr 2015 Dec 7;2(1). Epub 2015 Jan 7.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, 9, Ireland.

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http://dx.doi.org/10.1186/s40348-014-0012-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407678PMC
December 2015

Unusual Acute Sequelae of α1-Antitrypsin Deficiency: A Myriad of Symptoms With One Common Cure.

Chest 2015 Nov;148(5):e136-e138

From the Respiratory Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1378/chest.15-0699DOI Listing
November 2015

The basophil surface marker CD203c identifies Aspergillus species sensitization in patients with cystic fibrosis.

J Allergy Clin Immunol 2016 Feb 18;137(2):436-443.e9. Epub 2015 Sep 18.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.jaci.2015.07.045DOI Listing
February 2016

The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling.

J Immunol 2015 Oct 14;195(8):3628-41. Epub 2015 Sep 14.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland; and

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http://dx.doi.org/10.4049/jimmunol.1500038DOI Listing
October 2015

Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function.

World J Crit Care Med 2015 Aug 4;4(3):179-91. Epub 2015 Aug 4.

Emer P Reeves, Cormac McCarthy, Oliver J McElvaney, Maya Sakthi N Vijayan, Michelle M White, Danielle M Dunlea, Kerstin Pohl, Noreen Lacey, Noel G McElvaney, Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.5492/wjccm.v4.i3.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524815PMC
August 2015

The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity.

J Immunol Res 2015 12;2015:507315. Epub 2015 Jul 12.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Health Sciences Building, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.

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http://dx.doi.org/10.1155/2015/507315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515294PMC
March 2016

miR-17 overexpression in cystic fibrosis airway epithelial cells decreases interleukin-8 production.

Eur Respir J 2015 Nov 9;46(5):1350-60. Epub 2015 Jul 9.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland

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http://erj.ersjournals.com/content/erj/early/2015/07/09/0903
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http://erj.ersjournals.com/lookup/doi/10.1183/09031936.00163
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http://dx.doi.org/10.1183/09031936.00163414DOI Listing
November 2015

The impact of smoke exposure on the clinical phenotype of alpha-1 antitrypsin deficiency in Ireland: exploiting a national registry to understand a rare disease.

COPD 2015 May;12 Suppl 1:2-9

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre , Beaumont Hospital, Dublin , Ireland.

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http://dx.doi.org/10.3109/15412555.2015.1021913DOI Listing
May 2015

Diagnosing α1-antitrypsin deficiency: how to improve the current algorithm.

Authors:
Noel G McElvaney

Eur Respir Rev 2015 Mar;24(135):52-7

Respiratory Research Division, Dept of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland

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http://err.ersjournals.com/lookup/doi/10.1183/09059180.10010
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http://dx.doi.org/10.1183/09059180.10010814DOI Listing
March 2015

Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes.

Ther Clin Risk Manag 2015 29;11:143-51. Epub 2015 Jan 29.

Department of Respiratory Medicine, Beaumont Hospital, Dublin, Republic of Ireland.

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http://dx.doi.org/10.2147/TCRM.S51474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321641PMC
February 2015

Identification and characterisation of eight novel SERPINA1 Null mutations.

Orphanet J Rare Dis 2014 Nov 26;9:172. Epub 2014 Nov 26.

Centre for Diagnosis of Inherited Alpha-1 Antitrypsin Deficiency, Laboratory of Biochemistry and Genetics, Institute for Respiratory Disease, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1186/s13023-014-0172-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255440PMC
November 2014

α1-Antitrypsin activates protein phosphatase 2A to counter lung inflammatory responses.

Am J Respir Crit Care Med 2014 Dec;190(11):1229-42

1 Division of Pulmonary and Critical Care Medicine, Mount Sinai Roosevelt Hospital, New York, New York.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.201405-0872O
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http://dx.doi.org/10.1164/rccm.201405-0872OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315812PMC
December 2014

miR-CATCH: microRNA capture affinity technology.

Methods Mol Biol 2015 ;1218:365-73

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.

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http://dx.doi.org/10.1007/978-1-4939-1538-5_23DOI Listing
June 2015

Therapeutic aerosol bioengineering of siRNA for the treatment of inflammatory lung disease by TNFα gene silencing in macrophages.

Mol Pharm 2014 Nov 13;11(11):4270-9. Epub 2014 Oct 13.

School of Pharmacy and §Department of Physiology, Royal College of Surgeons in Ireland , Dublin 2, Ireland.

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http://pubs.acs.org/doi/10.1021/mp500473d
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http://dx.doi.org/10.1021/mp500473dDOI Listing
November 2014

Alpha-1 antitrypsin augmentation therapy corrects accelerated neutrophil apoptosis in deficient individuals.

J Immunol 2014 Oct 12;193(8):3978-91. Epub 2014 Sep 12.

Respiratory Research Division, Department of Medicine Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.4049/jimmunol.1400132DOI Listing
October 2014

Ivacaftor: from bench to bedside... and back again.

Am J Respir Crit Care Med 2014 Jul;190(2):128-9

1 Respiratory Research Division Royal College of Surgeons in Ireland Dublin, Ireland and.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.201406-1122E
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http://dx.doi.org/10.1164/rccm.201406-1122EDDOI Listing
July 2014

Immunoevasive Aspergillus virulence factors.

Mycopathologia 2014 Dec 28;178(5-6):363-70. Epub 2014 Jun 28.

Department of Medicine, Education and Research Centre, Beaumont Hospital, Royal College of Surgeons in Ireland, Beaumont Road, Dublin 9, Republic of Ireland,

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http://dx.doi.org/10.1007/s11046-014-9768-yDOI Listing
December 2014

Outcome in patients with cystic fibrosis liver disease.

J Cyst Fibros 2015 Jan 7;14(1):120-6. Epub 2014 Jun 7.

St Vincent's University Hospital Elm Park, Dublin 4, Ireland; Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland.

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http://dx.doi.org/10.1016/j.jcf.2014.05.013DOI Listing
January 2015

The role and importance of glycosylation of acute phase proteins with focus on alpha-1 antitrypsin in acute and chronic inflammatory conditions.

J Proteome Res 2014 Jul 12;13(7):3131-43. Epub 2014 Jun 12.

Respiratory Research Division, Royal College of Surgeons in Ireland , Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1021/pr500146yDOI Listing
July 2014

Long noncoding RNA are aberrantly expressed in vivo in the cystic fibrosis bronchial epithelium.

Int J Biochem Cell Biol 2014 Jul 12;52:184-91. Epub 2014 Mar 12.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.02.022DOI Listing
July 2014

Fungi in the cystic fibrosis lung: bystanders or pathogens?

Int J Biochem Cell Biol 2014 Jul 10;52:161-73. Epub 2014 Mar 10.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.03.001DOI Listing
July 2014

Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung.

J Immunol 2014 Mar 29;192(5):2418-31. Epub 2014 Jan 29.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland;

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http://dx.doi.org/10.4049/jimmunol.1300711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997615PMC
March 2014

Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.

Am J Respir Crit Care Med 2014 Feb;189(4):419-27

1 Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland; and.

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http://dx.doi.org/10.1164/rccm.201311-1984OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955067PMC
February 2014

The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity.

Sci Transl Med 2014 Jan;6(217):217ra1

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1126/scitranslmed.3007116DOI Listing
January 2014

Increased outer arm and core fucose residues on the N-glycans of mutated alpha-1 antitrypsin protein from alpha-1 antitrypsin deficient individuals.

J Proteome Res 2014 Feb 13;13(2):596-605. Epub 2013 Dec 13.

Respiratory Research Division, Royal College of Surgeons in Ireland , Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1021/pr400752tDOI Listing
February 2014

Aspergillus-associated airway disease, inflammation, and the innate immune response.

Biomed Res Int 2013 21;2013:723129. Epub 2013 Jul 21.

Department of Respiratory Medicine, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1155/2013/723129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736487PMC
February 2014

Is there a therapeutic role for selenium in alpha-1 antitrypsin deficiency?

Nutrients 2013 Mar 11;5(3):758-70. Epub 2013 Mar 11.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.3390/nu5030758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705318PMC
March 2013

Regulation of cystic fibrosis transmembrane conductance regulator by microRNA-145, -223, and -494 is altered in ΔF508 cystic fibrosis airway epithelium.

J Immunol 2013 Apr 22;190(7):3354-62. Epub 2013 Feb 22.

Respiratory Research Division, Department of Medicine, Education and Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.4049/jimmunol.1202960DOI Listing
April 2013

Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis.

J Inflamm Res 2013 23;6:1-11. Epub 2013 Jan 23.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.2147/JIR.S40081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576001PMC
February 2013

Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique.

Nucleic Acids Res 2013 Apr 15;41(6):e71. Epub 2013 Jan 15.

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Republic of Ireland.

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http://dx.doi.org/10.1093/nar/gks1466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616726PMC
April 2013

The CF-ABLE score: a novel clinical prediction rule for prognosis in patients with cystic fibrosis.

Chest 2013 May;143(5):1358-1364

Respiratory Research Division, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Respiratory Medicine, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1378/chest.12-2022DOI Listing
May 2013

Endothelial progenitor cells in mothers of low-birthweight infants: a link between defective placental vascularization and increased cardiovascular risk?

J Clin Endocrinol Metab 2013 Jan 15;98(1):E33-9. Epub 2012 Nov 15.

Department of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin 15, Ireland.

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http://dx.doi.org/10.1210/jc.2012-2793DOI Listing
January 2013