Publications by authors named "Nobuyuki Mitsuhashi"

2 Publications

  • Page 1 of 1

Free flap reconstruction of Achilles tendon and overlying skin defect using ALT and TFL fabricated chimeric flap.

Case Reports Plast Surg Hand Surg 2019 4;6(1):82-85. Epub 2019 Jul 4.

Department of Plastic and Reconstructive Surgery, Iwate Medical University Hospital, Morioka, Japan.

A 33-year-old man developed a left Achilles tendon rupture and skin necrosis. We reconstructed the defect using an anterolateral thigh flap and a tensor fasciae lata muscle flap in a chimeric fashion. he was able to stand on a toe of the operated foot without help 6 months postoperatively.
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http://dx.doi.org/10.1080/23320885.2019.1635023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609348PMC
July 2019

An improvement in the bending ability of a hinged trisaccharide with the assistance of a sugar-sugar interaction.

Chemistry 2005 Nov;11(22):6478-90

Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B3 Nagatsutacho, Midoriku, Yokohama 226-8501, Japan.

Hinged di- and trisaccharides incorporating 2,4-diamino-beta-D-xylopyranoside as a hinge unit (Hin) were synthesized. Bridging of the diamino group of Hin by carbonylation or chelation to a metal ion results in a conformational change from (4)C1 to (1)C4, which in turn causes a bending of the oligosaccharides. In this study, the bending abilities of the hinged oligosaccharides were compared, in terms of the reactivities toward carbonylation and chelation. Di- or trisaccharides containing a 6-O-glycosylated mannopyranoside or galactopyranoside at their reducing ends had bending abilities similar to that of the Hin monosaccharide, probably because there were neither attractive nor repulsive interactions between the reducing and nonreducing ends. However, when Hin was attached at O2 of methyl mannopyranoside (Man alphaMe), the bending ability was dependent on the nonreducing sugar and the reaction conditions. Typically, a disaccharide--Hin beta(1,2)Man alphaMe--was difficult to bend under all the tested reaction conditions, and the bent population in the presence of Zn(II) was only 4%. On the other hand, a trisaccharide--Man alpha(1,3)Hin beta(1,2)Man alphaMe--was bent immediately after the addition of Zn(II) or Hg(II), and the bent population reached 75%, much larger than those of all the other hinged trisaccharides ever tested (<40%). This excellent bending ability suggests an attractive interaction between the reducing and nonreducing ends. The extended conformation was recovered by the addition of triethylenetetramine, a metal ion chelator. Reversible, quick, and efficient bending of the hinged trisaccharide was thus achieved.
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http://dx.doi.org/10.1002/chem.200500096DOI Listing
November 2005