Nobuo Sakaguchi

Nobuo Sakaguchi

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Nobuo Sakaguchi

Nobuo Sakaguchi

Publications by authors named "Nobuo Sakaguchi"

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A Novel Cytological Model of B-Cell/Macrophage Biphenotypic Cell Hodgkin Lymphoma in -Transgenic Mice.

Cancers (Basel) 2020 Jan 14;12(1). Epub 2020 Jan 14.

Department of Diagnostic Pathology, Fujita Health University School of Medicine, Aichi 470-1192, Japan.

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http://dx.doi.org/10.3390/cancers12010204DOI Listing
January 2020

Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.

Nat Commun 2017 11 15;8(1):1518. Epub 2017 Nov 15.

Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1038/s41467-017-01788-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686073PMC
November 2017

Activation-induced deoxycytidine deaminase: Structural basis for favoring WRC hot motif specificities unique among APOBEC family members.

DNA Repair (Amst) 2017 06 28;54:8-12. Epub 2017 Mar 28.

Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, United States; Department of Chemistry, University of Southern California, Los Angeles, CA 90089, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408873PMC
June 2017

Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells.

Int Immunol 2017 05;29(5):211-220

World Premier International Research Center Initiative (WPI) Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1093/intimm/dxx032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890899PMC
May 2017

Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification.

DNA Repair (Amst) 2016 07 13;43:48-56. Epub 2016 May 13.

Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, United States; Department of Chemistry, University of Southern California, Los Angeles, CA 90089, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2016.05.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917410PMC
July 2016

Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates.

ACS Infect Dis 2016 05 11;2(5):361-76. Epub 2016 Apr 11.

Tsinghua-Peking Center for Life Sciences & School of Pharmaceutical Sciences, Tsinghua University , Haidian District, Beijing 100084, People's Republic of China.

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http://dx.doi.org/10.1021/acsinfecdis.6b00006DOI Listing
May 2016

Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities.

Sci Rep 2016 Jan 7;6:19035. Epub 2016 Jan 7.

Department of Retrovirology and Self-Defense, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1038/srep19035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704027PMC
January 2016

JNK regulatory molecule G5PR induces IgG autoantibody-producing plasmablasts from peritoneal B1a cells.

J Immunol 2015 Feb 19;194(4):1480-8. Epub 2015 Jan 19.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan;

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http://dx.doi.org/10.4049/jimmunol.1401127DOI Listing
February 2015

NF-κB-inducing kinase in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells.

J Immunol 2014 Nov 26;193(9):4356-67. Epub 2014 Sep 26.

Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, Tokushima 770-8503, Japan; and

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http://dx.doi.org/10.4049/jimmunol.1400389DOI Listing
November 2014

Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability.

Stem Cells 2014 Mar;32(3):623-35

Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China.

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http://dx.doi.org/10.1002/stem.1580DOI Listing
March 2014

GANP interacts with APOBEC3G and facilitates its encapsidation into the virions to reduce HIV-1 infectivity.

J Immunol 2013 Dec 6;191(12):6030-6039. Epub 2013 Nov 6.

Department of Immunology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.4049/jimmunol.1302057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086635PMC
December 2013

CA-S27: a novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma.

Cancer Sci 2013 Oct 6;104(10):1278-84. Epub 2013 Aug 6.

Department of Biochemistry, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1111/cas.12222DOI Listing
October 2013

Dynamic appearance of antigenic epitopes effective for viral neutralization during membrane fusion initiated by interactions between HIV-1 envelope proteins and CD4/CXCR4.

Immunobiology 2012 Sep 23;217(9):864-72. Epub 2011 Dec 23.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S017129851100283
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http://dx.doi.org/10.1016/j.imbio.2011.12.007DOI Listing
September 2012

A novel serum carbohydrate marker on mucin 5AC: values for diagnostic and prognostic indicators for cholangiocarcinoma.

Cancer 2011 Aug 1;117(15):3393-403. Epub 2011 Feb 1.

Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

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http://dx.doi.org/10.1002/cncr.25912DOI Listing
August 2011

Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons.

Nucleic Acids Res 2011 Jul 12;39(13):5538-54. Epub 2011 Mar 12.

Department of Retrovirology and Self-Defense, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1093/nar/gkr124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141244PMC
July 2011

Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression.

J Immunol 2010 Nov 24;185(9):5180-7. Epub 2010 Sep 24.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.4049/jimmunol.1002026DOI Listing
November 2010

GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.

J Biol Chem 2010 Jul 27;285(31):23945-53. Epub 2010 May 27.

Department of Immunology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1074/jbc.M110.131441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911284PMC
July 2010

Germinal center-associated nuclear protein (GANP) is involved in mRNA export of Shugoshin-1 required for centromere cohesion and in sister-chromatid exchange.

Genes Cells 2010 May 7;15(5):471-84. Epub 2010 Apr 7.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2010.01396.xDOI Listing
May 2010

A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsiveness.

J Immunol 2010 Feb 11;184(4):1728-36. Epub 2010 Jan 11.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.0903023
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http://dx.doi.org/10.4049/jimmunol.0903023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818872PMC
February 2010

Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas.

Cancer Sci 2009 Nov 21;100(11):2069-76. Epub 2009 Jul 21.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2009.01293.xDOI Listing
November 2009

Generation of high affinity monoclonal antibodies for the prevention of HIV infection.

Recent Pat DNA Gene Seq 2009 ;3(2):88-95

Department of Immunology, Kumamoto University, Honjo, Japan.

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http://dx.doi.org/10.2174/187221509788654133DOI Listing
September 2009

GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells.

Mol Immunol 2009 Mar 1;46(6):1031-41. Epub 2009 Feb 1.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S016158900800631
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http://dx.doi.org/10.1016/j.molimm.2008.08.272DOI Listing
March 2009

The immature B-cell subpopulation with low RAG1 expression is increased in the autoimmune New Zealand Black mouse.

Eur J Immunol 2009 Feb;39(2):600-11

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1002/eji.200838644DOI Listing
February 2009

Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury.

Am J Physiol Heart Circ Physiol 2008 Aug 13;295(2):H708-16. Epub 2008 Jun 13.

Dept. of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto Univ., Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1152/ajpheart.00252.2008DOI Listing
August 2008

Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes.

Mol Immunol 2008 Apr 19;45(7):2028-37. Epub 2007 Nov 19.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1016/j.molimm.2007.10.028DOI Listing
April 2008

Germinal center B-cell-associated DNA hypomethylation at transcriptional regions of the AID gene.

Mol Immunol 2008 Mar 9;45(6):1712-9. Epub 2007 Nov 9.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1016/j.molimm.2007.09.023DOI Listing
March 2008

Increased expression of germinal center-associated nuclear protein (GANP) is associated with malignant transformation of melanocytes.

J Dermatol Sci 2006 Apr 23;42(1):55-63. Epub 2006 Jan 23.

Department of Dermatology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1016/j.jdermsci.2005.12.007DOI Listing
April 2006

Regulation of CaMKII by alpha4/PP2Ac contributes to learning and memory.

Brain Res 2006 Apr 3;1082(1):1-10. Epub 2006 Mar 3.

Department of Immunology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S000689930600251
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http://dx.doi.org/10.1016/j.brainres.2006.01.101DOI Listing
April 2006

BCR-crosslinking induces a transcription of protein phosphatase component G5PR that is required for mature B-cell survival.

Biochem Biophys Res Commun 2006 Feb 7;340(1):338-46. Epub 2005 Dec 7.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.11.169DOI Listing
February 2006

Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis.

J Exp Med 2005 Sep 29;202(5):707-19. Epub 2005 Aug 29.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Japan.

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http://dx.doi.org/10.1084/jem.20050637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212881PMC
September 2005

IL-6 blocks a discrete early step in lymphopoiesis.

Blood 2005 Aug 14;106(3):879-85. Epub 2005 Apr 14.

Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1182/blood-2005-02-0456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761686PMC
August 2005

Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis.

Cancer Res 2005 Jul;65(13):5925-34

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3259DOI Listing
July 2005

Early lymphoid progenitors in mouse and man are highly sensitive to glucocorticoids.

Int Immunol 2005 May 3;17(5):501-11. Epub 2005 Mar 3.

Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1093/intimm/dxh230DOI Listing
May 2005

The heterodimer of alpha4 and PP2Ac is associated with S6 kinase1 in B cells.

Biochem Biophys Res Commun 2005 May;330(2):439-45

Department of Immunology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.003DOI Listing
May 2005

Generation of high-affinity antibody against T cell-dependent antigen in the Ganp gene-transgenic mouse.

J Immunol 2005 Apr;174(8):4485-94

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan.

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http://dx.doi.org/10.4049/jimmunol.174.8.4485DOI Listing
April 2005

[Origin of antibody diversity].

Authors:
Nobuo Sakaguchi

Nihon Rinsho 2005 Apr;63 Suppl 4:254-9

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University.

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April 2005

The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells.

J Biol Chem 2004 Oct 18;279(44):46182-90. Epub 2004 Aug 18.

Departments of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1074/jbc.M405347200DOI Listing
October 2004

Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin.

Immunity 2004 Jul;21(1):43-53

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.immuni.2004.06.011DOI Listing
July 2004

Microarray analysis of Lyn-deficient B cells reveals germinal center-associated nuclear protein and other genes associated with the lymphoid germinal center.

J Immunol 2004 Apr;172(7):4133-41

Department of Pediatrics, University of Pittsburgh, School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.4049/jimmunol.172.7.4133DOI Listing
April 2004

Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.

Proc Natl Acad Sci U S A 2004 Jan 8;101(4):1010-5. Epub 2004 Jan 8.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto 860-8556, Japan.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0307609100
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http://dx.doi.org/10.1073/pnas.0307609100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC327142PMC
January 2004

Unique properties of fetal lymphoid progenitors identified according to RAG1 gene expression.

Immunity 2003 Sep;19(3):365-75

Immunobiology & Cancer Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1016/s1074-7613(03)00231-0DOI Listing
September 2003

T cell-specific gene targeting reveals that alpha4 is required for early T cell development.

Eur J Immunol 2003 Jul;33(7):1899-906

Department of Immunology, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

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http://dx.doi.org/10.1002/eji.200323720DOI Listing
July 2003

Spontaneous increase of plasma-like cells with high GANP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice.

J Autoimmun 2003 Jun;20(4):291-301

Department of Immunology, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860-0811, Japan.

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http://dx.doi.org/10.1016/s0896-8411(03)00041-6DOI Listing
June 2003

Lymphoid lineage cells in adult murine bone marrow diverge from those of other blood cells at an early, hormone-sensitive stage.

Semin Immunol 2002 Dec;14(6):385-94

Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1016/s1044532302000738DOI Listing
December 2002

[Role of GANP in B cell activation].

Tanpakushitsu Kakusan Koso 2002 Dec;47(16 Suppl):2300-5

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December 2002

A developing picture of lymphopoiesis in bone marrow.

Immunol Rev 2002 Nov;189:28-40

Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850235PMC
http://dx.doi.org/10.1034/j.1600-065x.2002.18904.xDOI Listing
November 2002

NF-kappaB is required for CD38-mediated induction of C(gamma)1 germline transcripts in murine B lymphocytes.

Int Immunol 2002 Sep;14(9):1055-64

Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan.

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http://dx.doi.org/10.1093/intimm/dxf072DOI Listing
September 2002

Involvement of GANP in B cell activation in T cell-dependent antigen response.

Dev Immunol 2002 Sep;9(3):169-72

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-0811, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276099PMC
http://dx.doi.org/10.1080/1044667031000137647DOI Listing
September 2002

MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR.

Genes Cells 2002 Aug;7(8):821-34

Department of Immunology, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto, 860-0811, Japan.

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http://dx.doi.org/10.1046/j.1365-2443.2002.00562.xDOI Listing
August 2002

Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow.

Immunity 2002 Aug;17(2):117-30

Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City 73104, USA.

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http://dx.doi.org/10.1016/s1074-7613(02)00366-7DOI Listing
August 2002