Nobuhisa Iwata

Nobuhisa Iwata

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Nobuhisa Iwata

Publications by authors named "Nobuhisa Iwata"

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Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells.

Sci Rep 2019 May 17;9(1):7508. Epub 2019 May 17.

Department of Genome-based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8521, Japan.

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http://dx.doi.org/10.1038/s41598-019-43535-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525155PMC
May 2019

Meet Our Regional Editor.

Authors:
Nobuhisa Iwata

Curr Neuropharmacol 2018 01;16(1)

Department of Genome-based Drug Discovery.

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http://dx.doi.org/10.2174/1570159X1601171214093100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771377PMC
January 2018

A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs).

J Biochem 2017 Dec;162(6):391-394

Department of Genome-based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan.

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http://dx.doi.org/10.1093/jb/mvx058DOI Listing
December 2017

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease.

Cell Rep 2017 Nov;21(8):2304-2312

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Drug-Discovery Cellular Basis Development Team, RIKEN BioResource Center, Kyoto 606-8507, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.109DOI Listing
November 2017

Elucidating Pathogenic Mechanisms of Early-onset Alzheimer's Disease in Down Syndrome Patients.

Yakugaku Zasshi 2017 ;137(7):801-805

Department of Genome-based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University.

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http://dx.doi.org/10.1248/yakushi.16-00236-2DOI Listing
September 2017

Paradigm shift from diagnosing patients based on common symptoms to categorizing patients into subtypes with different pathogenic mechanisms to guide treatment for Alzheimer's disease.

J Biochem 2017 Jun;161(6):463-470

Department of Genome-based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan.

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http://dx.doi.org/10.1093/jb/mvx015DOI Listing
June 2017

Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts.

Biol Pharm Bull 2017 ;40(3):327-333

Department of Genome-based Drug Discovery, Graduation School of Biomedical Sciences, Nagasaki University.

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http://dx.doi.org/10.1248/bpb.b16-00825DOI Listing
March 2017

Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice.

Proteomics 2015 Oct 13;15(19):3349-55. Epub 2015 Aug 13.

Karolinska Institutet, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Division for Neurogeriatrics, Huddinge, Sweden.

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http://dx.doi.org/10.1002/pmic.201400211DOI Listing
October 2015

Involvement of calpains in adult neurogenesis: implications for stroke.

Front Cell Neurosci 2015 4;9:22. Epub 2015 Feb 4.

Regenerative Medicine Program, Department of Biomedical Sciences and Medicine, University of Algarve Faro, Portugal ; IBB-Institute for Biotechnology and Bioengineering, Center for Molecular and Structural Biomedicine, University of Algarve Faro, Portugal ; Center for Biomedical Research, CBMR, University of Algarve Faro, Portugal ; Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal.

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http://dx.doi.org/10.3389/fncel.2015.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316774PMC
February 2015

Single App knock-in mouse models of Alzheimer's disease.

Nat Neurosci 2014 May 13;17(5):661-3. Epub 2014 Apr 13.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan.

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http://dx.doi.org/10.1038/nn.3697DOI Listing
May 2014

[A pathogenic mechanism of N-terminally pyroglutamylated Aβ and possible application of Alzheimer's disease by inhibition of the pyroglutamylation].

Rinsho Shinkeigaku 2012 ;52(11):1162-4

Graduate School of Biomedical Sciences, Nagasaki University.

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http://dx.doi.org/10.5692/clinicalneurol.52.1162DOI Listing
April 2014

Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis.

J Immunol 2013 Oct 28;191(7):3778-88. Epub 2013 Aug 28.

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813;

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http://dx.doi.org/10.4049/jimmunol.1300972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783572PMC
October 2013

Aβ secretion and plaque formation depend on autophagy.

Cell Rep 2013 Oct 3;5(1):61-9. Epub 2013 Oct 3.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.08.042DOI Listing
October 2013

A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.

Nat Commun 2012 ;3:1307

CREST, Japan Science and Technology Agency, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://www.nature.com/articles/ncomms2303
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http://dx.doi.org/10.1038/ncomms2303DOI Listing
June 2013

Assessment of substrate inhibition of bacterial oligopeptidase B.

Biol Pharm Bull 2012 ;35(11):2010-6

Graduate School of Biomedical Sciences, Nagasaki University, 1–14 Bunkyo-machi, Nagasaki 852–8521, Japan.

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http://dx.doi.org/10.1248/bpb.b12-00544DOI Listing
April 2013

Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology.

FASEB J 2012 Mar 15;26(3):1204-17. Epub 2011 Dec 15.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1096/fj.11-187740DOI Listing
March 2012

An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model.

FASEB J 2011 Oct 11;25(10):3720-30. Epub 2011 Jul 11.

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.

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http://dx.doi.org/10.1096/fj.11-182154DOI Listing
October 2011

[Physiological degradation of Abeta in the brain].

Nihon Rinsho 2011 Oct;69 Suppl 8:48-53

Division of Biotechnology, Department of Molecular Medicinal Sciences, Graduate School of Biomedical Sciences, Nagasaki University.

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October 2011

Potent amyloidogenicity and pathogenicity of Aβ43.

Nat Neurosci 2011 Jul 3;14(8):1023-32. Epub 2011 Jul 3.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan.

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http://dx.doi.org/10.1038/nn.2858DOI Listing
July 2011

Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.

J Neurochem 2011 May 15;117(3):504-15. Epub 2011 Mar 15.

Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07222.xDOI Listing
May 2011

Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease.

J Neurosci Res 2010 Dec 1;88(16):3588-97. Epub 2010 Oct 1.

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.

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http://dx.doi.org/10.1002/jnr.22503DOI Listing
December 2010

Gene therapy in Alzheimer's disease - potential for disease modification.

J Cell Mol Med 2010 Apr 16;14(4):741-57. Epub 2010 Feb 16.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan.

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http://dx.doi.org/10.1111/j.1582-4934.2010.01038.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823109PMC
April 2010

Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification.

Int J Alzheimers Dis 2009 Jul 14;2009. Epub 2009 Jul 14.

School of Health Sciences, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8514, Japan.

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http://dx.doi.org/10.4061/2009/689285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925098PMC
July 2009

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model.

Neuron 2007 Feb;53(3):337-51

The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089662730700030
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http://dx.doi.org/10.1016/j.neuron.2007.01.010DOI Listing
February 2007

Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion.

Biochem Biophys Res Commun 2007 Jan 15;352(2):498-502. Epub 2006 Nov 15.

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Iruma-gun, Saitama 350-0495, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2006.11.043DOI Listing
January 2007

Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.

Biochemistry 2006 Jul;45(28):8649-56

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi060597g
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http://dx.doi.org/10.1021/bi060597gDOI Listing
July 2006

Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

J Biol Chem 2006 Jun 24;281(26):17941-51. Epub 2006 Apr 24.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1074/jbc.M601372200DOI Listing
June 2006

Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory.

J Pharmacol Exp Ther 2006 Apr 28;317(1):334-40. Epub 2005 Dec 28.

Department of Pharmacology, School of Pharmacy, Shenyang Pharmaceutical University, China.

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http://dx.doi.org/10.1124/jpet.105.095687DOI Listing
April 2006

Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy.

Neurosci Res 2006 Apr 2;54(4):235-53. Epub 2006 Feb 2.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan.

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http://dx.doi.org/10.1016/j.neures.2005.12.015DOI Listing
April 2006

Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory.

Behav Brain Res 2006 Mar 19;168(1):83-91. Epub 2005 Dec 19.

Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8560, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S016643280500458
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http://dx.doi.org/10.1016/j.bbr.2005.10.014DOI Listing
March 2006

[Experimental gene therapy for Alzheimer's disease--animal models].

Nihon Rinsho 2005 Dec;63 Suppl 12:691-8

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute.

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December 2005

Metabolism of amyloid-beta peptide and Alzheimer's disease.

Pharmacol Ther 2005 Nov 19;108(2):129-48. Epub 2005 Aug 19.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.pharmthera.2005.03.010DOI Listing
November 2005

The potential role of amyloid beta in the pathogenesis of age-related macular degeneration.

J Clin Invest 2005 Oct 15;115(10):2793-800. Epub 2005 Sep 15.

Department of Ophthalmology and Visual Science and Instrumental Analysis Research Center, Tokyo Medical and Dental University, Tokyo, Japan.

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http://www.jci.org/cgi/doi/10.1172/JCI24635
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http://dx.doi.org/10.1172/JCI24635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201663PMC
October 2005

[Presymptomatic diagnosis, prevention and therapy].

No To Shinkei 2005 Oct;57(10):855-66

Laboratory for Proteolytic Neuroscience, RIKEN Brain Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

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October 2005

Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions.

Biochim Biophys Acta 2005 Aug 17;1751(1):60-7. Epub 2005 Mar 17.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.bbapap.2005.02.013DOI Listing
August 2005

Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain.

Brain Res 2005 May 25;1045(1-2):224-8. Epub 2005 Apr 25.

Gunma University School of Health Sciences, 3-39-15 Showa-machi, Maebashi 371-8514, Japan.

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http://dx.doi.org/10.1016/j.brainres.2005.03.017DOI Listing
May 2005

Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain.

Neurobiol Aging 2005 Apr;26(4):409-18

Gunma University School of Health Sciences, 3-39-15 Showa-machi, 371-8514 Maebashi, Japan.

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http://dx.doi.org/10.1016/j.neurobiolaging.2004.04.008DOI Listing
April 2005

Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.

J Biol Chem 2005 Apr 2;280(16):16175-84. Epub 2005 Feb 2.

Laboratories for Proteolytic Neuroscience and Behavioral Genetics, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1074/jbc.M414552200DOI Listing
April 2005

Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.

J Biol Chem 2005 Apr 7;280(15):15229-37. Epub 2005 Feb 7.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1074/jbc.M500939200DOI Listing
April 2005

19F and 1H MRI detection of amyloid beta plaques in vivo.

Nat Neurosci 2005 Apr 13;8(4):527-33. Epub 2005 Mar 13.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitoma 351-0198, Japan.

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http://dx.doi.org/10.1038/nn1422DOI Listing
April 2005

Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

Nat Med 2005 Apr 20;11(4):434-9. Epub 2005 Mar 20.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1038/nm1206DOI Listing
April 2005

[Gene therapy for Alzheimer' s disease].

Nihon Rinsho 2005 Mar;63(3):394-400

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute.

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March 2005

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons.

J Biol Chem 2004 Jul 20;279(29):30259-64. Epub 2004 Apr 20.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

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http://www.jbc.org/content/279/29/30259.full.pdf
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https://www.frontiersin.org/articles/10.3389/fnagi.2013.0009
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http://www.jbc.org/lookup/doi/10.1074/jbc.M401891200
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http://dx.doi.org/10.1074/jbc.M401891200DOI Listing
July 2004

Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques.

Eur J Med Chem 2004 Jul;39(7):573-8

Dojindo Laboratories, Tabaru 2025-5, Mashiki-machi, Kumamoto 861-2202, Japan.

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http://dx.doi.org/10.1016/j.ejmech.2004.02.013DOI Listing
July 2004

Oxidized neprilysin in aging and Alzheimer's disease brains.

Biochem Biophys Res Commun 2003 Oct;310(1):236-41

Department of Neuroscience and Pathology (Neuropathology), Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1016/j.bbrc.2003.09.003DOI Listing
October 2003

[Amyloid-beta peptide metabolism and Alzheimer's disease].

Nihon Yakurigaku Zasshi 2003 Jul;122(1):5-14

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan.

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http://dx.doi.org/10.1254/fpj.122.5DOI Listing
July 2003

[Identification of the major A beta 1-42-degrading catabolic pathway in brain parenchyma].

Authors:
Nobuhisa Iwata

Seikagaku 2003 Feb;75(2):97-107

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198.

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February 2003

Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism.

Sci Aging Knowledge Environ 2003 Jan 22;2003(3):PE1. Epub 2003 Jan 22.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

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January 2003

In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons.

Brain Res Mol Brain Res 2002 Dec;108(1-2):18-32

Laboratory for Proteolytic Neuroscience, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/s0169-328x(02)00486-2DOI Listing
December 2002

Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.

J Neurosci Res 2002 Nov;70(3):493-500

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Saitama, Japan.

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http://dx.doi.org/10.1002/jnr.10390DOI Listing
November 2002

In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture.

Pharmacol Res 2002 Aug;46(2):155-63

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/s1043-6618(02)00081-6DOI Listing
August 2002