Noam Shoresh

Noam Shoresh

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Noam Shoresh

Noam Shoresh

Publications by authors named "Noam Shoresh"

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30Publications

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Defining the core essential genome of .

Proc Natl Acad Sci U S A 2019 May 29;116(20):10072-10080. Epub 2019 Apr 29.

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1900570116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525520PMC
May 2019

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.

Cell 2017 Jul;170(3):522-533.e15

Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785707PMC
July 2017

An Experimental Framework for Quantifying Bacterial Tolerance.

Biophys J 2017 Jun;112(12):2664-2671

The Racah Institute of Physics and the Center for NanoScience and NanoTechnology, Edmond J. Safra Campus, The Hebrew University, Jerusalem, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479142PMC
June 2017

Antibiotic tolerance facilitates the evolution of resistance.

Science 2017 02 9;355(6327):826-830. Epub 2017 Feb 9.

Racah Institute of Physics and the Harvey M. Kruger Family Center for Nanoscience and Nanotechnology, Edmond J. Safra Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1126/science.aaj2191DOI Listing
February 2017

Single-molecule decoding of combinatorially modified nucleosomes.

Science 2016 May;352(6286):717-21

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/science.aad7701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904710PMC
May 2016

High-Throughput Single-Cell Labeling (Hi-SCL) for RNA-Seq Using Drop-Based Microfluidics.

PLoS One 2015 22;10(5):e0116328. Epub 2015 May 22.

Department of Physics and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116328PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441486PMC
March 2016

Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state.

Nat Biotechnol 2015 Nov 12;33(11):1165-72. Epub 2015 Oct 12.

Epigenomics Program, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636926PMC
November 2015

Polyploidy can drive rapid adaptation in yeast.

Nature 2015 Mar 2;519(7543):349-52. Epub 2015 Mar 2.

1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA [2] Department of Cell Biology, Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02215, USA [3] Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815, USA [4] Department of Pediatric Hematology/Oncology, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature14187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497379PMC
March 2015

Genetic and epigenetic fine mapping of causal autoimmune disease variants.

Nature 2015 Feb 29;518(7539):337-43. Epub 2014 Oct 29.

1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA [3] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA [4] Center for Systems Biology and Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature13835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336207PMC
February 2015

Integrative analysis of 111 reference human epigenomes.

Nature 2015 Feb;518(7539):317-30

1] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, Massachusetts 02139, USA. [2] The Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature14248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530010PMC
February 2015

Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations.

Nature 2014 Sep 25;513(7518):418-21. Epub 2014 Jun 25.

Racah Institute of Physics, The Sudarsky Center for Computational Biology and the Center for NanoScience, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/nature13469DOI Listing
September 2014

Comparative analysis of metazoan chromatin organization.

Nature 2014 Aug;512(7515):449-52

1] Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Informatics Program, Children's Hospital, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature13415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227084PMC
August 2014

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.

Nucleic Acids Res 2013 Oct 14;41(19):e181. Epub 2013 Aug 14.

Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA, Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA, Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 01238, USA, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA and Howard Hughes Medical Institute, Chevy Chase, MD 02815, USA.

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http://dx.doi.org/10.1093/nar/gkt716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799455PMC
October 2013

Points of view: Data exploration.

Nat Methods 2012 Jan;9(1)

Broad Institute.

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January 2012

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence.

Proc Natl Acad Sci U S A 2010 Jul 28;107(28):12541-6. Epub 2010 Jun 28.

Racah Institute of Physics, Center for Nanoscience and Nanotechnology, Sudarsky Center for Computational Biology, Hebrew University, Jerusalem 91904, Israel.

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http://www.pnas.org/lookup/doi/10.1073/pnas.1004333107
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http://dx.doi.org/10.1073/pnas.1004333107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906590PMC
July 2010

Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA.

Nat Methods 2010 Jan 29;7(1):47-9. Epub 2009 Nov 29.

Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://www.nature.com/doifinder/10.1038/nmeth.1404
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http://dx.doi.org/10.1038/nmeth.1404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862482PMC
January 2010

Accelerated evolution of resistance in multidrug environments.

Proc Natl Acad Sci U S A 2008 Sep 8;105(37):13977-81. Epub 2008 Sep 8.

Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0805965105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544564PMC
September 2008

Evolution exacerbates the paradox of the plankton.

Proc Natl Acad Sci U S A 2008 Aug 19;105(34):12365-9. Epub 2008 Aug 19.

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0803032105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527917PMC
August 2008

Analytical results for individual and group selection of any intensity.

Bull Math Biol 2008 Jul 2;70(5):1410-24. Epub 2008 Apr 2.

Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, Cambridge, MA, 02138, USA.

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http://dx.doi.org/10.1007/s11538-008-9305-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574888PMC
July 2008

Exposing the fitness contribution of duplicated genes.

Nat Genet 2008 May 13;40(5):676-81. Epub 2008 Apr 13.

Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ng.123DOI Listing
May 2008

An equivalence principle for the incorporation of favorable mutations in asexual populations.

Science 2006 Mar;311(5767):1615-7

Bauer Center for Genomics Research, Harvard University, Cambridge, MA 02138, USA.

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http://kishony.med.harvard.edu/pdf/Hegreness_2006.pdf
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http://www.sciencemag.org/cgi/doi/10.1126/science.1122469
Publisher Site
http://dx.doi.org/10.1126/science.1122469DOI Listing
March 2006