Publications by authors named "Noam D Beckmann"

22 Publications

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A Molecular network approach reveals shared cellular and molecular signatures between chronic fatigue syndrome and other fatiguing illnesses.

Authors:
Phillip H Comella Edgar Gonzalez-Kozlova Roman Kosoy Alexander W Charney Irene Font Peradejordi Shreya Chandrasekar Scott R Tyler Wenhui Wang Bojan Losic Jun Zhu Gabriel E Hoffman Seunghee Kim-Schulze Jingjing Qi Manishkumar Patel Andrew Kasarskis Mayte Suarez-Farinas Zeynep H Gümüş Carmen Argmann Miriam Merad Christian Becker Noam D Beckmann Eric E Schadt

medRxiv 2021 Feb 2. Epub 2021 Feb 2.

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February 2021

An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease.

Authors:
Ariella T Cohain William T Barrington Daniel M Jordan Noam D Beckmann Carmen A Argmann Sander M Houten Alexander W Charney Raili Ermel Katyayani Sukhavasi Oscar Franzen Simon Koplev Carl Whatling Gillian M Belbin Jialiang Yang Ke Hao Eimear E Kenny Zhidong Tu Jun Zhu Li-Ming Gan Ron Do Chiara Giannarelli Jason C Kovacic Arno Ruusalepp Aldons J Lusis Johan L M Bjorkegren Eric E Schadt

Nat Commun 2021 01 22;12(1):547. Epub 2021 Jan 22.

Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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January 2021

Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness.

Authors:
Ivan Carcamo-Orive Marc Y R Henrion Kuixi Zhu Noam D Beckmann Paige Cundiff Sara Moein Zenan Zhang Melissa Alamprese Sunita L D'Souza Martin Wabitsch Eric E Schadt Thomas Quertermous Joshua W Knowles Rui Chang

PLoS Comput Biol 2020 12 23;16(12):e1008491. Epub 2020 Dec 23.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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December 2020

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease.

Authors:
Minghui Wang Aiqun Li Michiko Sekiya Noam D Beckmann Xiuming Quan Nadine Schrode Michael B Fernando Alex Yu Li Zhu Jiqing Cao Liwei Lyu Emrin Horgusluoglu Qian Wang Lei Guo Yuan-Shuo Wang Ryan Neff Won-Min Song Erming Wang Qi Shen Xianxiao Zhou Chen Ming Seok-Man Ho Sezen Vatansever H Ümit Kaniskan Jian Jin Ming-Ming Zhou Kanae Ando Lap Ho Paul A Slesinger Zhenyu Yue Jun Zhu Pavel Katsel Sam Gandy Michelle E Ehrlich Valentina Fossati Scott Noggle Dongming Cai Vahram Haroutunian Koichi M Iijima Eric Schadt Kristen J Brennand Bin Zhang

Neuron 2021 01 24;109(2):257-272.e14. Epub 2020 Nov 24.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address:

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January 2021

Machine Learning to Predict Mortality and Critical Events in a Cohort of Patients With COVID-19 in New York City: Model Development and Validation.

Authors:
Akhil Vaid Sulaiman Somani Adam J Russak Jessica K De Freitas Fayzan F Chaudhry Ishan Paranjpe Kipp W Johnson Samuel J Lee Riccardo Miotto Felix Richter Shan Zhao Noam D Beckmann Nidhi Naik Arash Kia Prem Timsina Anuradha Lala Manish Paranjpe Eddye Golden Matteo Danieletto Manbir Singh Dara Meyer Paul F O'Reilly Laura Huckins Patricia Kovatch Joseph Finkelstein Robert M Freeman Edgar Argulian Andrew Kasarskis Bethany Percha Judith A Aberg Emilia Bagiella Carol R Horowitz Barbara Murphy Eric J Nestler Eric E Schadt Judy H Cho Carlos Cordon-Cardo Valentin Fuster Dennis S Charney David L Reich Erwin P Bottinger Matthew A Levin Jagat Narula Zahi A Fayad Allan C Just Alexander W Charney Girish N Nadkarni Benjamin S Glicksberg

J Med Internet Res 2020 11 6;22(11):e24018. Epub 2020 Nov 6.

The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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November 2020

Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children.

Authors:
Noam D Beckmann Phillip H Comella Esther Cheng Lauren Lepow Aviva G Beckmann Konstantinos Mouskas Nicole W Simons Gabriel E Hoffman Nancy J Francoeur Diane Marie Del Valle Gurpawan Kang Emily Moya Lillian Wilkins Jessica Le Berichel Christie Chang Robert Marvin Sharlene Calorossi Alona Lansky Laura Walker Nancy Yi Alex Yu Matthew Harnett Melody Eaton Sandra Hatem Hajra Jamal Alara Akyatan Alexandra Tabachnikova Lora E Liharska Liam Cotter Brian Fennessey Akhil Vaid Guillermo Barturen Scott R Tyler Hardik Shah Yinh-Chih Wang Shwetha Hara Sridhar Juan Soto Swaroop Bose Kent Madrid Ethan Ellis Elyze Merzier Konstantinos Vlachos Nataly Fishman Manying Tin Melissa Smith Hui Xie Manishkumar Patel Kimberly Argueta Jocelyn Harris Neha Karekar Craig Batchelor Jose Lacunza Mahlet Yishak Kevin Tuballes Leisha Scott Arvind Kumar Suraj Jaladanki Ryan Thompson Evan Clark Bojan Losic Jun Zhu Wenhui Wang Andrew Kasarskis Benjamin S Glicksberg Girish Nadkarni Dusan Bogunovic Cordelia Elaiho Sandeep Gangadharan George Ofori-Amanfo Kasey Alesso-Carra Kenan Onel Karen M Wilson Carmen Argmann Marta E Alarcón-Riquelme Thomas U Marron Adeeb Rahman Seunghee Kim-Schulze Sacha Gnjatic Bruce D Gelb Miriam Merad Robert Sebra Eric E Schadt Alexander W Charney

medRxiv 2020 Sep 2. Epub 2020 Sep 2.

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September 2020

An inflammatory cytokine signature predicts COVID-19 severity and survival.

Authors:
Diane Marie Del Valle Seunghee Kim-Schulze Hsin-Hui Huang Noam D Beckmann Sharon Nirenberg Bo Wang Yonit Lavin Talia H Swartz Deepu Madduri Aryeh Stock Thomas U Marron Hui Xie Manishkumar Patel Kevin Tuballes Oliver Van Oekelen Adeeb Rahman Patricia Kovatch Judith A Aberg Eric Schadt Sundar Jagannath Madhu Mazumdar Alexander W Charney Adolfo Firpo-Betancourt Damodara Rao Mendu Jeffrey Jhang David Reich Keith Sigel Carlos Cordon-Cardo Marc Feldmann Samir Parekh Miriam Merad Sacha Gnjatic

Nat Med 2020 10 24;26(10):1636-1643. Epub 2020 Aug 24.

Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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October 2020

Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.

Authors:
Noam D Beckmann Wei-Jye Lin Minghui Wang Ariella T Cohain Alexander W Charney Pei Wang Weiping Ma Ying-Chih Wang Cheng Jiang Mickael Audrain Phillip H Comella Amanda K Fakira Siddharth P Hariharan Gillian M Belbin Kiran Girdhar Allan I Levey Nicholas T Seyfried Eric B Dammer Duc Duong James J Lah Jean-Vianney Haure-Mirande Ben Shackleton Tomas Fanutza Robert Blitzer Eimear Kenny Jun Zhu Vahram Haroutunian Pavel Katsel Sam Gandy Zhidong Tu Michelle E Ehrlich Bin Zhang Stephen R Salton Eric E Schadt

Nat Commun 2020 08 7;11(1):3942. Epub 2020 Aug 7.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.

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August 2020

An inflammatory cytokine signature helps predict COVID-19 severity and death.

Authors:
Diane Marie Del Valle Seunghee Kim-Schulze Huang Hsin-Hui Noam D Beckmann Sharon Nirenberg Bo Wang Yonit Lavin Talia Swartz Deepu Madduri Aryeh Stock Thomas Marron Hui Xie Manish Kumar Patel Oliver van Oekelen Adeeb Rahman Patricia Kovatch Judith Aberg Eric Schadt Sundar Jagannath Madhu Mazumdar Alexander Charney Adolfo Firpo-Betancourt Damodara Rao Mendu Jeffrey Jhang David Reich Keith Sigel Carlos Cordon-Cardo Marc Feldmann Samir Parekh Miriam Merad Sacha Gnjatic

medRxiv 2020 May 30. Epub 2020 May 30.

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May 2020

Late-onset megaconial myopathy in mice lacking group I Paks.

Authors:
Giselle A Joseph Margaret Hung Aviva J Goel Mingi Hong Marysia-Kolbe Rieder Noam D Beckmann Madhavika N Serasinghe Jerry E Chipuk Parvathi M Devarakonda David J Goldhamer Paulina Aldana-Hernandez Jonathan Curtis René L Jacobs Robert S Krauss

Skelet Muscle 2019 02 21;9(1). Epub 2019 Feb 21.

Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1020, New York, NY, 10029, USA.

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February 2019

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease.

Authors:
Minghui Wang Noam D Beckmann Panos Roussos Erming Wang Xianxiao Zhou Qian Wang Chen Ming Ryan Neff Weiping Ma John F Fullard Mads E Hauberg Jaroslav Bendl Mette A Peters Ben Logsdon Pei Wang Milind Mahajan Lara M Mangravite Eric B Dammer Duc M Duong James J Lah Nicholas T Seyfried Allan I Levey Joseph D Buxbaum Michelle Ehrlich Sam Gandy Pavel Katsel Vahram Haroutunian Eric Schadt Bin Zhang

Sci Data 2018 09 11;5:180185. Epub 2018 Sep 11.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

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September 2018

The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target.

Authors:
Vladislav A Petyuk Rui Chang Manuel Ramirez-Restrepo Noam D Beckmann Marc Y R Henrion Paul D Piehowski Kuixi Zhu Sven Wang Jennifer Clarke Matthew J Huentelman Fang Xie Victor Andreev Anzhelika Engel Toumy Guettoche Loida Navarro Philip De Jager Julie A Schneider Christopher M Morris Ian G McKeith Robert H Perry Simon Lovestone Randall L Woltjer Thomas G Beach Lucia I Sue Geidy E Serrano Andrew P Lieberman Roger L Albin Isidre Ferrer Deborah C Mash Christine M Hulette John F Ervin Eric M Reiman John A Hardy David A Bennett Eric Schadt Richard D Smith Amanda J Myers

Brain 2018 09;141(9):2721-2739

Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.

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September 2018

Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.

Authors:
Ben Readhead Jean-Vianney Haure-Mirande Cory C Funk Matthew A Richards Paul Shannon Vahram Haroutunian Mary Sano Winnie S Liang Noam D Beckmann Nathan D Price Eric M Reiman Eric E Schadt Michelle E Ehrlich Sam Gandy Joel T Dudley

Neuron 2018 07 21;99(1):64-82.e7. Epub 2018 Jun 21.

Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn Institute of Genomic Sciences and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Next Generation Healthcare, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ 85287-5001, USA. Electronic address:

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July 2018

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.

Authors:
Ivan Carcamo-Orive Gabriel E Hoffman Paige Cundiff Noam D Beckmann Sunita L D'Souza Joshua W Knowles Achchhe Patel Dimitri Papatsenko Fahim Abbasi Gerald M Reaven Sean Whalen Philip Lee Mohammad Shahbazi Marc Y R Henrion Kuixi Zhu Sven Wang Panos Roussos Eric E Schadt Gaurav Pandey Rui Chang Thomas Quertermous Ihor Lemischka

Cell Stem Cell 2017 04 22;20(4):518-532.e9. Epub 2016 Dec 22.

Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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April 2017

Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks.

Authors:
Benjamin S Glicksberg Li Li Marcus A Badgeley Khader Shameer Roman Kosoy Noam D Beckmann Nam Pho Jörg Hakenberg Meng Ma Kristin L Ayers Gabriel E Hoffman Shuyu Dan Li Eric E Schadt Chirag J Patel Rong Chen Joel T Dudley

Bioinformatics 2016 06;32(12):i101-i110

Department of Genetics and Genomic Sciences Icahn Institute for Genomics and Multiscale Biology Harris Center for Precision Wellness, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA Department of Population Health Science and Policy, New York City, NY 10029, USA.

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June 2016

A new molecular signature method for prediction of driver cancer pathways from transcriptional data.

Authors:
Dmitry Rykunov Noam D Beckmann Hui Li Andrew Uzilov Eric E Schadt Boris Reva

Nucleic Acids Res 2016 06 20;44(11):e110. Epub 2016 Apr 20.

Icahn Institute for Genomics and Multiscale Biology, New York, 10029, USA

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June 2016

Detecting epigenetic motifs in low coverage and metagenomics settings.

Authors:
Noam D Beckmann Sashank Karri Gang Fang Ali Bashir

BMC Bioinformatics 2014 10;15 Suppl 9:S16. Epub 2014 Sep 10.

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December 2014

A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders.

Authors:
Flore Zufferey Elliott H Sherr Noam D Beckmann Ellen Hanson Anne M Maillard Loyse Hippolyte Aurélien Macé Carina Ferrari Zoltán Kutalik Joris Andrieux Elizabeth Aylward Mandy Barker Raphael Bernier Sonia Bouquillon Philippe Conus Bruno Delobel W Andrew Faucett Robin P Goin-Kochel Ellen Grant Louise Harewood Jill V Hunter Sébastien Lebon David H Ledbetter Christa Lese Martin Katrin Männik Danielle Martinet Pratik Mukherjee Melissa B Ramocki Sarah J Spence Kyle J Steinman Jennifer Tjernagel John E Spiro Alexandre Reymond Jacques S Beckmann Wendy K Chung Sébastien Jacquemont

J Med Genet 2012 Oct;49(10):660-8

Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

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October 2012

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.

Authors:
Sébastien Jacquemont Alexandre Reymond Flore Zufferey Louise Harewood Robin G Walters Zoltán Kutalik Danielle Martinet Yiping Shen Armand Valsesia Noam D Beckmann Gudmar Thorleifsson Marco Belfiore Sonia Bouquillon Dominique Campion Nicole de Leeuw Bert B A de Vries Tõnu Esko Bridget A Fernandez Fernando Fernández-Aranda José Manuel Fernández-Real Mònica Gratacòs Audrey Guilmatre Juliane Hoyer Marjo-Riitta Jarvelin R Frank Kooy Ants Kurg Cédric Le Caignec Katrin Männik Orah S Platt Damien Sanlaville Mieke M Van Haelst Sergi Villatoro Gomez Faida Walha Bai-Lin Wu Yongguo Yu Azzedine Aboura Marie-Claude Addor Yves Alembik Stylianos E Antonarakis Benoît Arveiler Magalie Barth Nathalie Bednarek Frédérique Béna Sven Bergmann Mylène Beri Laura Bernardini Bettina Blaumeiser Dominique Bonneau Armand Bottani Odile Boute Han G Brunner Dorothée Cailley Patrick Callier Jean Chiesa Jacqueline Chrast Lachlan Coin Charles Coutton Jean-Marie Cuisset Jean-Christophe Cuvellier Albert David Bénédicte de Freminville Bruno Delobel Marie-Ange Delrue Bénédicte Demeer Dominique Descamps Gérard Didelot Klaus Dieterich Vittoria Disciglio Martine Doco-Fenzy Séverine Drunat Bénédicte Duban-Bedu Christèle Dubourg Julia S El-Sayed Moustafa Paul Elliott Brigitte H W Faas Laurence Faivre Anne Faudet Florence Fellmann Alessandra Ferrarini Richard Fisher Elisabeth Flori Lukas Forer Dominique Gaillard Marion Gerard Christian Gieger Stefania Gimelli Giorgio Gimelli Hans J Grabe Agnès Guichet Olivier Guillin Anna-Liisa Hartikainen Délphine Heron Loyse Hippolyte Muriel Holder Georg Homuth Bertrand Isidor Sylvie Jaillard Zdenek Jaros Susana Jiménez-Murcia Géraldine Joly Helas Philippe Jonveaux Satu Kaksonen Boris Keren Anita Kloss-Brandstätter Nine V A M Knoers David A Koolen Peter M Kroisel Florian Kronenberg Audrey Labalme Emilie Landais Elisabetta Lapi Valérie Layet Solenn Legallic Bruno Leheup Barbara Leube Suzanne Lewis Josette Lucas Kay D MacDermot Pall Magnusson Christian Marshall Michèle Mathieu-Dramard Mark I McCarthy Thomas Meitinger Maria Antonietta Mencarelli Giuseppe Merla Alexandre Moerman Vincent Mooser Fanny Morice-Picard Mafalda Mucciolo Matthias Nauck Ndeye Coumba Ndiaye Ann Nordgren Laurent Pasquier Florence Petit Rolph Pfundt Ghislaine Plessis Evica Rajcan-Separovic Gian Paolo Ramelli Anita Rauch Roberto Ravazzolo Andre Reis Alessandra Renieri Cristobal Richart Janina S Ried Claudine Rieubland Wendy Roberts Katharina M Roetzer Caroline Rooryck Massimiliano Rossi Evald Saemundsen Véronique Satre Claudia Schurmann Engilbert Sigurdsson Dimitri J Stavropoulos Hreinn Stefansson Carola Tengström Unnur Thorsteinsdóttir Francisco J Tinahones Renaud Touraine Louis Vallée Ellen van Binsbergen Nathalie Van der Aa Catherine Vincent-Delorme Sophie Visvikis-Siest Peter Vollenweider Henry Völzke Anneke T Vulto-van Silfhout Gérard Waeber Carina Wallgren-Pettersson Robert M Witwicki Simon Zwolinksi Joris Andrieux Xavier Estivill James F Gusella Omar Gustafsson Andres Metspalu Stephen W Scherer Kari Stefansson Alexandra I F Blakemore Jacques S Beckmann Philippe Froguel

Nature 2011 Aug 31;478(7367):97-102. Epub 2011 Aug 31.

Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.

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August 2011

Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene.

Authors:
Karen Kapur Toby Johnson Noam D Beckmann Joban Sehmi Toshiko Tanaka Zoltán Kutalik Unnur Styrkarsdottir Weihua Zhang Diana Marek Daniel F Gudbjartsson Yuri Milaneschi Hilma Holm Angelo Diiorio Dawn Waterworth Yun Li Andrew B Singleton Unnur S Bjornsdottir Gunnar Sigurdsson Dena G Hernandez Ranil Desilva Paul Elliott Gudmundur I Eyjolfsson Jack M Guralnik James Scott Unnur Thorsteinsdottir Stefania Bandinelli John Chambers Kari Stefansson Gérard Waeber Luigi Ferrucci Jaspal S Kooner Vincent Mooser Peter Vollenweider Jacques S Beckmann Murielle Bochud Sven Bergmann

PLoS Genet 2010 Jul 22;6(7):e1001035. Epub 2010 Jul 22.

Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.

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July 2010

Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins.

Authors:
Barbara Kollerits Stefan Coassin Noam D Beckmann Alexander Teumer Stefan Kiechl Angela Döring Maryam Kavousi Steven C Hunt Claudia Lamina Bernhard Paulweber Zoltán Kutalik Matthias Nauck Cornelia M van Duijn Iris M Heid Johann Willeit Anita Brandstätter Ted D Adams Vincent Mooser Yurii S Aulchenko Henry Völzke Florian Kronenberg

Hum Mol Genet 2009 Dec 3;18(23):4669-76. Epub 2009 Sep 3.

Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria.

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December 2009

Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.

Authors:
Xin Yuan Dawn Waterworth John R B Perry Noha Lim Kijoung Song John C Chambers Weihua Zhang Peter Vollenweider Heide Stirnadel Toby Johnson Sven Bergmann Noam D Beckmann Yun Li Luigi Ferrucci David Melzer Dena Hernandez Andrew Singleton James Scott Paul Elliott Gerard Waeber Lon Cardon Timothy M Frayling Jaspal S Kooner Vincent Mooser

Am J Hum Genet 2008 Oct;83(4):520-8

Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA.

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October 2008