Nirav Malani

Nirav Malani

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Nirav Malani

Nirav Malani

Publications by authors named "Nirav Malani"

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43Publications

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Structural and sequencing analysis of local target DNA recognition by MLV integrase.

Nucleic Acids Res 2015 Jun 12;43(11):5647-63. Epub 2015 May 12.

Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA

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http://dx.doi.org/10.1093/nar/gkv410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477651PMC
June 2015

Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions.

Mol Ther Methods Clin Dev 2015 29;2:15015. Epub 2015 Apr 29.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead , Westmead, Australia ; The University of Sydney, Discipline of Paediatrics and Child Health , Westmead, Australia.

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http://dx.doi.org/10.1038/mtm.2015.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445430PMC
June 2015

A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.

N Engl J Med 2014 Oct;371(15):1407-17

From the Departments of Biotherapy (S.H.-B.-A., J. Blondeau, L.C., F.T., M.C.) and Immunology and Pediatric Hematology (S.B., G.C., D.M., B.N., C.P., F.T., A.F.) and the Centre d'Étude des Déficits Immunitaires (C.P.), Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), the Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, AP-HP, INSERM (S.H.-B.-A., J. Blondeau, L.C., F.T., M.C.), Unité de Technologies Chimiques et Biologiques pour la Santé, Centre National de la Recherche Scientifique, 8258-INSERM Unité 1022, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes (S.H.-B.-A.), Immunology Laboratory, Groupe Hospitalier Universitaire Paris-Sud, AP-HP, Le Kremlin-Bicêtre (S.H.-B.-A.), Imagine Institute, Paris Descartes-Sorbonne Paris Cité University (S.B., J. Blondeau, L.C., D.M., B.N., C.P., E.S., A.F., M.C.), INSERM Unités Mixtes de Recherche 1163, Laboratory of Human Lymphohematopoiesis (J. Blondeau, L.C., E.S., F.T., A.F., M.C.), Groupe Immunoscope, Immunology Department, Institut Pasteur (A.L.), and Collège de France (A.F.) - all in Paris; Division of Hematology-Oncology (S.-Y.P., H.B., D.G., C.E.H., G.H., L.E.L., W.B.L., D.A.W.) and Division of Immunology (L.D.N.), Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute (S.-Y.P., D.G., L.E.L., W.B.L., D.A.W.), Harvard Medical School (S.-Y.P., M.A., L.E.L., W.B.L., J.R., L.E.S., A.T., L.D.N., D.A.W.), Center for Human Cell Therapy, Program in Cellular and Molecular Medicine, Boston Children's Hospital (M.A., J.R., L.E.S., A.T.), Division of Hematologic Malignancies, Dana-Farber Cancer Institute (J.R.), and the Manton Center for Orphan Disease Research (L.D.N.) - all in Boston; Great Ormond Street Hospital for Children NHS Foundation Trust (H.B.G., J.X.-B., A.J.T.) and Section of Molecular and Cellular Immunology, University College London Institute of Child Health (H.B.G., K.F.B., A.

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http://dx.doi.org/10.1056/NEJMoa1404588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274995PMC
October 2014

Comparing DNA integration site clusters with scan statistics.

Bioinformatics 2014 Jun 30;30(11):1493-500. Epub 2014 Jan 30.

Division of Biostatistics and BioInformatics, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, CA 92093-0901 and Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, 425 Johnson Pavilion, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029028PMC
June 2014

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction.

Nucleic Acids Res 2014 May 12;42(9):5917-28. Epub 2014 Mar 12.

Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, 675 Hoes Lane, Piscataway, NJ 08854, USA Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA

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http://dx.doi.org/10.1093/nar/gku175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027182PMC
May 2014

A new class of multimerization selective inhibitors of HIV-1 integrase.

PLoS Pathog 2014 May 29;10(5):e1004171. Epub 2014 May 29.

Center for Retrovirus Research and College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038613PMC
May 2014

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes.

Nucleic Acids Res 2014 Apr 11;42(8):4868-81. Epub 2014 Feb 11.

Center for Retrovirus Research and College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA and Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1093/nar/gku135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005663PMC
April 2014

The major cellular sterol regulatory pathway is required for Andes virus infection.

PLoS Pathog 2014 Feb 6;10(2):e1003911. Epub 2014 Feb 6.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916400PMC
February 2014

Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag.

Proc Natl Acad Sci U S A 2013 Jun 9;110(23):9487-92. Epub 2013 May 9.

Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA.

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http://www.pnas.org/lookup/doi/10.1073/pnas.1221736110
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http://dx.doi.org/10.1073/pnas.1221736110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677494PMC
June 2013

piggyBac transposase tools for genome engineering.

Proc Natl Acad Sci U S A 2013 Jun 30;110(25):E2279-87. Epub 2013 May 30.

Howard Hughes Medical Institute and Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.1305987110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690869PMC
June 2013

Quantitation of HIV DNA integration: effects of differential integration site distributions on Alu-PCR assays.

J Virol Methods 2013 Apr 21;189(1):53-7. Epub 2013 Jan 21.

University of Pennsylvania Perelman School of Medicine, Department of Microbiology, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, United States.

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http://dx.doi.org/10.1016/j.jviromet.2013.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608829PMC
April 2013

A resurrected mammalian hAT transposable element and a closely related insect element are highly active in human cell culture.

Proc Natl Acad Sci U S A 2013 Feb 22;110(6):E478-87. Epub 2012 Oct 22.

The Howard Hughes Medical Institute and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1121543109
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http://dx.doi.org/10.1073/pnas.1121543109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568352PMC
February 2013

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells.

Retrovirology 2012 Oct 9;9:84. Epub 2012 Oct 9.

Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium.

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http://dx.doi.org/10.1186/1742-4690-9-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485173PMC
October 2012

Gammaretroviral integration into nucleosomal target DNA in vivo.

J Virol 2011 Jul 11;85(14):7393-401. Epub 2011 May 11.

University of Pennsylvania School of Medicine, Department of Microbiology, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1128/JVI.00635-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126552PMC
July 2011

A method to sequence and quantify DNA integration for monitoring outcome in gene therapy.

Nucleic Acids Res 2011 Jun 16;39(11):e72. Epub 2011 Mar 16.

Department of Microbiology, University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1093/nar/gkr140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113588PMC
June 2011

LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.

Mol Ther 2010 Mar 5;18(3):552-60. Epub 2010 Jan 5.

Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/mt.2010.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839429PMC
March 2010

Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells.

Mol Ther 2009 May 3;17(5):844-50. Epub 2009 Mar 3.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.

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http://dx.doi.org/10.1038/mt.2009.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835137PMC
May 2009

Methods for integration site distribution analyses in animal cell genomes.

Methods 2009 Apr 25;47(4):261-8. Epub 2008 Nov 25.

Institute of Microbiology, University Hospital Center and University of Lausanne, Bugnon 48, Lausanne 1011, Switzerland.

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http://dx.doi.org/10.1016/j.ymeth.2008.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104535PMC
April 2009

Integration target site selection by a resurrected human endogenous retrovirus.

Genes Dev 2009 Mar;23(5):633-42

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1762309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658518PMC
March 2009

Massively parallel pyrosequencing in HIV research.

AIDS 2008 Jul;22(12):1411-5

Department of Microbiology, University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1097/QAD.0b013e3282fc972eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221253PMC
July 2008