Ningyan Zhang

Ningyan Zhang

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Ningyan Zhang

Publications by authors named "Ningyan Zhang"

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48Publications

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Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity.

Mol Cell Biol 2020 Mar 30;40(8). Epub 2020 Mar 30.

Center for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, Texas, USA

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http://dx.doi.org/10.1128/MCB.00564-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108820PMC
March 2020

Neural Differentiation of Mouse Neural Stem Cells as a Tool to Assess Developmental Neurotoxicity of Drinking Water in Taihu Lake.

Biol Trace Elem Res 2019 Jul 22;190(1):172-186. Epub 2018 Nov 22.

Stem Cell Translational Research Center, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200065, People's Republic of China.

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http://dx.doi.org/10.1007/s12011-018-1533-5DOI Listing
July 2019

Identification of adipocyte plasma membrane-associated protein as a novel modulator of human cytomegalovirus infection.

PLoS Pathog 2019 07 29;15(7):e1007914. Epub 2019 Jul 29.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687193PMC
July 2019

Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes.

PLoS Pathog 2019 06 6;15(6):e1007716. Epub 2019 Jun 6.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553876PMC
June 2019

EGFL6 promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulating tumor angiogenesis.

Oncogene 2019 03 19;38(12):2123-2134. Epub 2018 Nov 19.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler St., Houston, TX, 77030, USA.

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http://www.nature.com/articles/s41388-018-0565-9
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http://dx.doi.org/10.1038/s41388-018-0565-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579606PMC
March 2019

Human endotrophin as a driver of malignant tumor growth.

JCI Insight 2019 03 21;5. Epub 2019 Mar 21.

Touchstone Diabetes Center, Departments of Internal Medicine and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1172/jci.insight.125094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538351PMC
March 2019

A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML.

Mol Ther 2018 10 7;26(10):2487-2495. Epub 2018 Aug 7.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183037
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http://dx.doi.org/10.1016/j.ymthe.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171100PMC
October 2018

Proteinase-nicked IgGs: an unanticipated target for tumor immunotherapy.

Oncoimmunology 2018 23;7(9):e1480300. Epub 2018 Jul 23.

The Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, Health Science Center, University of Texas Medical School at Houston, Texas, USA.

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http://dx.doi.org/10.1080/2162402X.2018.1480300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140550PMC
July 2018

Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo.

Breast Cancer Res 2018 06 1;20(1):43. Epub 2018 Jun 1.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, the University of Texas Health Science Center at Houston, 1825 Pressler St., Suite 532, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13058-018-0972-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984793PMC
June 2018

Glutamic acid-valine-citrulline linkers ensure stability and efficacy of antibody-drug conjugates in mice.

Nat Commun 2018 06 28;9(1):2512. Epub 2018 Jun 28.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1881 East Road, Houston, TX, 77054, USA.

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http://dx.doi.org/10.1038/s41467-018-04982-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023893PMC
June 2018

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

Neuron 2018 03;97(5):1023-1031.e7

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889092PMC
March 2018

Targeting Human-Cytomegalovirus-Infected Cells by Redirecting T Cells Using an Anti-CD3/Anti-Glycoprotein B Bispecific Antibody.

Antimicrob Agents Chemother 2018 01 21;62(1). Epub 2017 Dec 21.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA

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http://dx.doi.org/10.1128/AAC.01719-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740302PMC
January 2018

Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis.

Cell Rep 2017 Dec;21(10):2785-2795

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749980PMC
December 2017

Enzymatic conjugation using branched linkers for constructing homogeneous antibody-drug conjugates with high potency.

Org Biomol Chem 2017 Jul;15(26):5635-5642

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1881 East Road, Houston, TX 77054, USA.

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http://dx.doi.org/10.1039/c7ob01027cDOI Listing
July 2017

Antibody therapies for the prevention and treatment of viral infections.

NPJ Vaccines 2017 10;2:19. Epub 2017 Jul 10.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX USA.

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http://dx.doi.org/10.1038/s41541-017-0019-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627241PMC
July 2017

HER3 and LINC00052 interplay promotes tumor growth in breast cancer.

Oncotarget 2017 Jan;8(4):6526-6539

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.14313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351650PMC
January 2017

Divergent functions of endotrophin on different cell populations in adipose tissue.

Am J Physiol Endocrinol Metab 2016 12 11;311(6):E952-E963. Epub 2016 Oct 11.

Center for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, Texas; and

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http://ajpendo.physiology.org/content/ajpendo/early/2016/10/
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http://ajpendo.physiology.org/content/ajpendo/311/6/E952.ful
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http://dx.doi.org/10.1152/ajpendo.00314.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189636PMC
December 2016

Crk II silencing down-regulates IGF-IR and inhibits migration and invasion of prostate cancer cells.

Biochem Biophys Rep 2016 Dec 28;8:382-388. Epub 2016 Oct 28.

Brown Foundation Institute of Molecular Medicine, University of Texas Medical School at Houston, TX, USA.

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http://dx.doi.org/10.1016/j.bbrep.2016.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614478PMC
December 2016

Novel association of DJ-1 with HER3 potentiates HER3 activation and signaling in cancer.

Oncotarget 2016 10;7(40):65758-65769

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.11613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323190PMC
October 2016

Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity.

ACS Chem Biol 2016 10 10;11(10):2724-2733. Epub 2016 Aug 10.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston , Houston, Texas 77054, United States.

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http://dx.doi.org/10.1021/acschembio.6b00604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502478PMC
October 2016

Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function.

Oncoimmunology 2016 May 29;5(5):e1122861. Epub 2015 Dec 29.

The Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centerl at Houston , Hosuton, TX, USA.

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http://dx.doi.org/10.1080/2162402X.2015.1122861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910702PMC
May 2016

HER3/ErbB3, an emerging cancer therapeutic target.

Acta Biochim Biophys Sin (Shanghai) 2016 Jan 24;48(1):39-48. Epub 2015 Oct 24.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA

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http://dx.doi.org/10.1093/abbs/gmv103DOI Listing
January 2016

Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity.

Clin Cancer Res 2015 Dec 29;21(23):5380-90. Epub 2015 Jul 29.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1057DOI Listing
December 2015

Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages.

J Immunol 2015 May 20;194(9):4379-86. Epub 2015 Mar 20.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030;

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http://dx.doi.org/10.4049/jimmunol.1402891DOI Listing
May 2015

A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies.

Mol Cancer Ther 2015 Mar 31;14(3):681-91. Epub 2014 Dec 31.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0715DOI Listing
March 2015

Regulation of ERBB3/HER3 signaling in cancer.

Oncotarget 2014 Nov;5(21):10222-36

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279368PMC
http://dx.doi.org/10.18632/oncotarget.2655DOI Listing
November 2014

Human decellularized adipose tissue scaffold as a model for breast cancer cell growth and drug treatments.

Biomaterials 2014 Jun 21;35(18):4940-9. Epub 2014 Mar 21.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler St., Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2014.03.003DOI Listing
June 2014

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction.

Nat Commun 2014 Mar 19;5:3485. Epub 2014 Mar 19.

1] Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA [2] Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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http://www.nature.com/articles/ncomms4485
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http://dx.doi.org/10.1038/ncomms4485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076823PMC
March 2014

HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways.

Protein Cell 2012 Oct 15;3(10):781-9. Epub 2012 Sep 15.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s13238-012-2065-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875347PMC
October 2012

ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells.

Cancer Med 2012 Aug 15;1(1):28-38. Epub 2012 Jul 15.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston Houston, Texas, USA.

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http://dx.doi.org/10.1002/cam4.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544427PMC
August 2012

Isolation and characterization of IgG1 with asymmetrical Fc glycosylation.

Glycobiology 2011 Aug 5;21(8):1087-96. Epub 2011 Apr 5.

Merck Research Laboratories, West Point, PA 19486, USA.

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http://dx.doi.org/10.1093/glycob/cwr047DOI Listing
August 2011

Improved activity and thermostability of Candida antarctica lipase B by DNA family shuffling.

Protein Eng Des Sel 2004 Feb 12;17(2):133-40. Epub 2004 Jan 12.

Biotransformations Group, Schering-Plough Research Institute, Union, NJ 07083, USA.

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http://dx.doi.org/10.1093/protein/gzh017DOI Listing
February 2004

Improving tolerance of Candida antarctica lipase B towards irreversible thermal inactivation through directed evolution.

Protein Eng 2003 Aug;16(8):599-605

Biotransformations Group and Structure Chemistry, Schering-Plough Research Institute, U-13-3000, 1011 Morris Avenue, Union, NJ 07083, USA.

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http://dx.doi.org/10.1093/protein/gzg074DOI Listing
August 2003