Dr Ning, Shunbin, PhD - East Tennessee State University - Associate Professor

Dr Ning, Shunbin

PhD

East Tennessee State University

Associate Professor

Johnson City, tn | United States

Additional Specialties: Innate immunity, viral cancers

ORCID logohttps://orcid.org/0000-0001-5484-5779

Dr Ning, Shunbin, PhD - East Tennessee State University - Associate Professor

Dr Ning, Shunbin

PhD

Introduction

Primary Affiliation: East Tennessee State University - Johnson City, tn , United States

Additional Specialties:

Research Interests:


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Publications

23Publications

687Reads

27Profile Views

322PubMed Central Citations

Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections.

Immun Ageing 2019 24;16:12. Epub 2019 Jun 24.

1Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 USA.

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http://dx.doi.org/10.1186/s12979-019-0153-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591813PMC
June 2019
4 Reads
2.316 Impact Factor

Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions.

Front Immunol 2019 22;10:1152. Epub 2019 May 22.

Center of Excellence for Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson, TN, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540964PMC
May 2019
10 Reads

p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress.

PLoS Pathog 2019 04 24;15(4):e1007541. Epub 2019 Apr 24.

Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502431PMC
April 2019
18 Reads

The Multifunctional Protein p62 and Its Mechanistic Roles in Cancers.

Curr Cancer Drug Targets 2019 ;19(6):468-478

Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States.

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http://dx.doi.org/10.2174/1568009618666181016164920DOI Listing
January 2019
53 Reads
3.522 Impact Factor

HCV-associated exosomes promote myeloid-derived suppressor cell expansion via inhibiting miR-124 to regulate T follicular cell differentiation and function.

Cell Discov 2018 11;4:51. Epub 2018 Sep 11.

1Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 USA.

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http://dx.doi.org/10.1038/s41421-018-0052-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131392PMC
September 2018
33 Reads

Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection.

Cell Death Dis 2018 09 5;9(9):900. Epub 2018 Sep 5.

Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614, USA.

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http://www.nature.com/articles/s41419-018-0897-y
Publisher Site
http://dx.doi.org/10.1038/s41419-018-0897-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125360PMC
September 2018
17 Reads
5.014 Impact Factor

Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection.

Cell Discov 2018 10;4:16. Epub 2018 Apr 10.

1Center of Excellence in Inflammation, Infectious Disease and Immunity, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 USA.

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http://dx.doi.org/10.1038/s41421-018-0015-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891503PMC
April 2018
35 Reads
3 Citations

The Linear Ubiquitin Assembly Complex Modulates Latent Membrane Protein 1 Activation of NF-κB and Interferon Regulatory Factor 7.

J Virol 2017 02 31;91(4). Epub 2017 Jan 31.

Center of Excellence for Inflammation, Infectious Diseases and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

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http://dx.doi.org/10.1128/JVI.01138-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286870PMC
February 2017
173 Reads
2 Citations
4.440 Impact Factor

Protein phosphatase 1 abrogates IRF7-mediated type I IFN response in antiviral immunity.

Eur J Immunol 2016 10 29;46(10):2409-2419. Epub 2016 Aug 29.

Center of Excellence for Inflammation, Infectious Diseases and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.

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http://dx.doi.org/10.1002/eji.201646491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175453PMC
October 2016
41 Reads
1 Citation
4.034 Impact Factor

MicroRNA regulation of viral immunity, latency, and carcinogenesis of selected tumor viruses and HIV.

Rev Med Virol 2015 Sep 10;25(5):320-41. Epub 2015 Aug 10.

Center of Excellence for Inflammation, Infectious Diseases and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.

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http://dx.doi.org/10.1002/rmv.1850DOI Listing
September 2015
56 Reads
9 Citations
5.574 Impact Factor

Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA.

J Biol Chem 2015 May 8;290(21):13344-53. Epub 2015 Apr 8.

From the Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, Florida 33136,

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http://dx.doi.org/10.1074/jbc.M115.653915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505584PMC
May 2015
45 Reads
7 Citations
4.573 Impact Factor

Gene expression profiling identifies IRF4-associated molecular signatures in hematological malignancies.

PLoS One 2014 10;9(9):e106788. Epub 2014 Sep 10.

Center for Inflammation, Infectious Diseases and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106788PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160201PMC
May 2015
29 Reads
8 Citations
3.234 Impact Factor

Interferon regulatory factor 4 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed cells.

J Virol 2013 Sep 26;87(17):9672-9. Epub 2013 Jun 26.

Viral Oncology Program, Division of Hematology/Oncology, Sylvester Comprehensive Cancer Center, Miami, Florida, USA.

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http://dx.doi.org/10.1128/JVI.01435-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754115PMC
September 2013
11 Reads
5 Citations
4.440 Impact Factor

Oncogenic IRFs provide a survival advantage for Epstein-Barr virus- or human T-cell leukemia virus type 1-transformed cells through induction of BIC expression.

J Virol 2011 Aug 15;85(16):8328-37. Epub 2011 Jun 15.

Division of Hematology/Oncology, Viral Oncology Program, Sylvester Comprehensive Cancer Center, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

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http://dx.doi.org/10.1128/JVI.00570-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147954PMC
August 2011
25 Reads
21 Citations
4.440 Impact Factor

Innate immune modulation in EBV infection.

Authors:
Shunbin Ning

Herpesviridae 2011 Jan 5;2(1). Epub 2011 Jan 5.

Viral Oncology Program, Sylvester Comprehensive Cancer Center; Division of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1186/2042-4280-2-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063194PMC
January 2011
4 Reads
12 Citations

The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7.

J Virol 2010 Jun 14;84(12):6130-8. Epub 2010 Apr 14.

Division of Hematology/Oncology, Department of Medicine, Miller School of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.

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http://jvi.asm.org/content/84/12/6130.full.pdf
Web Search
http://jvi.asm.org/cgi/doi/10.1128/JVI.00364-10
Publisher Site
http://dx.doi.org/10.1128/JVI.00364-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876664PMC
June 2010
11 Reads
25 Citations
4.440 Impact Factor

The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity.

J Virol 2009 May 25;83(9):4345-53. Epub 2009 Feb 25.

Departments of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1128/JVI.02195-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668490PMC
May 2009
6 Reads
28 Citations
4.440 Impact Factor

TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.

Mol Cell Biol 2008 Oct 18;28(20):6536-46. Epub 2008 Aug 18.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1128/MCB.00785-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577435PMC
October 2008
5 Reads
44 Citations
4.780 Impact Factor

Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination.

Mol Cell Biol 2007 Apr 12;27(8):2910-8. Epub 2007 Feb 12.

Lineberger Comprehensive Cancer Center, University of North Carolina, Campus Box 7295, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1128/MCB.02256-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899925PMC
April 2007
12 Reads
33 Citations
4.780 Impact Factor

Interferon regulatory factor 5 represses expression of the Epstein-Barr virus oncoprotein LMP1: braking of the IRF7/LMP1 regulatory circuit.

J Virol 2005 Sep;79(18):11671-6

Lineberger Comprehensive Cancer Center, University of North Carolina, School of Medicine, Campus Box 7295, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1128/JVI.79.18.11671-11676.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1212628PMC
September 2005
11 Reads
21 Citations
4.440 Impact Factor

Interferon regulatory factor 7 is negatively regulated by the Epstein-Barr virus immediate-early gene, BZLF-1.

J Virol 2005 Aug;79(15):10040-52

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, 27599, USA.

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http://dx.doi.org/10.1128/JVI.79.15.10040-10052.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1181586PMC
August 2005
20 Reads
18 Citations
4.440 Impact Factor

Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling.

J Biol Chem 2005 Apr 21;280(13):12262-70. Epub 2005 Jan 21.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M404260200DOI Listing
April 2005
49 Reads
36 Citations
4.573 Impact Factor

Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit.

J Virol 2003 Sep;77(17):9359-68

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187426PMC
http://dx.doi.org/10.1128/jvi.77.17.9359-9368.2003DOI Listing
September 2003
19 Reads
49 Citations
4.440 Impact Factor

Top co-authors

Shunbin Ning
Shunbin Ning

University of North Carolina

23
Ling Wang
Ling Wang

State Key Laboratory Breeding Base of Dao-di Herbs

14
Zhi Q Yao
Zhi Q Yao

East Tennessee State University

10
Jonathan P Moorman
Jonathan P Moorman

East Tennessee State University

10
Joseph S Pagano
Joseph S Pagano

Lineberger Comprehensive Cancer Center

8
Juan Zhao
Juan Zhao

Peking University First Hospital

7
Xindi Dang
Xindi Dang

1Center of Excellence in Inflammation

5
Leslie E Huye
Leslie E Huye

Center for Cell and Gene Therapy

5
Dechao Cao
Dechao Cao

1Center of Excellence in Inflammation

5