Nils Wierup

Nils Wierup

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Nils Wierup

Publications by authors named "Nils Wierup"

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No direct effect of SGLT2 activity on glucagon secretion.

Diabetologia 2019 06 22;62(6):1011-1023. Epub 2019 Mar 22.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Panum Institute, Blegdamsvej 3B, DK-2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s00125-019-4849-6DOI Listing
June 2019

Defective exocytosis and processing of insulin in a cystic fibrosis mouse model.

J Endocrinol 2019 Feb 1. Epub 2019 Feb 1.

L Eliasson, Dept Clinical Sciences in Malmö, Lunds Universitet, Malmö, 214 28, Sweden.

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http://dx.doi.org/10.1530/JOE-18-0570DOI Listing
February 2019

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.

Diabetes 2018 03 11;67(3):372-384. Epub 2017 Dec 11.

Unit of Molecular Metabolism, Department of Clinical Sciences, Lund University Diabetes Centre, Clinical Research Centre, Skåne University Hospital, Malmö, Sweden

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http://dx.doi.org/10.2337/db16-1441DOI Listing
March 2018

Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation.

Mol Cell Endocrinol 2017 10 22;454:146-157. Epub 2017 Jun 22.

KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Norway; Department of Biomedicine, University of Bergen, Bergen, Norway; Department of Biomedical Laboratory Sciences and Chemical Engineering, Western Norway University of Applied Sciences, Bergen, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.06.020DOI Listing
October 2017

Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington's disease.

Sci Rep 2017 10 24;7(1):13896. Epub 2017 Oct 24.

Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Brain Disease Biomarker Unit, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1038/s41598-017-13713-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654969PMC
October 2017

Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells.

Mol Metab 2017 07 19;6(7):651-663. Epub 2017 May 19.

Department of Clinical Sciences Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Skåne University Hospital, 20502, Malmö, Sweden.

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http://dx.doi.org/10.1016/j.molmet.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485242PMC
July 2017

Ghrelin Is a Regulator of Glucagon-Like Peptide 1 Secretion and Transcription in Mice.

Front Endocrinol (Lausanne) 2017 19;8:135. Epub 2017 Jun 19.

Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.

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http://dx.doi.org/10.3389/fendo.2017.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5475379PMC
June 2017

Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes.

Diabetes 2017 04 17;66(4):880-885. Epub 2017 Jan 17.

Turku PET Centre, University of Turku, Turku, Finland

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http://dx.doi.org/10.2337/db16-0762DOI Listing
April 2017

Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels.

Peptides 2017 04 24;90:78-82. Epub 2017 Feb 24.

Lund University Diabetes Centre, Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2017.02.009DOI Listing
April 2017

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.

Sci Rep 2017 03 7;7(1):90. Epub 2017 Mar 7.

Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, CRC, SUS Malmö, Malmö, Sweden.

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http://dx.doi.org/10.1038/s41598-017-00098-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428348PMC
March 2017

Roux-en-Y gastric bypass versus calorie restriction: support for surgery per se as the direct contributor to altered responses of insulin and incretins to a mixed meal.

Surg Obes Relat Dis 2017 Feb 28;13(2):234-242. Epub 2016 Sep 28.

Lund University Diabetes Centre, Lund University, Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.soard.2016.09.017DOI Listing
February 2017

Mucosal glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide cell numbers in the super-obese human foregut after gastric bypass.

Surg Obes Relat Dis 2015 Nov-Dec;11(6):1237-46. Epub 2015 Apr 2.

Aleris Obesity, Lund, Sweden; Department of Surgery, Clinical Sciences, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.soard.2015.03.021DOI Listing
October 2016

Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Diabetologia 2016 Apr 6;59(4):744-54. Epub 2016 Jan 6.

Lund University Diabetes Centre, Department of Clinical Sciences, Unit of Diabetes and Celiac disease, Clinical Research Centre, Jan Waldenströms gata 35, Clinical Research Centre House 91:10, Skåne University Hospital Malmö, SE-20502, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00125-015-3847-6DOI Listing
April 2016

Decreased insulin secretion and glucose clearance in exocrine pancreas-insufficient pigs.

Exp Physiol 2016 Jan 9;101(1):100-12. Epub 2015 Dec 9.

Department of Biology, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1113/EP085431DOI Listing
January 2016

Short- and long-term hormonal and metabolic consequences of reversing gastric bypass to normal anatomy in a type 2 diabetes patient.

Obes Surg 2015 Jan;25(1):180-5

Clinical Research Centre, Neuroendocrine Cell Biology, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Skåne University Hospital, Jan Waldenströms gata 35, Malmö, Sweden,

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http://dx.doi.org/10.1007/s11695-014-1459-8DOI Listing
January 2015

Gastric bypass improves β-cell function and increases β-cell mass in a porcine model.

Diabetes 2014 May 31;63(5):1665-71. Epub 2014 Jan 31.

Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.

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http://dx.doi.org/10.2337/db13-0969DOI Listing
May 2014

The islet ghrelin cell.

J Mol Endocrinol 2014 Feb 19;52(1):R35-49. Epub 2013 Dec 19.

Unit of Neuroendocrine Cell Biology, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Clinical Research Centre, Scania University Hospital, Jan Waldenströms gata 35, SE 205 02 Malmö, Sweden Imaging Team, Novo Nordisk A/S, Novo Nordisk Park, DK2760 Måløv, Denmark.

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http://dx.doi.org/10.1530/JME-13-0122DOI Listing
February 2014

Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.

Regul Pept 2014 Feb 8;189:11-6. Epub 2014 Jan 8.

Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö Sweden.

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http://dx.doi.org/10.1016/j.regpep.2013.12.009DOI Listing
February 2014

Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets.

J Biol Chem 2013 Oct 9;288(40):29013-23. Epub 2013 Aug 9.

From the Department of Clinical Sciences, Lund University Diabetes Center, Lund University, Skåne University Hospital SUS, SE-205 02 Malmö, Sweden and.

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http://www.jbc.org/content/288/40/29013.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M113.478222
Publisher Site
http://dx.doi.org/10.1074/jbc.M113.478222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789998PMC
October 2013

Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.

Mol Cell Endocrinol 2013 Aug 22;375(1-2):35-42. Epub 2013 May 22.

Lund University Diabetes Center, Department of Clinical Sciences, Diabetes & Endocrinology, Skåne University Hospital, Lund University, Malmö 20502, Sweden.

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http://dx.doi.org/10.1016/j.mce.2013.05.003DOI Listing
August 2013

Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans.

J Clin Endocrinol Metab 2013 May 30;98(5):E856-61. Epub 2013 Apr 30.

Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, SE-205 02 Malmö, Sweden.

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http://dx.doi.org/10.1210/jc.2012-3996DOI Listing
May 2013

A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.

Endocrinology 2012 Dec 12;153(12):5782-95. Epub 2012 Oct 12.

Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, 2200 Denmark.

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http://dx.doi.org/10.1210/en.2012-1595DOI Listing
December 2012

β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia.

Int J Endocrinol 2011 17;2011:401258. Epub 2011 Nov 17.

Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.

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http://www.hindawi.com/journals/ije/2011/401258/
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http://dx.doi.org/10.1155/2011/401258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227460PMC
August 2012

Expression of cocaine- and amphetamine-regulated transcript is associated with worse survival in small bowel carcinoid tumors.

Clin Cancer Res 2012 Jul 2;18(13):3668-76. Epub 2012 May 2.

Department of Surgery, Ryhov Hospital, Jönköping, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2513DOI Listing
July 2012

Cocaine- and amphetamine-regulated transcript in neuroendocrine tumors.

Neuroendocrinology 2011 11;94(3):228-36. Epub 2011 Aug 11.

Department of Surgery, Ryhov Hospital, Jönköping, Sweden.

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http://dx.doi.org/10.1159/000329044DOI Listing
March 2012

Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects.

Cell Tissue Res 2011 Dec 23;346(3):393-405. Epub 2011 Nov 23.

Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00441-011-1268-5DOI Listing
December 2011

Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.

Neurobiol Dis 2011 Oct 23;44(1):1-8. Epub 2011 May 23.

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, BMC A10, Lund, Sweden.

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http://dx.doi.org/10.1016/j.nbd.2011.05.006DOI Listing
October 2011

Increased β-cell volume in mice fed a high-fat diet: a dynamic study over 12 months.

Islets 2010 Nov-Dec;2(6):353-6. Epub 2010 Nov 1.

Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

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http://dx.doi.org/10.4161/isl.2.6.13619DOI Listing
August 2011

Distribution of melatonin receptors in murine pancreatic islets.

J Pineal Res 2011 May 1;50(4):412-7. Epub 2011 Mar 1.

Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, Malmö, Sweden.

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http://dx.doi.org/10.1111/j.1600-079X.2011.00859.xDOI Listing
May 2011

Biomechanical properties and innervation of the female caveolin-1-deficient detrusor.

Br J Pharmacol 2011 Mar;162(5):1156-70

Department of Experimental Medical Science, Lund University, Biomedical Centre, Lund, Sweden.

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http://dx.doi.org/10.1111/j.1476-5381.2010.01115.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051387PMC
March 2011

First report on metastasizing small bowel carcinoids in first-degree relatives in three generations.

Neuroendocrinology 2010 12;91(4):318-23. Epub 2010 May 12.

Department of Surgery, Ryhov Hospital, Jönköping, Sweden.

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http://dx.doi.org/10.1159/000299790DOI Listing
November 2010

Covariation of plasma ghrelin and motilin in irritable bowel syndrome.

Peptides 2010 Jun 23;31(6):1109-12. Epub 2010 Mar 23.

Department of Internal Medicine, Trelleborg Hospital, Hedvägen 46, S-231 85 Trelleborg, Sweden.

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http://dx.doi.org/10.1016/j.peptides.2010.03.021DOI Listing
June 2010

Apelin is a novel islet peptide.

Regul Pept 2010 Jun 24;162(1-3):44-51. Epub 2010 Mar 24.

Department of Experimental Medical Science, Lund University, Lund, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S01670115100005
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http://dx.doi.org/10.1016/j.regpep.2010.03.005DOI Listing
June 2010

Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.

Nutrition 2010 Feb 31;26(2):230-9. Epub 2009 Jul 31.

Department of Experimental Medical Science, Division of Diabetes, Metabolism and Endocrinology, Lund University, BMC, Lund, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S089990070900253
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http://dx.doi.org/10.1016/j.nut.2009.06.007DOI Listing
February 2010

Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion.

Biochem Biophys Res Commun 2008 Nov 18;376(3):558-62. Epub 2008 Sep 18.

Department of Experimental Medical Science, Division of Diabetes, Metabolism and Endocrinology, Lund University, BMC C11, SE-221 84 Lund, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0801772
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http://dx.doi.org/10.1016/j.bbrc.2008.09.045DOI Listing
November 2008

Long-term nicotine exposure causes increased concentrations of trypsinogens and amylase in pancreatic extracts in the rat.

Pancreas 2008 Oct;37(3):288-94

Department of Clinical Sciences, Malmö University Hospital, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1097/MPA.0b013e31816a7744DOI Listing
October 2008

Islet beta-cell area and hormone expression are unaltered in Huntington's disease.

Histochem Cell Biol 2008 May 8;129(5):623-9. Epub 2008 Feb 8.

Unit of Molecular Metabolism, Department of Experimental Medical Science, Lund University, CRC 91-11, 205 02 Malmö, Sweden.

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http://dx.doi.org/10.1007/s00418-008-0393-zDOI Listing
May 2008

Increased metabolism in the R6/2 mouse model of Huntington's disease.

Neurobiol Dis 2008 Jan 24;29(1):41-51. Epub 2007 Aug 24.

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden.

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http://dx.doi.org/10.1016/j.nbd.2007.07.029DOI Listing
January 2008

Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine.

J Clin Endocrinol Metab 2007 Sep 26;92(9):3573-81. Epub 2007 Jun 26.

Lund University, Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Unit of Neuroendocrine Cell Biology, BMC B11, SE-22 184 Lund, Sweden.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2006-2756DOI Listing
September 2007

Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance.

J Endocrinol 2007 Sep;194(3):551-5

Department of Experimental Medical Science, Lund University, SE-22184 Lund, Sweden.

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http://dx.doi.org/10.1677/JOE-07-0161DOI Listing
September 2007

Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.

Cell Signal 2007 Jul 12;19(7):1505-13. Epub 2007 Feb 12.

Department of Experimental Medical Science, Biomedical Center C11, Lund University, SE-221 84 Lund, Sweden.

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http://dx.doi.org/10.1016/j.cellsig.2007.01.030DOI Listing
July 2007

Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands.

BMC Neurosci 2007 Jul 11;8:51. Epub 2007 Jul 11.

Department of Experimental Medical Science, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1186/1471-2202-8-51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934373PMC
July 2007

Gastric ghrelin cell development is hampered and plasma ghrelin is reduced by delayed weaning in rats.

J Endocrinol 2007 Feb;192(2):345-52

Department of cell and Organism biology, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1677/joe.1.07077DOI Listing
February 2007

CART is a novel islet regulatory peptide.

Peptides 2006 Aug 13;27(8):2031-6. Epub 2006 Jul 13.

Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1016/j.peptides.2006.02.011DOI Listing
August 2006

Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model.

J Proteome Res 2006 Jul;5(7):1701-10

Department of Experimental Medical Science, Lund University, BMC C11, SE-221 84 Lund, Sweden.

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http://pubs.acs.org/doi/abs/10.1021/pr060101h
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http://dx.doi.org/10.1021/pr060101hDOI Listing
July 2006

CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.

Diabetes 2006 Feb;55(2):305-11

Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Sweden.

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http://dx.doi.org/10.2337/diabetes.55.02.06.db04-1383DOI Listing
February 2006

Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout mice.

Endocrinology 2005 Oct 7;146(10):4464-71. Epub 2005 Jul 7.

Department of Clinical Biochemistry, KB-3011, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/en.2004-0938DOI Listing
October 2005

Antral G-cell in gastrin and gastrin-cholecystokinin knockout animals.

Cell Tissue Res 2005 Jul 20;321(1):141-6. Epub 2005 May 20.

Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://link.springer.com/10.1007/s00441-005-1110-z
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http://dx.doi.org/10.1007/s00441-005-1110-zDOI Listing
July 2005

Ultrastructure of islet ghrelin cells in the human fetus.

Cell Tissue Res 2005 Mar 25;319(3):423-8. Epub 2005 Jan 25.

Department of Physiological Sciences, Section for Neuroendocrine Cell Biology, Lund University, BMC F10, 22184, Lund. Sweden,

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http://dx.doi.org/10.1007/s00441-004-1044-xDOI Listing
March 2005

Orexin loss in Huntington's disease.

Hum Mol Genet 2005 Jan 3;14(1):39-47. Epub 2004 Nov 3.

Department of Physiological Sciences, Section for Neuronal Survival, Lund, Sweden.

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http://dx.doi.org/10.1093/hmg/ddi004DOI Listing
January 2005

Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice.

Endocrinology 2004 Jul 24;145(7):3190-6. Epub 2004 Mar 24.

Department of Medicine, Lund University, B11 Biomedical Centre, SE-221 84 Lund, Sweden.

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http://dx.doi.org/10.1210/en.2003-1700DOI Listing
July 2004