Nils Mandahl

Nils Mandahl

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Nils Mandahl

Nils Mandahl

Publications by authors named "Nils Mandahl"

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Most gene fusions in cancer are stochastic events.

Genes Chromosomes Cancer 2019 09 18;58(9):607-611. Epub 2019 Mar 18.

Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1002/gcc.22745DOI Listing
September 2019

Cancer chromosome breakpoints cluster in gene-rich genomic regions.

Genes Chromosomes Cancer 2019 03 26;58(3):149-154. Epub 2018 Dec 26.

Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.

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http://doi.wiley.com/10.1002/gcc.22713
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http://dx.doi.org/10.1002/gcc.22713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590459PMC
March 2019

Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years.

Nat Commun 2018 09 10;9(1):3662. Epub 2018 Sep 10.

Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, SE-221 84, Lund, Sweden.

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http://www.nature.com/articles/s41467-018-06098-0
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http://dx.doi.org/10.1038/s41467-018-06098-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131146PMC
September 2018

Scattered genomic amplification in dedifferentiated liposarcoma.

Mol Cytogenet 2017 24;10:25. Epub 2017 Jun 24.

Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, SE-221 84 Lund, Sweden.

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http://dx.doi.org/10.1186/s13039-017-0325-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483303PMC
June 2017

Genetic heterogeneity in rhabdomyosarcoma revealed by SNP array analysis.

Genes Chromosomes Cancer 2016 Jan 20;55(1):3-15. Epub 2015 Oct 20.

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1002/gcc.22285DOI Listing
January 2016

Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection.

Mol Oncol 2015 Jun 18;9(6):1129-39. Epub 2015 Feb 18.

Department of Molecular Oncology, Institute for Cancer Research, Division of Cancer Medicine Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528761PMC
June 2015

RNA sequencing of sarcomas with simple karyotypes: identification and enrichment of fusion transcripts.

Lab Invest 2015 Jun 13;95(6):603-9. Epub 2015 Apr 13.

Department of Clinical Genetics, University and Regional Laboratories, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1038/labinvest.2015.50DOI Listing
June 2015

Recurrent PRDM10 gene fusions in undifferentiated pleomorphic sarcoma.

Clin Cancer Res 2015 Feb 16;21(4):864-9. Epub 2014 Dec 16.

Department of Clinical Genetics, University and Regional Laboratories, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2399DOI Listing
February 2015

Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma.

Int J Biochem Cell Biol 2014 Aug 8;53:475-81. Epub 2014 Apr 8.

Department of Clinical Genetics, University and Regional Laboratories, Lund University, SE-221 85 Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.03.027DOI Listing
August 2014

Integrative genome and transcriptome analyses reveal two distinct types of ring chromosome in soft tissue sarcomas.

Hum Mol Genet 2014 Feb 26;23(4):878-88. Epub 2013 Sep 26.

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, 221 84 Lund, Sweden.

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http://dx.doi.org/10.1093/hmg/ddt479DOI Listing
February 2014

Rearrangements of chromosome bands 15q12-q21 are secondary to HMGA2 deregulation in conventional lipoma.

Oncol Rep 2014 Feb 2;31(2):807-11. Epub 2013 Dec 2.

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.3892/or.2013.2889DOI Listing
February 2014

Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas.

Genes Chromosomes Cancer 2014 Jan 5;53(1):15-24. Epub 2013 Nov 5.

Ludwig Center, the Howard Hughes Medical Institutions, and the Departmentof Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.

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http://dx.doi.org/10.1002/gcc.22114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007004PMC
January 2014

Cytogenetic and single nucleotide polymorphism array findings in soft tissue tumors in infants.

Cancer Genet 2013 Jul-Aug;206(7-8):299-303. Epub 2013 Aug 12.

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden; Department of Pathology, University and Regional Laboratories, Skåne University Hospital, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2013.06.004DOI Listing
December 2013

Molecular genetic characterization of the 11q13 breakpoint in a desmoplastic fibroma of bone.

Cancer Genet 2012 Jul-Aug;205(7-8):410-3

Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo (FG), Italy.

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http://dx.doi.org/10.1016/j.cancergen.2012.05.002DOI Listing
October 2012

The MDM2 SNP309 G allele is not preferentially amplified in bone and soft tissue tumors.

Cancer Genet 2012 Sep;205(9):470-3

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergen.2012.06.001DOI Listing
September 2012

Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma.

Neoplasia 2012 Sep;14(9):807-12

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459276PMC
http://dx.doi.org/10.1593/neo.12930DOI Listing
September 2012

Disease-associated patterns of disomic chromosomes in hyperhaploid neoplasms.

Genes Chromosomes Cancer 2012 Jun 15;51(6):536-44. Epub 2012 Feb 15.

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1002/gcc.21947DOI Listing
June 2012

HMGA2 and MDM2 expression in lipomatous tumors with partial, low-level amplification of sequences from the long arm of chromosome 12.

Cancer Genet 2011 Oct;204(10):550-6

Department of Clinical Genetics, Lund University, University and Regional Laboratories, Skåne University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergen.2011.09.005DOI Listing
October 2011

Gene expression and single nucleotide polymorphism array analyses of spindle cell lipomas and conventional lipomas with 13q14 deletion.

Genes Chromosomes Cancer 2011 Aug 11;50(8):619-32. Epub 2011 May 11.

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1002/gcc.20884DOI Listing
August 2011

Chromosome banding analysis of cells from fine-needle aspiration biopsy samples from soft tissue and bone tumors: is it clinically meaningful?

Cancer Genet 2011 Apr;204(4):203-6

Department of Pathology, University and Regional Laboratories, Lund University Hospital, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergen.2011.01.001DOI Listing
April 2011

The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4.

Int J Cancer 2011 Jan;128(2):487-91

Department of Clinical Genetics, University and Regional Laboratories, Lund University Hospital, Lund University, Lund, Sweden.

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http://doi.wiley.com/10.1002/ijc.25353
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http://dx.doi.org/10.1002/ijc.25353DOI Listing
January 2011

Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.

Proc Natl Acad Sci U S A 2010 Dec 15;107(49):21122-7. Epub 2010 Nov 15.

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.1073/pnas.1013512107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000312PMC
December 2010

Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis.

Proc Natl Acad Sci U S A 2010 Nov 8;107(47):20489-93. Epub 2010 Nov 8.

Department of Clinical Genetics, Lund University, University and Regional Laboratories, University Hospital, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.1073/pnas.1006829107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996656PMC
November 2010

Fusion of the FUS and CREB3L2 genes in a supernumerary ring chromosome in low-grade fibromyxoid sarcoma.

Cancer Genet Cytogenet 2010 Jun;199(2):143-6

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergencyto.2010.02.011DOI Listing
June 2010

Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group.

J Clin Oncol 2010 Mar 16;28(9):1573-82. Epub 2010 Feb 16.

Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1200/JCO.2009.24.8989DOI Listing
March 2010

Genomic characteristics of soft tissue sarcomas.

Virchows Arch 2010 Feb 3;456(2):129-39. Epub 2009 Feb 3.

Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1007/s00428-009-0736-8DOI Listing
February 2010

Characterization of a hotspot region on chromosome 12 for amplification in ring chromosomes in atypical lipomatous tumors.

Genes Chromosomes Cancer 2009 Nov;48(11):993-1001

Department of Genetics and Microbiology, University of Bari, Bari, Italy.

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http://dx.doi.org/10.1002/gcc.20700DOI Listing
November 2009

Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors.

Neuro Oncol 2009 Oct 30;11(5):514-28. Epub 2009 Jan 30.

Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway.

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http://dx.doi.org/10.1215/15228517-2008-127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765341PMC
October 2009

Cytogenetic analysis of 101 giant cell tumors of bone: nonrandom patterns of telomeric associations and other structural aberrations.

Genes Chromosomes Cancer 2009 Jul;48(7):583-602

Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1002/gcc.20667DOI Listing
July 2009

Bidirectionality and transcriptional activity of the EWSR1 promoter region.

Oncol Rep 2009 Mar;21(3):641-8

Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden.

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March 2009

Heterogeneous genetic profiles in soft tissue myoepitheliomas.

Mod Pathol 2008 Nov 4;21(11):1311-9. Epub 2008 Jul 4.

Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1038/modpathol.2008.124DOI Listing
November 2008

Cytogenetic and molecular cytogenetic findings in lipoblastoma.

Cancer Genet Cytogenet 2008 May;183(1):60-3

Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergencyto.2008.01.017DOI Listing
May 2008

Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors.

Genes Chromosomes Cancer 2008 Jan;47(1):21-5

Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1002/gcc.20501DOI Listing
January 2008

Fusion of the COL1A1 and USP6 genes in a benign bone tumor.

Cancer Genet Cytogenet 2008 Jan;180(1):70-3

Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergencyto.2007.09.017DOI Listing
January 2008

Successful treatment of a child with t(15;19)-positive tumor.

Pediatr Blood Cancer 2007 Dec;49(7):1015-7

Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1002/pbc.20755DOI Listing
December 2007

Microarray analysis of gliomas reveals chromosomal position-associated gene expression patterns and identifies potential immunotherapy targets.

J Neurooncol 2007 Oct 17;85(1):11-24. Epub 2007 Jul 17.

Department of Neurosurgery, The Rausing Laboratory, Lund University, 22100 Lund, Sweden.

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http://dx.doi.org/10.1007/s11060-007-9383-6DOI Listing
October 2007

Comparison of the proximal promoter regions of the PAX3 and PAX7 genes.

Cancer Genet Cytogenet 2007 Oct;178(2):114-9

Department of Clinical Genetics, Lund University Hospital, Getingevägen 4, 221 85, Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergencyto.2007.06.006DOI Listing
October 2007

Unstable translocation (8;22) in a case of giant cell reparative granuloma.

Cancer Genet Cytogenet 2007 Aug;177(1):59-63

Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergencyto.2007.04.017DOI Listing
August 2007

Fusion genes in angiomatoid fibrous histiocytoma.

Cancer Lett 2007 Jun 22;251(1):158-63. Epub 2006 Dec 22.

Department of Clinical Genetics, University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1016/j.canlet.2006.11.014DOI Listing
June 2007

Characterization of the native CREB3L2 transcription factor and the FUS/CREB3L2 chimera.

Genes Chromosomes Cancer 2007 Feb;46(2):181-91

Department of Clinical Genetics, University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1002/gcc.20395DOI Listing
February 2007

Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone.

Cancer Genet Cytogenet 2007 Jan;172(1):80-3

Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergencyto.2006.08.007DOI Listing
January 2007

Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.

Int J Cancer 2006 Mar;118(5):1181-6

Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.1002/ijc.21490DOI Listing
March 2006

Prognostic significance of chromosome aberrations in high-grade soft tissue sarcomas.

J Clin Oncol 2006 Jan 5;24(2):315-20. Epub 2005 Dec 5.

Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1200/JCO.2005.03.0999DOI Listing
January 2006

Biallelic somatic inactivation of the NF1 gene through chromosomal translocations in a sporadic neurofibroma.

Int J Cancer 2005 Dec;117(6):1055-7

Department of Genetics and Microbiology, University of Bari, Bari, Italy.

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http://dx.doi.org/10.1002/ijc.21248DOI Listing
December 2005

Ewing tumours and synovial sarcomas have critical features of karyotype evolution in common with epithelial tumours.

Int J Cancer 2005 Sep;116(3):401-6

Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1002/ijc.21021DOI Listing
September 2005

Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12.

Oncol Rep 2005 Apr;13(4):649-52

Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden.

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April 2005

Absence of mutations of the BRAF gene in malignant melanoma of soft parts (clear cell sarcoma of tendons and aponeuroses).

Cancer Genet Cytogenet 2005 Jan;156(1):74-6

Department of Clinical Genetics, Lund University Hospital, S-221 85 Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergencyto.2004.04.008DOI Listing
January 2005

Molecular genetic characterization of the genomic ACTB-GLI fusion in pericytoma with t(7;12).

Biochem Biophys Res Commun 2004 Dec;325(4):1318-23

Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2004.10.172DOI Listing
December 2004

A novel FISH assay for SS18-SSX fusion type in synovial sarcoma.

Lab Invest 2004 Sep;84(9):1185-92

Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1038/labinvest.3700142DOI Listing
September 2004

Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora's lesion).

Hum Pathol 2004 Sep;35(9):1063-9

Department of Clinical Genetics and Pathology, University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1016/j.humpath.2004.02.008DOI Listing
September 2004

Expression of DOL54 is not restricted to myxoid liposarcomas with the FUS-DDIT3 chimera but is found in various sarcomas.

Oncol Rep 2004 Jul;12(1):107-10

Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

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July 2004

Combined binary ratio labeling fluorescence in situ hybridization analysis of chordoma.

Cancer Genet Cytogenet 2004 Jun;151(2):178-81

Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1016/j.cancergencyto.2003.09.015DOI Listing
June 2004

Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas.

Int J Cancer 2004 Apr;109(3):363-9

Department of Clinical Genetics, University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1002/ijc.11716DOI Listing
April 2004

Mitotic instability associated with late genomic changes in bone and soft tissue tumours.

Cancer Lett 2004 Mar;206(1):69-76

Department of Clinical Genetics, University Hospital, Lund SE-221 85, Sweden.

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http://dx.doi.org/10.1016/j.canlet.2003.10.022DOI Listing
March 2004

Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas.

Mod Pathol 2003 Nov;16(11):1132-40

Department of Clinical Genetics, University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1097/01.MP.0000092954.42656.94DOI Listing
November 2003

Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma.

Hum Mol Genet 2003 Sep 22;12(18):2349-58. Epub 2003 Jul 22.

Department of Clinical Genetics, University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1093/hmg/ddg237DOI Listing
September 2003

Ring chromosomes and low-grade gene amplification in an atypical lipomatous tumor with minimal nuclear atypia.

Int J Oncol 2003 Jul;23(1):67-71

Department of Clinical Genetics, Lund University Hospital, 221 85 Lund, Sweden.

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July 2003

A novel fusion gene, SS18L1/SSX1, in synovial sarcoma.

Genes Chromosomes Cancer 2003 Jun;37(2):195-200

Department of Clinical Genetics, University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1002/gcc.10210DOI Listing
June 2003

Chromosomal abnormalities in inflammatory pseudotumor of the urinary bladder.

Cancer Genet Cytogenet 2003 Jun;143(2):169-71

Department of Surgical Urology, Faculty of Medicine, Upper Nile University, Upper Nile State, Sudan.

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http://dx.doi.org/10.1016/s0165-4608(02)00846-4DOI Listing
June 2003

Establishment and characterisation of a human clear cell sarcoma model in nude mice.

Int J Cancer 2002 Oct;101(6):505-11

Department of Orthopaedics, University Hospital, Umeå, Sweden.

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http://dx.doi.org/10.1002/ijc.10588DOI Listing
October 2002

Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15.

Int J Oncol 2002 Aug;21(2):321-6

Department of Occupational and Environmental Medicine, University Hospital, SE-221 85 Lund, Sweden.

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August 2002

SYT-SSX is critical for cyclin D1 expression in synovial sarcoma cells: a gain of function of the t(X;18)(p11.2;q11.2) translocation.

Cancer Res 2002 Jul;62(13):3861-7

Department of Oncology and Pathology, Karolinska Hospital, SE-171 76 Stockholm, Sweden.

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July 2002

RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells.

J Orthop Res 2002 Jul;20(4):723-9

Department of Orthopaedics and Sports Medicine, School of Medicine, University of Washington, Seattle 98108, USA.

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http://dx.doi.org/10.1016/S0736-0266(02)00006-2DOI Listing
July 2002

Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas.

Oncogene 2002 Jun;21(26):4181-90

Department of Oncology and Pathology, Karolinska Hospital CCK R8:04, SE-171 76 Stockohlm, Sweden.

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http://dx.doi.org/10.1038/sj.onc.1205569DOI Listing
June 2002

Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma.

Genes Chromosomes Cancer 2002 Feb;33(2):133-40

Department of Clinical Genetics, University Hospital, Lund, Sweden.

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February 2002

Cytogenetic aberrations and their prognostic impact in chondrosarcoma.

Genes Chromosomes Cancer 2002 Feb;33(2):188-200

Department of Clinical Genetics, University Hospital, Lund, Sweden.

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February 2002