Dr. Nikos K Karamanos, PhD - University of Patras - Professor

Dr. Nikos K Karamanos

PhD

University of Patras

Professor

Patras | Greece

Main Specialties: Chemistry

Additional Specialties: Biochemistry

ORCID logohttps://orcid.org/0000-0003-3618-0288


Top Author

Dr. Nikos K Karamanos, PhD - University of Patras - Professor

Dr. Nikos K Karamanos

PhD

Introduction

Nikos K. Karamanos is a Professor of Biochemistry at the University of Patras. He is an associate editor of Matrix Biology and editorial/advisory board member and academic editor of several peer-review journals. Dr. Karamanos is coordinator of the Hellenic Matrix Biology Section of HSBMB and chairman of the Advanced Lecture Courses in “Matrix Pathobiology, Signaling and Molecular Targets”. He is the editor of the International book edition: Extracellular Matrix: Pathobiology & Signaling, Berlin/Boston (2012). His interests involve matrix pathobiology, cell signaling, pharmacological targeting, preclinical evaluation/cytotoxicity and structure analysis with particular emphasis in the role of proteoglycans, glycosaminoglycans and matrix metalloproteinases in cancer. He has published over 280 peer-review articles and received ca 10000 citations.

Primary Affiliation: University of Patras - Patras , Greece

Specialties:

Additional Specialties:

Research Interests:


View Dr. Nikos K Karamanos’s Resume / CV

Metrics

Number of Publications

403

Publications

Number of Profile Views

720

Profile Views

Number of Article Reads

830

Reads

Number of Citations

1520

Citations

Education

Jan 1994
Karoliska Institute, Sweden
Laboratory Medicine
Nov 1988
UPatras
Biochemistry

Experience

Oct 2018
Deputy Editor
Matrix Biology Plus
Oct 2018
Deputy Editor
Matrix Biology
Jan 2016
Accociate Editor
Matrix Biology
May 2007
Chairman
Matrix Pathobiology
Jun 2003
Professor
Biochemistry

Top co-authors

Achilleas D Theocharis
Achilleas D Theocharis

Laboratory of Biochemistry

36
George N Tzanakakis
George N Tzanakakis

Laboratory of Anatomy-Histology-Embryology

33
Dragana Nikitovic
Dragana Nikitovic

Laboratory of Anatomy-Histology-Embryology

22
Spyros S Skandalis
Spyros S Skandalis

Laboratory of Biochemistry

16
Aikaterini Berdiaki
Aikaterini Berdiaki

Laboratory of Anatomy-Histology-Embryology

13
Dimitris Kletsas
Dimitris Kletsas

Laboratory of Cell Proliferation and Ageing

13
Chrisostomi Gialeli
Chrisostomi Gialeli

Laboratory of Biochemistry

11
Pavlos Katonis
Pavlos Katonis

University Hospital of Heraklion

10
Panagiotis Bouris
Panagiotis Bouris

Laboratory of Biochemistry

8
Fotini N Lamari
Fotini N Lamari

Laboratory of Pharmacognosy and Chemistry of Natural Products

8

Publications

403Publications

830Reads

1520PubMed Central Citations

Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling.

Matrix Biol 2018 Dec 26;74:35-51. Epub 2018 May 26.

Biochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras 26110, Greece. Electronic address:

View Article
December 2018
2 Reads
5.070 Impact Factor

Advances in targeting epidermal growth factor receptor signaling pathway in mammary cancer.

Cell Signal 2018 Nov 31;51:99-109. Epub 2018 Jul 31.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110, Greece; Foundation for Research and Technology-Hellas (FORTH), Institute of Chemical Engineering Sciences (ICE-HT), 26504 Patras, Greece. Electronic address:

View Article
November 2018
11 Reads
4.320 Impact Factor

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.

Chem Rev 2018 Sep 11;118(18):9152-9232. Epub 2018 Sep 11.

Department of Pathology, Anatomy and Cell Biology, Sidney Kimmel Medical College , Thomas Jefferson University , Philadelphia , Pennsylvania 10107 , United States.

View Article
September 2018
18 Reads
45.660 Impact Factor

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases.

Matrix Biol 2018 Aug 18. Epub 2018 Aug 18.

Department of Pathology, Anatomy, and Cell Biology, Cancer Cell Biology and Signaling Program, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.

View Article
August 2018
9 Reads
5.070 Impact Factor

Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors.

Matrix Biol 2018 Apr 16. Epub 2018 Apr 16.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110 Patras, Greece. Electronic address:

View Article
April 2018
5 Reads
5.070 Impact Factor

The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery.

Adv Drug Deliv Rev 2018 Apr 5;129:4-15. Epub 2018 Apr 5.

Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address:

View Article
April 2018
9 Reads
15.040 Impact Factor

Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing.

Adv Drug Deliv Rev 2018 Apr 24;129:16-36. Epub 2017 Oct 24.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras 26110, Greece. Electronic address:

View Article
April 2018
15 Reads
15.040 Impact Factor

Estrogen receptor beta as epigenetic mediator of miR-10b and miR-145 in mammary cancer.

Matrix Biol 2017 12 8;64:94-111. Epub 2017 Aug 8.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras 26110, Greece. Electronic address:

View Article
December 2017
7 Reads
5.070 Impact Factor

Proteoglycans remodeling in cancer: Underlying molecular mechanisms.

Matrix Biol 2017 Nov 8. Epub 2017 Nov 8.

Biochemistry, Biochemical Analysis & Matrix Pathobiochemistry Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece. Electronic address:

View Article
November 2017
6 Reads
2 Citations
5.070 Impact Factor

Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis.

Matrix Biol 2017 Oct 21. Epub 2017 Oct 21.

Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos", Athens, Greece. Electronic address:

View Article
October 2017
7 Reads
2 Citations
5.070 Impact Factor

Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer.

Matrix Biol 2017 05 13;59:3-22. Epub 2016 Oct 13.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece. Electronic address:

View Article
May 2017
7 Reads
14 Citations
5.070 Impact Factor

IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules.

Sci Rep 2017 01 12;7:40138. Epub 2017 Jan 12.

Biochemistry, Biochemical Analysis &Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras 26110, Greece.

View Article
January 2017
5 Reads
3 Citations
5.080 Impact Factor

Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease.

FEBS J 2017 01;284(1):7-9

Biochemistry Laboratory, Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Department of Chemistry, University of Patras, Greece.

View Article
January 2017
4 Reads
1 Citation
4.000 Impact Factor

Syndecans - key regulators of cell signaling and biological functions.

FEBS J 2017 01 18;284(1):27-41. Epub 2016 Nov 18.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece.

View Article
January 2017
8 Reads
14 Citations
4.000 Impact Factor

Estrogen receptor beta modulates breast cancer cells functional properties, signaling and expression of matrix molecules.

Matrix Biol 2016 12 11;56:4-23. Epub 2016 May 11.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece; Foundation for Research and Technology-Hellas (FORTH), Patras, Greece. Electronic address:

View Article
December 2016
13 Reads
5 Citations
5.070 Impact Factor

Data on the putative role of p53 in breast cancer cell adhesion: Technical information for adhesion assay.

Data Brief 2016 Dec 30;9:568-572. Epub 2016 Sep 30.

Department of Anatomy-Histology-Embryology, School of Medicine, University of Crete, Heraklion, Greece.

View Article
December 2016
9 Reads

Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines.

Biomed Res Int 2015 25;2015:690721. Epub 2015 Oct 25.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece.

View Article
September 2016
9 Reads
4 Citations

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β.

Aging (Albany NY) 2016 08;8(8):1650-69

Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos", Athens, Greece.

View Article
August 2016
13 Reads
7 Citations
6.430 Impact Factor

Synthesis and antiproliferative activity of two diastereomeric lignan amides serving as dimeric caffeic acid-l-DOPA hybrids.

Bioorg Chem 2016 06 23;66:132-44. Epub 2016 Apr 23.

Laboratory of Synthetic Organic Chemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece.

View Article
June 2016
14 Reads
2.150 Impact Factor

Vectors for inhaled gene therapy in lung cancer. Application for nano oncology and safety of bio nanotechnology.

Int J Mol Sci 2012 29;13(9):10828-62. Epub 2012 Aug 29.

Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece; E-Mails: (K.P.); (K.D.); (K.Z.) ; Pulmonary Department-Interventional Unit, "Ruhrland Klinik", University of Essen, Essen 45239, Germany.

View Article
March 2016
6 Reads
6 Citations
2.860 Impact Factor

Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties.

Petridis T, Giannakopoulou D, Stamatopoulou V, Grafanaki K, Kostopoulos CG, Papadaki H, Malavaki CJ, Karamanos NK, Douroumi S, Papachristou D, Magoulas GE, Papaioannou D, Drainas D, Birth defects research. Part B, Developmental and reproductive toxicology, 2016, vol. 107, no. 1, pp. 32-44

http://europepmc.org/abstract/med/26762583

View Article
March 2016
1 Read

Extracellular matrix structure.

Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK, Advanced drug delivery reviews, 2016, vol. 97, pp. 4-27

http://europepmc.org/abstract/med/26562801

View Article
March 2016
2 Reads

Extracellular matrix structure.

Adv Drug Deliv Rev 2016 Feb 10;97:4-27. Epub 2015 Nov 10.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece. Electronic address:

View Article
February 2016
16 Reads
49 Citations
15.040 Impact Factor

Preparation and toxicological assessment of functionalized carbon nanotube-polymer hybrids.

PLoS One 2014 17;9(9):e107029. Epub 2014 Sep 17.

Department of Chemistry, University of Patras, Patras, Greece; Foundation for Research and Technology-Hellas (FORTH) / Institute of Chemical Engineering Sciences (ICE-HT), Rio-Patras, Greece.

View Article
January 2016
18 Reads
2 Citations
3.230 Impact Factor

Validated capillary electrophoretic assays for disaccharide composition analysis of galactosaminoglycans in biologic samples and drugs/nutraceuticals.

Asimakopoulou AP, Malavaki C, Afratis NA, Theocharis AD, Lamari FN, Karamanos NK, Methods in molecular biology (Clifton, N.J.), 2015, vol. 1229, pp. 129-141

http://europepmc.org/abstract/med/25325950

View Article
2015
2 Reads

Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines.

Korpetinou A, Papachristou DJ, Lampropoulou A, Bouris P, Labropoulou VT, Noulas A, Karamanos NK, Theocharis AD, BioMed research international, 2015, vol. 2015, pp. 690721

http://europepmc.org/abstract/med/26581653

View Article
2015
2 Reads

Increased β-glucuronidase activity in bronchoalveolar lavage fluid of children with bacterial lung infection: A case-control study.

Panagiotopoulou EC, Fouzas S, Douros K, Triantaphyllidou IE, Malavaki C, Priftis KN, Karamanos NK, Anthracopoulos MB, Respirology (Carlton, Vic.), 2015, vol. 20, no. 8, pp. 1248-1254

http://europepmc.org/abstract/med/26172956

View Article
December 2015
2 Reads

Increased β-glucuronidase activity in bronchoalveolar lavage fluid of children with bacterial lung infection: A case-control study.

Respirology 2015 Nov 14;20(8):1248-54. Epub 2015 Jul 14.

Respiratory Unit, Department of Paediatrics, University General Hospital of Patras, Rion-Patras, Greece.

View Article
November 2015
9 Reads
1 Citation
3.500 Impact Factor

Syndecan-1 alters heparan sulfate composition and signaling pathways in malignant mesothelioma.

Heidari-Hamedani G, Vivès RR, Seffouh A, Afratis NA, Oosterhof A, van Kuppevelt TH, Karamanos NK, Metintas M, Hjerpe A, Dobra K, Szatmári T, Cellular signalling, 2015, vol. 27, no. 10, pp. 2054-2067

http://europepmc.org/abstract/med/26210886

View Article
October 2015
2 Reads

Syndecan-1 alters heparan sulfate composition and signaling pathways in malignant mesothelioma.

Cell Signal 2015 Oct 23;27(10):2054-67. Epub 2015 Jul 23.

Karolinska Institutet, Department of Laboratory Medicine, Division of Pathology, Stockholm, Sweden.

View Article
October 2015
6 Reads
5 Citations
4.320 Impact Factor

PDGF/PDGFR signaling and targeting in cancer growth and progression: Focus on tumor microenvironment and cancer-associated fibroblasts.

Curr Pharm Des 2014 ;20(17):2843-8

Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110 Patras, Greece.

View Article
September 2015
21 Reads
9 Citations
3.450 Impact Factor

Anti-TNFα treatment decreases the previously increased serum Indian Hedgehog levels in patients with ankylosing spondylitis and affects the expression of functional Hedgehog pathway target genes.

Semin Arthritis Rheum 2015 Jun 23;44(6):646-51. Epub 2015 Jan 23.

Department of Rheumatology, University of Patras Medical School, Patras University Hospital, Rion 26504, Patras, Greece.

View Article
June 2015
8 Reads
3.920 Impact Factor

Synthesis and evaluation of anticancer activity in cells of novel stoichiometric pegylated fullerene-doxorubicin conjugates.

Pharm Res 2015 May 8;32(5):1676-93. Epub 2014 Nov 8.

Laboratory of Synthetic Organic Chemistry, Department of Chemistry, University of Patras, 26504, Patras, Greece.

View Article
May 2015
10 Reads
3 Citations
3.420 Impact Factor

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine.

Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Sanderson RD, Schaefer L, Iozzo RV, Karamanos NK, Biochimica et biophysica acta, 2015, vol. 1855, no. 2, pp. 276-300

http://europepmc.org/abstract/med/25829250

View Article
May 2015
2 Reads

Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer.

Adv Cancer Res 2014 ;123:277-317

Biochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece; Foundation for Research and Technology, Institute of Chemical Engineering Sciences (FORTH/ICE-HT), Patras, Greece. Electronic address:

View Article
April 2015
6 Reads
7 Citations
5.320 Impact Factor

Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells.

Matrix Biol 2015 Apr 27;43:42-60. Epub 2015 Feb 27.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras 26110, Greece. Electronic address:

View Article
April 2015
4 Reads
15 Citations
5.070 Impact Factor

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine.

Biochim Biophys Acta 2015 Apr 28;1855(2):276-300. Epub 2015 Mar 28.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece. Electronic address:

View Article
April 2015
7 Reads
26 Citations

Syndecans as modulators and potential pharmacological targets in cancer progression.

Barbouri D, Afratis N, Gialeli C, Vynios DH, Theocharis AD, Karamanos NK, Frontiers in oncology, 2014, vol. 4, pp. 4

http://europepmc.org/abstract/med/24551591

View Article
2014
1 Read

Novel insights into matrix pathobiology regulatory mechanisms in health and disease.

FEBS J 2014 Nov 6;281(22):4978-9. Epub 2014 Nov 6.

Department of Chemistry, Laboratory of Biochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, University of Patras, Greece.

View Article
November 2014
4.000 Impact Factor

Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer.

FEBS J 2014 Nov 6;281(22):5023-42. Epub 2014 Nov 6.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece.

View Article
November 2014
9 Reads
20 Citations
4.000 Impact Factor

Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells.

PLoS One 2013 31;8(10):e78157. Epub 2013 Oct 31.

Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece.

View Article
September 2014
3 Reads
18 Citations
3.230 Impact Factor

EMMPRIN/CD147-encriched membrane vesicles released from malignant human testicular germ cells increase MMP production through tumor-stroma interaction.

Biochim Biophys Acta 2014 Aug 6;1840(8):2581-8. Epub 2014 Mar 6.

Université Paris-Est, Laboratoire CRRET, CNRS CAE 4971, Créteil, France.

View Article
August 2014
3 Reads
3 Citations

The differential proliferative response of fetal and adult human skin fibroblasts to TGF-β is retained when cultured in the presence of fibronectin or collagen.

Biochim Biophys Acta 2014 Aug 13;1840(8):2635-42. Epub 2014 Apr 13.

Laboratory for Cell Proliferation & Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos", 153 10 Athens, Greece. Electronic address:

View Article
August 2014
5 Reads
2 Citations

Matrix-mediated cell behaviour and properties.

Biochim Biophys Acta 2014 Aug;1840(8):2385

View Article
August 2014
4 Reads

EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules.

Biochim Biophys Acta 2014 Aug 2;1840(8):2651-61. Epub 2014 May 2.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece. Electronic address:

View Article
August 2014
3 Citations

FACE analysis as a fast and reliable methodology to monitor the sulfation and total amount of chondroitin sulfate in biological samples of clinical importance.

Molecules 2014 Jun 12;19(6):7959-80. Epub 2014 Jun 12.

Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece.

View Article
June 2014
12 Reads
3 Citations
2.420 Impact Factor

Syndecans as modulators and potential pharmacological targets in cancer progression.

Front Oncol 2014 3;4. Epub 2014 Feb 3.

Biochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras , Patras , Greece.

View Article
June 2014
4 Reads
22 Citations

Lumican affects tumor cell functions, tumor-ECM interactions, angiogenesis and inflammatory response.

Matrix Biol 2014 Apr 21;35:206-14. Epub 2013 Sep 21.

Department of Anatomy-Histology-Embryology, Medical School, University of Crete, Heraklion 71003, Greece.

View Article
April 2014
8 Reads
22 Citations
5.070 Impact Factor

Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of proteoglycans.

Matrix Biol 2014 Apr 21;35:182-93. Epub 2013 Sep 21.

Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras 26110, Greece. Electronic address:

View Article
April 2014
14 Reads
18 Citations
5.070 Impact Factor

The roles of hyaluronan/RHAMM/CD44 and their respective interactions along the insidious pathways of fibrosarcoma progression.

Biomed Res Int 2013 5;2013:929531. Epub 2013 Sep 5.

Department of Histology-Embryology, School of Medicine, University of Crete, 71003 Heraklion, Greece.

View Article
April 2014
9 Reads
15 Citations

Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours.

Biomed Res Int 2013 15;2013:214864. Epub 2013 Jun 15.

Hematology Division, Department of Internal Medicine, University Hospital of Patras, 26500 Patras, Greece.

View Article
February 2014
11 Reads
3 Citations

Serglycin: at the crossroad of inflammation and malignancy.

Front Oncol 2014 Jan 13;3:327. Epub 2014 Jan 13.

Laboratory of Biochemistry, Department of Chemistry, University of Patras , Patras , Greece.

View Article
January 2014
17 Reads
19 Citations

The effect of synbiotics on acute radiation-induced diarrhea and its association with mucosal inflammatory and adaptive responses in rats.

Dig Dis Sci 2013 Sep 22;58(9):2487-98. Epub 2013 May 22.

1st Department of Propaedeutic Surgery, Hippokration Hospital, University of Athens School of Medicine, 114 Vasilissis Sofias Avenue, 11527, Athens, Greece.

View Article
September 2013
13 Reads
2.550 Impact Factor

New insights into the pathobiology of Down syndrome--hyaluronan synthase-2 overexpression is regulated by collagen VI α2 chain.

FEBS J 2013 May 28;280(10):2418-30. Epub 2013 Mar 28.

Laboratory of Biochemistry, Department of Surgical and Morphological Sciences, School of Medicine, University of Insubria, Varese, Italy.

View Article
May 2013
3 Citations
4.000 Impact Factor

Special issue: Proteoglycans: signaling, targeting and therapeutics: introduction.

FEBS J 2013 May 18;280(10):2119. Epub 2013 Apr 18.

Biochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece.

View Article
May 2013
5 Reads
2 Citations
4.000 Impact Factor

Cell-surface serglycin promotes adhesion of myeloma cells to collagen type I and affects the expression of matrix metalloproteinases.

FEBS J 2013 May 1;280(10):2342-52. Epub 2013 Mar 1.

Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece.

View Article
May 2013
3 Reads
13 Citations
4.000 Impact Factor

Efficacy versus safety concerns for aerosol chemotherapy in non-small-cell lung cancer: a future dilemma for micro-oncology.

Future Oncol 2013 Apr;9(4):505-25

University Pulmonary Department-Interventional Unit, Ruhrland Clinic, University of Duisburg-Essen, Essen, Germany.

View Article
April 2013
24 Reads
13 Citations
2.480 Impact Factor

Syndecan-2 is a key regulator of transforming growth factor beta 2/Smad2-mediated adhesion in fibrosarcoma cells.

IUBMB Life 2013 Feb 7;65(2):134-43. Epub 2013 Jan 7.

Department of Histology-Embryology, Medical School, University of Crete, Heraklion, Greece.

View Article
February 2013
12 Reads
8 Citations
3.140 Impact Factor

The biology of small leucine-rich proteoglycans in bone pathophysiology.

J Biol Chem 2012 Oct 9;287(41):33926-33. Epub 2012 Aug 9.

Department of Histology-Embryology, Medical School, University of Crete, Greece.

View Article
October 2012
7 Reads
34 Citations
4.570 Impact Factor

Wild blueberry (V. angustifolium)-enriched diets alter aortic glycosaminoglycan profile in the spontaneously hypertensive rat.

J Nutr Biochem 2012 Aug 16;23(8):961-5. Epub 2011 Sep 16.

Food Science and Human Nutrition, University of Maine, Orono, ME 04469, USA.

View Article
August 2012
4 Reads
1 Citation
3.790 Impact Factor

Glycosaminoglycans: from "cellular glue" to novel therapeutical agents.

Curr Opin Pharmacol 2012 Apr 9;12(2):220-2. Epub 2012 Feb 9.

University of Patras, Greece.

View Article
April 2012
3 Reads
8 Citations
4.590 Impact Factor

Glycosaminoglycans: key players in cancer cell biology and treatment.

FEBS J 2012 Apr 12;279(7):1177-97. Epub 2012 Mar 12.

Department of Chemistry, University of Patras, Patras, Greece.

View Article
April 2012
4 Reads
86 Citations
4.000 Impact Factor

Extracellular Matrix: Pathobiology and Signaling

Karamanos, N, 2012, , DE GRUYTER, Berlin, Boston.

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January 2012
2 Reads

8.2 Targeting the tumor microenvironment in cancer progression

Misra, S, Karamanos, N, Hascall, V, Karamanos, N, Markwald, R & Ghatak, S, 2012, , DE GRUYTER, Berlin, Boston.

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January 2012
2 Reads

1.1 Extracellular matrix: a functional scaffold

Theocharis, A, Karamanos, N, Gialeli, C, Hascall, V & Karamanos, N, 2012, , DE GRUYTER, Berlin, Boston.

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January 2012
1 Read

Low molecular weight heparin inhibits melanoma cell adhesion and migration through a PKCa/JNK signaling pathway inducing actin cytoskeleton changes.

Cancer Lett 2011 Dec 22;312(2):235-44. Epub 2011 Aug 22.

Department of Histology-Embryology, Medical School, University of Crete, Heraklion, Greece.

View Article
December 2011
2 Reads
9 Citations
5.620 Impact Factor

Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion.

J Biol Chem 2011 Nov 13;286(44):38509-20. Epub 2011 Sep 13.

Department of Histology-Embryology, University of Crete, Heraklion 71003, Greece.

View Article
November 2011
19 Reads
27 Citations
4.570 Impact Factor

Parathyroid hormone affects the fibroblast growth factor-proteoglycan signaling axis to regulate osteosarcoma cell migration.

FEBS J 2011 Oct 8;278(19):3782-92. Epub 2011 Sep 8.

Department of Histology-Embryology, Medical School, University of Crete, Heraklion, Greece.

View Article
October 2011
5 Reads
8 Citations
4.000 Impact Factor

Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity.

Int J Biochem Cell Biol 2011 Jun 21;43(6):928-35. Epub 2011 Mar 21.

Department of Histology-Embryology, Medical School, University of Crete, Heraklion, Greece.

View Article
June 2011
5 Reads
21 Citations
4.050 Impact Factor

Hyaluronan-CD44 interactions as potential targets for cancer therapy.

FEBS J 2011 May 25;278(9):1429-43. Epub 2011 Mar 25.

Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

View Article
May 2011
90 Citations
4.000 Impact Factor

A modified protocol for isolation and purity evaluation of a staphylococcal acidic polysaccharide by chromatography and capillary electrophoresis.

Biomed Chromatogr 2011 May 23;25(5):531-4. Epub 2010 Aug 23.

Laboratory of Microbiology, School of Medicine, University of Patras, Patras, Greece.

View Article
May 2011
3 Reads
1 Citation
1.720 Impact Factor

Syntheses, antiproliferative activity and theoretical characterization of acitretin-type retinoids with changes in the lipophilic part.

Eur J Med Chem 2011 Feb 14;46(2):721-37. Epub 2010 Dec 14.

Laboratory of Synthetic Organic Chemistry, Department of Chemistry, University of Patras, GR-265 04 Patras, Greece.

View Article
February 2011
3 Reads
5 Citations
3.450 Impact Factor

Heparan sulfate: biological significance, tools for biochemical analysis and structural characterization.

Biomed Chromatogr 2011 Jan;25(1-2):11-20

Department of Chemistry, Laboratory of Biochemistry, University of Patras, Patras, Greece.

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January 2011
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Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases.

Planta Med 2011 Jan 27;77(2):146-51. Epub 2010 Aug 27.

Department of Pharmacy, Laboratory of Pharmacognosy & Chemistry of Natural Products, University of Patras, Rion, Greece.

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January 2011
14 Citations
2.150 Impact Factor

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting.

FEBS J 2011 Jan 19;278(1):16-27. Epub 2010 Nov 19.

Department of Chemistry, Laboratory of Biochemistry, University of Patras, Greece.

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January 2011
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4.000 Impact Factor

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting.

FEBS J 2010 Oct 31;277(19):3904-23. Epub 2010 Aug 31.

Department of Chemistry, University of Patras, Patras, Greece.

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October 2010
2 Reads
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4.000 Impact Factor

Tear analysis of ascorbic acid, uric acid and malondialdehyde with capillary electrophoresis.

Biomed Chromatogr 2010 Aug;24(8):852-7

Department of Ophthalmology, School of Medicine, University of Patras, 26504 Patras, Greece.

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August 2010
4 Reads
1.720 Impact Factor

Parathyroid hormone (PTH) peptides through the regulation of hyaluronan metabolism affect osteosarcoma cell migration.

IUBMB Life 2010 May;62(5):377-86

Department of Histology, Division of Morphology, School of Medicine, University of Crete, Heraklion, Greece.

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May 2010
4 Reads
6 Citations
3.140 Impact Factor

bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells.

Biochim Biophys Acta 2009 Oct 3;1790(10):1258-65. Epub 2009 Jul 3.

Department of Histology, Division of Morphology, School of Medicine, University of Crete, 71110, Heraklion, Greece.

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October 2009
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The impact of zoledronic acid therapy in survival of lung cancer patients with bone metastasis.

Int J Cancer 2009 Oct;125(7):1705-9

Lung Tumor Research Section, Pulmonary Department, Aristotle University of Thessaloniki, G. Papanikolaou Hospital, Thessaloniki, Greece.

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October 2009
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Fibroblast growth factor-2 modulates melanoma adhesion and migration through a syndecan-4-dependent mechanism.

Int J Biochem Cell Biol 2009 Jun 6;41(6):1323-31. Epub 2008 Dec 6.

Department of Histology, Medical School, University of Crete, Heraklion, 71003, Greece.

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June 2009
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Lumican, a small leucine-rich proteoglycan.

IUBMB Life 2008 Dec;60(12):818-23

Lab of Histology, Medical School, University of Crete, Heraklion, Greece.

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December 2008
10 Reads
26 Citations
3.140 Impact Factor

Estradiol-estrogen receptor: a key interplay of the expression of syndecan-2 and metalloproteinase-9 in breast cancer cells.

Mol Oncol 2008 Oct 18;2(3):223-32. Epub 2008 Jun 18.

Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 261 10 Patras, Greece.

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October 2008
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22 Citations
5.330 Impact Factor

Hyaluronan and chondroitin sulfate proteoglycans in the supramolecular organization of the mammalian vitreous body.

Connect Tissue Res 2008 ;49(3):124-8

Laboratory of Biological Chemistry, School of Medicine, University of Patras, Patras, Greece.

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September 2008
5 Reads
5 Citations
1.610 Impact Factor

Glycosaminoglycan in cerebrum, cerebellum and brainstem of young sheep brain with particular reference to compositional and structural variations of chondroitin-dermatan sulfate and hyaluronan.

Biomed Chromatogr 2008 Sep;22(9):931-8

Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26500 Patras, Greece.

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September 2008
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1 Citation
1.720 Impact Factor

The biological role of chondroitin sulfate in cancer and chondroitin-based anticancer agents.

In Vivo 2008 May-Jun;22(3):385-9

Department of Chemistry, Laboratory of Biochemistry, University of Patras, Greece.

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August 2008
6 Reads
19 Citations
1.150 Impact Factor

Heparin--a unique stimulator of human colon cancer cells' growth.

IUBMB Life 2008 May;60(5):333-40

Department of Histology, Division of Morphology, School of Medicine, University of Crete, Heraklion, Greece.

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May 2008
2 Reads
2 Citations
3.140 Impact Factor

Imatinib mesylate inhibits proliferation and exerts an antifibrotic effect in human breast stroma fibroblasts.

Mol Cancer Res 2008 May;6(5):706-14

Laboratory of Cell Proliferation and Ageing, Institute of Biology, National Center for Scientific Research "Demokritos," 153 10 Athens, Greece.

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May 2008
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4.380 Impact Factor

Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells.

Mol Cancer Res 2008 May;6(5):785-94

Department of Histology, Division of Morphology, School of Medicine, University of Crete, 71110 Heraklion, Greece.

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May 2008
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4.380 Impact Factor

Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells.

Bioorg Med Chem 2008 Mar 7;16(6):3445-55. Epub 2007 Mar 7.

Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.

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March 2008
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2.790 Impact Factor

Capillary electrophoresis for the quality control of chondroitin sulfates in raw materials and formulations.

Anal Biochem 2008 Mar 9;374(1):213-20. Epub 2007 Nov 9.

Department of Chemistry, Laboratory of Biochemistry, University of Patras, 26500 Patras, Greece.

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March 2008
4 Reads
6 Citations
2.220 Impact Factor

Lumican expression is positively correlated with the differentiation and negatively with the growth of human osteosarcoma cells.

FEBS J 2008 Jan 17;275(2):350-61. Epub 2007 Dec 17.

Department of Histology, Medical School, University of Crete, Heraklion, Greece.

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January 2008
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4.000 Impact Factor

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Int J Cancer 2007 Dec;121(12):2808-14

Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece.

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December 2007
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Design, synthesis, and evaluation of the antiproliferative activity of a series of novel fused xanthenone aminoderivatives in human breast cancer cells.

J Med Chem 2007 Apr 3;50(7):1716-9. Epub 2007 Mar 3.

Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.

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April 2007
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1 Citation
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Design and synthesis of new pyranoxanthenones bearing a nitro group or an aminosubstituted side chain on the pyran ring. Evaluation of their growth inhibitory activity in breast cancer cells.

Eur J Med Chem 2007 Mar 4;42(3):307-19. Epub 2006 Dec 4.

Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.

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March 2007
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Structure of chondroitin sulfate.

Adv Pharmacol 2006 ;53:33-48

Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26500 Patras, Greece.

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Chondroitin sulfate as a key molecule in the development of atherosclerosis and cancer progression.

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Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece.

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Dietary manganese affects the concentration, composition and sulfation pattern of heparan sulfate glycosaminoglycans in Sprague-Dawley rat aorta.

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October 2006
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1 Citation
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Biomed Chromatogr 2006 Jun-Jul;20(6-7):539-50

Department of Pharmacy, Laboratory of Pharmacognosy and Chemistry of Natural Products, University of Patras, Greece.

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August 2006
7 Reads
6 Citations
1.720 Impact Factor

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Biochim Biophys Acta 2006 Jul 9;1760(7):1046-53. Epub 2006 Mar 9.

Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26500 Patras, Greece.

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July 2006
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Wild blueberry (Vaccinium angustifolium) consumption affects the composition and structure of glycosaminoglycans in Sprague-Dawley rat aorta.

J Nutr Biochem 2006 Feb 20;17(2):109-16. Epub 2005 Jun 20.

Department of Food Science and Human Nutrition, University of Maine, Orono, ME 04469, USA.

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February 2006
8 Reads
3 Citations
3.790 Impact Factor

Synthesis and study of the electrophoretic behavior of mannan conjugates with cyclic peptide analogue of myelin basic protein using lysine-glycine linker.

Anal Biochem 2005 Dec 3;347(1):121-8. Epub 2005 Oct 3.

Department of Chemistry, Section of Organic Chemistry, Biochemistry, and Natural Products, University of Patras, Greece.

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December 2005
11 Reads
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2.220 Impact Factor

Application of polyacrylamide gel electrophoresis of fluorophore-labeled saccharides for analysis of hyaluronan and chondroitin sulfate in human and animal tissues and cell cultures.

Biomed Chromatogr 2005 Dec;19(10):761-5

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December 2005
7 Reads
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IGF-I affects glycosaminoglycan/proteoglycan synthesis in breast cancer cells through tyrosine kinase-dependent and -independent pathways.

Biochimie 2004 Apr-May;86(4-5):251-9

Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110 Patras, Greece.

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January 2005
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Variations in content and structure of glycosaminoglycans of the vitreous gel from different mammalian species.

Biomed Chromatogr 2004 Sep;18(7):457-61

Department of Chemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, University of Patras 26110 Patras, Greece.

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September 2004
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Large matrix proteoglycans, versican and perlecan, are expressed and secreted by human leukemic monocytes.

Anticancer Res 2003 Jul-Aug;23(4):3303-9

Department of Chemistry, Section of Organic Chemistry, Biochemistry & Natural Products, University of Patras, 26500 Patras, Greece.

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September 2003
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Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece.

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August 2003
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1 Citation

Derivatization of carbohydrates for chromatographic, electrophoretic and mass spectrometric structure analysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2003 Aug;793(1):15-36

Department of Chemistry, University of Patras, 261 10, Patras, Greece.

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August 2003
6 Reads
15 Citations

Inhibition of receptor tyrosine kinase-based signal transduction as specific target for cancer treatment.

In Vivo 2002 Nov-Dec;16(6):459-69

Department of Chemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, University of Patras, 261 10 Patras, Greece.

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May 2003
2 Reads

Synthesis and expression of mRNA encoding for different versican splice variants is related to the aggregation of human epithelial mesothelioma cells.

Anticancer Res 2002 Nov-Dec;22(6C):4157-62

Department of Chemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, University of Patras, 26110 Patras, Greece.

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March 2003
3 Reads
1 Citation

In vitro effects of genistein on the synthesis and distribution of glycosaminoglycans/proteoglycans by estrogen receptor-positive and -negative human breast cancer epithelial cells.

Anticancer Res 2002 Sep-Oct;22(5):2841-6

Department of Chemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, University of Patras, 265 00 Patras, Greece.

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February 2003
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3 Citations

Decreased biglycan expression and differential decorin localization in human abdominal aortic aneurysms.

Atherosclerosis 2002 Dec;165(2):221-30

Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, Laboratory of Biochemistry, University of Patras, 261 10, Patras, Greece.

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December 2002
1 Read
7 Citations

Separation methods for sialic acids and critical evaluation of their biologic relevance.

J Chromatogr B Analyt Technol Biomed Life Sci 2002 Dec;781(1-2):3-19

Department of Chemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, University of Patras, 261 10 Patras, Greece.

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December 2002
4 Reads

Compositional and structural alterations of chondroitin and dermatan sulfates during the progression of atherosclerosis and aneurysmal dilatation of the human abdominal aorta.

Biochimie 2002 Jul;84(7):667-74

Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26110 Patras, Greece.

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July 2002
3 Reads
8 Citations

Pig vitreous gel: macromolecular composition with particular reference to hyaluronan-binding proteoglycans.

Biochimie 2002 Apr;84(4):295-302

Department of Chemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, University of Patras, 26110, Patras, Greece.

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April 2002
6 Reads
2 Citations

Determination of twelve heparin- and heparan sulfate-derived disaccharides as 2-aminoacridone derivatives by capillary zone electrophoresis using ultraviolet and laser-induced fluorescence detection.

Electrophoresis 2002 Apr;23(7-8):1104-9

Department of Chemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, University of Patras, Greece.

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April 2002
6 Reads
23 Citations

Structure analysis of lipoglycans and lipoglycan-derived carbohydrates by capillary electrophoresis and mass spectrometry.

Biomed Chromatogr 2002 Apr;16(2):116-26

Department of Chemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, University of Patras, 261 10 Patras, Greece.

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April 2002
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