Publications by authors named "Nikolaus Fortelny"

19Publications

Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data.

Genome Biol 2020 08 3;21(1):190. Epub 2020 Aug 3.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1186/s13059-020-02100-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397672PMC
August 2020

Structural cells are key regulators of organ-specific immune responses.

Nature 2020 07 1;583(7815):296-302. Epub 2020 Jul 1.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/s41586-020-2424-4DOI Listing
July 2020

Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets.

Genome Biol 2020 05 6;21(1):106. Epub 2020 May 6.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090, Vienna, Austria.

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http://dx.doi.org/10.1186/s13059-020-02006-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201533PMC
May 2020

C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.

Nat Commun 2018 06 20;9(1):2416. Epub 2018 Jun 20.

Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, 4.401-2350 Health Sciences Mall, Vancouver, V6T 1Z3, BC, Canada.

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http://dx.doi.org/10.1038/s41467-018-04717-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010466PMC
June 2018

Can we predict protein from mRNA levels?

Nature 2017 07;547(7664):E19-E20

Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/nature22293DOI Listing
July 2017

Interactome disassembly during apoptosis occurs independent of caspase cleavage.

Mol Syst Biol 2017 01 12;13(1):906. Epub 2017 Jan 12.

Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293159PMC
http://dx.doi.org/10.15252/msb.20167067DOI Listing
January 2017

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Cell Rep 2016 08 28;16(6):1762-1773. Epub 2016 Jul 28.

Centre for Blood Research, Life Sciences Institute and Faculty of Dentistry, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.086DOI Listing
August 2016

The path of no return--Truncated protein N-termini and current ignorance of their genesis.

Proteomics 2015 Jul 15;15(14):2547-52. Epub 2015 Jun 15.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British, Columbia, Canada.

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http://dx.doi.org/10.1002/pmic.201500043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736679PMC
July 2015

Proteome TopFIND 3.0 with TopFINDer and PathFINDer: database and analysis tools for the association of protein termini to pre- and post-translational events.

Nucleic Acids Res 2015 Jan 20;43(Database issue):D290-7. Epub 2014 Oct 20.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada

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http://academic.oup.com/nar/article/43/D1/D290/2435434/Prote
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http://dx.doi.org/10.1093/nar/gku1012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383881PMC
January 2015

TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage.

Blood 2014 Dec 20;124(26):e49-60. Epub 2014 Oct 20.

Centre for Blood Research, and Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1182/blood-2014-04-569640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271184PMC
December 2014

Network analyses reveal pervasive functional regulation between proteases in the human protease web.

PLoS Biol 2014 May 27;12(5):e1001869. Epub 2014 May 27.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada; Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada; Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1371/journal.pbio.1001869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035269PMC
May 2014