Publications by authors named "Nikolas H Stoecklein"

78Publications

Magnetic-Based Enrichment of Rare Cells from High Concentrated Blood Samples.

Cancers (Basel) 2020 Apr 10;12(4). Epub 2020 Apr 10.

Department of General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty of the Heinrich-Heine University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.3390/cancers12040933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225976PMC
April 2020

FGF Signalling in the Self-Renewal of Colon Cancer Organoids.

Sci Rep 2019 11 22;9(1):17365. Epub 2019 Nov 22.

Institute for Stem Cell Research and Regenerative Medicine, University Hospital and Medical Faculty of the Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/s41598-019-53907-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874569PMC
November 2019

Spatiotemporally controlled induction of gene expression in vivo allows tracking the fate of tumor cells that traffic through the lymphatics.

Int J Cancer 2020 Aug 21;147(4):1190-1198. Epub 2019 Nov 21.

Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), Campus Nord, Karlsruhe, Germany.

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http://dx.doi.org/10.1002/ijc.32766DOI Listing
August 2020

Circulating biomarkers for early detection and clinical management of colorectal cancer.

Mol Aspects Med 2019 10 14;69:107-122. Epub 2019 Jun 14.

Gastrointestinal & Pancreatic Oncology Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) / Hospital Clínic of Barcelona/ Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2019.06.002DOI Listing
October 2019

Detection of circulating tumor cells in colorectal cancer patients using the GILUPI CellCollector: results from a prospective, single-center study.

Mol Oncol 2019 07 17;13(7):1548-1558. Epub 2019 Jun 17.

Department of General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty of the Heinrich-Heine-University Düsseldorf, Germany.

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http://dx.doi.org/10.1002/1878-0261.12507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599844PMC
July 2019

Label-Free Enrichment and Molecular Characterization of Viable Circulating Tumor Cells from Diagnostic Leukapheresis Products.

Clin Chem 2019 04 8;65(4):549-558. Epub 2019 Feb 8.

Department of Obstetrics and Gynecology, University Hospital and Medical Faculty of the Heinrich Heine University Düsseldorf, Düsseldorf, Germany;

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http://dx.doi.org/10.1373/clinchem.2018.296814DOI Listing
April 2019

Minimal Residual Disease in Head and Neck Cancer and Esophageal Cancer.

Adv Exp Med Biol 2018;1100:55-82

Department of General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

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http://link.springer.com/10.1007/978-3-319-97746-1_4
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http://dx.doi.org/10.1007/978-3-319-97746-1_4DOI Listing
July 2019

BRAF mutation: A promising target in colorectal neuroendocrine carcinoma.

Int J Cancer 2019 03 30;144(6):1379-1390. Epub 2018 Oct 30.

Department of Surgery (A), Medical Faculty, Heinrich-Heine-University and University Hospital Duesseldorf, Duesseldorf, Germany.

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http://dx.doi.org/10.1002/ijc.31828DOI Listing
March 2019

Clinicopathological and functional implications of the inhibitor of apoptosis proteins survivin and XIAP in esophageal cancer.

Oncol Lett 2018 Mar 9;15(3):3779-3789. Epub 2018 Jan 9.

Department of Surgery (A), Heinrich-Heine-University and University Hospital Düsseldorf, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.3892/ol.2018.7755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796362PMC
March 2018

Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases.

BMC Res Notes 2017 Nov 6;10(1):560. Epub 2017 Nov 6.

Department of General, Visceral, and Pediatric Surgery, Heinrich-Heine-University and University Hospital Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, Germany.

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http://dx.doi.org/10.1186/s13104-017-2886-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674747PMC
November 2017

Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma.

Br J Cancer 2017 Aug 20;117(5):725-733. Epub 2017 Jul 20.

Department of General, Visceral and Paediatric Surgery, University Hospital and Medical Faculty of the Heinrich-Heine-University Duesseldorf, Moorenstr. 5, Duesseldorf 40225, Germany.

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http://www.nature.com/doifinder/10.1038/bjc.2017.233
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http://dx.doi.org/10.1038/bjc.2017.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572184PMC
August 2017

Immunohistochemical detection of lymph node-DTCs in patients with node-negative HNSCC.

Int J Cancer 2017 05 8;140(9):2112-2124. Epub 2017 Feb 8.

Department of General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital of the Heinrich-Heine-University Düsseldorf, Germany.

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http://dx.doi.org/10.1002/ijc.30617DOI Listing
May 2017

Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion.

Oncotarget 2017 Jan;8(1):1884-1912

Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University of Munich, Munich, Germany.

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http://dx.doi.org/10.18632/oncotarget.12242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352105PMC
January 2017

EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer.

PLoS One 2015 22;10(12):e0144535. Epub 2015 Dec 22.

Department of Obstetrics and Gynecology, University Hospital and Medical Faculty of the Heinrich-Heine University Duesseldorf, Duesseldorf, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144535PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687932PMC
June 2016

Challenges for CTC-based liquid biopsies: low CTC frequency and diagnostic leukapheresis as a potential solution.

Expert Rev Mol Diagn 2016 16;16(2):147-64. Epub 2015 Dec 16.

d Department of Medical Cell BioPhysics, MIRA Institute , University of Twente , Enschede , The Netherlands.

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http://dx.doi.org/10.1586/14737159.2016.1123095DOI Listing
November 2016

Characterization of DNA Methylation in Circulating Tumor Cells.

Genes (Basel) 2015 Oct 21;6(4):1053-75. Epub 2015 Oct 21.

Department of General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty of the Heinrich-Heine University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.

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http://www.mdpi.com/2073-4425/6/4/1053
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http://dx.doi.org/10.3390/genes6041053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690028PMC
October 2015

Laser Microdissection of FFPE Tissue Areas and Subsequent Whole Genome Amplification by Ampli1™.

Methods Mol Biol 2015 ;1347:141-62

Project Group, Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Josef-Engert-Straße 9, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-2990-0_11DOI Listing
June 2016

Peritoneal sarcomatosis: site of origin for the establishment of an in vitro and in vivo cell line model to study therapeutic resistance in dedifferentiated liposarcoma.

Tumour Biol 2016 Feb 15;37(2):2341-51. Epub 2015 Sep 15.

Department of Surgery (A), Heinrich-Heine-University and University Hospital Duesseldorf, Moorenstr. 5, Bldg. 12.46, 40225, Duesseldorf, Germany.

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http://dx.doi.org/10.1007/s13277-015-4050-6DOI Listing
February 2016

Analysis of Copy-Number Alterations in Single Cells Using Microarray-Based Comparative Genomic Hybridization (aCGH).

Curr Protoc Cell Biol 2014 Dec 1;65:22.19.1-23. Epub 2014 Dec 1.

Department of Surgery (A), Heinrich Heine University and University Hospital Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1002/0471143030.cb2219s65DOI Listing
December 2014

Integrin expression in esophageal squamous cell carcinoma: loss of the physiological integrin expression pattern correlates with disease progression.

PLoS One 2014 14;9(11):e109026. Epub 2014 Nov 14.

Department of Surgery (A), Heinrich-Heine-University and University Hospital Düsseldorf, Düsseldorf, Germany; Department of General, Visceral, and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Pediatric Surgery, University Hospital Rostock, Rostock, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109026PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232252PMC
July 2015

Dynamic EpCAM expression on circulating and disseminating tumor cells: causes and consequences.

Cell Mol Life Sci 2014 Nov 8;71(22):4393-402. Epub 2014 Aug 8.

Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377, Munich, Germany,

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http://dx.doi.org/10.1007/s00018-014-1693-1DOI Listing
November 2014

Clinically staged cT2 adenocarcinomas of the gastroesophageal junction: accuracy of staging and therapeutic consequences.

Oncol Res Treat 2014 21;37(3):97-104. Epub 2014 Feb 21.

Department of General, Visceral and Pediatric Surgery, University of Dusseldorf, Dusseldorf, Germany.

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http://dx.doi.org/10.1159/000360177DOI Listing
December 2014

Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer.

Cancer Res 2014 Mar 5;74(6):1694-704. Epub 2014 Mar 5.

Authors' Affiliations: Department of General, Gastrointestinal and Transplant Surgery; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg; German Cancer Research Center, Division of Biostatistics, Heidelberg; Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Department of General, Visceral and Paediatric Surgery, Medical Faculty, University Hospital, Heinrich Heine University, Düsseldorf, Germany; and Edwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1885DOI Listing
March 2014

Diagnostic leukapheresis enables reliable detection of circulating tumor cells of nonmetastatic cancer patients.

Proc Natl Acad Sci U S A 2013 Oct 24;110(41):16580-5. Epub 2013 Sep 24.

Institute for Transplantation Diagnostics and Cell Therapeutics and Departments of Obstetrics and Gynecology and General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1073/pnas.1313594110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799344PMC
October 2013

Expression of TRAIL-splice variants in gastric carcinomas: identification of TRAIL-γ as a prognostic marker.

BMC Cancer 2013 Aug 12;13:384. Epub 2013 Aug 12.

Department of Surgery A, Heinrich Heine University and University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany.

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http://dx.doi.org/10.1186/1471-2407-13-384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751299PMC
August 2013

High EpCAM expression is linked to proliferation and lauren classification in gastric cancer.

BMC Res Notes 2013 Jul 5;6:253. Epub 2013 Jul 5.

Department of Surgery (A), Heinrich-Heine-University and University Hospital Duesseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1186/1756-0500-6-253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724596PMC
July 2013

Prognostic and clinicopathological significance of survivin in colorectal cancer: a meta-analysis.

PLoS One 2013 3;8(6):e65338. Epub 2013 Jun 3.

Department of Surgery A, Heinrich-Heine-University and University Hospital Duesseldorf, Duesseldorf, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670901PMC
January 2015

Snail1 expression in colorectal cancer and its correlation with clinical and pathological parameters.

BMC Cancer 2013 Mar 22;13:145. Epub 2013 Mar 22.

Department of Surgery (A), Heinrich-Heine-University and University Hospital Duesseldorf, Düsseldorf, 40225, Germany.

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http://dx.doi.org/10.1186/1471-2407-13-145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617032PMC
March 2013

Validation of markers for the screening and identification of disseminating tumor cells in lymph nodes and bone marrow.

Int J Clin Pharmacol Ther 2013 Jan;51(1):77-9

Experimental Surgical Oncology, Department of General, Visceral and Pediatric Surgery, Düsseldorf, Germany.

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http://dx.doi.org/10.5414/cpp51077DOI Listing
January 2013

EPCAM-A novel molecular target for the treatment of pediatric and adult germ cell tumors.

Genes Chromosomes Cancer 2013 Jan 14;52(1):24-32. Epub 2012 Sep 14.

Department of Pediatric Hematology and Oncology, University of Bonn, University Children's Hospital Bonn, Germany.

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http://dx.doi.org/10.1002/gcc.22002DOI Listing
January 2013

Vascular invasion in pancreatic cancer: tumor biology or tumor topography?

Surgery 2012 Sep 3;152(3 Suppl 1):S143-51. Epub 2012 Jul 3.

Department of Surgery, Heinrich Heine University, Düsseldorf, Germany.

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http://dx.doi.org/10.1016/j.surg.2012.05.012DOI Listing
September 2012

Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis.

Mol Cancer 2011 Mar 23;10:30. Epub 2011 Mar 23.

Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum Düsseldorf, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1186/1476-4598-10-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078897PMC
March 2011

Increased numbers of tumor-lysing monocytes in cancer patients.

Mol Cell Endocrinol 2011 Apr 1;337(1-2):52-61. Epub 2011 Feb 1.

Endocrine Tumor Center, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Germany.

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http://dx.doi.org/10.1016/j.mce.2011.01.020DOI Listing
April 2011

Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases.

Clin Cancer Res 2010 Feb 26;16(3):790-9. Epub 2010 Jan 26.

Department of General, Visceral and Pediatric Surgery, University of Duesseldorf, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2446DOI Listing
February 2010

Increased EpCAM expression in malignant insulinoma: potential clinical implications.

Eur J Endocrinol 2010 Feb;162(2):391-8

Department of General, Institute of Pathology, University Hospital of the Heinrich-Heine University Düsseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1530/EJE-08-0916DOI Listing
February 2010

Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis.

Int J Cancer 2010 Feb;126(3):589-98

Department of General, Visceral, and Pediatric Surgery, Heinrich-Heine-University and University Hospital Düsseldorf, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1002/ijc.24916DOI Listing
February 2010

Lessons from an aggressive cancer: evolutionary dynamics in esophageal carcinoma.

Cancer Res 2009 Jul 23;69(13):5285-8. Epub 2009 Jun 23.

Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4586DOI Listing
July 2009

Occult disseminated tumor cells in lymph nodes of patients with gastric carcinoma. A critical appraisal of assessment and relevance.

Langenbecks Arch Surg 2009 Jan 15;394(1):105-13. Epub 2008 Jul 15.

Department of General Surgery, University Hospital Düsseldorf, Heinrich-Heine-University, Moorenstr. 5, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1007/s00423-008-0369-4DOI Listing
January 2009

High-resolution array comparative genomic hybridization of single micrometastatic tumor cells.

Nucleic Acids Res 2008 Apr 15;36(7):e39. Epub 2008 Mar 15.

Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1093/nar/gkn101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367728PMC
April 2008

Occult tumor cells in lymph nodes as a predictor for tumor relapse in pancreatic adenocarcinoma.

Langenbecks Arch Surg 2008 May 18;393(3):359-65. Epub 2007 Aug 18.

Department of General Surgery, Heinrich-Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1007/s00423-007-0215-0DOI Listing
May 2008

Benefit of surgical treatment of lung metastasis in soft tissue sarcoma.

Arch Surg 2007 Jan;142(1):70-5; discission 76

Klinik für Allgemein- und Viszeralchirurgie, Universitätsklinikum Düsseldorf, Heinrich-Heine Universität, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1001/archsurg.142.1.70DOI Listing
January 2007

Squamous cell carcinoma of the esophagus can be detected by microsatellite analysis in tumor and serum.

Clin Cancer Res 2003 Sep;9(11):4178-83

Department of General Surgery, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

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September 2003

Molecular markers and staging of early esophageal cancer.

Langenbecks Arch Surg 2003 Apr 20;388(2):77-82. Epub 2003 Feb 20.

Abteilung für Allgemein-, Viszeral- und Thoraxchirurgie, Klinik und Poliklinik für Chirurgie, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00423-003-0353-yDOI Listing
April 2003