Nikolaos K Robakis

Nikolaos K Robakis

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Nikolaos K Robakis

Nikolaos K Robakis

Publications by authors named "Nikolaos K Robakis"

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The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis.

Cell Mol Life Sci 2018 08 10;75(15):2813-2826. Epub 2018 Feb 10.

Center for Molecular Biology and Genetics of Neurodegeneration, Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://link.springer.com/10.1007/s00018-018-2762-7
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http://dx.doi.org/10.1007/s00018-018-2762-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023733PMC
August 2018

Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15.

FASEB J 2018 01 30;32(1):243-253. Epub 2017 Aug 30.

Department of Psychiatry, Center for Molecular Biology and Genetics of Neurodegeneration, Icahn School of Medicine at Mount Sinai, New York, New York, USA;

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http://dx.doi.org/10.1096/fj.201700447RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731132PMC
January 2018

Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations.

Neurobiol Aging 2016 06 4;42:41-9. Epub 2016 Mar 4.

Department of Psychiatry, Center for Molecular Biology and Genetics of Neurodegeneration, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neuroscience, Center for Molecular Biology and Genetics of Neurodegeneration, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.02.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857890PMC
June 2016

Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

Sci Signal 2016 Jan 12;9(410):ra5. Epub 2016 Jan 12.

Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.aab0467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819166PMC
January 2016

Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms.

FASEB J 2015 Sep 18;29(9):3702-12. Epub 2015 May 18.

*Departments of Psychiatry and Neuroscience, Center for Molecular Biology and Genetics of Neurodegeneration, Icahn School of Medicine at Mount Sinai, New York, New York, USA; School of Medicine, University of Crete, Heraklion, Crete, Greece; and James J. Peters Department of Veterans Affairs Medical Center, General Medical Research Service, Bronx, New York, USA

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http://www.fasebj.org/content/29/9/3702.full.pdf
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http://www.fasebj.org/cgi/doi/10.1096/fj.15-270645
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http://dx.doi.org/10.1096/fj.15-270645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550373PMC
September 2015

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.

Proc Natl Acad Sci U S A 2015 Sep 8;112(38):11965-70. Epub 2015 Sep 8.

Research & Development, James J. Peters VA Medical Center, Bronx, NY 10468; Department of Neurology, Alzheimer Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029;

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http://dx.doi.org/10.1073/pnas.1510011112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586834PMC
September 2015

Molecular neuropathology of Alzheimer dementia and therapeutic approaches.

Adv Exp Med Biol 2015 ;822

Department of Psychiatry, Neuroscience and Experimental Therapeutics, Mount Sinai School of Medicine, NYU, New York, NY, USA,

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http://dx.doi.org/10.1007/978-3-319-08927-0_1DOI Listing
April 2015

Cell signaling abnormalities may drive neurodegeneration in familial Alzheimer disease.

Neurochem Res 2014 23;39(3):570-5. Epub 2013 Feb 23.

Departments of Psychiatry and Neuroscience, Mount Sinai School of Medicine, New York University, One Gustave Levy Pl., Box 1229, New York, NY, 10029, USA,

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http://dx.doi.org/10.1007/s11064-013-1003-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718870PMC
November 2014

A role for noncoding variation in schizophrenia.

Cell Rep 2014 Nov 6;9(4):1417-29. Epub 2014 Nov 6.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(14)00869-9.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400869
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http://dx.doi.org/10.1016/j.celrep.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255904PMC
November 2014

Allelic interference: a mechanism for trans-dominant transmission of loss of function in the neurodegeneration of familial Alzheimer's disease.

Neurodegener Dis 2014 24;13(2-3):126-30. Epub 2013 Sep 24.

Departments of Psychiatry and Neuroscience, Center for Molecular Biology and Genetics of Neurodegeneration, Ican School of Medicine at Mount Sinai Medical Center, New York University, New York, N.Y., USA.

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http://dx.doi.org/10.1159/000354241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992934PMC
September 2014

Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B.

J Biol Chem 2013 Oct 11;288(42):30495-501. Epub 2013 Sep 11.

From the Center for Molecular Biology and Genetics of Neurodegeneration, Departments of Psychiatry and Neuroscience, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.

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http://dx.doi.org/10.1074/jbc.M113.499004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798513PMC
October 2013

Inge Grundke-Iqbal, Ph.D. (1937–2012): the discoverer of the abnormal hyperphosphorylation of tau in Alzheimer’s disease.

J Mol Neurosci 2013 Feb;49(2):430-5

Biology Department, Center for Developmental Neurosciences, College of Staten Island, The City University of New York, 2800 Victory Boulevard, Staten Island, NY 10314, USA.

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http://dx.doi.org/10.1007/s12031-012-9925-zDOI Listing
February 2013

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity.

Prog Neurobiol 2012 Aug 20;98(2):166-75. Epub 2012 May 20.

Center for Molecular Biology and Genetics of Neurodegeneration, Departments of Psychiatry and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.pneurobio.2012.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404154PMC
August 2012

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling.

Neurobiol Aging 2011 Dec 4;32(12):2326.e5-16. Epub 2011 Aug 4.

Center for Molecular Biology and Genetics of Neurodegeneration, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01974580110023
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http://dx.doi.org/10.1016/j.neurobiolaging.2011.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375317PMC
December 2011

Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein.

FASEB J 2011 Oct 11;25(10):3594-604. Epub 2011 Jul 11.

Center for Molecular Biology and Genetics of Neurodegeneration, Department of Psychiatry, Mt. Sinai School of Medicine, New York University, 1 Gustave L. Levy Pl., Box 1229, New York, NY 10029, USA.

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http://dx.doi.org/10.1096/fj.11-187856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177584PMC
October 2011

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.

FASEB J 2011 Sep 19;25(9):2937-46. Epub 2011 May 19.

Department of Psychiatry, Mt. Sinai School of Medicine, New York University, New York, NY 10029, USA.

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http://dx.doi.org/10.1096/fj.11-183806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157694PMC
September 2011

Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives.

Neurobiol Aging 2011 Mar 1;32(3):372-9. Epub 2010 Jul 1.

Department of Psychiatry, Mount Sinai School of Medicine, New York University, One Gustave Levy Pl. Box 1229, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385412PMC
March 2011

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis.

J Neurosci 2010 Nov;30(45):14946-54

Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4305-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426835PMC
November 2010

Are Abeta and its derivatives causative agents or innocent bystanders in AD?

Neurodegener Dis 2010 13;7(1-3):32-7. Epub 2010 Feb 13.

Center for Molecular Biology and Genetics of Neurodegeneration, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA.

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http://dx.doi.org/10.1159/000266476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214827PMC
July 2010

Alzheimer's disease: new light on etiology and management.

Mt Sinai J Med 2010 Jan-Feb;77(1):1-2

A.P. Slaner Professor for Alzheimer's Disease Research, Professor of Neurobiology, Center for Molecular Biology and Genetics of Neurodegeneration, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1002/msj.20166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802860PMC
April 2010

Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptors.

J Biol Chem 2009 Oct 6;284(40):27220-8. Epub 2009 Aug 6.

Center for Molecular Biology and Genetics of Neurodegeneration, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M109.048728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785649PMC
October 2009

p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide.

J Biol Chem 2009 Jan 13;284(4):1954-61. Epub 2008 Nov 13.

Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M806250200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629097PMC
January 2009

Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling.

J Neurosci 2008 Jan;28(2):483-90

Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4067-07.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670519PMC
January 2008

Novel processing of Notch 1 within its intracellular domain by a cysteine protease.

Neurodegener Dis 2007 ;4(2-3):148-55

Division of Animal and Human Physiology, Department of Biology, University of Athens, Athens, Greece.

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http://dx.doi.org/10.1159/000101839DOI Listing
October 2007

Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.

J Biol Chem 2007 Jun 10;282(22):16155-63. Epub 2007 Apr 10.

Department of Psychiatry and Neuroscience, Mount Sinai School of Medicine New York University, New York, NY 10029, USA, and Institute for Molecular Cardiovascular Research, University Hospital Reinisch-West Faelische Technische Hochschule, Aachen, Germany.

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http://dx.doi.org/10.1074/jbc.M611449200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005067PMC
June 2007

FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta.

J Neurochem 2007 May 24;101(3):674-81. Epub 2007 Jan 24.

Department of Psychiatry, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA.

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http://doi.wiley.com/10.1111/j.1471-4159.2006.04391.x
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http://dx.doi.org/10.1111/j.1471-4159.2006.04391.xDOI Listing
May 2007

It may take inflammation, phosphorylation and ubiquitination to 'tangle' in Alzheimer's disease.

Neurodegener Dis 2006 4;3(6):313-9. Epub 2006 Sep 4.

Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10021, USA.

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http://dx.doi.org/10.1159/000095638DOI Listing
February 2007

The discovery and mapping to chromosome 21 of the Alzheimer's amyloid gene: history revised.

J Alzheimers Dis 2006 Dec;10(4):453-5

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December 2006

The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors.

J Neurochem 2006 Feb 26;96(4):1182-8. Epub 2006 Jan 26.

Department of Psychiatry, Mount Sinai School of Medicine, New York 10029, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03616.xDOI Listing
February 2006

Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability.

J Biol Chem 2005 Oct 26;280(43):36007-12. Epub 2005 Aug 26.

Department of Psychiatry, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M507503200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005066PMC
October 2005

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations.

EMBO J 2004 Jul 10;23(13):2586-96. Epub 2004 Jun 10.

Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7600251
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http://dx.doi.org/10.1038/sj.emboj.7600251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC449766PMC
July 2004

Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin-binding neuroregulatory factors.

FEBS Lett 2004 Jan;557(1-3):233-8

Department of Biochemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.

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http://dx.doi.org/10.1016/s0014-5793(03)01506-0DOI Listing
January 2004

Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity.

J Biol Chem 2003 Dec 24;278(51):50970-7. Epub 2003 Sep 24.

Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M307699200DOI Listing
December 2003

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations.

Cell 2003 Sep;114(5):635-45

Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.cell.2003.08.008DOI Listing
September 2003

An Alzheimer's disease hypothesis based on transcriptional dysregulation.

Amyloid 2003 Jun;10(2):80-5

Department of Psychiatry, Fishberg Reserch Center for Neurobiology, Mount Sinai School of Medicine, New York University, One Gustave L. Levy Place, New York, NY 10029, USA.

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June 2003

Presenilin-1 is expressed in neural progenitor cells in the hippocampus of adult mice.

Neurosci Lett 2002 Jan;318(2):53-6

Department of Psychiatry, P.O. Box 1229, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/s0304-3940(01)02485-5DOI Listing
January 2002

Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease.

J Alzheimers Dis 1999 Oct;1(3):139-145

Department of Pathology, University of Louisville - Veterans Affairs Medical Center, Louisville, KY, USA.

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October 1999