Nigel S Key

Nigel S Key

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Nigel S Key

Publications by authors named "Nigel S Key"

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Association of sickle cell trait with measures of cognitive function and dementia in African Americans.

eNeurologicalSci 2019 Sep 22;16:100201. Epub 2019 Jul 22.

Aflac Cancer and Blood Disorder Center of Children's Healthcare of Atlanta, Emory Department of Pediatrics, Atlanta, GA, United States of America.

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http://dx.doi.org/10.1016/j.ensci.2019.100201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661502PMC
September 2019

The relationship between pancreatic cancer and hypercoagulability: a comprehensive review on epidemiological and biological issues.

Br J Cancer 2019 Aug 22;121(5):359-371. Epub 2019 Jul 22.

Division of Haematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41416-019-0510-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738049PMC
August 2019

How to discuss gene therapy for haemophilia? A patient and physician perspective.

Haemophilia 2019 Jul 21;25(4):545-557. Epub 2019 May 21.

Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1111/hae.13769DOI Listing
July 2019

Prolonged Remission of Cancer of Unknown Primary following Initiation of Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria.

Case Rep Hematol 2019 2;2019:2587597. Epub 2019 Jul 2.

Department of Medicine, Division of Hematology/Oncology, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1155/2019/2587597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636445PMC
July 2019

Neutrophils: back in the thrombosis spotlight.

Blood 2019 May 21;133(20):2186-2197. Epub 2019 Mar 21.

Department of Medicine.

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http://dx.doi.org/10.1182/blood-2018-10-862243DOI Listing
May 2019

Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products.

Blood Adv 2019 May;3(9):1429-1440

Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapeutics, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.

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http://dx.doi.org/10.1182/bloodadvances.2018030452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517663PMC
May 2019

Re-evaluation of hematocrit as a determinant of thrombotic risk in erythrocytosis.

Haematologica 2019 Apr 14;104(4):653-658. Epub 2019 Mar 14.

Division of Hematology and Hematologic Malignancies, University of Utah and Huntsman Cancer Center, Salt Lake City, UT, USA

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http://www.haematologica.org/lookup/doi/10.3324/haematol.201
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http://dx.doi.org/10.3324/haematol.2018.210732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442963PMC
April 2019

Effect of eptifibatide on inflammation during acute pain episodes in sickle cell disease.

Am J Hematol 2018 08 30;93(4):E99-E101. Epub 2018 Jan 30.

Division of Hematology and Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/ajh.25032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926197PMC
August 2018

Nephrin as a biomarker of sickle cell glomerulopathy in Malawi.

Pediatr Blood Cancer 2018 06 7;65(6):e26993. Epub 2018 Feb 7.

Division of Hematology/Oncology, University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/pbc.26993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911184PMC
June 2018

Red Blood Cell Adhesion to Heme-Activated Endothelial Cells Reflects Clinical Phenotype in Sickle Cell Disease.

Am J Hematol 2018 Jun 15. Epub 2018 Jun 15.

Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, USA.

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http://doi.wiley.com/10.1002/ajh.25159
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http://dx.doi.org/10.1002/ajh.25159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295270PMC
June 2018

Microparticles in sickle cell disease.

Clin Hemorheol Microcirc 2018 ;68(2-3):319-329

Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.3233/CH-189014DOI Listing
May 2018

Antifibrinolytic Therapy and Perioperative Considerations.

Anesthesiology 2018 03;128(3):657-670

From the Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina (J.H.L, Q.J.Q.); Institute of Anesthesiology, Heart and Diabetes Center North Rhine Westphalia, Bad Oeynhausen, Ruhr-University Bochum, Bochum, Germany (A.K.); Seton Dell Medical School Stroke Institute, Austin, Texas (T.J.M.); and the Department of Medicine, Division of Hematology/Oncology, University of North Carolina, Chapel Hill, North Carolina (N.S.K.).

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http://dx.doi.org/10.1097/ALN.0000000000001997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811331PMC
March 2018

Analysis of anticoagulation strategies for venous thromboembolism during severe thrombocytopenia in patients with hematologic malignancies: a retrospective cohort.

Leuk Lymphoma 2017 11 9;58(11):2573-2581. Epub 2017 Apr 9.

a Department of Medicine, Division of Hematology/Oncology , University of North Carolina , Chapel Hill , NC , USA.

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http://dx.doi.org/10.1080/10428194.2017.1306644DOI Listing
November 2017

In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps.

Blood 2017 02 5;129(8):1021-1029. Epub 2016 Dec 5.

Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC; and.

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http://dx.doi.org/10.1182/blood-2016-06-722298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324715PMC
February 2017

Corrigendum to "Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays" [Thromb. Res. 139 (2016) 90-97].

Thromb Res 2016 11 24;147:63. Epub 2016 Sep 24.

McAllister Heart Institute, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2016.09.009DOI Listing
November 2016

Coagulation abnormalities of sickle cell disease: Relationship with clinical outcomes and the effect of disease modifying therapies.

Blood Rev 2016 07 24;30(4):245-56. Epub 2015 Dec 24.

Division of Hematology/Oncology, University of North Carolina at Chapel Hill, USA. Electronic address:

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http://dx.doi.org/10.1016/j.blre.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919240PMC
July 2016

Prospective, multicenter study of postoperative deep-vein thrombosis in patients with haemophilia undergoing major orthopaedic surgery.

Thromb Haemost 2016 07 24;116(1):42-9. Epub 2016 Mar 24.

Tyler W. Buckner, MD, MSc, Division of Hematology, University of Colorado School of Medicine, 13199 E. Montview Blvd, Suite 100, Mailstop F416, Aurora, CO 80045, USA, Tel.: +1 303 724 6182, Fax: +1 303 724 0947, E-mail:

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http://dx.doi.org/10.1160/TH15-10-0802DOI Listing
July 2016

How I treat patients with inherited bleeding disorders who need anticoagulant therapy.

Blood 2016 07 22;128(2):178-84. Epub 2016 Apr 22.

Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-12-63
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http://dx.doi.org/10.1182/blood-2015-12-635094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946199PMC
July 2016

Microparticles in sickle cell anaemia: promise and pitfalls.

Br J Haematol 2016 07 2;174(1):16-29. Epub 2016 May 2.

Division of Haematology and Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1111/bjh.14112DOI Listing
July 2016

Protective and detrimental effects of neuroectodermal cell-derived tissue factor in mouse models of stroke.

JCI Insight 2016 Jul;1(11)

McAllister Heart Institute, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Division of Hematology and Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1172/jci.insight.86663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968952PMC
July 2016

Thrombosis in Cancer: Research Priorities Identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group.

Cancer Res 2016 07 20;76(13):3671-5. Epub 2016 Jun 20.

Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3100DOI Listing
July 2016

8(th) Symposium on Hemostasis: Translational and Basic Science Discoveries.

Thromb Res 2016 May;141 Suppl 2:S1-3

Department of Medicine, Division of Hematology-Oncology, University of North Carolina, Chapel Hill, NC, U.S.A.. Electronic address:

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http://dx.doi.org/10.1016/S0049-3848(16)30352-8DOI Listing
May 2016

Genetic basis of ethnic disparities in VTE risk.

Blood 2016 Apr;127(15):1844-5

UNIVERSITY OF WASHINGTON.

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http://dx.doi.org/10.1182/blood-2016-03-701698DOI Listing
April 2016

Potent irreversible P2Y12 inhibition does not reduce LPS-induced coagulation activation in a randomized, double-blind, placebo-controlled trial.

Clin Sci (Lond) 2016 Mar 9;130(6):433-40. Epub 2015 Nov 9.

Department of Emergency Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

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http://dx.doi.org/10.1042/CS20150591DOI Listing
March 2016

Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.

Blood 2016 Mar 27;127(10):1371-3. Epub 2016 Jan 27.

McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC; Division of Hematology and Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.1182/blood-2015-11-681114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786843PMC
March 2016

Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays.

Thromb Res 2016 03 18;139:90-7. Epub 2016 Jan 18.

McAllister Heart Institute, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2016.01.011DOI Listing
March 2016

Microparticle analysis in disorders of hemostasis and thrombosis.

Cytometry A 2016 Feb 20;89(2):111-22. Epub 2015 Feb 20.

Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/cyto.a.22647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545474PMC
February 2016

In vitro and in vivo characterization of a reversible synthetic heparin analog.

Thromb Res 2016 Feb 10;138:121-129. Epub 2015 Dec 10.

Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2015.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751072PMC
February 2016

Sickle Cell Trait Worsens Oxidative Stress, Abnormal Blood Rheology, and Vascular Dysfunction in Type 2 Diabetes.

Diabetes Care 2015 Nov 31;38(11):2120-7. Epub 2015 Aug 31.

CRIS EA 647 Laboratory, Team Vascular Biology and Red Blood Cell, University Claude Bernard Lyon 1, Villeurbanne, France Institut Universitaire de France, Paris, France Laboratory of Excellence in Red Blood Cell (LABEX GR-Ex), PRES Sorbonne, Paris, France

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http://dx.doi.org/10.2337/dc15-0699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613921PMC
November 2015

Coagulation activation in sickle cell trait: an exploratory study.

Br J Haematol 2015 Nov 7;171(4):638-46. Epub 2015 Sep 7.

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1111/bjh.13641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782194PMC
November 2015

New players in Trousseau syndrome.

Authors:
Nigel S Key

Blood 2015 Sep;126(11):1270-2

UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL.

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http://dx.doi.org/10.1182/blood-2015-07-657932DOI Listing
September 2015

Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory.

Br J Haematol 2015 Jul 7;170(1):5-14. Epub 2015 Mar 7.

Division of Nephrology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1111/bjh.13363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478149PMC
July 2015

Changes in bleeding patterns in von Willebrand disease after institution of long-term replacement therapy: results from the von Willebrand Disease Prophylaxis Network.

Blood Coagul Fibrinolysis 2015 Jun;26(4):383-8

aLund University, Malmö Centre for Thrombosis and Haemostasis, Skåne University Hospital, Malmö, Sweden bMedical Sciences Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin cDepartment of Biostatistics, Rho, Inc., Chapel Hill, North Carolina, USA dHaemostasis and Thrombosis Unit, La Paz University Hospital, Madrid, Spain eManchester Blood Centre and the University of Manchester, Manchester, UK fDepartment of Paediatrics, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada gAngelo Bianchi Bonomi Hemophilia Thrombosis Centre, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital and Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy hPediatric Hematology, Medical College of Wisconsin, Comprehensive Center for Bleeding Disorders, Blood Center of Wisconsin, Milwaukee, Wisconsin, USA iGerinnungszentrum Rhein-Ruhr, Duisburg, Germany jAflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta and Emory University, and Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia kDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina lDepartment of Medicine, Rochester General Hospital, Rochester, New York, USA mThrombosis and Hemostasis Unit, Rigshospitalet, Copenhagen, Denmark nDepartment of Benigne Hematology Van Creveldkliniek, Erasmus University Medical Center, Rotterdam, The Netherlands oDepartment of Cardiovascular Science, University of Sheffield, Sheffield, UK pAngelo Bianchi Bonomi Hemophilia and Thrombosis Center and Scientific Director of Fondazione IRCCS Cá Granda-Ospedale Maggiore Policlinico, Milan, Italy qUniversity Medical Center Utrecht, Department of Benigne Hematology Van Creveldkliniek, The Netherlands rHematology Research, CHOC Children's Hospital, Orange, California sRush University Medical Center, Chicago, Illinois, USA tCHU Sainte-Justine Hospital, Hemophilia Treatment Centre, Mo

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http://dx.doi.org/10.1097/MBC.0000000000000257DOI Listing
June 2015

Protocol adherence when managing massive bleeding following complex cardiac surgery: a study design pilot.

J Cardiothorac Vasc Anesth 2015 Apr 17;29(2):303-10. Epub 2014 Dec 17.

Pediatric Hematology/Oncology and Pediatric Critical Care, University of Minnesota School of Medicine, Minneapolis, Minnesota.

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http://dx.doi.org/10.1053/j.jvca.2014.08.009DOI Listing
April 2015

Excess of heme induces tissue factor-dependent activation of coagulation in mice.

Haematologica 2015 Mar 16;100(3):308-14. Epub 2015 Jan 16.

Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

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http://dx.doi.org/10.3324/haematol.2014.114728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349268PMC
March 2015

Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update 2014.

J Clin Oncol 2015 Feb 20;33(6):654-6. Epub 2015 Jan 20.

Gary H. Lyman, Fred Hutchinson Cancer Research Center; Gary H. Lyman and Nicole M. Kuderer, University of Washington, Seattle, WA; Kari Bohlke and Mark R. Somerfield, American Society of Clinical Oncology, Alexandria, VA; Alok A. Khorana, Cleveland Clinic, Cleveland, OH; Agnes Y. Lee, University of British Columbia, Vancouver, British Columbia; Mark N. Levine, McMaster University, Hamilton, Ontario, Canada; Juan Ignacio Arcelus, Hospital Universitario Virgen de las Nieves, University of Granada, Granada, Spain; Edward P. Balaban, Cancer Care Partnership, Mount Nittany Health and Penn State Hershey Cancer Institute, State College, PA; Jeffrey M. Clarke, Duke University Medical Center, Durham; Nigel S. Key, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC; Christopher R. Flowers, Emory University School of Medicine, Atlanta, GA; Charles W. Francis, James P. Wilmot Cancer Center and University of Rochester, Rochester, NY; Leigh E. Gates, Patient Representative, Denver, CO; Ajay K. Kakkar, Thrombosis Research Institute, London, United Kingdom; Howard A. Liebman, University of Southern California Keck School of Medicine and Norris Comprehensive Cancer Center, Los Angeles; Margaret A. Tempero, University of California San Francisco Pancreas Center, San Francisco, CA; Sandra L. Wong, University of Michigan, Ann Arbor, MI; and Anna Falanga, Hospital Papa Giovanni XXIII, Bergamo, Italy.

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http://dx.doi.org/10.1200/JCO.2014.59.7351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881372PMC
February 2015

Sickle cell disease and venous thromboembolism in pregnancy and the puerperium.

Thromb Res 2015 Feb 9;135 Suppl 1:S46-8. Epub 2015 Feb 9.

Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/S0049-3848(15)50442-8DOI Listing
February 2015

Epidemiologic and clinical data linking factors XI and XII to thrombosis.

Authors:
Nigel S Key

Hematology Am Soc Hematol Educ Program 2014 Dec 18;2014(1):66-70. Epub 2014 Nov 18.

Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.1182/asheducation-2014.1.66DOI Listing
December 2014

Impact of sickle hemoglobinopathies on pregnancy-related venous thromboembolism.

Am J Perinatol 2014 Oct 12;31(9):805-9. Epub 2013 Dec 12.

Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.

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https://www.thieme-connect.com/products/ejournals/pdf/10.105
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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1361931
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http://dx.doi.org/10.1055/s-0033-1361931DOI Listing
October 2014

A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?

Br J Haematol 2014 Oct 8;167(1):110-20. Epub 2014 Jul 8.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Department of Pathology and Laboratory Animal Medicine, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1111/bjh.13005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167465PMC
October 2014

Sickle cell trait and incident ischemic stroke in the Atherosclerosis Risk in Communities study.

Stroke 2014 Oct 19;45(10):2863-7. Epub 2014 Aug 19.

From the Departments of Medicine (M.C.C., N.S.K., V.K.D., A.V.K.) and Epidemiology (M.C.C., L.R.L., G.H.), University of North Carolina at Chapel Hill; Department of Neurology, Johns Hopkins University School of Medicine; Baltimore, MD (R.F.G.); and School of Public Health, Human Genetics Center, The University of Texas Health Science Center, Houston (M.L.G.).

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http://dx.doi.org/10.1161/STROKEAHA.114.006110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174726PMC
October 2014

De novo synthesis of a narrow size distribution low-molecular-weight heparin.

Glycobiology 2014 May 13;24(5):476-86. Epub 2014 Mar 13.

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, Rm 303, Beard Hall.

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http://dx.doi.org/10.1093/glycob/cwu016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976284PMC
May 2014

Red blood cells and thrombin generation in sickle cell disease.

Thromb Res 2014 May;133 Suppl 1:S52-3

Division of Hematology/Oncology, Department of Medicine, University of NC at Chapel Hill, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00493848140014
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http://dx.doi.org/10.1016/j.thromres.2014.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031037PMC
May 2014

Homogeneous low-molecular-weight heparins with reversible anticoagulant activity.

Nat Chem Biol 2014 Apr 23;10(4):248-50. Epub 2014 Feb 23.

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nchembio.1459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393012PMC
April 2014

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease.

Blood 2014 Mar 21;123(11):1747-56. Epub 2014 Jan 21.

Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC;

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http://dx.doi.org/10.1182/blood-2013-08-523936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954055PMC
March 2014

Blood utilization in patients with burn injury and association with clinical outcomes (CME).

Transfusion 2013 Oct 24;53(10):2212-21; quiz 2211. Epub 2012 Dec 24.

Department of Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Biostatistics and North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Surgery, North Carolina Jaycee Burn Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Surgery, Division of Trauma and Critical Care Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.1111/trf.12057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620962PMC
October 2013

Hemostatic abnormalities in sickle cell disease.

Curr Opin Hematol 2013 Sep;20(5):472-7

Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1097/MOH.0b013e328363442fDOI Listing
September 2013

Circulating microparticle tissue factor, thromboembolism and survival in pancreaticobiliary cancers.

Thromb Res 2013 Aug 13;132(2):180-4. Epub 2013 Jul 13.

Departments of Medicine and Biostatistics, Roswell Park Cancer Institute, Buffalo, N.Y. USA.

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http://dx.doi.org/10.1016/j.thromres.2013.06.026DOI Listing
August 2013

Role of procoagulant microparticles in mediating complications and outcome of acute liver injury/acute liver failure.

Hepatology 2013 Jul 14;58(1):304-13. Epub 2013 May 14.

Section of Hepatology and Hume-Lee Transplant Center, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1002/hep.26307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571831PMC
July 2013

Major burn injury is not associated with acute traumatic coagulopathy.

J Trauma Acute Care Surg 2013 Jun;74(6):1474-9

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1097/TA.0b013e3182923193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342258PMC
June 2013

Characteristics of abdominal vein thrombosis in children and adults.

Thromb Haemost 2013 Apr 14;109(4):625-32. Epub 2013 Feb 14.

Thomas L. Ortel, MD, PhD, Duke Thrombosis and Hemostasis Center, Box 3422 DUMC, Durham, NC 27710, USA.

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http://dx.doi.org/10.1160/TH12-08-0568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963260PMC
April 2013

Bench to bedside: new developments in our understanding of the pathophysiology of thrombosis.

Authors:
Nigel S Key

J Thromb Thrombolysis 2013 Apr;35(3):342-5

Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1007/s11239-013-0898-8DOI Listing
April 2013

Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives.

Blood 2013 Mar 14;121(11):1944-50. Epub 2013 Jan 14.

Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1182/blood-2012-08-378935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645054PMC
March 2013

Microparticles in cardiovascular disease pathophysiology and outcomes.

J Am Soc Hypertens 2012 Jul-Aug;6(4):243-52

Hypertension Research Program, Department of Family Medicine, University of North Carolina at Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.jash.2012.06.003DOI Listing
January 2013

Studies on the mechanism of action of the aptamer BAX499, an inhibitor of tissue factor pathway inhibitor.

Thromb Res 2012 Sep 30;130(3):e151-7. Epub 2012 May 30.

Department of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.thromres.2012.05.010DOI Listing
September 2012

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease.

Blood 2012 Jul 1;120(3):636-46. Epub 2012 Jun 1.

Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1182/blood-2012-04-424143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401215PMC
July 2012

Association of coagulation activation with clinical complications in sickle cell disease.

PLoS One 2012 11;7(1):e29786. Epub 2012 Jan 11.

Division of Hematology/Oncology, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029786PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256184PMC
May 2012

Tissue factor-positive monocytes in children with sickle cell disease: correlation with biomarkers of haemolysis.

Br J Haematol 2012 May 24;157(3):370-80. Epub 2012 Feb 24.

Division of Research Haematology, Department of Pediatrics, Marian Anderson Comprehensive Sickle Cell Anaemia Care and Research Centre, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://doi.wiley.com/10.1111/j.1365-2141.2012.09065.x
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http://dx.doi.org/10.1111/j.1365-2141.2012.09065.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323750PMC
May 2012

A review of current methods for assessing hemostasis in vivo and introduction to a potential alternative approach.

Thromb Res 2012 May 8;129 Suppl 2:S57-61. Epub 2012 Mar 8.

Joint Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1016/j.thromres.2012.02.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928126PMC
May 2012

Acquired hemophilia in malignancy.

Thromb Res 2012 Apr;129 Suppl 1:S66-8

Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, NC, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S004938481270019
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http://dx.doi.org/10.1016/S0049-3848(12)70019-1DOI Listing
April 2012

Medical management of venous thromboembolism: what the interventional radiologist needs to know.

Semin Intervent Radiol 2012 Mar;29(1):3-9

Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1055/s-0032-1302445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348766PMC
March 2012

Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity.

Thromb Res 2012 Feb 16;129(2):197-203. Epub 2011 Jul 16.

Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1016/j.thromres.2011.06.022DOI Listing
February 2012

Venous thrombosis in blacks.

Circulation 2012 Feb;125(6):837-9

Pathology and Laboratory Medicine, Chapel Hill, NC 27599, USA. .

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http://dx.doi.org/10.1161/CIRCULATIONAHA.111.073098DOI Listing
February 2012

Variant hemoglobin phenotypes may account for differential erythropoiesis-stimulating agent dosing in African-American hemodialysis patients.

Kidney Int 2011 Nov 17;80(9):992-999. Epub 2011 Aug 17.

Division of Nephrology and Hypertension, Department of Medicine, UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/ki.2011.247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311876PMC
November 2011

Sickle-cell trait: novel clinical significance.

Hematology Am Soc Hematol Educ Program 2010 ;2010:418-22

Division of Hematology/Oncology, UNC Kidney Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1182/asheducation-2010.1.418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299004PMC
April 2011

Association of soluble fms-like tyrosine kinase-1 with pulmonary hypertension and haemolysis in sickle cell disease.

Br J Haematol 2011 Feb 11;152(4):485-91. Epub 2011 Jan 11.

Comprehensive Sickle Cell Program Division of Hematology/Oncology Department of Biochemistry and Biophysics Department of Biostatistics Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599-7305, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08410.xDOI Listing
February 2011

Microparticles in thrombosis and hemostasis.

Semin Thromb Hemost 2010 Nov 3;36(8):805-6. Epub 2010 Nov 3.

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http://dx.doi.org/10.1055/s-0030-1267033DOI Listing
November 2010

Tissue factor and its measurement in whole blood, plasma, and microparticles.

Semin Thromb Hemost 2010 Nov 3;36(8):865-75. Epub 2010 Nov 3.

Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1055/s-0030-1267040DOI Listing
November 2010

Novel oral anticoagulants: implications in the perioperative setting.

Anesthesiology 2010 Sep;113(3):726-45

Department of Anesthesiology, Emory University School of Medicine and Emory Healthcare, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1097/ALN.0b013e3181ebdb15DOI Listing
September 2010