Nigel M Hooper

Nigel M Hooper

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Nigel M Hooper

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Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake.

Sci Rep 2019 Aug 6;9(1):11416. Epub 2019 Aug 6.

School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1038/s41598-019-47814-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684651PMC
August 2019

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gennady Roshchupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 Aug 15. Epub 2019 Aug 15.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0495-7DOI Listing
August 2019

Soluble Amyloid Precursor Protein α: Friend or Foe?

Adv Exp Med Biol 2018;1112:177-183

Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/978-981-13-3065-0_13DOI Listing
July 2019

Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms.

J Neurochem 2019 May 14;149(3):399-412. Epub 2019 Feb 14.

Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/jnc.14666DOI Listing
May 2019

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.

J Biol Chem 2019 Apr 14;294(17):7085-7097. Epub 2019 Mar 14.

From the Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT,

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http://dx.doi.org/10.1074/jbc.RA118.005364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497954PMC
April 2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gennady Roshchupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Modelling Sporadic Alzheimer's Disease Using Induced Pluripotent Stem Cells.

Neurochem Res 2018 Dec 1;43(12):2179-2198. Epub 2018 Nov 1.

Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s11064-018-2663-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267251PMC
December 2018

Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective.

Trends Biotechnol 2018 04 6;36(4):457-472. Epub 2018 Feb 6.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tibtech.2018.01.003DOI Listing
April 2018

Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.

Biometals 2018 04 7;31(2):267-276. Epub 2018 Mar 7.

Centre for Advanced Discovery and Experimental Therapeutics (CADET), Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s10534-018-0089-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978903PMC
April 2018

A step-by-step translation of evidence into a psychosocial intervention for everyday activities in dementia: a focus group study.

Aging Ment Health 2018 03 12;22(3):323-329. Epub 2016 Dec 12.

d Together Dementia Support , Manchester , UK.

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http://dx.doi.org/10.1080/13607863.2016.1262819DOI Listing
March 2018

Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.

J Alzheimers Dis 2018 ;63(1):13-33

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.3233/JAD-170959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900574PMC
January 2018

Tau Diagnostics and Clinical Studies.

J Mol Neurosci 2017 Oct;63(2):123-130

Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, Centre for ageing and Health, AgeCap, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1007/s12031-017-0983-0DOI Listing
October 2017

Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer's Disease?

ACS Chem Neurosci 2017 07 6;8(7):1435-1437. Epub 2017 Jun 6.

Laboratoire de Biochimie Théorique, UPR 9080 CNRS, Université Paris Diderot, Sorbonne Paris Cité, IBPC, 13 Rue Pierre et Marie Curie, 75005 Paris, France.

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http://dx.doi.org/10.1021/acschemneuro.7b00188DOI Listing
July 2017

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.

J Biol Chem 2016 09 29;291(37):19235-44. Epub 2016 Jul 29.

the Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom

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http://dx.doi.org/10.1074/jbc.R116.746032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016663PMC
September 2016

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event.

Cell Mol Life Sci 2016 Feb 23;73(3):667-83. Epub 2015 Aug 23.

Department of Medicine, RMH, The University of Melbourne, Parkville, VIC, 3010, Australia.

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http://dx.doi.org/10.1007/s00018-015-2022-zDOI Listing
February 2016

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein.

J Biol Chem 2016 Feb 30;291(7):3174-83. Epub 2015 Dec 30.

From the Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PT and

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http://dx.doi.org/10.1074/jbc.R115.702704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751366PMC
February 2016

The Role of Tissue Non-specific Alkaline Phosphatase (TNAP) in Neurodegenerative Diseases: Alzheimer's Disease in the Focus.

Subcell Biochem 2015 ;76:363-74

Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, M13 9PT, UK,

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http://dx.doi.org/10.1007/978-94-017-7197-9_17DOI Listing
January 2016

The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11α.

Biochim Biophys Acta 2015 Nov 20;1850(11):2213-21. Epub 2015 Aug 20.

UCD School of Biomolecular and Biomedical Science, Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2015.08.010DOI Listing
November 2015

Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease.

Front Cell Dev Biol 2014 20;2:41. Epub 2014 Aug 20.

Faculty of Medical and Human Sciences, Institute of Brain, Behaviour and Mental Health, University of Manchester Manchester, UK.

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http://dx.doi.org/10.3389/fcell.2014.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206978PMC
November 2014

BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging.

PLoS One 2013 21;8(10):e78806. Epub 2013 Oct 21.

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078806PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804620PMC
August 2014

Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421.

Clin Sci (Lond) 2014 Aug;127(4):243-9

†School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.

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http://dx.doi.org/10.1042/CS20130420DOI Listing
August 2014

A label-free electrical impedimetric biosensor for the specific detection of Alzheimer's amyloid-beta oligomers.

Biosens Bioelectron 2014 Jun 24;56:83-90. Epub 2013 Dec 24.

School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1016/j.bios.2013.12.036DOI Listing
June 2014

Neuronal zinc regulation and the prion protein.

Prion 2013 May-Jun;7(3):203-8

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.4161/pri.24503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783104PMC
January 2014

Prion protein facilitates uptake of zinc into neuronal cells.

Nat Commun 2012 ;3:1134

Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1038/ncomms2135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493655PMC
March 2013

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design.

J Med Chem 2013 Mar 22;56(5):1843-52. Epub 2013 Feb 22.

School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1021/jm301127xDOI Listing
March 2013

Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1.

J Biol Chem 2013 Mar 5;288(13):8935-51. Epub 2013 Feb 5.

School of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M112.400358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610967PMC
March 2013

Regulation of amyloid-β production by the prion protein.

Prion 2012 Jul 1;6(3):217-22. Epub 2012 Jul 1.

Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK.

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http://www.tandfonline.com/doi/abs/10.4161/pri.18988
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http://dx.doi.org/10.4161/pri.18988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399542PMC
July 2012

Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.

PLoS One 2012 21;7(2):e31754. Epub 2012 Feb 21.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283671PMC
June 2012

Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease.

Neurodegener Dis 2012 20;9(1):31-7. Epub 2011 Oct 20.

Neurodegeneration and Mental Health Research Group, School of Community-Based Medicine, University of Manchester, UK.

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http://dx.doi.org/10.1159/000329722DOI Listing
March 2012

Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease.

J Alzheimers Dis 2010 ;22(3):1023-31

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.3233/JAD-2010-101071DOI Listing
June 2011

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Authors:
Paul Hollingworth Denise Harold Rebecca Sims Amy Gerrish Jean-Charles Lambert Minerva M Carrasquillo Richard Abraham Marian L Hamshere Jaspreet Singh Pahwa Valentina Moskvina Kimberley Dowzell Nicola Jones Alexandra Stretton Charlene Thomas Alex Richards Dobril Ivanov Caroline Widdowson Jade Chapman Simon Lovestone John Powell Petroula Proitsi Michelle K Lupton Carol Brayne David C Rubinsztein Michael Gill Brian Lawlor Aoibhinn Lynch Kristelle S Brown Peter A Passmore David Craig Bernadette McGuinness Stephen Todd Clive Holmes David Mann A David Smith Helen Beaumont Donald Warden Gordon Wilcock Seth Love Patrick G Kehoe Nigel M Hooper Emma R L C Vardy John Hardy Simon Mead Nick C Fox Martin Rossor John Collinge Wolfgang Maier Frank Jessen Eckart Rüther Britta Schürmann Reiner Heun Heike Kölsch Hendrik van den Bussche Isabella Heuser Johannes Kornhuber Jens Wiltfang Martin Dichgans Lutz Frölich Harald Hampel John Gallacher Michael Hüll Dan Rujescu Ina Giegling Alison M Goate John S K Kauwe Carlos Cruchaga Petra Nowotny John C Morris Kevin Mayo Kristel Sleegers Karolien Bettens Sebastiaan Engelborghs Peter P De Deyn Christine Van Broeckhoven Gill Livingston Nicholas J Bass Hugh Gurling Andrew McQuillin Rhian Gwilliam Panagiotis Deloukas Ammar Al-Chalabi Christopher E Shaw Magda Tsolaki Andrew B Singleton Rita Guerreiro Thomas W Mühleisen Markus M Nöthen Susanne Moebus Karl-Heinz Jöckel Norman Klopp H-Erich Wichmann V Shane Pankratz Sigrid B Sando Jan O Aasly Maria Barcikowska Zbigniew K Wszolek Dennis W Dickson Neill R Graff-Radford Ronald C Petersen Cornelia M van Duijn Monique M B Breteler M Arfan Ikram Anita L DeStefano Annette L Fitzpatrick Oscar Lopez Lenore J Launer Sudha Seshadri Claudine Berr Dominique Campion Jacques Epelbaum Jean-François Dartigues Christophe Tzourio Annick Alpérovitch Mark Lathrop Thomas M Feulner Patricia Friedrich Caterina Riehle Michael Krawczak Stefan Schreiber Manuel Mayhaus S Nicolhaus Stefan Wagenpfeil Stacy Steinberg Hreinn Stefansson Kari Stefansson Jon Snaedal Sigurbjörn Björnsson Palmi V Jonsson Vincent Chouraki Benjamin Genier-Boley Mikko Hiltunen Hilkka Soininen Onofre Combarros Diana Zelenika Marc Delepine Maria J Bullido Florence Pasquier Ignacio Mateo Ana Frank-Garcia Elisa Porcellini Olivier Hanon Eliecer Coto Victoria Alvarez Paolo Bosco Gabriele Siciliano Michelangelo Mancuso Francesco Panza Vincenzo Solfrizzi Benedetta Nacmias Sandro Sorbi Paola Bossù Paola Piccardi Beatrice Arosio Giorgio Annoni Davide Seripa Alberto Pilotto Elio Scarpini Daniela Galimberti Alexis Brice Didier Hannequin Federico Licastro Lesley Jones Peter A Holmans Thorlakur Jonsson Matthias Riemenschneider Kevin Morgan Steven G Younkin Michael J Owen Michael O'Donovan Philippe Amouyel Julie Williams

Nat Genet 2011 May 3;43(5):429-35. Epub 2011 Apr 3.

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1038/ng.803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084173PMC
May 2011

Glypican-1 facilitates prion conversion in lipid rafts.

Authors:
Nigel M Hooper

J Neurochem 2011 Mar;116(5):721-5

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06936.xDOI Listing
March 2011

PCSK9: an emerging target for treatment of hypercholesterolemia.

Expert Opin Ther Targets 2011 Feb 5;15(2):157-68. Epub 2011 Jan 5.

University of Leeds, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1517/14728222.2011.547480DOI Listing
February 2011

The role of lipid rafts in prion protein biology.

Front Biosci (Landmark Ed) 2011 Jan 1;16:151-68. Epub 2011 Jan 1.

Department of Pathology, University of Melbourne, Victoria 3010, Australia.

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January 2011

The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway.

J Biol Chem 2010 Dec 20;285(53):41443-54. Epub 2010 Oct 20.

Proteolysis Research Group, Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.141390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009870PMC
December 2010

The role of zinc in Alzheimer's disease.

Int J Alzheimers Dis 2010 Dec 20;2011:971021. Epub 2010 Dec 20.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.4061/2011/971021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010690PMC
December 2010

Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes.

Int J Alzheimers Dis 2010 Dec 27;2011:603052. Epub 2010 Dec 27.

Institute of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.4061/2011/603052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014710PMC
December 2010

Prion protein and Alzheimer disease.

Prion 2009 Oct-Dec;3(4):190-4. Epub 2009 Oct 2.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807690PMC
http://dx.doi.org/10.4161/pri.3.4.9980DOI Listing
March 2010

Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis.

Traffic 2010 Jan;11(1):161-74

Endothelial Cell Biology Unit, Institute of Molecular and Cellular Biology, LIGHT Laboratories, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1111/j.1600-0854.2009.01001.xDOI Listing
January 2010

Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening.

Bioorg Med Chem Lett 2009 Dec 2;19(23):6770-4. Epub 2009 Oct 2.

School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1016/j.bmcl.2009.09.103DOI Listing
December 2009

Glypican-1 mediates both prion protein lipid raft association and disease isoform formation.

PLoS Pathog 2009 Nov 20;5(11):e1000666. Epub 2009 Nov 20.

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.

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https://dx.plos.org/10.1371/journal.ppat.1000666
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http://dx.doi.org/10.1371/journal.ppat.1000666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773931PMC
November 2009

Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein.

J Biol Chem 2009 Aug 29;284(34):22590-600. Epub 2009 Jun 29.

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.032599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755666PMC
August 2009

Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells.

Arterioscler Thromb Vasc Biol 2009 Jul 16;29(7):1119-24. Epub 2009 Apr 16.

Endothelial Cell Biology Unit, Institute for Molecular & Cellular Biology, LIGHT Laboratories, University of Leeds, UK.

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http://dx.doi.org/10.1161/ATVBAHA.109.186239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704050PMC
July 2009

Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor.

Biochem J 2009 May;419(3):577-84

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, U.K.

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http://biochemj.org/lookup/doi/10.1042/BJ20082407
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http://dx.doi.org/10.1042/BJ20082407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669217PMC
May 2009

Plasma angiotensin-converting enzyme in Alzheimer's disease.

J Alzheimers Dis 2009 ;16(3):609-18

Divison of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.3233/JAD-2009-1002DOI Listing
May 2009

alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts.

Mol Cell Neurosci 2009 Feb 12;40(2):242-8. Epub 2008 Nov 12.

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS29JT, UK.

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http://dx.doi.org/10.1016/j.mcn.2008.10.012DOI Listing
February 2009

Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway.

Exp Cell Res 2009 Jan 7;315(2):348-56. Epub 2008 Nov 7.

Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.

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http://dx.doi.org/10.1016/j.yexcr.2008.10.038DOI Listing
January 2009

Mechanism of the metal-mediated endocytosis of the prion protein.

Biochem Soc Trans 2008 Dec;36(Pt 6):1272-6

Faculty of Biological Sciences, Proteolysis Research Group, Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1042/BST0361272DOI Listing
December 2008

The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill.

J Renin Angiotensin Aldosterone Syst 2008 Dec;9(4):221-5

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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http://journals.sagepub.com/doi/10.1177/1470320308096405
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December 2008

Emerging and potential therapies for Alzheimer's disease.

Expert Opin Ther Targets 2008 Jun;12(6):693-704

University of Leeds, Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Leeds Institute of Genetics, Health and Therapeutics, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1517/14728222.12.6.693 DOI Listing
June 2008

A new take on prions: preventing Alzheimer's disease.

Trends Biochem Sci 2008 Apr 17;33(4):151-5. Epub 2008 Mar 17.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1016/j.tibs.2008.01.004DOI Listing
April 2008

Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.

Biochem Pharmacol 2008 Feb 17;75(4):781-6. Epub 2007 Aug 17.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1016/j.bcp.2007.08.012DOI Listing
February 2008

Visualization of detergent solubilization of membranes: implications for the isolation of rafts.

Biophys J 2008 Feb 12;94(4):1326-40. Epub 2007 Oct 12.

Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00063495087064
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http://dx.doi.org/10.1529/biophysj.107.114108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212709PMC
February 2008

Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis.

Biochim Biophys Acta 2008 Jan 29;1778(1):125-32. Epub 2007 Sep 29.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1016/j.bbamem.2007.09.016DOI Listing
January 2008

Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain.

FEBS Lett 2008 Jan 10;582(2):385-90. Epub 2007 Dec 10.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1016/j.febslet.2007.11.085DOI Listing
January 2008

Sphingomyelin chain length influences the distribution of GPI-anchored proteins in rafts in supported lipid bilayers.

Mol Membr Biol 2007 May-Jun;24(3):233-42

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1080/09687860601127770DOI Listing
December 2007

Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease.

J Alzheimers Dis 2007 Dec;12(4):285-90

Academic Unit of Molecular Vascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, LS2 9JT, UK.

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December 2007

Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins.

Semin Cell Dev Biol 2007 Oct 24;18(5):638-48. Epub 2007 Jul 24.

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1016/j.semcdb.2007.07.008DOI Listing
October 2007

Cellular prion protein protects against reactive-oxygen-species-induced DNA damage.

Free Radic Biol Med 2007 Sep 13;43(6):959-67. Epub 2007 Jun 13.

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S089158490700389
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http://dx.doi.org/10.1016/j.freeradbiomed.2007.06.004DOI Listing
September 2007

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.

Proc Natl Acad Sci U S A 2007 Jun 15;104(26):11062-7. Epub 2007 Jun 15.

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0609621104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904148PMC
June 2007

Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE.

BMC Genomics 2007 Jun 27;8:194. Epub 2007 Jun 27.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1186/1471-2164-8-194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925091PMC
June 2007

Release of renal dipeptidase from glycosylphosphatidylinositol anchor by insulin-triggered phospholipase C/intracellular Ca2+.

Arch Pharm Res 2007 May;30(5):608-15

College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.

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May 2007

Contamination of nuclear fractions with plasma membrane lipid rafts.

Proteomics 2007 Apr;7(7):1059-64

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1002/pmic.200600849DOI Listing
April 2007

The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein.

Biochem J 2007 Feb;402(1):17-23

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1042/BJ20061736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783995PMC
February 2007

Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study.

Hypertension 2006 Nov 25;48(5):914-20. Epub 2006 Sep 25.

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT United Kingdom.

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https://www.ahajournals.org/doi/10.1161/01.HYP.0000244543.91
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http://dx.doi.org/10.1161/01.HYP.0000244543.91937.79DOI Listing
November 2006

Effect of hydrophobic mismatch on phase behavior of lipid membranes.

Biophys J 2006 Jun 13;90(11):4104-18. Epub 2006 Mar 13.

School of Biochemistry & Microbiology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1529/biophysj.105.062778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459530PMC
June 2006

Foreword: lipid rafts/biophysics, cell signalling, trafficking and processing.

Authors:
Nigel M Hooper

Mol Membr Biol 2006 Jan-Feb;23(1):1-3

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, UK.

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http://dx.doi.org/10.1080/09687860500500879DOI Listing
May 2006

The prion protein and lipid rafts.

Mol Membr Biol 2006 Jan-Feb;23(1):89-99

Proteolysis Research Group, Leeds Institute of Genetics, Health and Therapeutics, Faculty of Biological Sciences, University of Leeds, UK.

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http://www.tandfonline.com/doi/full/10.1080/0968786050044999
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http://dx.doi.org/10.1080/09687860500449994DOI Listing
May 2006

The involvement of lipid rafts in Alzheimer's disease.

Mol Membr Biol 2006 Jan-Feb;23(1):111-22

Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, UK.

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http://dx.doi.org/10.1080/09687860500496417DOI Listing
May 2006

Isolation and characterization of glycosylphosphatidylinositol-anchored peptides by hydrophilic interaction chromatography and MALDI tandem mass spectrometry.

Anal Chem 2006 May;78(10):3335-41

Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

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http://pubs.acs.org/doi/abs/10.1021/ac0517949
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May 2006

Emerging therapeutics for Alzheimer's disease.

Expert Rev Neurother 2006 May;6(5):695-704

University of Leeds, Academic Unit of Molecular Vascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, Clarendon Way, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1586/14737175.6.5.695DOI Listing
May 2006

A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates.

Proteomics 2006 Apr;6(7):2112-20

Proteolysis Research Group, School of Biochemistry and Microbiology, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1002/pmic.200500153DOI Listing
April 2006

Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells.

J Biol Chem 2005 Nov 15;280(47):39353-62. Epub 2005 Sep 15.

Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M508914200DOI Listing
November 2005

Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis.

J Cell Sci 2005 Nov;118(Pt 21):5141-53

Proteolysis Research Group, School of Biochemistry and Microbiology, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1242/jcs.02627DOI Listing
November 2005

Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress.

J Biol Chem 2005 Oct 24;280(43):35914-21. Epub 2005 Aug 24.

Proteolysis Research Group, School of Biochemistry and Microbiology, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M507327200DOI Listing
October 2005

Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease.

Trends Mol Med 2005 Oct 8;11(10):464-72. Epub 2005 Sep 8.

Academic Unit of Molecular Vascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1016/j.molmed.2005.08.004DOI Listing
October 2005

Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).

J Biol Chem 2005 Aug 27;280(34):30113-9. Epub 2005 Jun 27.

Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M505111200DOI Listing
August 2005

The kinetics of phase separation in asymmetric membranes.

Biophys J 2005 Jun 18;88(6):4072-83. Epub 2005 Mar 18.

School of Biochemistry & Microbiology, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S000634950573458
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http://dx.doi.org/10.1529/biophysj.104.054288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1305638PMC
June 2005

N-glycans as apical targeting signals in polarized epithelial cells.

Biochem Soc Symp 2005 (72):39-45

School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, U.K.

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March 2005

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism.

Biochem J 2004 Oct;383(Pt 1):45-51

Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1042/BJ20040634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134042PMC
October 2004

N-glycans, not the GPI anchor, mediate the apical targeting of a naturally glycosylated, GPI-anchored protein in polarised epithelial cells.

J Cell Sci 2004 Oct;117(Pt 21):5079-86

School of Biochemistry and Microbiology, University of Leeds, LS2 9JT, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.01386
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October 2004

Secretase-mediated cell surface shedding of the angiotensin-converting enzyme.

Protein Pept Lett 2004 Oct;11(5):423-32

Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

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October 2004

Normalized proliferation of normal and psoriatic keratinocytes by suppression of sAPPalpha-release.

J Invest Dermatol 2004 Sep;123(3):556-63

Institute of Cell Biology and Bonner Forum Biomedizin, University of Bonn, Ulrich-Haberland-Strasse 61A, 53121 Bonn, Germany.

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http://dx.doi.org/10.1111/j.0022-202X.2004.23320.xDOI Listing
September 2004

ACE2: from vasopeptidase to SARS virus receptor.

Trends Pharmacol Sci 2004 Jun;25(6):291-4

School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016561470400097
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http://dx.doi.org/10.1016/j.tips.2004.04.001DOI Listing
June 2004

Dual mechanisms for shedding of the cellular prion protein.

J Biol Chem 2004 Mar 7;279(12):11170-8. Epub 2004 Jan 7.

Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M312105200DOI Listing
March 2004

ADAMs family members as amyloid precursor protein alpha-secretases.

J Neurosci Res 2003 Nov;74(3):342-52

Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1002/jnr.10737DOI Listing
November 2003

Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence.

Biochemistry 2003 Nov;42(45):13185-92

School of Biochemistry and Molecular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom.

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http://pubs.acs.org/doi/abs/10.1021/bi035268s
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http://dx.doi.org/10.1021/bi035268sDOI Listing
November 2003

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein.

Proc Natl Acad Sci U S A 2003 Sep 22;100(20):11735-40. Epub 2003 Sep 22.

Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1635130100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC208827PMC
September 2003