Nigel Leigh

Nigel Leigh

UNVERIFIED PROFILE

Are you Nigel Leigh?   Register this Author

Register author
Nigel Leigh

Nigel Leigh

Publications by authors named "Nigel Leigh"

Are you Nigel Leigh?   Register this Author

100Publications

2879Reads

15Profile Views

Relative preservation of triceps over biceps strength in upper limb-onset ALS: the 'split elbow'.

J Neurol Neurosurg Psychiatry 2019 Jul 7;90(7):730-733. Epub 2019 Mar 7.

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2018-319894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585260PMC
July 2019

Critical design considerations for time-to-event endpoints in amyotrophic lateral sclerosis clinical trials.

J Neurol Neurosurg Psychiatry 2019 Jul 10. Epub 2019 Jul 10.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2019-320998DOI Listing
July 2019

Predicting the future of ALS: the impact of demographic change and potential new treatments on the prevalence of ALS in the United Kingdom, 2020-2116.

Amyotroph Lateral Scler Frontotemporal Degener 2019 May 9;20(3-4):264-274. Epub 2019 Apr 9.

a Department of Basic and Clinical Neuroscience , King's College London, Maurice Wohl Clinical Neuroscience Institute , London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2019.1587629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567553PMC
May 2019

Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS.

J Neurol Neurosurg Psychiatry 2019 Apr 25;90(4):404-411. Epub 2018 Oct 25.

Department of Neuroscience, Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Brighton, UK.

View Article

Download full-text PDF

Source
http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-318830
Publisher Site
http://dx.doi.org/10.1136/jnnp-2018-318830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581155PMC
April 2019

An Overview of MicroRNAs as Biomarkers of ALS.

Front Neurol 2019 7;10:186. Epub 2019 Mar 7.

School of Life Sciences, University of Sussex, Brighton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2019.00186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416171PMC
March 2019

Emerging Magnetic Resonance Imaging Techniques and Analysis Methods in Amyotrophic Lateral Sclerosis.

Front Neurol 2018 4;9:1065. Epub 2018 Dec 4.

Hurstwood Park Neurological Centre Haywards Heath, West Sussex, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2018.01065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288229PMC
December 2018

Stage of prolonged survival in ALS - Author's reply.

Lancet Neurol 2018 07;17(7):579-580

Department of Pharmacology, Pitié-Salpêtrière Hospital, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(18)30208-4DOI Listing
July 2018

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study.

Lancet Neurol 2018 05 7;17(5):416-422. Epub 2018 Mar 7.

King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, London, UK; King's College Hospital, Denmark Hill, London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(18)30054-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899963PMC
May 2018

The benefit of evolving multidisciplinary care in ALS: a diagnostic cohort survival comparison.

Amyotroph Lateral Scler Frontotemporal Degener 2017 11 18;18(7-8):569-575. Epub 2017 Jul 18.

a Department of Basic and Clinical Neuroscience , Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London , London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2017.1349151DOI Listing
November 2017

Analysis of terms used for the diagnosis and classification of amyotrophic lateral sclerosis and motor neuron disease.

Amyotroph Lateral Scler Frontotemporal Degener 2016 Oct - Nov;17(7-8):600-604. Epub 2016 May 18.

a Department of Basic and Clinical Neuroscience , Maurice Wohl Clinical Neuroscience Institute, King's College London , London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2016.1181766DOI Listing
October 2017

Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2016 Oct - Nov;17(7-8):593-599. Epub 2016 Sep 1.

a Maurice Wohl Clinical Neuroscience Institute, King's College London, Institute of Psychiatry, Psychology and Neuroscience , London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2016.1213852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125285PMC
October 2017

Late-onset Tay-Sachs disease.

Pract Neurol 2017 Oct 24;17(5):396-399. Epub 2017 Jul 24.

Department of Neurology, Hurstwood Park Neurosciences Centre, Haywards Heath, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/practneurol-2017-001665DOI Listing
October 2017

Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials.

Neurology 2017 Oct 4;89(18):1915-1922. Epub 2017 Oct 4.

From the Department of Neurology, Brain Centre Rudolf Magnus (R.P.A.v.E., F.P.D., W.v.R., J.H.V., L.H.v.d.B., M.A.v.E.), and Department of Biostatistics and Research Support (M.J.C.E.), University Medical Centre Utrecht, the Netherlands; Maurice Wohl Clinical Neuroscience Institute and United Kingdom Dementia Research Institute Centre (A.R.J., W.S., A.S., C.E.S., A.A.-C.), Department of Basic and Clinical Neuroscience, King's College London; Sheffield Institute for Translational Neuroscience (SITraN) (P.J.S.), University of Sheffield, South Yorkshire; Department of Clinical Neuroscience (P.N.L.), Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Falmer, Brighton; The Walton Centre NHS Trust (C.A.Y.), Liverpool, UK; Istituti Clinici Scientifici Maugeri IRCSS (G.M.), Milan; Department of Neuroscience (J.M.), Sant'Agostino-Estense Hospital and University of Modena and Reggio Emilia, Modena; Department of Neurology (G.B.), Azienda Universitario Ospedaliera di Cagliari and University of Cagliari; Istituti Clinici Scientifici Maugeri IRCSS (P.V.), Mistretta, Italy; Rijnstate Ziekenhuis (E.V.), Arnhem, the Netherlands; Rita Levi Montalcini' Department of Neuroscience (A.C.), ALS Centre, University of Torino; and Azienda Ospedaliera Città della Salute e della Scienza (A.C.), Turin, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664299PMC
October 2017

Comparison of the King's and MiToS staging systems for ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2017 05 5;18(3-4):227-232. Epub 2017 Jan 5.

a Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience , King's College London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678421.2016.1265565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425622PMC
May 2017

A clinical tool for predicting survival in ALS.

J Neurol Neurosurg Psychiatry 2016 12 4;87(12):1361-1367. Epub 2016 Jul 4.

Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2015-312908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136716PMC
December 2016

Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2015 24;17(1-2):69-76. Epub 2015 Aug 24.

f King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychology , London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/21678421.2015.1071397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732449PMC
October 2016

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

Regionality of disease progression predicts prognosis in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2015 17;16(7-8):442-7. Epub 2015 Jun 17.

a Department of Basic and Clinical Neuroscience , Institute of Psychiatry, Psychology & Neuroscience, King's College London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/21678421.2015.1051987DOI Listing
August 2016

Cortical thickness, surface area and volume measures in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy.

PLoS One 2014 2;9(12):e114167. Epub 2014 Dec 2.

King's College London, Institute of Psychiatry, London, United Kingdom; National Institute for Health Research Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, London, United Kingdom; National Institute for Health Research Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114167PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252086PMC
January 2016

Diffusion tensor imaging of Parkinson's disease, multiple system atrophy and progressive supranuclear palsy: a tract-based spatial statistics study.

PLoS One 2014 18;9(11):e112638. Epub 2014 Nov 18.

Institute of Psychiatry, King's College London, London, United Kingdom; National Institute for Health Research Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, London, United Kingdom; National Institute for Health Research Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112638PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236070PMC
July 2015

Use of clinical staging in amyotrophic lateral sclerosis for phase 3 clinical trials.

J Neurol Neurosurg Psychiatry 2015 Jan 24;86(1):45-9. Epub 2014 Jan 24.

King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK.

View Article

Download full-text PDF

Source
http://jnnp.bmj.com/content/early/2014/11/28/jnnp-2013-30686
Web Search
http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2013-306865
Publisher Site
http://dx.doi.org/10.1136/jnnp-2013-306865DOI Listing
January 2015

Evidence of an environmental effect on survival in ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Dec 27;15(7-8):528-33. Epub 2014 May 27.

King's College London Medical School , London.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/21678421.2014.911326DOI Listing
December 2014

Health utility decreases with increasing clinical stage in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Jun 7;15(3-4):285-91. Epub 2014 Feb 7.

Department of Clinical Neuroscience, Institute of Psychiatry , King's College London, London.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/21678421.2013.872149DOI Listing
June 2014

Estimating clinical stage of amyotrophic lateral sclerosis from the ALS Functional Rating Scale.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Jun 10;15(3-4):279-84. Epub 2014 Apr 10.

King's College London, Institute of Psychiatry, Department of Clinical Neuroscience.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/21678421.2014.897357DOI Listing
June 2014

Homozygosity analysis in amyotrophic lateral sclerosis.

Eur J Hum Genet 2013 Dec 24;21(12):1429-35. Epub 2013 Apr 24.

Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, and Department of Clinical Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ejhg.2013.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829775PMC
December 2013

Behavioural and emotional symptoms of apathy are associated with distinct patterns of brain atrophy in neurodegenerative disorders.

J Neurol 2013 Oct 23;260(10):2481-90. Epub 2013 Jun 23.

Department of Neurology, Royal Free London NHS Foundation Trust, London, NW3 2QG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-013-6989-9DOI Listing
October 2013

Symptom prevalence, severity and palliative care needs assessment using the Palliative Outcome Scale: a cross-sectional study of patients with Parkinson's disease and related neurological conditions.

Palliat Med 2013 Sep 3;27(8):722-31. Epub 2012 Dec 3.

Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0269216312465783DOI Listing
September 2013

Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis?

J Neurol Neurosurg Psychiatry 2013 May 2;84(5):494-8. Epub 2012 Oct 2.

King's College London, Institute of Psychiatry, Department of Psychology, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2012-303526DOI Listing
May 2013

Chapter 8 Spinobulbar muscular atrophy (Kennedy's disease).

Handb Clin Neurol 2007 ;82:155-69

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0072-9752(07)80011-XDOI Listing
October 2012

Chapter 13 Amyotrophic lateral sclerosis.

Authors:
P Nigel Leigh

Handb Clin Neurol 2007 ;82:249-78

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0072-9752(07)80016-9DOI Listing
October 2012

Eating-derived pleasure in amyotrophic lateral sclerosis as a predictor of non-oral feeding.

Amyotroph Lateral Scler 2012 Oct 7;13(6):555-9. Epub 2012 Aug 7.

Speech and Language Therapy Department, King's College Hospital, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/17482968.2012.704925DOI Listing
October 2012

Processing and memory for emotional and neutral material in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler 2012 Oct 8;13(6):592-8. Epub 2012 Aug 8.

King's College London, KHP Centre for Neurodegeneration Research, Department of Psychology, Institute of Psychiatry, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/17482968.2012.708936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898366PMC
October 2012

A proposed staging system for amyotrophic lateral sclerosis.

Brain 2012 Mar 23;135(Pt 3):847-52. Epub 2012 Jan 23.

MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London SE5 8AF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awr351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286327PMC
March 2012

The anatomy of cognitive impairment in amyotrophic lateral sclerosis: more than frontal lobe dysfunction.

Cortex 2012 Feb 12;48(2):166-82. Epub 2011 Feb 12.

MRC Centre for Neurodegeneration Research, Department of Psychology, Institute of Psychiatry, King's College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cortex.2011.02.004DOI Listing
February 2012

No evidence for a large difference in ALS frequency in populations of African and European origin: a population based study in inner city London.

Amyotroph Lateral Scler 2012 Jan;13(1):66-8

Department of Neurology, Neuromuscular Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/17482968.2011.636049DOI Listing
January 2012

The risk to relatives of patients with sporadic amyotrophic lateral sclerosis.

Brain 2011 Dec 20;134(Pt 12):3454-7. Epub 2011 Sep 20.

MRC Centre for Neurodegeneration Research, Institute of Psychiatry P 041, London SE5 8AF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awr248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235555PMC
December 2011

Marital relationships in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler 2010 Aug;11(4):344-50

Cancer Research UK Promoting Early Presentation Group, Institute of Psychiatry, King's College London, St. Thomas' Hospital, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/17482960903307797DOI Listing
August 2010

Nutritional factors associated with survival following enteral tube feeding in patients with motor neurone disease.

J Hum Nutr Diet 2010 Aug 13;23(4):408-15. Epub 2010 May 13.

Department of Nutrition & Dietetics, King's College Hospital, London SE5 9RS, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-277X.2010.01057.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-277X.2010.01057.xDOI Listing
August 2010

Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy.

Brain 2010 Aug 24;133(Pt 8):2382-93. Epub 2010 Jun 24.

King's College London, MRC Centre of Neurodegeneration Research, Institute of Psychiatry, Department of Psychology, PO77, London SE5 8AF, UK.

View Article

Download full-text PDF

Source
http://brain.oxfordjournals.org/content/brain/133/8/2382.ful
Web Search
http://www.brain.oxfordjournals.org/cgi/doi/10.1093/brain/aw
Publisher Site
http://dx.doi.org/10.1093/brain/awq158DOI Listing
August 2010

Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: a double- blind, randomized, multicentre, placebo-controlled trial.

Amyotroph Lateral Scler 2009 Oct-Dec;10(5-6):378-83

Fédération des Maladies du Système Nerveux, Hôpital de la Salpétrière, 47 Boulevard de l'Hôpital, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/17482960902803432DOI Listing
February 2010

Geographical clustering of amyotrophic lateral sclerosis in South-East England: a population study.

Neuroepidemiology 2009 27;32(2):81-8. Epub 2008 Nov 27.

King's College Medical School at Guy's, King's College and St. Thomas's Hospitals, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000177032DOI Listing
December 2009

TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations.

Neuropathology 2009 Dec 3;29(6):672-83. Epub 2009 Jun 3.

Department of Clinical Neuroscience, Medical Research Council Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London SE5 9RS, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1440-1789.2009.01029.x
Publisher Site
http://dx.doi.org/10.1111/j.1440-1789.2009.01029.xDOI Listing
December 2009

Latent cluster analysis of ALS phenotypes identifies prognostically differing groups.

PLoS One 2009 Sep 22;4(9):e7107. Epub 2009 Sep 22.

Department of Clinical Neuroscience, MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007107PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741575PMC
September 2009

Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.

PLoS One 2009 Sep 22;4(9):e7114. Epub 2009 Sep 22.

MRC Centre for Neurodegeneration Research, King's College London, Department of Clinical Neuroscience, Institute of Psychiatry, and NIHR Biomedical Research Centre, London, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007114PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743996PMC
September 2009

Defining survival as an outcome measure in amyotrophic lateral sclerosis.

Arch Neurol 2009 Jun;66(6):758-61

Department of Neurology, Columbia University, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/archneurol.2009.1DOI Listing
June 2009

Imaging the brain during sniffing: a pilot fMRI study.

Pulm Pharmacol Ther 2009 Apr 5;22(2):97-101. Epub 2008 Nov 5.

Institute of Clinical Neurophysiology, Division of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S109455390800102
Publisher Site
http://dx.doi.org/10.1016/j.pupt.2008.10.009DOI Listing
April 2009

Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.

Neurosci Lett 2009 Apr 3;454(2):161-4. Epub 2009 Mar 3.

MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2009.02.061DOI Listing
April 2009

Amyotrophic lateral sclerosis.

Orphanet J Rare Dis 2009 Feb 3;4. Epub 2009 Feb 3.

MRC centre for Neurodegeneration Research, Department of Clinical Neuroscience, Institute of Psychiatry, Kings College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-1172-4-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656493PMC
February 2009

Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study.

Brain 2009 Jan 23;132(Pt 1):156-71. Epub 2008 Nov 23.

Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris & UPMC University Paris 06, UMR 7087, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awn291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638696PMC
January 2009

Biomarkers in amyotrophic lateral sclerosis.

Lancet Neurol 2009 Jan;8(1):94-109

Department of Clinical Neurology, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(08)70293-XDOI Listing
January 2009

Interaction between PON1 and population density in amyotrophic lateral sclerosis.

Neuroreport 2009 Jan;20(2):186-90

MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WNR.0b013e32831af220DOI Listing
January 2009

Diffusion tensor imaging in sporadic and familial (D90A SOD1) forms of amyotrophic lateral sclerosis.

Arch Neurol 2009 Jan;66(1):109-15

Medical Research Council Centre for Neurodegeneration Research and Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London SE5 8AF, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/archneurol.2008.527DOI Listing
January 2009

Commentary on 'a novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS'.

Amyotroph Lateral Scler 2008 Aug;9(4):254-6

Department of Neurology, SUNY Upstate Medical University, Syracuse, New York 13210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17482960802192324DOI Listing
August 2008

Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport.

FEBS Lett 2008 Jun 2;582(15):2303-2308. Epub 2008 Jun 2.

MRC Centre for Neurodegeneration Research, Department of Neuroscience P037, Institute of Psychiatry, King's College, De Crespigny Park, Denmark Hill, London SE58AF, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2008.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516414PMC
June 2008

Symptom prevalence among people affected by advanced and progressive neurological conditions--a systematic review.

J Palliat Care 2007 ;23(4):291-9

Department of Palliative Care, Policy & Rehabilitation, King's College London, UK.

View Article

Download full-text PDF

Source
April 2008

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.

Science 2008 Mar 28;319(5870):1668-72. Epub 2008 Feb 28.

Department of Clinical Neuroscience, King's College London, Medical Research Council (MRC) Centre for Neurodegeneration Research, and Institute of Psychiatry, London, SE5 8AF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1154584DOI Listing
March 2008

Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study.

Amyotroph Lateral Scler 2008 Feb;9(1):43-9

MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Psychology, London.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17482960701737716DOI Listing
February 2008

Birth order and the genetics of amyotrophic lateral sclerosis.

J Neurol 2008 Jan 19;255(1):99-102. Epub 2007 Dec 19.

MRC Centre for Neurodegeneration, Research, P043, King's College London, Dept. of Neurology, Institute of Psychiatry, London, SE5 8AF, UK,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-007-0709-2DOI Listing
January 2008

A longitudinal study of diffusion tensor MRI in ALS.

Amyotroph Lateral Scler 2007 Dec 8;8(6):348-55. Epub 2007 Oct 8.

King's College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, Department of Clinical Neuroscience, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17482960701548139DOI Listing
December 2007

Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis.

Amyotroph Lateral Scler 2007 Dec;8(6):343-7

Department of Neurology, John Radcliffe Hospital, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17482960701538734DOI Listing
December 2007

Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis.

Brain Res 2007 Oct 3;1172:145-51. Epub 2007 Aug 3.

MRC Centre for Neurodegeneration Research and Department of Clinical Neuroscience, King's College London, Institute of Psychiatry PO41, De Crespigny Park, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2007.07.044DOI Listing
October 2007

Clinical care of patients with amyotrophic lateral sclerosis.

Lancet Neurol 2007 Oct;6(10):913-25

MRC Centre for Neurodegeneration Research, Department of Clinical Neuroscience, PO 41, Institute of Psychiatry, King's College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(07)70244-2DOI Listing
October 2007