Niels de Wind

Niels de Wind

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Niels de Wind

Publications by authors named "Niels de Wind"

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Effect of sequence context on Polζ-dependent error-prone extension past (6-4) photoproducts.

DNA Repair (Amst) 2019 Dec 14;87:102771. Epub 2019 Dec 14.

Department of Life Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo, 171-8588, Japan; Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka, 565-0871, Japan; National Institute of Genetics, 1111 Yata, Mishima, Shizuoka, 411-8540, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.102771DOI Listing
December 2019

Mutagenic replication: target for tumor therapy?

Cell Res 2019 Oct;29(10):783-784

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41422-019-0218-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796867PMC
October 2019

DNA mismatch repair: from biophysics to bedside.

DNA Repair (Amst) 2016 Feb 8;38:1-2. Epub 2015 Dec 8.

Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.11.007DOI Listing
February 2016

FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress.

Nucleic Acids Res 2015 Sep 17;43(17):8325-39. Epub 2015 Jul 17.

Key Laboratory of Genomics and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

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http://dx.doi.org/10.1093/nar/gkv737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787816PMC
September 2015

When mismatch repair met translesion synthesis.

Cell Cycle 2015 Aug 23;14(15):2377-8. Epub 2015 Jun 23.

a Department of Human Genetics ; Leiden University Medical Center ; Leiden , The Netherlands.

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http://dx.doi.org/10.1080/15384101.2015.1063288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613724PMC
August 2015

Post-translesion synthesis repair.

Oncotarget 2015 Aug;6(23):19342-3

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637279PMC
http://dx.doi.org/10.18632/oncotarget.4938DOI Listing
August 2015

Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease.

DNA Repair (Amst) 2015 May 21;29:56-64. Epub 2015 Jan 21.

Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300RC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.01.001DOI Listing
May 2015

Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet light.

Nucleic Acids Res 2014 28;42(17):11071-82. Epub 2014 Aug 28.

Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands

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http://dx.doi.org/10.1093/nar/gku779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176164PMC
February 2015

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage.

Nucleic Acids Res 2015 Jan 10;43(1):282-94. Epub 2014 Dec 10.

Division of Biological Stress Responses, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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http://dx.doi.org/10.1093/nar/gku1301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288191PMC
January 2015

Maternal aldehyde elimination during pregnancy preserves the fetal genome.

Mol Cell 2014 Sep 21;55(6):807-817. Epub 2014 Aug 21.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK; Department of Medicine, Level 5, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140060
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http://dx.doi.org/10.1016/j.molcel.2014.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175174PMC
September 2014

Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein.

Mol Genet Genomic Med 2014 Jul 6;2(4):352-5. Epub 2014 May 6.

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen DK-2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1002/mgg3.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113276PMC
July 2014

Persistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A.

Nucleic Acids Res 2014 Apr 23;42(7):4406-13. Epub 2014 Jan 23.

Department of Toxicogenetics, Leiden University Medical Center, PO box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkt1412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985633PMC
April 2014

In memory of John Bruce Hays (1937-2014).

DNA Repair (Amst) 2014 Apr;16:vi-vii

Department of Biology, Stanford University, CA, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S15687864140007
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http://dx.doi.org/10.1016/S1568-7864(14)00071-8DOI Listing
April 2014

Inactivation of DNA mismatch repair by variants of uncertain significance in the PMS2 gene.

Hum Mutat 2013 Nov 11;34(11):1477-80. Epub 2013 Sep 11.

Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/humu.22426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858603PMC
November 2013

Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.

Eur J Immunol 2013 Oct 5;43(10):2765-70. Epub 2013 Aug 5.

Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/eji.201243191DOI Listing
October 2013

Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome.

Proc Natl Acad Sci U S A 2013 Jun 20;110(23):9403-8. Epub 2013 May 20.

Department of Toxicogenetics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1073/pnas.1220537110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677471PMC
June 2013

Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future.

Hum Mutat 2012 Dec 13;33(12):1617-25. Epub 2012 Aug 13.

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.

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http://doi.wiley.com/10.1002/humu.22168
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http://dx.doi.org/10.1002/humu.22168DOI Listing
December 2012

Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome.

DNA Repair (Amst) 2012 Jun 20;11(6):550-8. Epub 2012 Apr 20.

Department of Toxicogenetics, Leiden University Medical Center-LUMC, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S156878641200078
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http://dx.doi.org/10.1016/j.dnarep.2012.03.007DOI Listing
June 2012

Different sets of translesion synthesis DNA polymerases protect from genome instability induced by distinct food-derived genotoxins.

Toxicol Sci 2012 May 13;127(1):130-8. Epub 2012 Feb 13.

Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1093/toxsci/kfs074DOI Listing
May 2012

A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants.

Hum Mutat 2012 Mar 29;33(3):488-94. Epub 2011 Dec 29.

Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/humu.22000
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http://dx.doi.org/10.1002/humu.22000DOI Listing
March 2012

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity.

Nucleic Acids Res 2012 Jan 9;40(1):170-80. Epub 2011 Sep 9.

Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel,

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http://dx.doi.org/10.1093/nar/gkr596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245908PMC
January 2012

Transient suppression of MLH1 allows effective single-nucleotide substitution by single-stranded DNA oligonucleotides.

Mutat Res 2011 Oct 27;715(1-2):52-60. Epub 2011 Jul 27.

Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.mrfmmm.2011.07.008DOI Listing
October 2011

PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

DNA Repair (Amst) 2011 Oct 1;10(10):1051-9. Epub 2011 Sep 1.

Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2011.08.005DOI Listing
October 2011

The Rev1 translesion synthesis polymerase has multiple distinct DNA binding modes.

DNA Repair (Amst) 2011 Sep 12;10(9):915-25. Epub 2011 Jul 12.

Department of Protein Chemistry, Leiden Institute of Chemistry, Gorlaeus Laboratory, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S15687864110013
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http://dx.doi.org/10.1016/j.dnarep.2011.04.033DOI Listing
September 2011

Transcription and replication: far relatives make uneasy bedfellows.

Cell Cycle 2010 Jun 15;9(12):2300-4. Epub 2010 Jun 15.

Department of Cancer Biology and Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.4161/cc.9.12.11987DOI Listing
June 2010

A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1.

Hum Mutat 2010 Mar;31(3):247-53

Departments of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/humu.21180
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http://dx.doi.org/10.1002/humu.21180DOI Listing
March 2010

Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesions.

DNA Repair (Amst) 2009 Dec 27;8(12):1444-51. Epub 2009 Sep 27.

Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2009.09.006DOI Listing
December 2009

Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia.

Proc Natl Acad Sci U S A 2009 Dec 10;106(51):21836-41. Epub 2009 Dec 10.

Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1073/pnas.0909507106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799833PMC
December 2009

The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.

Mol Pharmacol 2009 Oct 29;76(4):927-34. Epub 2009 Jul 29.

Institute of Toxicology, University Medicine Mainz, Mainz D-55131, Germany.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.109.05
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http://dx.doi.org/10.1124/mol.109.058131DOI Listing
October 2009

The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.

Mol Pharmacol 2009 Oct 29;76(4):927-34. Epub 2009 Jul 29.

Institute of Toxicology, University Medicine Mainz, Mainz D-55131, Germany.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.109.05
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http://dx.doi.org/10.1124/mol.109.058131DOI Listing
October 2009

Two distinct translesion synthesis pathways across a lipid peroxidation-derived DNA adduct in mammalian cells.

J Biol Chem 2009 Jan 3;284(1):191-8. Epub 2008 Nov 3.

Laboratory of Chemical Biology, Department of Pharmacological Sciences, State University of New York, Stony Brook, New York 11794, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M806414200
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http://dx.doi.org/10.1074/jbc.M806414200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610493PMC
January 2009

Tumor characteristics as an analytic tool for classifying genetic variants of uncertain clinical significance.

Hum Mutat 2008 Nov;29(11):1292-303

Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1002/humu.20894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966299PMC
November 2008

Assessment of functional effects of unclassified genetic variants.

Hum Mutat 2008 Nov;29(11):1314-26

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1002/humu.20899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771414PMC
November 2008

Functional analysis of HNPCC-related missense mutations in MSH2.

Mutat Res 2008 Oct 4;645(1-2):44-55. Epub 2008 Sep 4.

Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S00275107080018
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http://dx.doi.org/10.1016/j.mrfmmm.2008.08.015DOI Listing
October 2008

Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells.

DNA Repair (Amst) 2008 Aug 9;7(8):1330-9. Epub 2008 Jun 9.

Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2008.04.015DOI Listing
August 2008

Send in the clamps: control of DNA translesion synthesis in eukaryotes.

Mol Cell 2007 Nov;28(4):522-9

Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molcel.2007.11.005DOI Listing
November 2007

DNA mismatch repair mediates protection from mutagenesis induced by short-wave ultraviolet light.

DNA Repair (Amst) 2006 Nov 1;5(11):1364-72. Epub 2006 Aug 1.

Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S156878640600208
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http://dx.doi.org/10.1016/j.dnarep.2006.06.005DOI Listing
November 2006

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice.

J Exp Med 2006 Feb 13;203(2):319-23. Epub 2006 Feb 13.

Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, Netherlands.

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http://dx.doi.org/10.1084/jem.20052227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118202PMC
February 2006

Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair.

EMBO J 2006 Jan 12;25(2):409-19. Epub 2006 Jan 12.

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/sj.emboj.7600936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383519PMC
January 2006

Spontaneous and mutagen-induced loss of DNA mismatch repair in Msh2-heterozygous mammalian cells.

Mutat Res 2005 Jul 20;574(1-2):50-7. Epub 2005 Apr 20.

Department of Toxicogenetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.mrfmmm.2005.01.021DOI Listing
July 2005

The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis.

Nucleic Acids Res 2005 13;33(1):356-65. Epub 2005 Jan 13.

Department of Toxicogenetics, Leiden University Medical Center 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1093/nar/gki189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546167PMC
February 2005

Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes.

DNA Repair (Amst) 2005 Jan;4(1):81-9

Department of Toxicogenetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2004.08.008DOI Listing
January 2005

ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.

J Biol Chem 2004 Oct 4;279(42):43879-85. Epub 2004 Aug 4.

Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M406380200
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http://dx.doi.org/10.1074/jbc.M406380200DOI Listing
October 2004

Biological functions of translesion synthesis proteins in vertebrates.

DNA Repair (Amst) 2003 Oct;2(10):1075-85

Department of Toxicogenetics, Leiden University Medical Center, Wassenaarseweg 72, 2300, RA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/s1568-7864(03)00119-8DOI Listing
October 2003

Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage.

Mol Cell Biol 2002 Apr;22(7):2159-69

Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center, 2300 RA Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133679PMC
http://dx.doi.org/10.1128/mcb.22.7.2159-2169.2002DOI Listing
April 2002