Niels P Riksen

Niels P Riksen

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Niels P Riksen

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Effect of two dosages of sodium chloride intake on the blood pressure response to caffeinated coffee in humans in vivo.

Int J Food Sci Nutr 2019 Apr 10:1-6. Epub 2019 Apr 10.

a Department of Internal Medicine , Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1080/09637486.2019.1595541DOI Listing
April 2019

Multidisciplinary care for people with Parkinson's disease: the new kids on the block!

Expert Rev Neurother 2019 Feb 9;19(2):145-157. Epub 2019 Jan 9.

a Department of Neurology, Donders Institute for Brain, Cognition and Behaviour , Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1080/14737175.2019.1561285DOI Listing
February 2019

Trained immunity and diabetic vascular disease.

Clin Sci (Lond) 2019 Jan 18;133(2):195-203. Epub 2019 Jan 18.

Department of Internal Medicine (463), Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands

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http://clinsci.org/lookup/doi/10.1042/CS20180905
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http://dx.doi.org/10.1042/CS20180905DOI Listing
January 2019

Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease.

Stroke 2018 Dec;49(12):2910-2917

From the Department of Internal Medicine, Radboud University Medical Center Behaviour, (M.P.N., L.A.B.J., M.G.N., N.P.R.), Nijmegen, the Netherlands.

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http://dx.doi.org/10.1161/STROKEAHA.118.023192DOI Listing
December 2018

Epigenetics and Trained Immunity.

Antioxid Redox Signal 2018 Oct 21;29(11):1023-1040. Epub 2017 Nov 21.

1 Department of Internal Medicine, Radboud University Medical Center , Nijmegen, The Netherlands .

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http://dx.doi.org/10.1089/ars.2017.7310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121175PMC
October 2018

Metabolism of innate immune cells: impact on atherosclerosis.

Curr Opin Lipidol 2018 Oct;29(5):359-367

Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen.

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http://dx.doi.org/10.1097/MOL.0000000000000539DOI Listing
October 2018

Be aware, innate immune cells remember.

Aging (Albany NY) 2018 Sep;10(9):2218-2219

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.18632/aging.101552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188483PMC
September 2018

Getting to the marrow of trained immunity.

Epigenomics 2018 09;10(9):1151-1154

Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.2217/epi-2018-0098DOI Listing
September 2018

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

EBioMedicine 2018 Jul 4;33:144-156. Epub 2018 Jul 4.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085583PMC
July 2018

The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis.

Cardiovasc Res 2018 Jun;114(7):944-953

Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvy092DOI Listing
June 2018

Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis.

Circ Res 2018 Mar 24;122(5):664-669. Epub 2018 Jan 24.

From the Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (J.L., S.B., L.A.B.J., M.G.N., N.P.R.); Department of Medical Genetics, University of Medicine and Pharmacy, Iuliu Haţieganu, Cluj-Napoca, Romania (L.A.B.J.); Department for Genomics & Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Germany (M.G.N.); Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia (D.P.B.); and Department of Pediatrics, University of Melbourne, Parkville, Victoria, Australia (D.P.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312465DOI Listing
March 2018

Monocyte and macrophage immunometabolism in atherosclerosis.

Semin Immunopathol 2018 02 2;40(2):203-214. Epub 2017 Oct 2.

Department of Internal Medicine (463) and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00281-017-0656-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809534PMC
February 2018

The acute effect of black tea consumption on resistance artery endothelial function in healthy subjects. A randomized controlled trial.

Clin Nutr ESPEN 2018 02 8;23:41-47. Epub 2017 Nov 8.

Department of Physiology, Radboud University Medical Centre, Nijmegen, The Netherlands; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.

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http://dx.doi.org/10.1016/j.clnesp.2017.10.011DOI Listing
February 2018

Epigenetics in diabetic nephropathy, immunity and metabolism.

Diabetologia 2018 Jan 11;61(1):6-20. Epub 2017 Nov 11.

Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.

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http://dx.doi.org/10.1007/s00125-017-4490-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448927PMC
January 2018

Metabolic Induction of Trained Immunity through the Mevalonate Pathway.

Cell 2018 01;172(1-2):135-146.e9

Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.025DOI Listing
January 2018

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

Cell 2018 01;172(1-2):162-175.e14

Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases & Immunology, UMass Medical School, Worcester, MA 01605, USA; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324559PMC
January 2018

A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction.

PLoS One 2017 23;12(8):e0183664. Epub 2017 Aug 23.

SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE), Department for Health Evidence, Nijmegen Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183664PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568412PMC
October 2017

Plasma galectin-3 concentrations in patients with primary aldosteronism.

J Hypertens 2017 09;35(9):1849-1856

aDepartment of Pharmacology and Toxicology bDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen cDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen dDepartment for Health Evidence eDepartment of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/HJH.0000000000001383DOI Listing
September 2017

A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.

Thromb Haemost 2017 08 6;117(9):1798-1807. Epub 2017 Jul 6.

Prof. N. P. Riksen, Dept. of Internal Medicine 463, Radboud University Medical Center, PO Box 9101, 6500HB Nijmegen, The Netherlands, Tel.: +31 24 3618819, Fax: +31 24 3616519, E-mail:

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http://dx.doi.org/10.1160/TH16-10-0799DOI Listing
August 2017

Specific and Complex Reprogramming of Cellular Metabolism in Myeloid Cells during Innate Immune Responses.

Cell Metab 2017 Jul;26(1):142-156

Department of Internal Medicine (463), Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands; Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.06.001DOI Listing
July 2017

Planarians SET New Paths for Innate Immune Memory.

EBioMedicine 2017 06 5;20:7-8. Epub 2017 May 5.

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478199PMC
June 2017

Impact of lifelong exercise training on endothelial ischemia-reperfusion and ischemic preconditioning in humans.

Am J Physiol Regul Integr Comp Physiol 2017 05 15;312(5):R828-R834. Epub 2017 Mar 15.

Radboud Institute for Health Sciences, Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands;

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http://dx.doi.org/10.1152/ajpregu.00466.2016DOI Listing
May 2017

Correction for Bekkering et al., " Experimental Model of Trained Innate Immunity in Human Primary Monocytes".

Clin Vaccine Immunol 2017 05 5;24(5). Epub 2017 May 5.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/CVI.00096-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424232PMC
May 2017

Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?

Cell Mol Life Sci 2016 12 28;73(24):4675-4684. Epub 2016 Jul 28.

Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Radboudumc, (463), P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00018-016-2316-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097107PMC
December 2016

In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes.

Clin Vaccine Immunol 2016 Dec 5;23(12):926-933. Epub 2016 Dec 5.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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http://dx.doi.org/10.1128/CVI.00349-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139603PMC
December 2016

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo.

Atherosclerosis 2016 11 12;254:228-236. Epub 2016 Oct 12.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.10.019DOI Listing
November 2016

[What is the correct time to take medication?].

Ned Tijdschr Geneeskd 2015 ;159:A9509

Radboudumc, Nijmegen.

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October 2016

Long-term activation of the innate immune system in atherosclerosis.

Semin Immunol 2016 08 22;28(4):384-93. Epub 2016 Apr 22.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2016.04.004DOI Listing
August 2016

BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice.

Atherosclerosis 2016 08 19;251:6-14. Epub 2016 May 19.

Dept. of Medicine, Div. of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.031DOI Listing
August 2016

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans.

Circulation 2016 Aug 5;134(8):611-24. Epub 2016 Aug 5.

From Department of Vascular Medicine (F.M.V.d.V., M.N., E.S.G.S.), Department of Molecular Cell Biology, Sanquin Research (J.K., J.D.v.B.), Experimental Vascular Biology, (J.v.d.B.), Department of Radiology (A.J.N.), and Department of Nuclear Medicine (H.J.V.), Academic Medical Center, Amsterdam, the Netherlands; Departments of Internal Medicine (S.B., L.A.B.J., M.G.N., N.P.R.) and Pharmacology-Toxicology (N.P.R.), Radboud UMC, Nijmegen, the Netherlands; Sulpizio Cardiovascular Center, Division of Cardiovascular Medicine (C.Y., S.T.) and Division of Endocrinology and Metabolism, Department of Medicine (J.L.W.), University California, San Diego, La Jolla; St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Canada (A.R.); Department of Chemistry, Biochemistry and Pharmacology, University of Windsor, Windsor, Canada (C.S.); and Robarts Research Institute, Schulich School of Medicine, Western University, London, Canada (M.L.K.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.020838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995139PMC
August 2016

Isolated arterial calcifications of the lower extremities: A clue for NT5E mutation.

Int J Cardiol 2016 Jun 19;212:248-50. Epub 2016 Mar 19.

Dept. of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.03.068DOI Listing
June 2016

Heart failure is associated with exaggerated endothelial ischaemia-reperfusion injury and attenuated effect of ischaemic preconditioning.

Eur J Prev Cardiol 2016 Jan 11;23(1):33-40. Epub 2014 Nov 11.

Department of Physiology, Radboud University Medical Centre, Nijmegen, The Netherlands Department of Pharmacology-Toxicology, Radboud University Medical Centre, Nijmegen, The Netherlands

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http://dx.doi.org/10.1177/2047487314558377DOI Listing
January 2016

The effect of eplerenone on adenosine formation in humans in vivo: a double-blinded randomised controlled study.

PLoS One 2014 30;9(10):e111248. Epub 2014 Oct 30.

Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111248PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214740PMC
December 2015

Effects of the 34C>T Variant of the AMPD1 Gene on Immune Function, Multi-Organ Dysfunction, and Mortality in Sepsis Patients.

Shock 2015 Dec;44(6):542-7

*Department of Pharmacology and Toxicology †Intensive Care Medicine ‡Internal Medicine §Human Genetics ¶Anesthesiology ||Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands #4th Department of Internal Medicine, University of Athens, Medical School, Athens **Intensive Care Unit, "G. Gennimatas" General Hospital, Thessaloniki ††1st Department of Critical Care Medicine, University of Athens, Medical School ‡‡Intensive Care Unit, Tzaneion General Hospital of Piraeus §§Department of Respiratory Medicine, "Sismanogleion" General Hospital ¶¶Department of Therapeutics, Alexandra General Hospital ||||1st Department of Propedeutic Surgery, University of Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.1097/SHK.0000000000000456DOI Listing
December 2015

Pharmacological treatment of aldosterone excess.

Pharmacol Ther 2015 Oct 26;154:120-33. Epub 2015 Jul 26.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.

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http://dx.doi.org/10.1016/j.pharmthera.2015.07.006DOI Listing
October 2015

Preface. Novel targets and drugs to prevent atherogenesis and its consequences.

Eur J Pharmacol 2015 Sep;763(Pt A):1-2

Department of Internal Medicine and Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.08.042DOI Listing
September 2015

Effect of metformin pretreatment on myocardial injury during coronary artery bypass surgery in patients without diabetes (MetCAB): a double-blind, randomised controlled trial.

Lancet Diabetes Endocrinol 2015 Aug 12;3(8):615-23. Epub 2015 Jul 12.

Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, Netherlands; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(15)00121-7DOI Listing
August 2015

The epigenetic memory of monocytes and macrophages as a novel drug target in atherosclerosis.

Clin Ther 2015 Apr 20;37(4):914-23. Epub 2015 Feb 20.

Department of Internal Medicine, Division of Vascular Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clinthera.2015.01.008DOI Listing
April 2015

Impact of metformin on endothelial ischemia-reperfusion injury in humans in vivo: a prospective randomized open, blinded-endpoint study.

PLoS One 2014 22;9(4):e96062. Epub 2014 Apr 22.

Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096062PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996005PMC
January 2015

The cardiovascular effects of metformin: lost in translation?

Curr Opin Lipidol 2014 Dec;25(6):446-51

aDepartment of Internal Medicine bPharmacology-Toxicology, Radboud university medical center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1097/MOL.0000000000000128DOI Listing
December 2014

[Clopidogrel cannot yet be exclusively for smokers].

Authors:
Niels P Riksen

Ned Tijdschr Geneeskd 2014 ;158:A7359

Universitair Medisch Centrum St Radboud, afd. Interne Geneeskunde en afd. Farmacologie-Toxicologie, Nijmegen.

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November 2014

Trained innate immunity as a mechanistic link between sepsis and atherosclerosis.

Crit Care 2014 Nov 25;18(6):645. Epub 2014 Nov 25.

Department of Internal Medicine, Division of Vascular Medicine and Experimental Internal Medicine, Radboud University Medical Center, Geert Grooteplein 10, Nijmegen, 6525 GA, The Netherlands.

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http://dx.doi.org/10.1186/s13054-014-0645-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243323PMC
November 2014

Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes.

Arterioscler Thromb Vasc Biol 2014 Aug 5;34(8):1731-8. Epub 2014 Jun 5.

From the Department of Internal Medicine, Division of Experimental Medicine (S.B., J.Q., L.A.B.J., J.W.M.v.d.M., M.G.N.), and Division of Vascular Medicine (N.P.R.), and the Department of Pharmacology-Toxicology (N.P.R.), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.114.303887DOI Listing
August 2014

The cardioprotective effects of mineralocorticoid receptor antagonists.

Pharmacol Ther 2014 Apr 23;142(1):72-87. Epub 2013 Nov 23.

Department of Pharmacology and Toxicology, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of General Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2013.11.006DOI Listing
April 2014

It takes more than one CAMERA to study cardiovascular protection by metformin.

Lancet Diabetes Endocrinol 2014 Feb 3;2(2):105-6. Epub 2014 Feb 3.

Department of Pharmacology-Toxicology, Radboud University Medical Centre, Geert Grooteplein 10, Nijmegen, 6525GA, Netherlands.

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http://dx.doi.org/10.1016/S2213-8587(13)70207-9DOI Listing
February 2014

Trained innate immunity and atherosclerosis.

Curr Opin Lipidol 2013 Dec;24(6):487-92

aDepartment of Internal Medicine, Division of Experimental Medicine, Radboud University Nijmegen Medical Centre bNijmegen Institute for Infection, Inflammation and Immunity (N4i) cDepartment of Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/MOL.0000000000000023DOI Listing
December 2013

The effect of remote ischemic preconditioning on exercise-induced plasma troponin I appearance in healthy volunteers.

Int J Cardiol 2013 Sep 11;168(2):1612-3. Epub 2013 Feb 11.

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ijcard.2013.01.029DOI Listing
September 2013

Dipyridamole augments the antiinflammatory response during human endotoxemia.

Crit Care 2011 30;15(6):R289. Epub 2011 Nov 30.

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/cc10576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388652PMC
June 2013

Metformin therapy in diabetes: the role of cardioprotection.

Curr Atheroscler Rep 2013 Apr;15(4):314

Department of Pharmacology-Toxicology 149, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s11883-013-0314-zDOI Listing
April 2013

Complete remission of coronary vasculitis in Churg-Strauss Syndrome by prednisone and cyclophosphamide.

Clin Rheumatol 2013 Mar 28;32 Suppl 1:S41-2. Epub 2010 Mar 28.

Department of Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein 21, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://link.springer.com/10.1007/s10067-010-1428-0
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http://dx.doi.org/10.1007/s10067-010-1428-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594814PMC
March 2013

The efficacy of renal angioplasty in patients with renal artery stenosis and flash oedema or congestive heart failure: a systematic review.

Eur J Heart Fail 2012 Jul 28;14(7):773-81. Epub 2012 Mar 28.

Department of Internal Medicine, Radboud University Nijmegen Medical Centre,PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/eurjhf/hfs037DOI Listing
July 2012

Targeting adenosine receptors in the development of cardiovascular therapeutics.

Expert Rev Clin Pharmacol 2012 Mar;5(2):199-218

Department of Pharmacology-Toxicology 149 and Internal Medicine 463, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1586/ecp.12.8DOI Listing
March 2012

Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury.

Crit Care 2011 6;15(1):R3. Epub 2011 Jan 6.

Department of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/cc9400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222030PMC
December 2011

The cardioprotective effects of metformin.

Curr Opin Lipidol 2011 Dec;22(6):445-53

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1097/MOL.0b013e32834ae1a7DOI Listing
December 2011

Modulation of innate immunity by adenosine receptor stimulation.

Shock 2011 Sep;36(3):208-15

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0b013e318225aee4DOI Listing
September 2011

NT5E mutations and arterial calcifications.

N Engl J Med 2011 04;364(16):1579; author reply 1579-80

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http://dx.doi.org/10.1056/NEJMc1102515DOI Listing
April 2011

The cardiovascular effects of methylxanthines.

Handb Exp Pharmacol 2011 (200):413-37

Department of Pharmacology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/978-3-642-13443-2_16DOI Listing
January 2011

Endotoxin tolerance does not limit mild ischemia-reperfusion injury in humans in vivo.

Innate Immun 2009 Dec;15(6):360-7

Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1177/1753425909105548DOI Listing
December 2009

Metformin prevents myocardial reperfusion injury by activating the adenosine receptor.

J Cardiovasc Pharmacol 2009 May;53(5):373-8

The Hatter Cardiovascular Institute, University College London Medical School, London, United Kingdom.

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http://dx.doi.org/10.1097/FJC.0b013e31819fd4e7DOI Listing
May 2009

Acute and long-term cardiovascular effects of coffee: implications for coronary heart disease.

Pharmacol Ther 2009 Feb 11;121(2):185-91. Epub 2008 Nov 11.

Department of Pharmacology-Toxicology and Internal Medicine, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.pharmthera.2008.10.006DOI Listing
February 2009

The 22G>A polymorphism in the adenosine deaminase gene impairs catalytic function but does not affect reactive hyperaemia in humans in vivo.

Pharmacogenet Genomics 2008 Oct;18(10):843-6

Departments of Pharmacology-Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/FPC.0b013e328305e630DOI Listing
October 2008

Erythropoietin: ready for prime-time cardioprotection.

Trends Pharmacol Sci 2008 May 21;29(5):258-67. Epub 2008 Mar 21.

The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London WC1E 6HX, United Kingdom.

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http://dx.doi.org/10.1016/j.tips.2008.02.002DOI Listing
May 2008

Human in vivo research on the vascular effects of adenosine.

Eur J Pharmacol 2008 May 15;585(2-3):220-7. Epub 2008 Mar 15.

Department of Pharmacology-Toxicology and Internal Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ejphar.2008.01.053DOI Listing
May 2008

Acute elevation of plasma non-esterified fatty acids increases pulse wave velocity and induces peripheral vasodilation in humans in vivo.

Clin Sci (Lond) 2007 Jul;113(1):33-40

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1042/CS20060365DOI Listing
July 2007

The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo.

Pharmacogenet Genomics 2007 Jul;17(7):551-4

Department of Pharmacology, Radboud University Nijmegen Medical Center, The Netherlands.

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http://dx.doi.org/10.1097/FPC.0b013e32803fb78fDOI Listing
July 2007

Antibodies against the CUB1-2 domains of ADAMTS13 in a patient with benign monoclonal gammopathy: no causal relationship.

Haematologica 2007 Jul;92(7):e74-6

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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July 2007

DNA methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients.

Mol Genet Metab 2007 May 2;91(1):55-60. Epub 2007 Mar 2.

Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ymgme.2007.01.008DOI Listing
May 2007

Augmented hyperaemia and reduced tissue injury in response to ischaemia in subjects with the 34C > T variant of the AMPD1 gene.

Eur Heart J 2007 May 21;28(9):1085-91. Epub 2007 Mar 21.

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 EZ, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehm032DOI Listing
May 2007

Caffeine prevents protection in two human models of ischemic preconditioning.

J Am Coll Cardiol 2006 Aug 24;48(4):700-7. Epub 2006 Jul 24.

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2006.04.083DOI Listing
August 2006

The effect of adenosine receptor agonists on cytokine release by human mononuclear cells depends on the specific Toll-like receptor subtype used for stimulation.

Cytokine 2006 Jul 11;35(1-2):95-9. Epub 2006 Sep 11.

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1016/j.cyto.2006.07.014DOI Listing
July 2006

Reduced adenosine receptor stimulation as a pathogenic factor in hyperhomocysteinemia.

Clin Chem Lab Med 2005 ;43(10):1001-6

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1515/CCLM.2005.175DOI Listing
December 2005

In vivo evidence against a role for adenosine in the exercise pressor reflex in humans.

J Appl Physiol (1985) 2005 Aug 7;99(2):522-7. Epub 2005 Apr 7.

Dept. of Pharmacology-Toxicology 233, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1152/japplphysiol.00108.2005DOI Listing
August 2005

Oral therapy with dipyridamole limits ischemia-reperfusion injury in humans.

Clin Pharmacol Ther 2005 Jul;78(1):52-9

Department of Pharmacology-Toxicology, Radbound University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.clpt.2005.03.003DOI Listing
July 2005

Enhanced cellular adenosine uptake limits adenosine receptor stimulation in patients with hyperhomocysteinemia.

Arterioscler Thromb Vasc Biol 2005 Jan 11;25(1):109-14. Epub 2004 Nov 11.

Department of Pharmacology-Toxicology 233, University Medical Centre Nijmegen, Geert Grooteplein 21, 6525 EZ Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1161/01.ATV.0000150651.85907.69DOI Listing
January 2005

Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans.

Circulation 2005 Jan 27;111(2):173-8. Epub 2004 Dec 27.

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Center, Nijmegen, Geert Grooteplein 21, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1161/01.CIR.0000151612.02223.F2DOI Listing
January 2005

Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia.

Cardiovasc Res 2003 Aug;59(2):271-6

Department of Pharmacology-Toxicology, University Medical Centre Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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August 2003

Stress susceptibility as a determinant of endothelium-dependent vascular reactivity in rat mesenteric arteries.

J Cardiovasc Pharmacol 2003 Apr;41(4):625-31

Departments of Pharmacology and Toxicology, University Medical Center Nijmegen, HB Nijmegen, The Netherlands.

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April 2003

Stress susceptibility as a determinant of the response to adrenergic stimuli in mesenteric resistance arteries of the rat.

J Cardiovasc Pharmacol 2002 Nov;40(5):678-83

Department of Pharmacology-Toxicology, University Medical Center Nijmegen, Nijmegen, the Netherlands.

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November 2002