Publications by authors named "Niels P Riksen"

100Publications

Trained Immunity: Long-Term Adaptation in Innate Immune Responses.

Arterioscler Thromb Vasc Biol 2020 Oct 22:ATVBAHA120314212. Epub 2020 Oct 22.

Department of Internal Medicine and Research Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands (H.T., N.P.R., L.A.B.J., M.G.N., S.B.).

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http://dx.doi.org/10.1161/ATVBAHA.120.314212DOI Listing
October 2020

Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content.

Cell Rep 2020 Oct;33(1):108212

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713AV, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108212DOI Listing
October 2020

A High Glycemic Burden Relates to Functional and Metabolic Alterations of Human Monocytes in Patients with Type 1 Diabetes.

Diabetes 2020 Sep 25. Epub 2020 Sep 25.

Department of Internal Medicine (463) & Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

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http://dx.doi.org/10.2337/db20-0568DOI Listing
September 2020

Immunometabolic control of trained immunity.

Mol Aspects Med 2020 Sep 2:100897. Epub 2020 Sep 2.

Dept. of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1016/j.mam.2020.100897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466946PMC
September 2020

Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity.

Arterioscler Thromb Vasc Biol 2020 07 28;40(7):1787-1800. Epub 2020 May 28.

From the Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (R.t.H., I.C.L.v.d.M., K.S., M.J., S.P.S., T.B., H.L., H.D., J.d.G., L.A.B.J., J.H.W.R., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.120.314508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310302PMC
July 2020

Acromegaly, inflammation and cardiovascular disease: a review.

Rev Endocr Metab Disord 2020 Dec;21(4):547-568

Department of Internal Medicine, Radboud University Medical Center Nijmegen, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s11154-020-09560-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560935PMC
December 2020

Trained Immunity: Linking Obesity and Cardiovascular Disease across the Life-Course?

Trends Endocrinol Metab 2020 05 8;31(5):378-389. Epub 2020 Feb 8.

Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2020.01.008DOI Listing
May 2020

Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo.

Circ Res 2020 Jul 3;127(2):269-283. Epub 2020 Apr 3.

From the Department of Internal Medicine (C.D.C.C.v.d.H., L.G., S.T.K., M.P.N., S.K., A.H., L.A.B.J., H.J.L.M.T., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315800DOI Listing
July 2020

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia.

PLoS Pathog 2020 04 2;16(4):e1008404. Epub 2020 Apr 2.

Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1008404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117655PMC
April 2020

Sixteen-Week Physical Activity Intervention in Subjects With Increased Cardiometabolic Risk Shifts Innate Immune Function Towards a Less Proinflammatory State.

J Am Heart Assoc 2019 11 18;8(21):e013764. Epub 2019 Oct 18.

Department of Internal Medicine Radboud Institute for Molecular Life Sciences (RIMLS) Radboud University Medical Center Nijmegen The Netherlands.

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http://dx.doi.org/10.1161/JAHA.119.013764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898840PMC
November 2019

Trained immunity and atherosclerotic cardiovascular disease.

Authors:
Niels P Riksen

Curr Opin Lipidol 2019 10;30(5):395-400

Department of Internal Medicine, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1097/MOL.0000000000000628DOI Listing
October 2019

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

Cell Metab 2019 07 13;30(1):1-2. Epub 2019 Jun 13.

Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.05.014DOI Listing
July 2019

Aldosterone induces trained immunity: the role of fatty acid synthesis.

Cardiovasc Res 2020 02;116(2):317-328

Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.

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https://academic.oup.com/cardiovascres/advance-article/doi/1
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http://dx.doi.org/10.1093/cvr/cvz137DOI Listing
February 2020

Immunometabolism orchestrates training of innate immunity in atherosclerosis.

Cardiovasc Res 2019 07;115(9):1416-1424

Department of Internal Medicine, Radboud University Medical Center Nijmegen, Geert Grooteplein Zuid 8, GA, HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvz107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910162PMC
July 2019

Effect of two dosages of sodium chloride intake on the blood pressure response to caffeinated coffee in humans .

Int J Food Sci Nutr 2019 Dec 10;70(8):1014-1019. Epub 2019 Apr 10.

Department of Internal Medicine, Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1080/09637486.2019.1595541DOI Listing
December 2019

Trained immunity and diabetic vascular disease.

Clin Sci (Lond) 2019 01 18;133(2):195-203. Epub 2019 Jan 18.

Department of Internal Medicine (463), Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands

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http://clinsci.org/lookup/doi/10.1042/CS20180905
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http://dx.doi.org/10.1042/CS20180905DOI Listing
January 2019

Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease.

Stroke 2018 12;49(12):2910-2917

From the Department of Internal Medicine, Radboud University Medical Center Behaviour, (M.P.N., L.A.B.J., M.G.N., N.P.R.), Nijmegen, the Netherlands.

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http://dx.doi.org/10.1161/STROKEAHA.118.023192DOI Listing
December 2018

Multidisciplinary care for people with Parkinson's disease: the new kids on the block!

Expert Rev Neurother 2019 02 9;19(2):145-157. Epub 2019 Jan 9.

a Department of Neurology, Donders Institute for Brain, Cognition and Behaviour , Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1080/14737175.2019.1561285DOI Listing
February 2019

Getting to the marrow of trained immunity.

Epigenomics 2018 09;10(9):1151-1154

Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.2217/epi-2018-0098DOI Listing
September 2018

Be aware, innate immune cells remember.

Aging (Albany NY) 2018 09;10(9):2218-2219

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.18632/aging.101552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188483PMC
September 2018

Metabolism of innate immune cells: impact on atherosclerosis.

Curr Opin Lipidol 2018 10;29(5):359-367

Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen.

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http://dx.doi.org/10.1097/MOL.0000000000000539DOI Listing
October 2018

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

EBioMedicine 2018 Jul 4;33:144-156. Epub 2018 Jul 4.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085583PMC
July 2018

The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis.

Cardiovasc Res 2018 06;114(7):944-953

Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvy092DOI Listing
June 2018

The acute effect of black tea consumption on resistance artery endothelial function in healthy subjects. A randomized controlled trial.

Clin Nutr ESPEN 2018 02 8;23:41-47. Epub 2017 Nov 8.

Department of Physiology, Radboud University Medical Centre, Nijmegen, The Netherlands; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.

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http://dx.doi.org/10.1016/j.clnesp.2017.10.011DOI Listing
February 2018

Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis.

Circ Res 2018 03 24;122(5):664-669. Epub 2018 Jan 24.

From the Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (J.L., S.B., L.A.B.J., M.G.N., N.P.R.); Department of Medical Genetics, University of Medicine and Pharmacy, Iuliu Haţieganu, Cluj-Napoca, Romania (L.A.B.J.); Department for Genomics & Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Germany (M.G.N.); Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia (D.P.B.); and Department of Pediatrics, University of Melbourne, Parkville, Victoria, Australia (D.P.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312465DOI Listing
March 2018

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

Cell 2018 01;172(1-2):162-175.e14

Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases & Immunology, UMass Medical School, Worcester, MA 01605, USA; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324559PMC
January 2018

Metabolic Induction of Trained Immunity through the Mevalonate Pathway.

Cell 2018 01;172(1-2):135-146.e9

Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.025DOI Listing
January 2018

Epigenetics in diabetic nephropathy, immunity and metabolism.

Diabetologia 2018 Jan 11;61(1):6-20. Epub 2017 Nov 11.

Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.

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http://dx.doi.org/10.1007/s00125-017-4490-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448927PMC
January 2018

Epigenetics and Trained Immunity.

Antioxid Redox Signal 2018 10 21;29(11):1023-1040. Epub 2017 Nov 21.

1 Department of Internal Medicine, Radboud University Medical Center , Nijmegen, The Netherlands .

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http://dx.doi.org/10.1089/ars.2017.7310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121175PMC
October 2018

Monocyte and macrophage immunometabolism in atherosclerosis.

Semin Immunopathol 2018 02 2;40(2):203-214. Epub 2017 Oct 2.

Department of Internal Medicine (463) and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00281-017-0656-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809534PMC
February 2018

A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction.

PLoS One 2017 23;12(8):e0183664. Epub 2017 Aug 23.

SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE), Department for Health Evidence, Nijmegen Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183664PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568412PMC
October 2017

A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.

Thromb Haemost 2017 08 6;117(9):1798-1807. Epub 2017 Jul 6.

Prof. N. P. Riksen, Dept. of Internal Medicine 463, Radboud University Medical Center, PO Box 9101, 6500HB Nijmegen, The Netherlands, Tel.: +31 24 3618819, Fax: +31 24 3616519, E-mail:

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http://dx.doi.org/10.1160/TH16-10-0799DOI Listing
August 2017

Specific and Complex Reprogramming of Cellular Metabolism in Myeloid Cells during Innate Immune Responses.

Cell Metab 2017 Jul;26(1):142-156

Department of Internal Medicine (463), Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands; Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.06.001DOI Listing
July 2017

Planarians SET New Paths for Innate Immune Memory.

EBioMedicine 2017 06 5;20:7-8. Epub 2017 May 5.

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478199PMC
June 2017

Correction for Bekkering et al., " Experimental Model of Trained Innate Immunity in Human Primary Monocytes".

Clin Vaccine Immunol 2017 05 5;24(5). Epub 2017 May 5.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/CVI.00096-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424232PMC
May 2017

Plasma galectin-3 concentrations in patients with primary aldosteronism.

J Hypertens 2017 09;35(9):1849-1856

aDepartment of Pharmacology and Toxicology bDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen cDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen dDepartment for Health Evidence eDepartment of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/HJH.0000000000001383DOI Listing
September 2017

Impact of lifelong exercise training on endothelial ischemia-reperfusion and ischemic preconditioning in humans.

Am J Physiol Regul Integr Comp Physiol 2017 05 15;312(5):R828-R834. Epub 2017 Mar 15.

Radboud Institute for Health Sciences, Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands;

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http://dx.doi.org/10.1152/ajpregu.00466.2016DOI Listing
May 2017

In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes.

Clin Vaccine Immunol 2016 Dec 5;23(12):926-933. Epub 2016 Dec 5.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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http://dx.doi.org/10.1128/CVI.00349-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139603PMC
December 2016

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo.

Atherosclerosis 2016 11 12;254:228-236. Epub 2016 Oct 12.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.10.019DOI Listing
November 2016

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans.

Circulation 2016 Aug 5;134(8):611-24. Epub 2016 Aug 5.

From Department of Vascular Medicine (F.M.V.d.V., M.N., E.S.G.S.), Department of Molecular Cell Biology, Sanquin Research (J.K., J.D.v.B.), Experimental Vascular Biology, (J.v.d.B.), Department of Radiology (A.J.N.), and Department of Nuclear Medicine (H.J.V.), Academic Medical Center, Amsterdam, the Netherlands; Departments of Internal Medicine (S.B., L.A.B.J., M.G.N., N.P.R.) and Pharmacology-Toxicology (N.P.R.), Radboud UMC, Nijmegen, the Netherlands; Sulpizio Cardiovascular Center, Division of Cardiovascular Medicine (C.Y., S.T.) and Division of Endocrinology and Metabolism, Department of Medicine (J.L.W.), University California, San Diego, La Jolla; St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Canada (A.R.); Department of Chemistry, Biochemistry and Pharmacology, University of Windsor, Windsor, Canada (C.S.); and Robarts Research Institute, Schulich School of Medicine, Western University, London, Canada (M.L.K.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.020838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995139PMC
August 2016

Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?

Cell Mol Life Sci 2016 12 28;73(24):4675-4684. Epub 2016 Jul 28.

Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Radboudumc, (463), P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00018-016-2316-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097107PMC
December 2016

BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice.

Atherosclerosis 2016 08 19;251:6-14. Epub 2016 May 19.

Dept. of Medicine, Div. of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.031DOI Listing
August 2016

Long-term activation of the innate immune system in atherosclerosis.

Semin Immunol 2016 08 22;28(4):384-93. Epub 2016 Apr 22.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2016.04.004DOI Listing
August 2016

Isolated arterial calcifications of the lower extremities: A clue for NT5E mutation.

Int J Cardiol 2016 Jun 19;212:248-50. Epub 2016 Mar 19.

Dept. of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.03.068DOI Listing
June 2016

[What is the correct time to take medication?].

Ned Tijdschr Geneeskd 2015 ;159:A9509

Radboudumc, Nijmegen.

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October 2016

Effects of the 34C>T Variant of the AMPD1 Gene on Immune Function, Multi-Organ Dysfunction, and Mortality in Sepsis Patients.

Shock 2015 Dec;44(6):542-7

*Department of Pharmacology and Toxicology †Intensive Care Medicine ‡Internal Medicine §Human Genetics ¶Anesthesiology ||Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands #4th Department of Internal Medicine, University of Athens, Medical School, Athens **Intensive Care Unit, "G. Gennimatas" General Hospital, Thessaloniki ††1st Department of Critical Care Medicine, University of Athens, Medical School ‡‡Intensive Care Unit, Tzaneion General Hospital of Piraeus §§Department of Respiratory Medicine, "Sismanogleion" General Hospital ¶¶Department of Therapeutics, Alexandra General Hospital ||||1st Department of Propedeutic Surgery, University of Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.1097/SHK.0000000000000456DOI Listing
December 2015

Preface. Novel targets and drugs to prevent atherogenesis and its consequences.

Eur J Pharmacol 2015 Sep;763(Pt A):1-2

Department of Internal Medicine and Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.08.042DOI Listing
September 2015

Pharmacological treatment of aldosterone excess.

Pharmacol Ther 2015 Oct 26;154:120-33. Epub 2015 Jul 26.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.

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http://dx.doi.org/10.1016/j.pharmthera.2015.07.006DOI Listing
October 2015

Effect of metformin pretreatment on myocardial injury during coronary artery bypass surgery in patients without diabetes (MetCAB): a double-blind, randomised controlled trial.

Lancet Diabetes Endocrinol 2015 Aug 12;3(8):615-23. Epub 2015 Jul 12.

Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, Netherlands; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(15)00121-7DOI Listing
August 2015

The epigenetic memory of monocytes and macrophages as a novel drug target in atherosclerosis.

Clin Ther 2015 Apr 20;37(4):914-23. Epub 2015 Feb 20.

Department of Internal Medicine, Division of Vascular Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clinthera.2015.01.008DOI Listing
April 2015

Trained innate immunity as a mechanistic link between sepsis and atherosclerosis.

Crit Care 2014 Nov 25;18(6):645. Epub 2014 Nov 25.

Department of Internal Medicine, Division of Vascular Medicine and Experimental Internal Medicine, Radboud University Medical Center, Geert Grooteplein 10, Nijmegen, 6525 GA, The Netherlands.

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http://dx.doi.org/10.1186/s13054-014-0645-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243323PMC
November 2014

Heart failure is associated with exaggerated endothelial ischaemia-reperfusion injury and attenuated effect of ischaemic preconditioning.

Eur J Prev Cardiol 2016 Jan 11;23(1):33-40. Epub 2014 Nov 11.

Department of Physiology, Radboud University Medical Centre, Nijmegen, The Netherlands Department of Pharmacology-Toxicology, Radboud University Medical Centre, Nijmegen, The Netherlands

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http://dx.doi.org/10.1177/2047487314558377DOI Listing
January 2016

The effect of eplerenone on adenosine formation in humans in vivo: a double-blinded randomised controlled study.

PLoS One 2014 30;9(10):e111248. Epub 2014 Oct 30.

Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111248PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214740PMC
December 2015

The cardiovascular effects of metformin: lost in translation?

Curr Opin Lipidol 2014 Dec;25(6):446-51

aDepartment of Internal Medicine bPharmacology-Toxicology, Radboud university medical center, Nijmegen, the Netherlands.

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December 2014

Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes.

Arterioscler Thromb Vasc Biol 2014 Aug 5;34(8):1731-8. Epub 2014 Jun 5.

From the Department of Internal Medicine, Division of Experimental Medicine (S.B., J.Q., L.A.B.J., J.W.M.v.d.M., M.G.N.), and Division of Vascular Medicine (N.P.R.), and the Department of Pharmacology-Toxicology (N.P.R.), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.114.303887DOI Listing
August 2014

Impact of metformin on endothelial ischemia-reperfusion injury in humans in vivo: a prospective randomized open, blinded-endpoint study.

PLoS One 2014 22;9(4):e96062. Epub 2014 Apr 22.

Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996005PMC
January 2015

It takes more than one CAMERA to study cardiovascular protection by metformin.

Lancet Diabetes Endocrinol 2014 Feb 3;2(2):105-6. Epub 2014 Feb 3.

Department of Pharmacology-Toxicology, Radboud University Medical Centre, Geert Grooteplein 10, Nijmegen, 6525GA, Netherlands.

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http://dx.doi.org/10.1016/S2213-8587(13)70207-9DOI Listing
February 2014

[Clopidogrel cannot yet be exclusively for smokers].

Authors:
Niels P Riksen

Ned Tijdschr Geneeskd 2014 ;158:A7359

Universitair Medisch Centrum St Radboud, afd. Interne Geneeskunde en afd. Farmacologie-Toxicologie, Nijmegen.

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November 2014

The cardioprotective effects of mineralocorticoid receptor antagonists.

Pharmacol Ther 2014 Apr 23;142(1):72-87. Epub 2013 Nov 23.

Department of Pharmacology and Toxicology, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of General Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands. Electronic address:

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April 2014

Trained innate immunity and atherosclerosis.

Curr Opin Lipidol 2013 Dec;24(6):487-92

aDepartment of Internal Medicine, Division of Experimental Medicine, Radboud University Nijmegen Medical Centre bNijmegen Institute for Infection, Inflammation and Immunity (N4i) cDepartment of Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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December 2013

Metformin therapy in diabetes: the role of cardioprotection.

Curr Atheroscler Rep 2013 Apr;15(4):314

Department of Pharmacology-Toxicology 149, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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April 2013

The effect of remote ischemic preconditioning on exercise-induced plasma troponin I appearance in healthy volunteers.

Int J Cardiol 2013 Sep 11;168(2):1612-3. Epub 2013 Feb 11.

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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September 2013

The efficacy of renal angioplasty in patients with renal artery stenosis and flash oedema or congestive heart failure: a systematic review.

Eur J Heart Fail 2012 Jul 28;14(7):773-81. Epub 2012 Mar 28.

Department of Internal Medicine, Radboud University Nijmegen Medical Centre,PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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July 2012

Targeting adenosine receptors in the development of cardiovascular therapeutics.

Expert Rev Clin Pharmacol 2012 Mar;5(2):199-218

Department of Pharmacology-Toxicology 149 and Internal Medicine 463, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1586/ecp.12.8DOI Listing
March 2012

Dipyridamole augments the antiinflammatory response during human endotoxemia.

Crit Care 2011 30;15(6):R289. Epub 2011 Nov 30.

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6500 HB, Nijmegen, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388652PMC
June 2013

The cardioprotective effects of metformin.

Curr Opin Lipidol 2011 Dec;22(6):445-53

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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December 2011

Modulation of innate immunity by adenosine receptor stimulation.

Shock 2011 Sep;36(3):208-15

Department of Pharmacology-Toxicology, Radboud University Nijmegen Medical Centre, The Netherlands.

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September 2011

NT5E mutations and arterial calcifications.

N Engl J Med 2011 04;364(16):1579; author reply 1579-80

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April 2011

Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury.

Crit Care 2011 6;15(1):R3. Epub 2011 Jan 6.

Department of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222030PMC
December 2011

The cardiovascular effects of methylxanthines.

Handb Exp Pharmacol 2011 (200):413-37

Department of Pharmacology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/978-3-642-13443-2_16DOI Listing
January 2011

Complete remission of coronary vasculitis in Churg-Strauss Syndrome by prednisone and cyclophosphamide.

Clin Rheumatol 2013 Mar 28;32 Suppl 1:S41-2. Epub 2010 Mar 28.

Department of Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein 21, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://link.springer.com/10.1007/s10067-010-1428-0
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http://dx.doi.org/10.1007/s10067-010-1428-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594814PMC
March 2013

Endotoxin tolerance does not limit mild ischemia-reperfusion injury in humans in vivo.

Innate Immun 2009 Dec;15(6):360-7

Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1177/1753425909105548DOI Listing
December 2009