Nicole Zitzmann

Nicole Zitzmann

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Nicole Zitzmann

Publications by authors named "Nicole Zitzmann"

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Iminosugars counteract the downregulation of the interferon γ receptor by dengue virus.

Antiviral Res 2019 Oct 12;170:104551. Epub 2019 Jul 12.

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S01663542193016
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http://dx.doi.org/10.1016/j.antiviral.2019.104551DOI Listing
October 2019

Use of Modified Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells.

Int J Mol Sci 2019 Sep 26;20(19). Epub 2019 Sep 26.

Charité-Universitätsmedizin Berlin, Institute of Clinical Physiology, Hindenburgdamm 30, 12203 Berlin, Germany.

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http://dx.doi.org/10.3390/ijms20194774DOI Listing
September 2019

Hepatitis C virus sequence divergence preserves p7 viroporin structural and dynamic features.

Sci Rep 2019 Jun 10;9(1):8383. Epub 2019 Jun 10.

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1038/s41598-019-44413-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557816PMC
June 2019

Structural Insights into the Broad-Spectrum Antiviral Target Endoplasmic Reticulum Alpha-Glucosidase II.

Adv Exp Med Biol 2018;1062:265-276

Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1007/978-981-10-8727-1_19DOI Listing
November 2018

Mechanisms of Antiviral Activity of Iminosugars Against Dengue Virus.

Adv Exp Med Biol 2018 ;1062:277-301

Department of Biochemistry, Antiviral Drug Discovery Group, Oxford Glycobiology Institute, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1007/978-981-10-8727-1_20DOI Listing
November 2018

Re-evaluating the p7 viroporin structure.

Nature 2018 10 17;562(7727):E8-E18. Epub 2018 Oct 17.

Department of Biochemistry, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/s41586-018-0561-9
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http://dx.doi.org/10.1038/s41586-018-0561-9DOI Listing
October 2018

In Planta Preliminary Screening of ER Glycoprotein Folding Quality Control (ERQC) Modulators.

Int J Mol Sci 2018 Jul 23;19(7). Epub 2018 Jul 23.

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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http://www.mdpi.com/1422-0067/19/7/2135
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http://dx.doi.org/10.3390/ijms19072135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073501PMC
July 2018

Iminosugars: Promising therapeutics for influenza infection.

Crit Rev Microbiol 2017 Sep 8;43(5):521-545. Epub 2016 Dec 8.

a Department of Biochemistry , University of Oxford Medical Sciences Division , Oxford , United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1080/1040841X.2016.1242868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470110PMC
September 2017

Absolute quantitation of disease protein biomarkers in a single LC-MS acquisition using apolipoprotein F as an example.

Sci Rep 2017 09 21;7(1):12072. Epub 2017 Sep 21.

Oxford Antiviral Drug Discovery Unit, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-12229-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608892PMC
September 2017

Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model.

PLoS One 2016 23;11(11):e0167018. Epub 2016 Nov 23.

Antiviral Research Unit, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167018PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120828PMC
June 2017

The role of the unfolded protein response in dengue virus pathogenesis.

Cell Microbiol 2017 05 8;19(5). Epub 2017 Mar 8.

Antiviral Research Unit, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/cmi.12734DOI Listing
May 2017

Iminosugar antivirals: the therapeutic sweet spot.

Biochem Soc Trans 2017 04;45(2):571-582

Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.

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http://dx.doi.org/10.1042/BST20160182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390498PMC
April 2017

Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer.

J Virol 2017 Jan 3;91(2). Epub 2017 Jan 3.

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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http://dx.doi.org/10.1128/JVI.01894-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215339PMC
January 2017

Multiple reaction monitoring and multiple reaction monitoring cubed based assays for the quantitation of apolipoprotein F.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Oct 27;1033-1034:278-286. Epub 2016 Aug 27.

Oxford Antiviral Drug Discovery Unit, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1016/j.jchromb.2016.08.038DOI Listing
October 2016

Native functionality and therapeutic targeting of arenaviral glycoproteins.

Curr Opin Virol 2016 06 19;18:70-5. Epub 2016 Apr 19.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2016.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983490PMC
June 2016

Emerging principles for the therapeutic exploitation of glycosylation.

Science 2014 Jan;343(6166):1235681

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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http://dx.doi.org/10.1126/science.1235681DOI Listing
January 2014

Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.

PLoS One 2012 26;7(6):e39603. Epub 2012 Jun 26.

Oxford Antiviral Drug Discovery Unit, Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039603PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383672PMC
March 2013

Liposome-mediated delivery of iminosugars enhances efficacy against dengue virus in vivo.

Antimicrob Agents Chemother 2012 Dec 15;56(12):6379-86. Epub 2012 Oct 15.

Department of Biochemistry, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1128/AAC.01554-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497178PMC
December 2012

New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients.

J Proteome Res 2011 May 30;10(5):2643-50. Epub 2011 Mar 30.

Oxford Antiviral Drug Discovery Unit, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1021/pr101077cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089987PMC
May 2011

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

Proc Natl Acad Sci U S A 2010 Oct 20;107(40):17176-81. Epub 2010 Sep 20.

Oxford Antiviral Drug Discovery Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1009445107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951407PMC
October 2010

Targeting a host process as an antiviral approach against dengue virus.

Trends Microbiol 2010 Jul 6;18(7):323-30. Epub 2010 May 6.

Department of Genetics and Biochemistry, Clemson University, 217 Biosystems Research Complex, 51 New Cherry Street, Clemson, SC 29634, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0966842X1000062
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http://dx.doi.org/10.1016/j.tim.2010.04.003DOI Listing
July 2010

Uptake and trafficking of liposomes to the endoplasmic reticulum.

FASEB J 2010 Jun 22;24(6):1866-78. Epub 2010 Jan 22.

Oxford Antiviral Drug Discovery Unit, Department of Biochemistry, University of Oxford, Oxford, UK.

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http://www.fasebj.org/doi/10.1096/fj.09-145755
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http://dx.doi.org/10.1096/fj.09-145755DOI Listing
June 2010

The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy.

Proc Natl Acad Sci U S A 2009 Aug 9;106(31):12712-6. Epub 2009 Jul 9.

Department of Biochemistry and Oxford Glycobiology Institute, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0905966106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722341PMC
August 2009

Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection.

J Proteome Res 2009 Jan;8(1):118-22

Oxford Antiviral Drug Discovery Unit, Oxford, OX1 3QU, UK.

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http://dx.doi.org/10.1021/pr800562jDOI Listing
January 2009

N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery.

AIDS 2008 Oct;22(15):1961-9

Oxford Antiviral Drug Discovery Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.

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https://insights.ovid.com/crossref?an=00002030-200810010-000
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http://dx.doi.org/10.1097/QAD.0b013e32830efd96DOI Listing
October 2008

Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.

AIDS 2008 Oct;22(16):2214-7

Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1097/QAD.0b013e328314b5dfDOI Listing
October 2008

Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity.

Antiviral Res 2007 Oct 22;76(1):30-7. Epub 2007 May 22.

Institute of Biochemistry, Splaiul Independentei, 296, Sector 6, Bucharest 77700, Romania.

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http://dx.doi.org/10.1016/j.antiviral.2007.04.004DOI Listing
October 2007

Novel serum biomarker candidates for liver fibrosis in hepatitis C patients.

Clin Chem 2007 Oct 16;53(10):1792-9. Epub 2007 Aug 16.

Oxford Antiviral Drug Discovery Unit, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1373/clinchem.2007.089144DOI Listing
October 2007

Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus.

Hepatology 2007 Aug;46(2):330-8

Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/hep.21686DOI Listing
August 2007

Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum.

J Proteome Res 2007 Jul 1;6(7):2802-11. Epub 2007 Jun 1.

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom.

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http://pubs.acs.org/doi/abs/10.1021/pr070021t
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http://dx.doi.org/10.1021/pr070021tDOI Listing
July 2007

Proteomics in uveal melanoma research: opportunities and challenges in biomarker discovery.

Expert Rev Proteomics 2007 Apr;4(2):273-86

Universidad de Santiago de Compostela, Laboratorio de Endocrinología Molecular, Departamento de Medicina, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.

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http://dx.doi.org/10.1586/14789450.4.2.273DOI Listing
April 2007

Exploiting the defensive sugars of HIV-1 for drug and vaccine design.

Nature 2007 Apr;446(7139):1038-45

Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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http://www.nature.com/doifinder/10.1038/nature05818
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http://dx.doi.org/10.1038/nature05818DOI Listing
April 2007

Unraveling adaptive evolution: how a single point mutation affects the protein coregulation network.

Nat Genet 2006 Sep 20;38(9):1015-22. Epub 2006 Aug 20.

Department of Plant Sciences, South Parks Road, Oxford OX1 3RB, UK.

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http://dx.doi.org/10.1038/ng1867DOI Listing
September 2006

Productive folding of tyrosinase ectodomain is controlled by the transmembrane anchor.

J Biol Chem 2006 Aug 31;281(31):21682-9. Epub 2006 May 31.

Institute of Biochemistry, Splaiul Independentei 296, 060031 Bucharest 17, Romania.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M603841200
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http://dx.doi.org/10.1074/jbc.M603841200DOI Listing
August 2006

Brefeldin A inhibits pestivirus release from infected cells, without affecting its assembly and infectivity.

Biochem Biophys Res Commun 2006 Aug 12;346(3):1083-90. Epub 2006 Jun 12.

Institute of Biochemistry, Splaiul Independentei, 296, Sector 6, Bucharest 77700, Romania.

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http://dx.doi.org/10.1016/j.bbrc.2006.06.023DOI Listing
August 2006

Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara.

Biochim Biophys Acta 2006 May 7;1764(5):863-71. Epub 2006 Apr 7.

Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, Wolfson Drive, Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1016/j.bbapap.2006.03.004DOI Listing
May 2006

Antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles.

J Gen Virol 2006 Apr;87(Pt 4):861-71

INSERM U271, Laboratoire des Virus Hépatiques et Pathologies Associées, 151 cours Albert Thomas, 69424 Lyon Cedex 03, France.

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http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/vir.0.81503-0DOI Listing
April 2006

Glycosylation: disease targets and therapy.

Adv Exp Med Biol 2005 ;564:1-2

Oxford University, Department of Biochemistry, Glycobiology Institute, Oxford.

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http://link.springer.com/10.1007/0-387-25515-X_1
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http://dx.doi.org/10.1007/0-387-25515-X_1DOI Listing
February 2006

Protein-protein interactions: modeling the hepatitis C virus ion channel p7.

J Med Chem 2006 Jan;49(2):648-55

Biomembrane Structure Unit, Department of Biochemistry, Oxford University, Oxford OX1 3QU, UK.

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http://dx.doi.org/10.1021/jm050721eDOI Listing
January 2006

Proteome analysis of a human uveal melanoma primary cell culture by 2-DE and MS.

Proteomics 2005 Dec;5(18):4980-93

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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http://doi.wiley.com/10.1002/pmic.200500030
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http://dx.doi.org/10.1002/pmic.200500030DOI Listing
December 2005

Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.

Immunity 2005 Dec;23(6):621-34

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S107476130500376
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http://dx.doi.org/10.1016/j.immuni.2005.11.003DOI Listing
December 2005

Applying proteomics technology to platelet research.

Mass Spectrom Rev 2005 Nov-Dec;24(6):918-30

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1002/mas.20047DOI Listing
November 2005

Abnormal cell cycle regulation in primary human uveal melanoma cultures.

J Cell Biochem 2004 Nov;93(4):708-20

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.

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http://doi.wiley.com/10.1002/jcb.20230
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http://dx.doi.org/10.1002/jcb.20230DOI Listing
November 2004

Analyzing the platelet proteome.

Semin Thromb Hemost 2004 Aug;30(4):485-9

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1055/s-2004-833483DOI Listing
August 2004

Role of N-glycan trimming in the folding and secretion of the pestivirus protein E(rns).

Biochem Biophys Res Commun 2004 Jun;319(2):655-62

Institute of Biochemistry, Splaiul Independentei, 296, Sector 6, Bucharest 77700, Romania.

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http://dx.doi.org/10.1016/j.bbrc.2004.05.039DOI Listing
June 2004

Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins.

Blood 2004 Mar 26;103(6):2088-95. Epub 2003 Nov 26.

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1182/blood-2003-07-2392DOI Listing
March 2004

Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry.

Proteomics 2004 Mar;4(3):656-68

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.

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http://dx.doi.org/10.1002/pmic.200300665DOI Listing
March 2004

Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus.

Antimicrob Agents Chemother 2004 Feb;48(2):497-504

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321564PMC
http://dx.doi.org/10.1128/aac.48.2.497-504.2004DOI Listing
February 2004

The pestivirus E(rns) glycoprotein interacts with E2 in both infected cells and mature virions.

Virology 2003 Sep;314(2):696-705

Institute of Biochemistry, Splaiul Independentei, 296, Sector 6, Bucharest 77700, Romania.

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http://dx.doi.org/10.1016/s0042-6822(03)00510-5DOI Listing
September 2003

Plastic surgery beyond the human genome.

Plast Reconstr Surg 2003 Jun;111(7):2479-80

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http://dx.doi.org/10.1097/01.PRS.0000063120.43729.42DOI Listing
June 2003

Role of disulfide bond formation in the folding and assembly of the envelope glycoproteins of a pestivirus.

Biochem Biophys Res Commun 2002 Aug;296(2):470-6

Institute of Biochemistry, Splaiul Independentei, 296, Sector 6, Bucharest, Romania.

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http://dx.doi.org/10.1016/s0006-291x(02)00907-5DOI Listing
August 2002

Antiviral effects of an iminosugar derivative on flavivirus infections.

J Virol 2002 Apr;76(8):3596-604

Graduate Institute of Life Sciences, National Defense Medical Center and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136089PMC
http://dx.doi.org/10.1128/jvi.76.8.3596-3604.2002DOI Listing
April 2002

Targeting glycosylation as a therapeutic approach.

Nat Rev Drug Discov 2002 Jan;1(1):65-75

Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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http://www.nature.com/articles/nrd708
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http://dx.doi.org/10.1038/nrd708DOI Listing
January 2002