Nicole Kleinstreuer

Nicole Kleinstreuer

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Nicole Kleinstreuer

Nicole Kleinstreuer

Publications by authors named "Nicole Kleinstreuer"

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Hierarchical Quantitative Structure-Activity Relationship Modeling Approach for Integrating Binary, Multiclass, and Regression Models of Acute Oral Systemic Toxicity.

Chem Res Toxicol 2020 Feb 5;33(2):353-366. Epub 2020 Feb 5.

Department of Chemistry, Bioinformatics Research Center , North Carolina State University , Raleigh , North Carolina 27695 , United States.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00259DOI Listing
February 2020

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity.

Environ Health Perspect 2020 Feb 7;128(2):27002. Epub 2020 Feb 7.

National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency (U.S. EPA), Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/EHP5580DOI Listing
February 2020

Identification and Profiling of Environmental Chemicals That Inhibit the TGFβ/SMAD Signaling Pathway.

Chem Res Toxicol 2019 Dec 11;32(12):2433-2444. Epub 2019 Nov 11.

National Center for Advancing Translational Sciences , National Institutes of Health , Bethesda , Maryland 20892 , United States.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00228DOI Listing
December 2019

Chronic inflammation in the etiology of disease across the life span.

Nat Med 2019 12 5;25(12):1822-1832. Epub 2019 Dec 5.

Cousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41591-019-0675-0DOI Listing
December 2019

Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to Eye Irritation Testing.

Altern Lab Anim 2019 Jul-Sep;47(3-4):140-157

Institute of Agrobiological Sciences (NIAS), National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1177/0261192919886665DOI Listing
December 2019

Identification of potential endocrine disrupting chemicals using gene expression biomarkers.

Toxicol Appl Pharmacol 2019 Oct 17;380:114683. Epub 2019 Jul 17.

National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2019.114683DOI Listing
October 2019

Exploring current read-across applications and needs among selected U.S. Federal Agencies.

Regul Toxicol Pharmacol 2019 Aug 10;106:197-209. Epub 2019 May 10.

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1016/j.yrtph.2019.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814248PMC
August 2019

Systems Modeling of Developmental Vascular Toxicity.

Curr Opin Toxicol 2019 Jun;15(1):55-63

National Center for Computational Toxicology (NCCT), Office of Research and Development (ORD), U.S. Environmental Protection Agency (USEPA) Research Triangle Park NC 27711.

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http://dx.doi.org/10.1016/j.cotox.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004230PMC
June 2019

Skin sensitization testing needs and data uses by US regulatory and research agencies.

Arch Toxicol 2019 02 30;93(2):273-291. Epub 2018 Oct 30.

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.

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http://link.springer.com/10.1007/s00204-018-2341-6
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http://dx.doi.org/10.1007/s00204-018-2341-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363849PMC
February 2019

Mice-to-men comparison of inhaled drug-aerosol deposition and clearance.

Respir Physiol Neurobiol 2019 02 13;260:82-94. Epub 2018 Nov 13.

Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, School of Medicine, United States; Department of Veterans Affairs, Atlanta VAMC, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S15699048183022
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http://dx.doi.org/10.1016/j.resp.2018.11.003DOI Listing
February 2019

Exploring drug space with ChemMaps.com.

Bioinformatics 2018 11;34(21):3773-3775

Department of Chemistry, Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454477PMC
November 2018

Regulatory acceptance of read-across.

ALTEX 2018;35(3):413-419

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1805081DOI Listing
November 2018

Predictive Models for Acute Oral Systemic Toxicity: A Workshop to Bridge the Gap from Research to Regulation.

Comput Toxicol 2018 Nov;8(11):21-24

National Center for Computational Toxicology (NCCT), Office of Research and Development, US Environmental Protection Agency, 109 TW Alexander Dr, Research Triangle Park (RTP), NC 27711, USA.

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http://dx.doi.org/10.1016/j.comtox.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178952PMC
November 2018

3S - Systematic, systemic, and systems biology and toxicology.

ALTEX 2018 ;35(2):139-162

Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1804051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696989PMC
October 2018

Evaluation and Optimization of Pharmacokinetic Models for to Extrapolation of Estrogenic Activity for Environmental Chemicals.

Environ Health Perspect 2018 09;126(9):97001

National Toxicology Program Division, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/EHP1655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375436PMC
September 2018

International regulatory requirements for skin sensitization testing.

Regul Toxicol Pharmacol 2018 Jun 6;95:52-65. Epub 2018 Mar 6.

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC, 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935556PMC
June 2018

Status of acute systemic toxicity testing requirements and data uses by U.S. regulatory agencies.

Regul Toxicol Pharmacol 2018 Apr 3;94:183-196. Epub 2018 Feb 3.

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2018.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878133PMC
April 2018

In vitro to in vivo extrapolation for high throughput prioritization and decision making.

Toxicol In Vitro 2018 Mar 5;47:213-227. Epub 2017 Dec 5.

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2017.11.016DOI Listing
March 2018

Embryonic vascular disruption adverse outcomes: Linking high-throughput signaling signatures with functional consequences.

Reprod Toxicol 2017 08 13;71:16-31. Epub 2017 Apr 13.

Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States.

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http://dx.doi.org/10.1016/j.reprotox.2017.04.003DOI Listing
August 2017

Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells.

Reprod Toxicol 2017 06 10;70:60-69. Epub 2016 Nov 10.

Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204, USA; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA. Electronic address:

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http://dx.doi.org/10.1016/j.reprotox.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425326PMC
June 2017

Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signatures with functional consequences.

Reprod Toxicol 2017 06 17;70:82-96. Epub 2017 May 17.

Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States.

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http://dx.doi.org/10.1016/j.reprotox.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706853PMC
June 2017

Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of Chemicals.

J Chem Inf Model 2017 05 10;57(5):1013-1017. Epub 2017 May 10.

Laboratory for Molecular Modeling and Drug Design, Faculty of Pharmacy, Federal University of Goiás , Goiânia, GO 74605-170, Brazil.

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http://dx.doi.org/10.1021/acs.jcim.7b00194DOI Listing
May 2017

An Integrated Chemical Environment to Support 21st-Century Toxicology.

Environ Health Perspect 2017 05 25;125(5):054501. Epub 2017 May 25.

NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, NTP, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA

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http://dx.doi.org/10.1289/EHP1759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644972PMC
May 2017

Multivariate models for prediction of human skin sensitization hazard.

J Appl Toxicol 2017 03 2;37(3):347-360. Epub 2016 Aug 2.

National Institutes of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1002/jat.3366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243794PMC
March 2017

A design thinking approach to primary ovarian insufficiency.

Panminerva Med 2017 Mar 9;59(1):15-32. Epub 2016 Nov 9.

Division of Intramural Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA -

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http://dx.doi.org/10.23736/S0031-0808.16.03259-6DOI Listing
March 2017

Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: Scientific Underpinnings and Research Recommendations.

Environ Health Perspect 2017 02 12;125(2):163-169. Epub 2016 Aug 12.

National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/EHP411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289915PMC
February 2017

In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning.

J Chem Inf Model 2017 01 9;57(1):36-49. Epub 2017 Jan 9.

National Toxicology Program, National Institute of Environmental Health Sciences , Research Triangle Park, North Carolina 27709, United States.

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http://dx.doi.org/10.1021/acs.jcim.6b00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131700PMC
January 2017

Supporting read-across using biological data.

ALTEX 2016 11;33(2):167-82. Epub 2016 Feb 11.

Johns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1601252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834201PMC
December 2016

QSAR models of human data can enrich or replace LLNA testing for human skin sensitization.

Green Chem 2016 Dec 6;18(24):6501-6515. Epub 2016 Oct 6.

Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1039/C6GC01836JDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473635PMC
December 2016

Integrated decision strategies for skin sensitization hazard.

J Appl Toxicol 2016 09 6;36(9):1150-62. Epub 2016 Feb 6.

NIH/NIEHS/DNTP/NICEATM, Research Triangle Park, North Carolina, 27709, USA.

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http://dx.doi.org/10.1002/jat.3281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945438PMC
September 2016

A Curated Database of Rodent Uterotrophic Bioactivity.

Environ Health Perspect 2016 05 2;124(5):556-62. Epub 2015 Oct 2.

Integrated Laboratory Systems, in support of the National Toxicology Program Interagency Center for Evaluation of Alternative Toxicological Methods (NICEATM), Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1510183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858395PMC
May 2016

Adverse outcome pathways: From research to regulation scientific workshop report.

Regul Toxicol Pharmacol 2016 Apr 14;76:39-50. Epub 2016 Jan 14.

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.yrtph.2016.01.007DOI Listing
April 2016

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model.

Environ Sci Technol 2015 Jul 26;49(14):8804-14. Epub 2015 Jun 26.

‡U.S. EPA, Office of Research and Development, Research Triangle Park, North Carolina 27709, United States.

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http://dx.doi.org/10.1021/acs.est.5b02641DOI Listing
July 2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Authors:
William H Goodson Leroy Lowe David O Carpenter Michael Gilbertson Abdul Manaf Ali Adela Lopez de Cerain Salsamendi Ahmed Lasfar Amancio Carnero Amaya Azqueta Amedeo Amedei Amelia K Charles Andrew R Collins Andrew Ward Anna C Salzberg Annamaria Colacci Ann-Karin Olsen Arthur Berg Barry J Barclay Binhua P Zhou Carmen Blanco-Aparicio Carolyn J Baglole Chenfang Dong Chiara Mondello Chia-Wen Hsu Christian C Naus Clement Yedjou Colleen S Curran Dale W Laird Daniel C Koch Danielle J Carlin Dean W Felsher Debasish Roy Dustin G Brown Edward Ratovitski Elizabeth P Ryan Emanuela Corsini Emilio Rojas Eun-Yi Moon Ezio Laconi Fabio Marongiu Fahd Al-Mulla Ferdinando Chiaradonna Firouz Darroudi Francis L Martin Frederik J Van Schooten Gary S Goldberg Gerard Wagemaker Gladys N Nangami Gloria M Calaf Graeme Williams Gregory T Wolf Gudrun Koppen Gunnar Brunborg H Kim Lyerly Harini Krishnan Hasiah Ab Hamid Hemad Yasaei Hideko Sone Hiroshi Kondoh Hosni K Salem Hsue-Yin Hsu Hyun Ho Park Igor Koturbash Isabelle R Miousse A Ivana Scovassi James E Klaunig Jan Vondráček Jayadev Raju Jesse Roman John Pierce Wise Jonathan R Whitfield Jordan Woodrick Joseph A Christopher Josiah Ochieng Juan Fernando Martinez-Leal Judith Weisz Julia Kravchenko Jun Sun Kalan R Prudhomme Kannan Badri Narayanan Karine A Cohen-Solal Kim Moorwood Laetitia Gonzalez Laura Soucek Le Jian Leandro S D'Abronzo Liang-Tzung Lin Lin Li Linda Gulliver Lisa J McCawley Lorenzo Memeo Louis Vermeulen Luc Leyns Luoping Zhang Mahara Valverde Mahin Khatami Maria Fiammetta Romano Marion Chapellier Marc A Williams Mark Wade Masoud H Manjili Matilde E Lleonart Menghang Xia Michael J Gonzalez Michalis V Karamouzis Micheline Kirsch-Volders Monica Vaccari Nancy B Kuemmerle Neetu Singh Nichola Cruickshanks Nicole Kleinstreuer Nik van Larebeke Nuzhat Ahmed Olugbemiga Ogunkua P K Krishnakumar Pankaj Vadgama Paola A Marignani Paramita M Ghosh Patricia Ostrosky-Wegman Patricia A Thompson Paul Dent Petr Heneberg Philippa Darbre Po Sing Leung Pratima Nangia-Makker Qiang Shawn Cheng R Brooks Robey Rabeah Al-Temaimi Rabindra Roy Rafaela Andrade-Vieira Ranjeet K Sinha Rekha Mehta Renza Vento Riccardo Di Fiore Richard Ponce-Cusi Rita Dornetshuber-Fleiss Rita Nahta Robert C Castellino Roberta Palorini Roslida Abd Hamid Sabine A S Langie Sakina E Eltom Samira A Brooks Sandra Ryeom Sandra S Wise Sarah N Bay Shelley A Harris Silvana Papagerakis Simona Romano Sofia Pavanello Staffan Eriksson Stefano Forte Stephanie C Casey Sudjit Luanpitpong Tae-Jin Lee Takemi Otsuki Tao Chen Thierry Massfelder Thomas Sanderson Tiziana Guarnieri Tove Hultman Valérian Dormoy Valerie Odero-Marah Venkata Sabbisetti Veronique Maguer-Satta W Kimryn Rathmell Wilhelm Engström William K Decker William H Bisson Yon Rojanasakul Yunus Luqmani Zhenbang Chen Zhiwei Hu

Carcinogenesis 2015 Jun;36 Suppl 1:S254-96

Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://www.ilcambiamento.it/files/carcinogenesi.pdf
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480130PMC
June 2015

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization.

Toxicol Appl Pharmacol 2015 Apr 3;284(2):273-80. Epub 2015 Jan 3.

Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2014.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408226PMC
April 2015

Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds.

Toxicol Appl Pharmacol 2015 Apr 3;284(2):262-72. Epub 2015 Jan 3.

Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2014.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546933PMC
April 2015

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms.

Nat Biotechnol 2014 Jun 18;32(6):583-91. Epub 2014 May 18.

National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1038/nbt.2914DOI Listing
June 2014

Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate.

Toxicol Sci 2013 Dec 17;136(2):308-27. Epub 2013 Sep 17.

* National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711;

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http://dx.doi.org/10.1093/toxsci/kft204DOI Listing
December 2013

A C. elegans screening platform for the rapid assessment of chemical disruption of germline function.

Environ Health Perspect 2013 Jun 19;121(6):717-24. Epub 2013 Apr 19.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 , USA.

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http://dx.doi.org/10.1289/ehp.1206301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672921PMC
June 2013

Predictive models and computational toxicology.

Methods Mol Biol 2013 ;947:343-74

U.S. Environmental Protection Agency, Office of Research and Development, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1007/978-1-62703-131-8_26DOI Listing
April 2013

A computational model predicting disruption of blood vessel development.

PLoS Comput Biol 2013 Apr 4;9(4):e1002996. Epub 2013 Apr 4.

National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1002996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616981PMC
April 2013

In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis.

Toxicol Sci 2013 Jan 28;131(1):40-55. Epub 2012 Sep 28.

National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfs285DOI Listing
January 2013

Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

Chem Res Toxicol 2012 Jul 15;25(7):1287-302. Epub 2012 May 15.

National Center for Computational Toxicology, Office of Research and Development, U. S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

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http://dx.doi.org/10.1021/tx3000939DOI Listing
July 2012

Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay.

PLoS One 2011 7;6(6):e18540. Epub 2011 Jun 7.

National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018540PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110185PMC
December 2011

Disruption of embryonic vascular development in predictive toxicology.

Birth Defects Res C Embryo Today 2011 Dec;93(4):312-23

National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

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http://doi.wiley.com/10.1002/bdrc.20223
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http://dx.doi.org/10.1002/bdrc.20223DOI Listing
December 2011

Environmental impact on vascular development predicted by high-throughput screening.

Environ Health Perspect 2011 Nov 25;119(11):1596-603. Epub 2011 Jul 25.

National Center for Computational Toxiciology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1103412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226499PMC
November 2011

Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.

Toxicol Sci 2011 Nov 26;124(1):109-27. Epub 2011 Aug 26.

National Center for Computational Toxicology, Office of Research & Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

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http://dx.doi.org/10.1093/toxsci/kfr220DOI Listing
November 2011

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.

Toxicology 2011 Mar 18;282(1-2):1-15. Epub 2011 Jan 18.

National Center for Computational Toxicology (B205-01), Office of Research & Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

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http://dx.doi.org/10.1016/j.tox.2010.12.010DOI Listing
March 2011