Publications by authors named "Nicolas Skuli"

42Publications

Even Cancer Cells Watch Their Cholesterol!

Mol Cell 2019 10 2;76(2):220-231. Epub 2019 Oct 2.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225778PMC
October 2019

The Use of Ribavirin as an Anticancer Therapeutic: Will It Go Viral?

Mol Cancer Ther 2019 07;18(7):1185-1194

Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0666DOI Listing
July 2019

Gamma-Glutamyltransferase 1 Promotes Clear Cell Renal Cell Carcinoma Initiation and Progression.

Mol Cancer Res 2019 09 31;17(9):1881-1892. Epub 2019 May 31.

Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726546PMC
September 2019

Inhibition of enhancer of zest homologue 2 is a potential therapeutic target for high-MYC medulloblastoma.

Neuropathology 2019 Apr 10;39(2):71-77. Epub 2019 Jan 10.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://doi.wiley.com/10.1111/neup.12534
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http://dx.doi.org/10.1111/neup.12534DOI Listing
April 2019

Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.

Front Immunol 2018 5;9:2565. Epub 2018 Nov 5.

Perelman School of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02565
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http://dx.doi.org/10.3389/fimmu.2018.02565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230677PMC
September 2019

PPARγ is dispensable for clear cell renal cell carcinoma progression.

Mol Metab 2018 08 21;14:139-149. Epub 2018 May 21.

Abramson Family Cancer Research Institute, USA; Department of Cell and Developmental Biology, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034040PMC
August 2018

Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen.

Oncotarget 2017 Sep 1;8(37):60727-60749. Epub 2017 Jun 1.

Department of Neurosurgery, Ulm University Hospital, Albert-Einstein-Allee, Ulm, Germany.

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http://www.oncotarget.com/fulltext/18337
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http://dx.doi.org/10.18632/oncotarget.18337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617382PMC
September 2017

The Bad, the Good and eIF3e/INT6.

Front Biosci (Landmark Ed) 2017 01 1;22:1-20. Epub 2017 Jan 1.

INSERM U1037, Centre de Recherche en Cancerologie de Toulouse, 2 Avenue Hubert Curien, Toulouse 31100, France,

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http://dx.doi.org/10.2741/4469DOI Listing
January 2017

HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo.

Development 2015 Jul 7;142(14):2405-12. Epub 2015 Jul 7.

Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Howard Hughes Medical Institute, 421 Curie Blvd., Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1242/dev.123026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510864PMC
July 2015

Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis.

Proc Natl Acad Sci U S A 2015 Jun 15;112(26):E3402-11. Epub 2015 Jun 15.

Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104; Howard Hughes Medical Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104

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http://dx.doi.org/10.1073/pnas.1420005112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491775PMC
June 2015

Feedback circuitry between miR-218 repression and RTK activation in glioblastoma.

Sci Signal 2015 May 5;8(375):ra42. Epub 2015 May 5.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scisignal.2005978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437515PMC
May 2015

The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability.

Blood 2015 May 8;125(21):3263-72. Epub 2015 Apr 8.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Howard Hughes Medical Institute, Philadelphia, PA; and.

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http://dx.doi.org/10.1182/blood-2014-10-607267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440881PMC
May 2015

Preclinical evidence that SSR128129E--a novel small-molecule multi-fibroblast growth factor receptor blocker--radiosensitises human glioblastoma.

Eur J Cancer 2014 Sep 18;50(13):2351-9. Epub 2014 Jun 18.

Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse F-31000, France; Institut Claudius Regaud, Toulouse F-31000, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.05.012DOI Listing
September 2014

Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells.

J Cell Sci 2014 Aug 20;127(Pt 16):3555-67. Epub 2014 Jun 20.

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1242/jcs.150862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132393PMC
August 2014

Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells.

Int J Mol Sci 2014 Jan 29;15(2):2172-90. Epub 2014 Jan 29.

INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, 20-24 Rue du Pont St Pierre, 31052 Toulouse, Cedex, France.

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http://dx.doi.org/10.3390/ijms15022172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958844PMC
January 2014

miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma.

Proc Natl Acad Sci U S A 2014 Jan 24;111(1):291-6. Epub 2013 Dec 24.

Abramson Family Cancer Research Institute, Howard Hughes Medical Institute, Penn Molecular Profiling Facility - Bioinformatics Group, and Departments of Cell and Developmental Biology, Pathology and Laboratory Medicine, Cancer Biology, and Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1073/pnas.1314341111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890843PMC
January 2014

Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinomas enhances HIF2α activity.

Cancer Discov 2014 Jan 4;4(1):53-60. Epub 2013 Nov 4.

1Abramson Family Cancer Research Institute; 2Howard Hughes Medical Institute; 3Department of Cell and Developmental Biology; 4Penn Molecular Profiling Facility, Bioinformatics Group; 5Department of Pathology and Laboratory Medicine; 6Department of Cancer Biology; 7Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and 8INSERM U1037, Institut Claudius Regaud, Rue du Pont St Pierre, Toulouse, France.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947282PMC
January 2014

Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.

Cancer Discov 2013 Oct 1;3(10):1190-205. Epub 2013 Aug 1.

1Abramson Family Cancer Research Institute; 2Perelman School of Medicine, University of Pennsylvania; 3The Wistar Institute, Philadelphia, Pennsylvania; Departments of 4Pharmacology and Cancer Biology and 5Radiation Oncology, Duke University Medical Center, Durham, North Carolina; 6Howard Hughes Medical Institute; 7Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts; and 8Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822914PMC
October 2013

ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.

Cancer Cell 2012 Nov;22(5):631-44

Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510660PMC
November 2012

Hypoxia-induced angiogenesis: good and evil.

Genes Cancer 2011 Dec;2(12):1117-33

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/1947601911423654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411127PMC
December 2011

O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling.

Mol Cell Biol 2012 Jan 17;32(1):36-49. Epub 2011 Oct 17.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/MCB.05857-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255700PMC
January 2012

The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology.

Cell Metab 2011 Jan;13(1):8-10

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cmet.2010.12.015DOI Listing
January 2011

Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha.

Cancer Res 2010 Dec 20;70(24):10351-61. Epub 2010 Oct 20.

Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005134PMC
December 2010

Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma.

Cancer Res 2009 Apr 7;69(8):3308-16. Epub 2009 Apr 7.

Institut National de la Santé et de la Recherche Médicale (INSERM) U563, Department of Signaling, Oncogenesis, and Therapeutic Innovation, Toulouse, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2158DOI Listing
April 2009

Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB.

Int J Cancer 2008 Jul;123(2):357-364

Institut Claudius Regaud, INSERMU563, Department of Oncogenesis, Signalling and Therapeutic Innovation, France.

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http://dx.doi.org/10.1002/ijc.23498DOI Listing
July 2008

Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells.

Cancer Res 2006 Jan;66(1):482-9

Institut National de la Sante et de la Recherche Medicale U563, Departement d'Innovation Thérapeutique et Oncologie Moléculaire, Centre de Lutte Contre le Cancer Claudius Regaud, Toulouse Cedex, France.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-2299DOI Listing
January 2006