Publications by authors named "Nicolas Mermod"

52Publications

Genome-wide analysis of single nucleotide variants allows for robust and accurate assessment of clonal derivation in cell lines used to produce biologics.

Authors:
Alexandre Kuhn Valérie Le Fourn Igor Fisch Nicolas Mermod

Biotechnol Bioeng 2020 Aug 11. Epub 2020 Aug 11.

Department of Fundamental Microbiology, Institute of Biotechnology, University of Lausanne, Switzerland.

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August 2020

Transient vitamin B5 starving improves mammalian cell homeostasis and protein production.

Authors:
Lucille Pourcel Flavien Buron Fanny Garcia Margaux-Sarah Delaloix Valérie Le Fourn Pierre-Alain Girod Nicolas Mermod

Metab Eng 2020 07 2;60:77-86. Epub 2020 Apr 2.

Center for Biotechnology and Department of Fundamental Microbiology, University of Lausanne, UNIL-EPFL, Lausanne, Switzerland.

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July 2020

Influence of cytoskeleton organization on recombinant protein expression by CHO cells.

Authors:
Lucille Pourcel Flavien Buron Ghislaine Arib Valérie Le Fourn Alexandre Regamey Iris Bodenmann Pierre-Alain Girod Nicolas Mermod

Biotechnol Bioeng 2020 04 23;117(4):1117-1126. Epub 2020 Feb 23.

Department of Fundamental Microbiology, Institute of Biotechnology, University of Lausanne, Lausanne, Switzerland.

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April 2020

Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells.

Authors:
Audrey Berger Valérie Le Fourn Jacqueline Masternak Alexandre Regamey Iris Bodenmann Pierre-Alain Girod Nicolas Mermod

Biotechnol Bioeng 2020 04 23;117(4):1101-1116. Epub 2020 Feb 23.

Department of Fundamental Microbiology, Institute of Biotechnology, University of Lausanne, Lausanne, Switzerland.

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April 2020

Characterization of mesoangioblast cell fate and improved promyogenic potential of a satellite cell-like subpopulation upon transplantation in dystrophic murine muscles.

Authors:
Lionel O Mavoungou Samuel Neuenschwander Uyen Pham Pavithra S Iyer Nicolas Mermod

Stem Cell Res 2019 12 25;41:101619. Epub 2019 Oct 25.

Institute of Biotechnology and Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland. Electronic address:

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December 2019

Characterization and mutagenesis of Chinese hamster ovary cells endogenous retroviruses to inactivate viral particle release.

Authors:
Pierre-Olivier Duroy Sandra Bosshard Emanuel Schmid-Siegert Samuel Neuenschwander Ghislaine Arib Philippe Lemercier Jacqueline Masternak Lucien Roesch Flavien Buron Pierre-Alain Girod Ioannis Xenarios Nicolas Mermod

Biotechnol Bioeng 2020 02 12;117(2):466-485. Epub 2019 Nov 12.

Institute of Biotechnology and Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.

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February 2020

A role for alternative end-joining factors in homologous recombination and genome editing in Chinese hamster ovary cells.

Authors:
Sandra Bosshard Pierre-Olivier Duroy Nicolas Mermod

DNA Repair (Amst) 2019 10 15;82:102691. Epub 2019 Aug 15.

Institute of Biotechnology and Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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October 2019

Autologous Cell Therapy Approach for Duchenne Muscular Dystrophy using PiggyBac Transposons and Mesoangioblasts.

Authors:
Pavithra S Iyer Lionel O Mavoungou Flavio Ronzoni Joanna Zemla Emanuel Schmid-Siegert Stefania Antonini Laurence A Neff Olivier M Dorchies Marisa Jaconi Malgorzata Lekka Graziella Messina Nicolas Mermod

Mol Ther 2018 04 2;26(4):1093-1108. Epub 2018 Feb 2.

Institute of Biotechnology, University of Lausanne, Lausanne, Switzerland. Electronic address:

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April 2018

Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently express and secrete a protein of interest.

Authors:
Xuan Droz Niamh Harraghy Etienne Lançon Valérie Le Fourn David Calabrese Thierry Colombet Pascal Liechti Amar Rida Pierre-Alain Girod Nicolas Mermod

Biotechnol Bioeng 2017 08 6;114(8):1791-1802. Epub 2017 Jun 6.

Department of Fundamental Microbiology, Institute of Biotechnology, University of Lausanne, Center for Biotechnology UNIL-EPFL, Lausanne, Switzerland.

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August 2017

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering.

Authors:
Kaja Kostyrko Samuel Neuenschwander Thomas Junier Alexandre Regamey Christian Iseli Emanuel Schmid-Siegert Sandra Bosshard Stefano Majocchi Valérie Le Fourn Pierre-Alain Girod Ioannis Xenarios Nicolas Mermod

Biotechnol Bioeng 2017 02 3;114(2):384-396. Epub 2016 Oct 3.

Department of Fundamental Microbiology, Institute of Biotechnology, University of Lausanne, and Center for Biotechnology UNIL-EPFL, Lausanne, Switzerland.

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February 2017

Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms.

Authors:
Kaja Kostyrko Nicolas Mermod

Nucleic Acids Res 2016 Apr 10;44(6):e56. Epub 2015 Dec 10.

Institute of Biotechnology, University of Lausanne, and Center for Biotechnology UNIL-EPFL, Lausanne, Switzerland

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April 2016

A role for homologous recombination proteins in cell cycle regulation.

Authors:
Kaja Kostyrko Sandra Bosshard Zuzanna Urban Nicolas Mermod

Cell Cycle 2015 30;14(17):2853-61. Epub 2015 Jun 30.

a Institute of Biotechnology ; University of Lausanne ; and Center for Biotechnology UNIL-EPFL ; Lausanne , Switzerland.

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June 2016

Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells.

Authors:
Niamh Harraghy David Calabrese Igor Fisch Pierre-Alain Girod Valérie LeFourn Alexandre Regamey Nicolas Mermod

Biotechnol J 2015 Jul 23;10(7):967-78. Epub 2015 Jun 23.

Institute of Biotechnology, University of Lausanne, Lausanne, Switzerland.

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July 2015

A PiggyBac-mediated approach for muscle gene transfer or cell therapy.

Authors:
Déborah Ley Ruthger Van Zwieten Stefania Puttini Pavithra Iyer Alessia Cochard Nicolas Mermod

Stem Cell Res 2014 Nov 8;13(3 Pt A):390-403. Epub 2014 Sep 8.

Institute of Biotechnology, University of Lausanne and Center for Biotechnology UNIL-EPFL, Lausanne, Switzerland. Electronic address:

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November 2014

Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration.

Authors:
Simone Edelmann René Fahrner Thomas Malinka Bryan H Song Deborah Stroka Nicolas Mermod

Liver Int 2015 Apr 25;35(4):1185-94. Epub 2014 Oct 25.

Institute of Biotechnology, University of Lausanne, Lausanne, Switzerland.

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April 2015

Assessing dystrophies and other muscle diseases at the nanometer scale by atomic force microscopy.

Authors:
Ruthger W van Zwieten Stefania Puttini Małgorzata Lekka Guillaume Witz Evelyne Gicquel-Zouida Isabelle Richard Johannes A Lobrinus François Chevalley Harald Brune Giovanni Dietler Andrzej Kulik Thierry Kuntzer Nicolas Mermod

Nanomedicine (Lond) 2014 Apr;9(4):393-406

Laboratory of Molecular Biotechnology, Center for Biotechnology UNIL-EPFL & Institute of Biotechnology, University of Lausanne, Station 6, EPFL, 1015 Lausanne, Switzerland

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April 2014

Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration.

Authors:
Ferenc Deák Lajos Mátés Eva Korpos Agnes Zvara Tibor Szénási Mónika Kiricsi Luca Mendler Anikó Keller-Pintér Béla Ozsvári Hajnalka Juhász Lydia Sorokin László Dux Nicolas Mermod László G Puskás Ibolya Kiss

J Cell Sci 2014 Aug 3;127(Pt 15):3240-56. Epub 2014 Jun 3.

Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, H-6701 Szeged, Hungary Avidin Ltd., H-6726 Szeged, Hungary

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August 2014

Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies.

Authors:
Stefania Puttini Petrica-Adrian Panaite Nicolas Mermod Susanne Renaud Andreas J Steck Thierry Kuntzer

J Neuroimmunol 2014 May 11;270(1-2):61-6. Epub 2014 Mar 11.

Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland. Electronic address:

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May 2014

Optimization of the piggyBac transposon using mRNA and insulators: toward a more reliable gene delivery system.

Authors:
Solenne Bire Déborah Ley Sophie Casteret Nicolas Mermod Yves Bigot Florence Rouleux-Bonnin

PLoS One 2013 3;8(12):e82559. Epub 2013 Dec 3.

GICC, UMR CNRS 7292, Université François Rabelais, Tours, France ; Institute of Biotechnology, University of Lausanne, and Center for Biotechnology UNIL-EPFL, Lausanne, Switzerland ; PRC, UMR INRA-CNRS 7247, Centre INRA Val de Loire, Nouzilly, France.

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February 2015

MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation.

Authors:
Stefania Puttini Ruthger W van Zwieten Damien Saugy Małgorzata Lekka Florence Hogger Deborah Ley Andrzej J Kulik Nicolas Mermod

BMC Mol Biol 2013 Dec 2;14:26. Epub 2013 Dec 2.

Institute of Biotechnology, University of Lausanne, Lausanne, Switzerland.

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December 2013