Nicolas Hohmann

Nicolas Hohmann

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Nicolas Hohmann

Nicolas Hohmann

Publications by authors named "Nicolas Hohmann"

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Simultaneous phenotyping of CYP2E1 and CYP3A using oral chlorzoxazone and midazolam microdoses.

Br J Clin Pharmacol 2019 Oct 9;85(10):2310-2320. Epub 2019 Aug 9.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.14040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783597PMC
October 2019

A follow-up report on potential drug interactions with clementines: Two single case experiments show no effect on CYP3A-dependent midazolam clearance.

Eur J Pharm Sci 2019 May 21;133:54-58. Epub 2019 Mar 21.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.03.013DOI Listing
May 2019

Impact of patient education on plasma concentrations and effectiveness of posaconazole oral suspension under clinical conditions.

Basic Clin Pharmacol Toxicol 2019 Jan 2;124(1):56-61. Epub 2018 Aug 2.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcpt.13093DOI Listing
January 2019

Autoinhibitory properties of the parent but not of the N-oxide metabolite contribute to infusion rate-dependent voriconazole pharmacokinetics.

Br J Clin Pharmacol 2017 Sep 18;83(9):1954-1965. Epub 2017 May 18.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.13297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555860PMC
September 2017

Clementine juice has the potential for drug interactions - In vitro comparison with grapefruit and mandarin juice.

Eur J Pharm Sci 2017 Jan 24;97:247-256. Epub 2016 Nov 24.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2016.11.021DOI Listing
January 2017

Dose-Dependent Bioavailability and CYP3A Inhibition Contribute to Non-Linear Pharmacokinetics of Voriconazole.

Clin Pharmacokinet 2016 12;55(12):1535-1545

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s40262-016-0416-1DOI Listing
December 2016

No Increased Risk of Ketoconazole Toxicity in Drug-Drug Interaction Studies.

J Clin Pharmacol 2016 10 22;56(10):1203-11. Epub 2016 Aug 22.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcph.795DOI Listing
October 2016

First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B.

J Hepatol 2016 09 27;65(3):483-9. Epub 2016 Apr 27.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; German Center for Infection Research (DZIF), Heidelberg Partner Site, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jhep.2016.04.013DOI Listing
September 2016

Treatment with rilpivirine does not alter plasma concentrations of the CYP3A substrates tadalafil and midazolam in humans.

J Antimicrob Chemother 2016 08 1;71(8):2241-7. Epub 2016 May 1.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany

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http://dx.doi.org/10.1093/jac/dkw125DOI Listing
August 2016

Ultrasensitive quantification of the CYP2E1 probe chlorzoxazone and its main metabolite 6-hydroxychlorzoxazone in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry after chlorzoxazone microdosing.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Aug 31;1027:207-13. Epub 2016 May 31.

Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, University of Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2016.05.049DOI Listing
August 2016

Estrogen Receptor Signaling and the PI3K/Akt Pathway Are Involved in Betulinic Acid-Induced eNOS Activation.

Molecules 2016 Jul 25;21(8). Epub 2016 Jul 25.

Department of Pharmacology, Johannes Gutenberg University Medical Center, Obere Zahlbacher Straße 67, Mainz 55131, Germany.

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http://dx.doi.org/10.3390/molecules21080973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273205PMC
July 2016

CYP3A activity: towards dose adaptation to the individual.

Expert Opin Drug Metab Toxicol 2016 May 26;12(5):479-97. Epub 2016 Mar 26.

a Department of Clinical Pharmacology and Pharmacoepidemiology , University Hospital Heidelberg , Heidelberg , Germany.

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http://dx.doi.org/10.1517/17425255.2016.1163337DOI Listing
May 2016

St. John's wort treatment in women bears risks beyond pharmacokinetic drug interactions.

Arch Toxicol 2016 Apr 12;90(4):1013-5. Epub 2015 May 12.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00204-015-1532-7DOI Listing
April 2016

Use of microdose phenotyping to individualise dosing of patients.

Clin Pharmacokinet 2015 Sep;54(9):893-900

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s40262-015-0278-yDOI Listing
September 2015

Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans.

Br J Clin Pharmacol 2015 Feb;79(2):278-85

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.12502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309633PMC
February 2015

Systemic exposure of topical erythromycin in comparison to oral administration and the effect on cytochrome P450 3A4 activity.

Br J Clin Pharmacol 2014 Dec;78(6):1433-40

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.12497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256632PMC
December 2014

Normal CYP3A activity during arsenic trioxide therapy.

Ann Hematol 2014 Nov 16;93(11):1941-2. Epub 2014 Apr 16.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00277-014-2076-2DOI Listing
November 2014

Effects and risks associated with novel psychoactive substances: mislabeling and sale as bath salts, spice, and research chemicals.

Dtsch Arztebl Int 2014 Feb;111(9):139-47

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital.

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http://dx.doi.org/10.3238/arztebl.2014.0139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965957PMC
February 2014