Nicolas Dzamko

Nicolas Dzamko

UNVERIFIED PROFILE

Are you Nicolas Dzamko?   Register this Author

Register author
Nicolas Dzamko

Nicolas Dzamko

Publications by authors named "Nicolas Dzamko"

Are you Nicolas Dzamko?   Register this Author

30Publications

414Reads

50Profile Views

Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells.

J Biol Chem 2019 Sep 2;294(39):14241-14256. Epub 2019 Aug 2.

ForeFront Dementia and Movement Disorders Laboratory, Brain and Mind Centre, Central Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales 2050, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA119.008733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768637PMC
September 2019

Recent Developments in LRRK2-Targeted Therapy for Parkinson's Disease.

Drugs 2019 Jul;79(10):1037-1051

Brain and Mind Centre, Central Clinical School, University of Sydney, Camperdown, NSW, 2050, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40265-019-01139-4DOI Listing
July 2019

Parkinson's progression prediction using machine learning and serum cytokines.

NPJ Parkinsons Dis 2019 25;5:14. Epub 2019 Jul 25.

ForeFront Dementia and Movement Disorders Laboratory, Brain and Mind Centre, Central Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2050 Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41531-019-0086-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658482PMC
July 2019

LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients.

Mov Disord 2019 03 30;34(3):406-415. Epub 2018 Dec 30.

Brain and Mind Centre, Central Clinical School, University of Sydney, Camperdown, NSW, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mds.27601DOI Listing
March 2019

Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.

Neurobiol Dis 2018 12 5;120:76-87. Epub 2018 Sep 5.

Central Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2050, Australia; School of Medical Sciences, Faculty of Medicine, University of New South Wales, Kensington, NSW 2033, Australia; Neuroscience Research Australia, Randwick, NSW 2031, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197399PMC
December 2018

LRRK2 and the Immune System.

Authors:
Nicolas L Dzamko

Adv Neurobiol 2017 ;14:123-143

School of Medical Sciences, University of NSW, Kensington, NSW, 2052, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-49969-7_7DOI Listing
September 2018

LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectives.

Clin Pharmacol 2016 20;8:177-189. Epub 2016 Oct 20.

School of Medical Sciences, Faculty of Medicine, University of New South Wales, Kensington, NSW, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CPAA.S102191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076802PMC
October 2016

Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers.

Mov Disord 2016 06 25;31(6):889-97. Epub 2016 Feb 25.

School of Medical Sciences, University of NSW, Kensington, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mds.26529DOI Listing
June 2016

Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation.

Eur J Med Chem 2015 May 3;95:29-34. Epub 2015 Mar 3.

School of Chemistry, University of Sydney, NSW 2006, Australia; Faculty of Health Sciences, University of Sydney, NSW 2006, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2015.03.003DOI Listing
May 2015

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.

Eur J Med Chem 2013 29;70:758-67. Epub 2013 Oct 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 250 Longwood Ave, SGM 628, Boston, MA 02115, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave, SGM 628, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2013.10.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914206PMC
September 2014

Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.

Front Mol Neurosci 2014 24;7:57. Epub 2014 Jun 24.

School of Medical Sciences, University of New South Wales Kensington, NSW, Australia ; Neuroscience Research Australia Randwick, NSW, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2014.00057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068290PMC
July 2014

Measurement of LRRK2 and Ser910/935 phosphorylated LRRK2 in peripheral blood mononuclear cells from idiopathic Parkinson's disease patients.

J Parkinsons Dis 2013 ;3(2):145-52

School of Medical Sciences, University of NSW and Neuroscience Research Australia, Sydney, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JPD-130174DOI Listing
June 2014

DNA extraction from fresh-frozen and formalin-fixed, paraffin-embedded human brain tissue.

Neurosci Bull 2013 Oct 30;29(5):649-54. Epub 2013 Aug 30.

Neuroscience Research Australia and the University of New South Wales, Sydney, 2031, Australia,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12264-013-1379-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562648PMC
October 2013

An emerging role for LRRK2 in the immune system.

Biochem Soc Trans 2012 Oct;40(5):1134-9

Neuroscience Research Australia, Barker Street, Sydney, NSW 2031, Australia.

View Article

Download full-text PDF

Source
http://biochemsoctrans.org/lookup/doi/10.1042/BST20120119
Publisher Site
http://dx.doi.org/10.1042/BST20120119DOI Listing
October 2012

AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance.

J Biol Chem 2010 Jan 5;285(1):115-22. Epub 2009 Nov 5.

Department of Medicine, St Vincent's Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.056762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804155PMC
January 2010

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.

Biochem J 2009 Oct 23;424(1):47-60. Epub 2009 Oct 23.

MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20091035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759966PMC
October 2009

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

Nat Med 2006 May 9;12(5):541-8. Epub 2006 Apr 9.

Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, 3083, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm1383DOI Listing
May 2006

Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms.

Diabetes 2004 Dec;53(12):3258-66

Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.53.12.3258DOI Listing
December 2004