Nicolas Chomont

Nicolas Chomont

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Nicolas Chomont

Publications by authors named "Nicolas Chomont"

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Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment.

J Vis Exp 2019 Jun 23(148). Epub 2019 Jun 23.

Department of Biological Sciences, Université de Québec à Montréal; Department of Microbiology & Immunology, McGill University; Département de microbiologie, infectiologie et immunologie, Université de Montréal;

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http://dx.doi.org/10.3791/59427DOI Listing
June 2019

Wake me up before you go: a strategy to reduce the latent HIV reservoir.

AIDS 2018 01;32(3):293-298

US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland.

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http://dx.doi.org/10.1097/QAD.0000000000001695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758429PMC
January 2018

Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise.

Retrovirology 2018 01 17;15(1). Epub 2018 Jan 17.

Department of Microbiology, Infectiology and Immunology, Faculté de Médecine, Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1186/s12977-017-0385-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773137PMC
January 2018

Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.

Nat Protoc 2017 Oct 7;12(10):2029-2049. Epub 2017 Sep 7.

Research Centre of the Centre Hospitalier de l'Université de Montréal (CRCHUM) and Université de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/nprot.2017.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697908PMC
October 2017

HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy.

AIDS 2017 01;31(1):35-48

aCHUM-Research Centre bDepartment of Microbiology, Infectiology and Immunology, Faculty of Medicine, Université de Montréal cInstitut de Recherche Clinique de Montréal, Montréal, Québec, Canada dUniversity of California Davis, Davis, California, USA eChronic Viral Illness Service and Research Institute fDivision of Gastroenterology and Hepatology gDivision of Hematology, McGill University Health Centre, Montreal, Québec, Canada.

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http://dx.doi.org/10.1097/QAD.0000000000001309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131694PMC
January 2017

Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.

AIDS 2016 11;30(18):2777-2786

aDepartment of Biological Sciences and BioMed Research Centre, Université du Québec à Montréal (UQAM) bChronic Viral Illness Service and Research Institute, McGill University Health Centre cFaculty of Medicine, McGill University dDepartment of Microbiology, Infectiology and Immunology, Faculty of Medicine, Université de Montréal, and Centre de recherche du CHUM eMetropolitan Centre for Plastic Surgery, Montreal, Québec fDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario gDivision of Hematology, McGill University Health Centre, Montreal, Québec, Canada.

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http://dx.doi.org/10.1097/QAD.0000000000001282DOI Listing
November 2016

HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART.

EBioMedicine 2016 Sep 20;11:68-72. Epub 2016 Jul 20.

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049918PMC
http://dx.doi.org/10.1016/j.ebiom.2016.07.024DOI Listing
September 2016

Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.

Cell Host Microbe 2016 Sep 18;20(3):368-380. Epub 2016 Aug 18.

Research Centre of the Centre Hospitalier de l'Université de Montréal (CRCHUM) and Université de Montréal, Montreal, QC H2X 0A9, Canada; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025389PMC
September 2016

Strategies for targeting residual HIV infection.

Curr Opin HIV AIDS 2016 07;11(4):359-61

aCentre de Recherche du CHUMbDepartment of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montréal, Quebec, CanadacDivision of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1097/COH.0000000000000291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913693PMC
July 2016

Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4+ T cells in HIV-infected individuals on antiretroviral therapy.

AIDS 2016 06;30(10):1511-20

aThe Peter Doherty Institute for Infection and Immunity, University of MelbournebDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, AustraliacDepartment of Microbiology, Infectiology and Immunology, Université de Montréal, Faculty of Medicine, and Centre de Recherche du CHUM, Montréal, Quebec, CanadadDepartment of MedicineeDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889535PMC
June 2016

Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+ T-cell recovery upon virologically suppressive combination antiretroviral therapy.

AIDS 2016 Apr;30(7):991-1003

aClinic of Infectious Diseases bDepartment of Health Sciences, University of Milan cSan Paolo University Hospital, Milan dPathology Unit eMicrobiology Laboratory fBiotechnology Research Centre, Sacred Heart Catholic University, Cremona, Italy gGastroenterology Unit hBiochemistry Laboratory iRoche Innovation Center, Penzberg, Germany jVaccine and Gene Therapy Institute Florida, Port St Lucie, Florida, USA kCentre de Recherche du CHUM et Université de Montréal, Département de Microbiologie, Infectiologie et Immunologie, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1097/QAD.0000000000001015DOI Listing
April 2016

Residual inflammation and viral reservoirs: alliance against an HIV cure.

Curr Opin HIV AIDS 2016 Mar;11(2):234-41

aDepartment of Microbiology, Infectiology and Immunology, Faculté de Médecine, Université de Montréal bCentre de Recherche du CHUM, Montréal, Quebec, Canada *Marta Massanella and Rémi Fromentin equally contributed to the writing of this article.

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http://dx.doi.org/10.1097/COH.0000000000000230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743501PMC
March 2016

Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques.

PLoS Pathog 2016 Feb 1;12(2):e1005412. Epub 2016 Feb 1.

Division of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735119PMC
February 2016

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency.

MBio 2015 Jul 7;6(4):e00465. Epub 2015 Jul 7.

Department of Immunology and Microbial Sciences, The Scripps Research Institute, Jupiter, Florida, USA

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http://dx.doi.org/10.1128/mBio.00465-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495168PMC
July 2015

Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation.

J Gen Virol 2015 Jun 27;96(Pt 6):1463-77. Epub 2015 Jan 27.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada Department of Microbiology, Infectiology and Immunology, Université de Montréal, Québec, Canada Vaccine & Gene Therapy Institute Florida, Port St Lucie, FL, USA Case Western Reserve University, Cleveland, OH, USA

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http://dx.doi.org/10.1099/vir.0.000065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635491PMC
June 2015

HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?

J Virus Erad 2015 Apr;1(2):59-66

Department of Microbiology, Infectiology and Immunology, Université de Montréal, Faculty of Medicine, and Centre de Recherche du CHUM, Montréal, Quebec, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593515PMC
April 2015

How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs?

Curr Opin HIV AIDS 2015 Jan;10(1):18-28

aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland cThe University of North Carolina, Chapel Hill, North Carolina dVaccine and Gene Therapy Institute Florida, Port St Lucie, Florida, USA.

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http://dx.doi.org/10.1097/COH.0000000000000122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271317PMC
January 2015

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy.

PLoS Pathog 2014 Oct 13;10(10):e1004473. Epub 2014 Nov 13.

Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia; Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia; Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1004473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231123PMC
October 2014

Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children.

AIDS 2014 Apr;28(7):1015-20

aThe HIV Netherlands Australia Thailand Research Collaboration bSEARCH, The Thai Red Cross AIDS Research Center cFaculty of Medicine, Department of Medicine dFaculty of Medicine, Department of Pediatrics, Chulalongkorn University eQueen Sirikit National Institute of Child Health fFaculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand gKirby Institute of Infection and Immunity in Society, The University of New South Wales, Sydney, Australia hVaccine and Gene Therapy Institute of Florida, Port St Lucie, Florida, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000178DOI Listing
April 2014

Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection.

J Immunol 2013 Sep 5;191(5):2194-204. Epub 2013 Aug 5.

Laboratoire d'Immunologie, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Saint-Luc, Montreal, Quebec H2X 1P1, Canada.

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http://dx.doi.org/10.4049/jimmunol.1200646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815464PMC
September 2013

High levels of CD2 expression identify HIV-1 latently infected resting memory CD4+ T cells in virally suppressed subjects.

J Virol 2013 Aug 12;87(16):9148-58. Epub 2013 Jun 12.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.01297-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754042PMC
August 2013

The immunological synapse: the gateway to the HIV reservoir.

Immunol Rev 2013 Jul;254(1):305-25

Division of Infectious Diseases, Vaccine and Gene Therapy Institute-Florida (VGTI-FL), Port Saint Lucie, FL 34987, USA.

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http://dx.doi.org/10.1111/imr.12080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707302PMC
July 2013

Immune activation and HIV persistence: implications for curative approaches to HIV infection.

Immunol Rev 2013 Jul;254(1):326-42

Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1111/imr.12065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694608PMC
July 2013

The role of cytokines in the establishment, persistence and eradication of the HIV reservoir.

Cytokine Growth Factor Rev 2012 Aug-Oct;23(4-5):143-9. Epub 2012 Jun 27.

VGTI Florida, Port St. Lucie, FL, USA.

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http://dx.doi.org/10.1016/j.cytogfr.2012.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767481PMC
January 2013

Conference highlights of the 5th international workshop on HIV persistence during therapy, 6-9 December 2011, St. Maartin, West Indies.

AIDS Res Ther 2012 Mar 12;9(1). Epub 2012 Mar 12.

Department of Infectious Diseases, General Hospital, 1208 avenue Colonel Picot, 83056, Toulon, France.

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http://dx.doi.org/10.1186/1742-6405-9-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338393PMC
March 2012

CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy.

J Clin Virol 2012 Jan 22;53(1):29-32. Epub 2011 Oct 22.

Division of Hematology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jcv.2011.09.018DOI Listing
January 2012

Finding a cure for HIV: will it ever be achievable?

J Int AIDS Soc 2011 Jan 24;14. Epub 2011 Jan 24.

Department of Medicine, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1186/1758-2652-14-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037295PMC
January 2011

HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals.

Science 2010 Jul;329(5988):174-80

School of Life Sciences and Frontiers-in-Genetics Program, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1126/science.1191047DOI Listing
July 2010

Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection.

Semin Immunol 2008 Jun 30;20(3):196-203. Epub 2008 Aug 30.

Laboratoire d'Immunologie, Centre de Recherche, Hôpital Saint-Luc, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/j.smim.2008.07.008DOI Listing
June 2008

Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection.

Nat Med 2008 Mar 2;14(3):266-74. Epub 2008 Mar 2.

Laboratoire d'Immunologie, Centre de Recherche, Hôpital Saint-Luc, Centre Hospitalier de l'Université de Montréal, 264 Boulevard Rene-Levesque Est, Montréal, Québec H2X 1P1, Canada.

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http://dx.doi.org/10.1038/nm1728DOI Listing
March 2008

Neutralizing monoclonal antibodies to human immunodeficiency virus type 1 do not inhibit viral transcytosis through mucosal epithelial cells.

Virology 2008 Jan 24;370(2):246-54. Epub 2007 Oct 24.

Université Paris V, et Unité Internationale INSERM 743 (Immunologie Humaine), Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomédicales des Cordeliers, Paris, France.

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http://dx.doi.org/10.1016/j.virol.2007.09.006DOI Listing
January 2008

Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections.

Curr Opin HIV AIDS 2007 May;2(3):219-27

aLaboratoire d'Immunologie, Centre de Recherche CHUM Saint-Luc, Montréal, Québec, Canada bLaboratoire d'Immunologie, Département de Microbiologie et d'Immunologie, Université de Montréal, Québec, Canada cINSERM U743, CR-CHUM, Université de Montréal, Montréal, Québec, Canada dDepartment of Microbiology and Immunology, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1097/COH.0b013e3280ebb5c9DOI Listing
May 2007

Drug resistance mutations and the cellular immune response: a valuable synergy for the development of novel immune therapies.

Curr Opin HIV AIDS 2007 Mar;2(2):116-22

Laboratoire d'Immunologie, Centre de Recherche CHUM Saint-Luc, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1097/COH.0b013e3280287a4dDOI Listing
March 2007

Early archives of genetically-restricted proviral DNA in the female genital tract after heterosexual transmission of HIV-1.

AIDS 2007 Jan;21(2):153-62

Université Paris V, Unité INSERM Internationale d'Immunologie Humaine U743, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomédicales des Cordeliers, and Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Paris, France.

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http://dx.doi.org/10.1097/QAD.0b013e328011f94bDOI Listing
January 2007

Opsonization of HIV with complement enhances infection of dendritic cells and viral transfer to CD4 T cells in a CR3 and DC-SIGN-dependent manner.

J Immunol 2007 Jan;178(2):1086-95

Université René Descartes Paris V and Institut National de la Santé et de la Recherche Médicale, Unité 743, Institut des Cordeliers, Paris, France.

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http://dx.doi.org/10.4049/jimmunol.178.2.1086DOI Listing
January 2007

[Inhibition of the PD-1 pathway restores the effector function of HIV-specific T cells].

Med Sci (Paris) 2007 Jan;23(1):24-5

Laboratoire d'Immunologie, Centre de recherche du Centre Hospitalier de l'Université de Montréal-Saint-Luc, Inserm U743, 264 boulevard René-Lévesque Est, Montréal (Québec) H2X 1P1, Canada.

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http://dx.doi.org/10.1051/medsci/200723124DOI Listing
January 2007

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction.

Nat Med 2006 Oct 20;12(10):1198-202. Epub 2006 Aug 20.

Laboratoire d'Immunologie, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM) Saint-Luc, 264 Rene Levesque Est, Montréal, Québec H2X1P1, Canada.

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http://dx.doi.org/10.1038/nm1482DOI Listing
October 2006

Opsonization of HIV-1 by semen complement enhances infection of human epithelial cells.

J Immunol 2002 Sep;169(6):3301-6

Institut National de la Santé et de la Recherche Médicale, Unité 430, and Université Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.4049/jimmunol.169.6.3301DOI Listing
September 2002