Publications by authors named "Nicolai Doliba"

42Publications

Beta-cell M muscarinic acetylcholine receptors as potential targets for novel antidiabetic drugs.

Int Immunopharmacol 2020 Apr 7;81:106267. Epub 2020 Feb 7.

Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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April 2020

Allosteric modulation of β-cell M muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice.

Proc Natl Acad Sci U S A 2019 09 26;116(37):18684-18690. Epub 2019 Aug 26.

Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;

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September 2019

Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic β cells.

Mol Metab 2019 08 24;26:45-56. Epub 2019 May 24.

Institute for Diabetes, Obesity, and Metabolism and the Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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August 2019

JUND regulates pancreatic β cell survival during metabolic stress.

Mol Metab 2019 07 11;25:95-106. Epub 2019 Apr 11.

Institute for Diabetes, Obesity, and Metabolism and the Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

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July 2019

Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.

JCI Insight 2019 04 23;5. Epub 2019 Apr 23.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.

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April 2019

The Role of Sodium in Diabetic Cardiomyopathy.

Front Physiol 2018 24;9:1473. Epub 2018 Oct 24.

School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States.

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October 2018

Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring.

Environ Health Perspect 2017 09 27;125(9):097022. Epub 2017 Sep 27.

Center for Research on Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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September 2017

Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor.

Mol Metab 2017 10 4;6(10):1240-1253. Epub 2017 Aug 4.

Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.

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October 2017

Functional and Metabolomic Consequences of K Channel Inactivation in Human Islets.

Diabetes 2017 07 25;66(7):1901-1913. Epub 2017 Apr 25.

Division of Endocrinology and Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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July 2017

Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

Mol Metab 2015 Dec 8;4(12):926-39. Epub 2015 Oct 8.

Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, United States; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, United States.

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December 2015

CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo.

Proc Natl Acad Sci U S A 2015 Dec 23;112(49):E6818-24. Epub 2015 Nov 23.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;

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December 2015

Loss-of-function mutations in ABCA1 and enhanced β-cell secretory capacity in young adults.

Diabetes 2015 Jan 14;64(1):193-9. Epub 2014 Aug 14.

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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January 2015

Pdx1 maintains β cell identity and function by repressing an α cell program.

Cell Metab 2014 Feb;19(2):259-71

Gastroenterology Division, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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February 2014

Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice.

PLoS One 2014 5;9(2):e86815. Epub 2014 Feb 5.

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America ; Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia, United States of America.

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November 2014

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.

Am J Physiol Endocrinol Metab 2012 Jan 27;302(1):E87-E102. Epub 2011 Sep 27.

Department of Biochemistry and Biophysics, University of Pennsylvania, 415 Curie Blvd., Philadelphia, PA 19104-6140, USA.

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January 2012

Glucokinase activators for diabetes therapy: May 2010 status report.

Diabetes Care 2011 May;34 Suppl 2:S236-43

Department of Biochemistry and Biophysics and Diabetes Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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May 2011

Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects.

Handb Exp Pharmacol 2011 (203):357-401

Department of Biochemistry and Biophysics, University of Pennsylvania, Institute for Diabetes, Obesity and Metabolism, 415 Curie Blvd, 605 CRB, Philadelphia, PA 19104, USA.

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May 2011

Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets.

Am J Physiol Endocrinol Metab 2010 Sep 6;299(3):E475-85. Epub 2010 Jul 6.

Department of Biochemistry and Biophysics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, 19104-6140, USA.

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September 2010

Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.

Mol Endocrinol 2010 Aug 9;24(8):1594-604. Epub 2010 Jun 9.

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6145, USA.

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August 2010

Analysis of gene expression in pancreatic islets from diet-induced obese mice.

Physiol Genomics 2008 Dec 14;36(1):43-51. Epub 2008 Oct 14.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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December 2008

Foxa2 controls vesicle docking and insulin secretion in mature Beta cells.

Cell Metab 2007 Oct;6(4):267-79

Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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October 2007

Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice.

Endocrinology 2007 Dec 23;148(12):5716-23. Epub 2007 Aug 23.

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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December 2007

Metabolic and ionic coupling factors in amino acid-stimulated insulin release in pancreatic beta-HC9 cells.

Am J Physiol Endocrinol Metab 2007 Jun 30;292(6):E1507-19. Epub 2007 Jan 30.

Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, PA, USA.

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June 2007

Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.

Mol Endocrinol 2007 Mar 21;21(3):765-73. Epub 2006 Dec 21.

Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Boulevard, 560 Clinical Research Building, Philadelphia, Pennsylvania 19104, USA.

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March 2007

Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation.

Diabetes 2006 Oct;55(10):2730-6

Department of Genetics and Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Blvd., Philadelphia, PA 19104-6145, USA.

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October 2006

Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets.

Am J Physiol Endocrinol Metab 2006 Sep 25;291(3):E525-35. Epub 2006 Apr 25.

Dept. of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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September 2006

Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase.

J Biol Chem 2006 Apr 13;281(15):10214-21. Epub 2006 Feb 13.

Donald Danforth Plant Science Center, 975 Warson Road, St. Louis, MO 63132, USA.

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April 2006

Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.

Am J Physiol Endocrinol Metab 2004 May 21;286(5):E834-43. Epub 2004 Jan 21.

Diabetes Research Center, Department of Biochemistry and Biophysics, Univ. of Pennsylvania, Philadelphia, PA 19104-6015, USA.

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May 2004

Insulin independence following isolated islet transplantation and single islet infusions.

Ann Surg 2003 Jun;237(6):741-9; discussion 749-50

Department of Surgery, University of Pennsylvania Health System, Hospital of the University of Pennsylvania, 4th Floor Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA.

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June 2003

Influence of ischemic preconditioning on intracellular sodium, pH, and cellular energy status in isolated perfused heart.

Exp Biol Med (Maywood) 2002 Jul;227(7):520-8

Department of Radiology, 207 Anatomy-Chemistry Building, University of Pennsylvania, 37th and Hamilton Walk, Philadelphia, PA 19104, USA.

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July 2002

Ischemic preconditioning improves mitochondrial tolerance to experimental calcium overload.

J Surg Res 2002 Apr;103(2):243-51

Division of Cardiothoracic Surgery, University of Maryland Medical System, Baltimore, Maryland 21201, USA.

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April 2002

Mitochondrial function during ischemic preconditioning.

Surgery 2002 Feb;131(2):172-8

Division of Cardiothoracic Surgery, University of Maryland Medical System, Baltimore, USA.

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February 2002

Effect of coenzyme Q10 supplementation on mitochondrial function after myocardial ischemia reperfusion.

J Surg Res 2002 Feb;102(2):221-8

Division of Cardiothoracic Surgery, University of Maryland Medical System, Baltimore, Maryland, USA.

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February 2002