Nicola Zamboni

Nicola Zamboni

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Nicola Zamboni

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Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance.

Cell Stem Cell 2020 Mar;26(3):431-440.e8

Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland; Department of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.02.007DOI Listing
March 2020

Metabolomics Identifies a Biomarker Revealing In Vivo Loss of Functional β-Cell Mass Before Diabetes Onset.

Diabetes 2019 12 19;68(12):2272-2286. Epub 2019 Sep 19.

Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, Geneva, Switzerland

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http://dx.doi.org/10.2337/db19-0131DOI Listing
December 2019

Metabolomics reveals tepotinib-related mitochondrial dysfunction in MET-activating mutations-driven models.

FEBS J 2019 Jul 11;286(14):2692-2710. Epub 2019 May 11.

Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Switzerland.

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http://dx.doi.org/10.1111/febs.14852DOI Listing
July 2019

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.

Mol Cell 2019 02 11;73(4):775-787.e10. Epub 2019 Jan 11.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183100
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http://dx.doi.org/10.1016/j.molcel.2018.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396316PMC
February 2019

Quantification of Cellular Folate Species by LC-MS after Stabilization by Derivatization.

Anal Chem 2018 06 5;90(12):7349-7356. Epub 2018 Jun 5.

Institute of Molecular Systems Biology , ETH Zürich , 8093 Zürich , Switzerland.

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http://dx.doi.org/10.1021/acs.analchem.8b00650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011177PMC
June 2018

Liposome-supported peritoneal dialysis in the treatment of severe hyperammonemia: An investigation on potential interactions.

J Control Release 2018 05 27;278:57-65. Epub 2018 Mar 27.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.03.030DOI Listing
May 2018

Metabotypes of breast cancer cell lines revealed by non-targeted metabolomics.

Metab Eng 2017 09 27;43(Pt B):173-186. Epub 2016 Dec 27.

Institute of Molecular Systems Biology, ETH Zurich, CH-8093 Zurich, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967176163027
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http://dx.doi.org/10.1016/j.ymben.2016.12.009DOI Listing
September 2017

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity.

Cell Rep 2017 Aug;20(9):2144-2155

Laboratory of Neural Plasticity, Faculty of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583518PMC
August 2017

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.

J Cell Biol 2017 07 31;216(7):2027-2045. Epub 2017 May 31.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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http://dx.doi.org/10.1083/jcb.201702058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496626PMC
July 2017

Non-targeted LC-MS based metabolomics analysis of the urinary steroidal profile.

Anal Chim Acta 2017 Apr 31;964:112-122. Epub 2017 Jan 31.

Institute of Molecular Systems Biology, ETH Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2017.01.055DOI Listing
April 2017

Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.

Nat Methods 2017 02 12;14(2):187-194. Epub 2016 Dec 12.

Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1038/nmeth.4103DOI Listing
February 2017

Frontiers of high-throughput metabolomics.

Curr Opin Chem Biol 2017 02 5;36:15-23. Epub 2017 Jan 5.

Institute of Molecular Systems Biology, ETH Zurich, Auguste-Piccard-Hof 1, CH-8093 Zurich, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13675931163019
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http://dx.doi.org/10.1016/j.cbpa.2016.12.006DOI Listing
February 2017

An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo.

BMC Genomics 2017 02 15;18(1):169. Epub 2017 Feb 15.

Institute of Molecular Systems Biology, ETH Zurich, Auguste-Piccard-Hof 1, 8093, Zürich, Switzerland.

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http://dx.doi.org/10.1186/s12864-017-3547-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312537PMC
February 2017

Genomewide landscape of gene-metabolome associations in Escherichia coli.

Mol Syst Biol 2017 01 16;13(1):907. Epub 2017 Jan 16.

Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293155PMC
http://dx.doi.org/10.15252/msb.20167150DOI Listing
January 2017

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.

Cell 2016 Oct 13;167(3):829-842.e13. Epub 2016 Oct 13.

Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500, Switzerland; Institute of Microbiology, ETH Zurich, Zurich 8093, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075284PMC
October 2016

SUMOFLUX: A Generalized Method for Targeted 13C Metabolic Flux Ratio Analysis.

PLoS Comput Biol 2016 09 14;12(9):e1005109. Epub 2016 Sep 14.

Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1371/journal.pcbi.1005109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023139PMC
September 2016

Systems proteomics of liver mitochondria function.

Science 2016 Jun;352(6291):aad0189

Laboratory of Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, CH-1015, Switzerland.

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http://dx.doi.org/10.1126/science.aad0189DOI Listing
June 2016

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.

Genes Dev 2016 06;30(11):1255-60

Metabolic Signaling, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland;

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http://dx.doi.org/10.1101/gad.277483.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911925PMC
June 2016

A Genome-Scale Database and Reconstruction of Caenorhabditis elegans Metabolism.

Cell Syst 2016 05 19;2(5):312-22. Epub 2016 May 19.

Research Group Medical Systems Biology, Christian-Albrechts-University Kiel, 24105 Kiel, Germany; Research Group Theoretical Systems Biology, Friedrich Schiller-University (FSU) Jena, 07745 Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.04.017DOI Listing
May 2016

Gut Microbiota Orchestrates Energy Homeostasis during Cold.

Cell 2015 Dec;163(6):1360-74

Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Division of Biosciences, Institute of Structural and Molecular Biology, University College London (UCL), London WC1E 6BT, UK. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)01484-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741501484
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http://dx.doi.org/10.1016/j.cell.2015.11.004DOI Listing
December 2015

Real-time metabolome profiling of the metabolic switch between starvation and growth.

Nat Methods 2015 Nov 14;12(11):1091-7. Epub 2015 Sep 14.

Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/nmeth.3584DOI Listing
November 2015

Dynamic exometabolome analysis reveals active metabolic pathways in non-replicating mycobacteria.

Environ Microbiol 2015 Nov 14;17(11):4802-15. Epub 2015 Oct 14.

Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1111/1462-2920.13056DOI Listing
November 2015

Biological insights through nontargeted metabolomics.

Curr Opin Biotechnol 2015 Aug 22;34:1-8. Epub 2014 Oct 22.

Institute of Molecular Systems Biology, ETH Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2014.10.001DOI Listing
August 2015

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells.

Mol Cell 2015 Aug 16;59(3):359-71. Epub 2015 Jul 16.

Institute of Molecular Systems Biology, ETH Zurich, Auguste-Piccard-Hof 1, 8093 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.06.017DOI Listing
August 2015

Rapid, randomized development of genetically encoded FRET sensors for small molecules.

Analyst 2015 Jul;140(13):4540-8

Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1039/c5an00707kDOI Listing
July 2015

Defining the metabolome: size, flux, and regulation.

Mol Cell 2015 May;58(4):699-706

Department of Chemistry and Department of Medicine, Washington University, St. Louis, MO 63130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831058PMC
May 2015

High-throughput discovery metabolomics.

Curr Opin Biotechnol 2015 Feb 3;31:73-8. Epub 2014 Sep 3.

ETH Zurich, Institute of Molecular Systems Biology, Auguste-Piccard-Hof 1, 8093 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2014.08.006DOI Listing
February 2015

Editorial overview: analytical biotechnology.

Curr Opin Biotechnol 2015 Feb 16;31:iv-vi. Epub 2014 Dec 16.

Molecular Systems Biology, ETH Zurich, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09581669140021
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http://dx.doi.org/10.1016/j.copbio.2014.12.001DOI Listing
February 2015

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population.

Cell 2014 Sep;158(6):1415-1430

Department of Biology, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich (ETHZ), Zurich 8093, Switzerland; Faculty of Science, University of Zurich, Zurich 8057, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179868PMC
September 2014

D-Glucosamine supplementation extends life span of nematodes and of ageing mice.

Nat Commun 2014 Apr 8;5:3563. Epub 2014 Apr 8.

1] Energy Metabolism Laboratory, ETH Zürich (Swiss Federal Institute of Technology Zurich), Zürich CH-8603, Switzerland [2] German Institute of Human Nutrition Potsdam-Rehbrücke, D-14558 Nuthetal, Germany [3] Department of Human Nutrition, Institute of Nutrition, University of Jena, D-07743 Jena, Germany.

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http://dx.doi.org/10.1038/ncomms4563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988823PMC
April 2014

Quantification and mass isotopomer profiling of α-keto acids in central carbon metabolism.

Anal Chem 2014 Mar 24;86(6):3232-7. Epub 2014 Feb 24.

Institute of Molecular Systems Biology, ETH Zurich , Zurich 8093, Switzerland.

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http://dx.doi.org/10.1021/ac500472cDOI Listing
March 2014

Non-stationary (13)C-metabolic flux ratio analysis.

Biotechnol Bioeng 2013 Dec 12;110(12):3164-76. Epub 2013 Aug 12.

Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Str. 16, 8093, Zurich, Switzerland; PhD Program Systems Biology, Life Science Zurich Graduate School, Zurich, Switzerland.

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http://dx.doi.org/10.1002/bit.25004DOI Listing
December 2013

Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast.

Mol Syst Biol 2013 ;9:651

Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/msb.2013.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693829PMC
September 2013

Nontargeted profiling of coenzyme A thioesters in biological samples by tandem mass spectrometry.

Anal Chem 2013 Sep 14;85(17):8284-90. Epub 2013 Aug 14.

Institute of Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli Strasse 16, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1021/ac401555nDOI Listing
September 2013

Metabolite Identification through Machine Learning- Tackling CASMI Challenge Using FingerID.

Metabolites 2013 Jun 6;3(2):484-505. Epub 2013 Jun 6.

Helsinki Institute for Information Technology HIIT; Department of Information and Computer Science, Aalto University, Konemiehentie 2, FI-02150 Espoo, Finland;.

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http://www.mdpi.com/2218-1989/3/2/484
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http://dx.doi.org/10.3390/metabo3020484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901273PMC
June 2013

The integrated response of primary metabolites to gene deletions and the environment.

Mol Biosyst 2013 Mar 23;9(3):440-6. Epub 2013 Jan 23.

Institute of Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli Strasse 16, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1039/c2mb25423aDOI Listing
March 2013

Metabolite identification and molecular fingerprint prediction through machine learning.

Bioinformatics 2012 Sep 18;28(18):2333-41. Epub 2012 Jul 18.

Department of Computer Science, University of Helsinki, Helsinki, 00014, Finland.

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http://dx.doi.org/10.1093/bioinformatics/bts437DOI Listing
September 2012

Identification and functional expression of the mitochondrial pyruvate carrier.

Science 2012 Jul 24;337(6090):93-6. Epub 2012 May 24.

Department of Cell Biology, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1126/science.1218530DOI Listing
July 2012

Multidimensional optimality of microbial metabolism.

Science 2012 May;336(6081):601-4

Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zurich, Zurich, Switzerland.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1216882
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http://dx.doi.org/10.1126/science.1216882DOI Listing
May 2012

Collisional fragmentation of central carbon metabolites in LC-MS/MS increases precision of ¹³C metabolic flux analysis.

Biotechnol Bioeng 2012 Mar 28;109(3):763-71. Epub 2011 Oct 28.

Institute of Molecular Systems Biology, ETH Zurich, Dr. Nicola Zamboni, Wolfgang-Pauli-Str. 16, CH-8093 Zurich, Switzerland.

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http://doi.wiley.com/10.1002/bit.24344
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http://dx.doi.org/10.1002/bit.24344DOI Listing
March 2012

High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry.

Anal Chem 2011 Sep 18;83(18):7074-80. Epub 2011 Aug 18.

Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1021/ac201267kDOI Listing
September 2011

13C metabolic flux analysis in complex systems.

Authors:
Nicola Zamboni

Curr Opin Biotechnol 2011 Feb 15;22(1):103-8. Epub 2010 Sep 15.

Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S095816691000139
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http://dx.doi.org/10.1016/j.copbio.2010.08.009DOI Listing
February 2011

Dynamic flux responses in riboflavin overproducing Bacillus subtilis to increasing glucose limitation in fed-batch culture.

Biotechnol Bioeng 2010 Mar;105(4):795-804

Institute of Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli-Str. 16, CH-8093 Zurich, Switzerland.

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http://doi.wiley.com/10.1002/bit.22591
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http://dx.doi.org/10.1002/bit.22591DOI Listing
March 2010

Novel biological insights through metabolomics and 13C-flux analysis.

Curr Opin Microbiol 2009 Oct 8;12(5):553-8. Epub 2009 Sep 8.

Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.mib.2009.08.003DOI Listing
October 2009

(13)C-based metabolic flux analysis.

Nat Protoc 2009 21;4(6):878-92. Epub 2009 May 21.

Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/nprot.2009.58DOI Listing
August 2009

High-throughput quantitative metabolomics: workflow for cultivation, quenching, and analysis of yeast in a multiwell format.

Anal Chem 2009 May;81(9):3623-9

Institute of Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli Strasse 16, 8093 Zurich, Switzerland.

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http://pubs.acs.org/doi/abs/10.1021/ac900002u
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http://dx.doi.org/10.1021/ac900002uDOI Listing
May 2009

Cross-platform comparison of methods for quantitative metabolomics of primary metabolism.

Anal Chem 2009 Mar;81(6):2135-43

Institute of Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli Strasse 16, 8093 Zurich, Switzerland.

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http://pubs.acs.org/doi/abs/10.1021/ac8022857
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http://dx.doi.org/10.1021/ac8022857DOI Listing
March 2009

From biomarkers to integrated network responses.

Nat Biotechnol 2008 Oct;26(10):1090-2

Institute of Molecular Systems Biology, ETH Zurich, Switzerland.

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http://dx.doi.org/10.1038/nbt1008-1090DOI Listing
October 2008

Screening of Bacillus subtilis transposon mutants with altered riboflavin production.

Metab Eng 2008 Sep 5;10(5):216-26. Epub 2008 Jun 5.

Institute of Molecular Systems Biology, ETH Zurich, CH-8093 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ymben.2008.06.002DOI Listing
September 2008

An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments.

BMC Bioinformatics 2008 Jun 6;9:266. Epub 2008 Jun 6.

Department of Computer Science, University of Helsinki, Finland.

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http://dx.doi.org/10.1186/1471-2105-9-266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430715PMC
June 2008

anNET: a tool for network-embedded thermodynamic analysis of quantitative metabolome data.

BMC Bioinformatics 2008 Apr 16;9:199. Epub 2008 Apr 16.

ETH Zurich, Institute of Molecular Systems Biology, Wolfgang-Pauli Strasse 16, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1186/1471-2105-9-199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375130PMC
April 2008

Genetics. Getting closer to the whole picture.

Science 2007 Apr;316(5824):550-1

Institute of Molecular Systems Biology, ETH Zurich, Switzerland.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1142502
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http://dx.doi.org/10.1126/science.1142502DOI Listing
April 2007

YtsJ has the major physiological role of the four paralogous malic enzyme isoforms in Bacillus subtilis.

J Bacteriol 2006 Jul;188(13):4727-36

Microbiologie et Génétique Moléculaire, INRA (UMR1238) CNRS (UMR2585) and INAP-G, F-78850 Thiverval-Grignon, France.

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http://dx.doi.org/10.1128/JB.00167-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482987PMC
July 2006

Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination.

Genome Biol 2004 16;5(12):R99. Epub 2004 Nov 16.

Institute of Biotechnology, ETH Zürich, CH-8093 Zürich, Switzerland.

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http://dx.doi.org/10.1186/gb-2004-5-12-r99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545802PMC
October 2005

FiatFlux--a software for metabolic flux analysis from 13C-glucose experiments.

BMC Bioinformatics 2005 Aug 25;6:209. Epub 2005 Aug 25.

Institute of Biotechnology, ETH Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1186/1471-2105-6-209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199586PMC
August 2005

Transient expression and flux changes during a shift from high to low riboflavin production in continuous cultures of Bacillus subtilis.

Biotechnol Bioeng 2005 Jan;89(2):219-32

Institute of Biotechnology, ETH Zürich, CH-8093 Zürich, Switzerland.

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http://dx.doi.org/10.1002/bit.20338DOI Listing
January 2005

The phosphoenolpyruvate carboxykinase also catalyzes C3 carboxylation at the interface of glycolysis and the TCA cycle of Bacillus subtilis.

Metab Eng 2004 Oct;6(4):277-84

Institute of Biotechnology, Swiss Federal Institute of Technology Zurich (ETH) ETH Zürich, Zürich 8093, Switzerland.

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http://dx.doi.org/10.1016/j.ymben.2004.03.001DOI Listing
October 2004

High-throughput metabolic flux analysis based on gas chromatography-mass spectrometry derived 13C constraints.

Anal Biochem 2004 Feb;325(2):308-16

Institute of Biotechnology, ETH Zürich CH-8093, Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.ab.2003.10.036DOI Listing
February 2004

Knockout of the high-coupling cytochrome aa3 oxidase reduces TCA cycle fluxes in Bacillus subtilis.

FEMS Microbiol Lett 2003 Sep;226(1):121-6

Institute of Biotechnology, ETH Zürich, CH-8093, Zürich, Switzerland.

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http://dx.doi.org/10.1016/S0378-1097(03)00614-1DOI Listing
September 2003

Reducing maintenance metabolism by metabolic engineering of respiration improves riboflavin production by Bacillus subtilis.

Metab Eng 2003 Jan;5(1):49-55

Institute of Biotechnology, Swiss Federal Institute of Technology Zürich, ETH Zürich, Honggerberg, CH-8093, Zürich, Switzerland.

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http://dx.doi.org/10.1016/s1096-7176(03)00007-7DOI Listing
January 2003