Nicola Whiffin

Nicola Whiffin

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Nicola Whiffin

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31Publications

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Improving the Understanding of Genetic Variants in Rare Disease With Large-scale Reference Populations.

Authors:
Nicola Whiffin James S Ware Anne O'Donnell-Luria

JAMA 2019 Aug 30. Epub 2019 Aug 30.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

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http://dx.doi.org/10.1001/jama.2019.12891DOI Listing
August 2019

Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy.

Authors:
Pablo Garcia-Pavia Yuri Kim Maria Alejandra Restrepo-Cordoba Ida G Lunde Hiroko Wakimoto Amanda M Smith Christopher N Toepfer Kelly Getz Joshua Gorham Parth Patel Kaoru Ito Jonathan A Willcox Zoltan Arany Jian Li Anjali T Owens Risha Govind Beatriz Nuñez Erica Mazaika Antoni Bayes-Genis Roddy Walsh Brian Finkelman Josep Lupon Nicola Whiffin Isabel Serrano William Midwinter Alicja Wilk Alfredo Bardaji Nathan Ingold Rachel Buchan Upasana Tayal Domingo A Pascual-Figal Antonio de Marvao Mian Ahmad Jose Manuel Garcia-Pinilla Antonis Pantazis Fernando Dominguez A John Baksi Declan P O'Regan Stuart D Rosen Sanjay K Prasad Enrique Lara-Pezzi Mariano Provencio Alexander R Lyon Luis Alonso-Pulpon Stuart A Cook Steven R DePalma Paul J R Barton Richard Aplenc Jonathan G Seidman Bonnie Ky James S Ware Christine E Seidman

Circulation 2019 Jul 16;140(1):31-41. Epub 2019 Apr 16.

Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613726PMC
July 2019

Association of Titin-Truncating Genetic Variants With Life-threatening Cardiac Arrhythmias in Patients With Dilated Cardiomyopathy and Implanted Defibrillators.

Authors:
Ben Corden Julian Jarman Nicola Whiffin Upasana Tayal Rachel Buchan Joban Sehmi Andrew Harper William Midwinter Karen Lascelles Vias Markides Mark Mason John Baksi Antonis Pantazis Dudley J Pennell Paul J Barton Sanjay K Prasad Tom Wong Stuart A Cook James S Ware

JAMA Netw Open 2019 Jun 5;2(6):e196520. Epub 2019 Jun 5.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.6520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604081PMC
June 2019

Evaluating the Clinical Validity of Hypertrophic Cardiomyopathy Genes.

Authors:
Jodie Ingles Jennifer Goldstein Courtney Thaxton Colleen Caleshu Edward W Corty Stephanie B Crowley Kristen Dougherty Steven M Harrison Jennifer McGlaughon Laura V Milko Ana Morales Bryce A Seifert Natasha Strande Kate Thomson J Peter van Tintelen Kathleen Wallace Roddy Walsh Quinn Wells Nicola Whiffin Leora Witkowski Christopher Semsarian James S Ware Ray E Hershberger Birgit Funke

Circ Genom Precis Med 2019 02;12(2):e002460

Department of Pathology, Harvard Medical School/Massachusetts General Hospital, Boston (L.W., B.F.).

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http://dx.doi.org/10.1161/CIRCGEN.119.002460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410971PMC
February 2019

Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial.

Authors:
Brian P Halliday Rebecca Wassall Amrit S Lota Zohya Khalique John Gregson Simon Newsome Robert Jackson Tsveta Rahneva Rick Wage Gillian Smith Lucia Venneri Upasana Tayal Dominique Auger William Midwinter Nicola Whiffin Ronak Rajani Jason N Dungu Antonis Pantazis Stuart A Cook James S Ware A John Baksi Dudley J Pennell Stuart D Rosen Martin R Cowie John G F Cleland Sanjay K Prasad

Lancet 2019 01 11;393(10166):61-73. Epub 2018 Nov 11.

Cardiovascular Research Centre and Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)32484-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319251PMC
January 2019

Using High-Resolution Variant Frequencies Empowers Clinical Genome Interpretation and Enables Investigation of Genetic Architecture.

Authors:
Nicola Whiffin Angharad M Roberts Eric Minikel Zach Zappala Roddy Walsh Anne H O'Donnell-Luria Konrad J Karczewski Steven M Harrison Kate L Thomson Helen Sage Alexander Y Ing Paul J R Barton Birgit Funke Stuart A Cook Daniel G MacArthur James S Ware

Am J Hum Genet 2019 01;104(1):187-190

Cardiovascular Genetics and Genomics, National Heart and Lung Institute, Imperial College Centre for Translational and Experimental Medicine, London, W12 0NN, UK; National Institute for Health Research Royal Brompton Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, SW7 2AZ, UK; Medical Research Council London Institute of Medical Sciences, Imperial College London, London, W12 0NN, UK; Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323549PMC
January 2019

Quantitative approaches to variant classification increase the yield and precision of genetic testing in Mendelian diseases: the case of hypertrophic cardiomyopathy.

Authors:
Roddy Walsh Francesco Mazzarotto Nicola Whiffin Rachel Buchan William Midwinter Alicja Wilk Nicholas Li Leanne Felkin Nathan Ingold Risha Govind Mian Ahmad Erica Mazaika Mona Allouba Xiaolei Zhang Antonio de Marvao Sharlene M Day Euan Ashley Steven D Colan Michelle Michels Alexandre C Pereira Daniel Jacoby Carolyn Y Ho Kate L Thomson Hugh Watkins Paul J R Barton Iacopo Olivotto Stuart A Cook James S Ware

Genome Med 2019 01 29;11(1). Epub 2019 Jan 29.

Cardiovascular Research Centre, Cardiovascular Genetics and Genomics group at Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK.

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https://genomemedicine.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13073-019-0616-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350371PMC
January 2019

CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation.

Authors:
Nicola Whiffin Roddy Walsh Risha Govind Matthew Edwards Mian Ahmad Xiaolei Zhang Upasana Tayal Rachel Buchan William Midwinter Alicja E Wilk Hanna Najgebauer Catherine Francis Sam Wilkinson Thomas Monk Laura Brett Declan P O'Regan Sanjay K Prasad Deborah J Morris-Rosendahl Paul J R Barton Elizabeth Edwards James S Ware Stuart A Cook

Genet Med 2018 10 25;20(10):1246-1254. Epub 2018 Jan 25.

National Heart & Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/gim.2017.258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558251PMC
October 2018

Congenital Titinopathy: Comprehensive characterization and pathogenic insights.

Authors:
Emily C Oates Kristi J Jones Sandra Donkervoort Amanda Charlton Susan Brammah John E Smith James S Ware Kyle S Yau Lindsay C Swanson Nicola Whiffin Anthony J Peduto Adam Bournazos Leigh B Waddell Michelle A Farrar Hugo A Sampaio Hooi Ling Teoh Phillipa J Lamont David Mowat Robin B Fitzsimons Alastair J Corbett Monique M Ryan Gina L O'Grady Sarah A Sandaradura Roula Ghaoui Himanshu Joshi Jamie L Marshall Melinda A Nolan Simranpreet Kaur Jaya Punetha Ana Töpf Elizabeth Harris Madhura Bakshi Casie A Genetti Minttu Marttila Ulla Werlauff Nathalie Streichenberger Alan Pestronk Ingrid Mazanti Jason R Pinner Carole Vuillerot Carla Grosmann Ana Camacho Payam Mohassel Meganne E Leach A Reghan Foley Diana Bharucha-Goebel James Collins Anne M Connolly Heather R Gilbreath Susan T Iannaccone Diana Castro Beryl B Cummings Richard I Webster Leïla Lazaro John Vissing Sandra Coppens Nicolas Deconinck Ho-Ming Luk Neil H Thomas Nicola C Foulds Marjorie A Illingworth Sian Ellard Catriona A McLean Rahul Phadke Gianina Ravenscroft Nanna Witting Peter Hackman Isabelle Richard Sandra T Cooper Erik-Jan Kamsteeg Eric P Hoffman Kate Bushby Volker Straub Bjarne Udd Ana Ferreiro Kathryn N North Nigel F Clarke Monkol Lek Alan H Beggs Carsten G Bönnemann Daniel G MacArthur Henk Granzier Mark R Davis Nigel G Laing

Ann Neurol 2018 06;83(6):1105-1124

Harry Perkins Institute, University of Western Australia, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1002/ana.25241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105519PMC
June 2018

Genetic Etiology for Alcohol-Induced Cardiac Toxicity.

Authors:
James S Ware Almudena Amor-Salamanca Upasana Tayal Risha Govind Isabel Serrano Joel Salazar-Mendiguchía Jose Manuel García-Pinilla Domingo A Pascual-Figal Julio Nuñez Gonzalo Guzzo-Merello Emiliano Gonzalez-Vioque Alfredo Bardaji Nicolas Manito Miguel A López-Garrido Laura Padron-Barthe Elizabeth Edwards Nicola Whiffin Roddy Walsh Rachel J Buchan William Midwinter Alicja Wilk Sanjay Prasad Antonis Pantazis John Baski Declan P O'Regan Luis Alonso-Pulpon Stuart A Cook Enrique Lara-Pezzi Paul J Barton Pablo Garcia-Pavia

J Am Coll Cardiol 2018 05;71(20):2293-2302

Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid, Spain; CIBER in Cardiovascular Diseases, Madrid, Spain; University Francisco de Vitoria (UFV), Pozuelo de Alarcón, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.03.462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957753PMC
May 2018

Adaptation and validation of the ACMG/AMP variant classification framework for MYH7-associated inherited cardiomyopathies: recommendations by ClinGen's Inherited Cardiomyopathy Expert Panel.

Authors:
Melissa A Kelly Colleen Caleshu Ana Morales Jillian Buchan Zena Wolf Steven M Harrison Stuart Cook Mitchell W Dillon John Garcia Eden Haverfield Jan D H Jongbloed Daniela Macaya Arjun Manrai Kate Orland Gabriele Richard Katherine Spoonamore Matthew Thomas Kate Thomson Lisa M Vincent Roddy Walsh Hugh Watkins Nicola Whiffin Jodie Ingles J Peter van Tintelen Christopher Semsarian James S Ware Ray Hershberger Birgit Funke

Genet Med 2018 03 4;20(3):351-359. Epub 2018 Jan 4.

Laboratory for Molecular Medicine, Partners Healthcare Personalized Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/gim.2017.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876064PMC
March 2018

Three-dimensional cardiovascular imaging-genetics: a mass univariate framework.

Authors:
Carlo Biffi Antonio de Marvao Mark I Attard Timothy J W Dawes Nicola Whiffin Wenjia Bai Wenzhe Shi Catherine Francis Hannah Meyer Rachel Buchan Stuart A Cook Daniel Rueckert Declan P O'Regan

Bioinformatics 2018 01;34(1):97-103

Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK.

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http://dx.doi.org/10.1093/bioinformatics/btx552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870605PMC
January 2018

Using high-resolution variant frequencies to empower clinical genome interpretation.

Authors:
Nicola Whiffin Eric Minikel Roddy Walsh Anne H O'Donnell-Luria Konrad Karczewski Alexander Y Ing Paul J R Barton Birgit Funke Stuart A Cook Daniel MacArthur James S Ware

Genet Med 2017 10 18;19(10):1151-1158. Epub 2017 May 18.

Cardiovascular Genetics and Genomics, National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/gim.2017.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563454PMC
October 2017

Phenotype and Clinical Outcomes of Titin Cardiomyopathy.

Authors:
Upasana Tayal Simon Newsome Rachel Buchan Nicola Whiffin Brian Halliday Amrit Lota Angharad Roberts A John Baksi Inga Voges Will Midwinter Alijca Wilk Risha Govind Roddy Walsh Piers Daubeney Julian W E Jarman Resham Baruah Michael Frenneaux Paul J Barton Dudley Pennell James S Ware Sanjay K Prasad Stuart A Cook

J Am Coll Cardiol 2017 Oct;70(18):2264-2274

National Heart Lung Institute, Imperial College London, London, United Kingdom; Cardiovascular Research Centre, Royal Brompton Hospital, London, United Kingdom; Medical Research Council London Institute of Medical Sciences, Imperial College London, London, United Kingdom; National Heart Centre, Singapore; Duke-NUS Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.08.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666113PMC
October 2017

Truncating Variants in Titin Independently Predict Early Arrhythmias in Patients With Dilated Cardiomyopathy.

Authors:
Upasana Tayal Simon Newsome Rachel Buchan Nicola Whiffin Roddy Walsh Paul J Barton James S Ware Stuart A Cook Sanjay K Prasad

J Am Coll Cardiol 2017 05;69(19):2466-2468

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http://dx.doi.org/10.1016/j.jacc.2017.03.530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423712PMC
May 2017

Development of a Comprehensive Sequencing Assay for Inherited Cardiac Condition Genes.

Authors:
Chee Jian Pua Jaydutt Bhalshankar Kui Miao Roddy Walsh Shibu John Shi Qi Lim Kingsley Chow Rachel Buchan Bee Yong Soh Pei Min Lio Jaclyn Lim Sebastian Schafer Jing Quan Lim Patrick Tan Nicola Whiffin Paul J Barton James S Ware Stuart A Cook

J Cardiovasc Transl Res 2016 Feb 17;9(1):3-11. Epub 2016 Feb 17.

National Heart Research Institute Singapore, National Heart Centre Singapore, 168752, Singapore, Singapore.

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http://link.springer.com/content/pdf/10.1007%2Fs12265-015-96
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http://link.springer.com/10.1007/s12265-016-9673-5
Publisher Site
http://dx.doi.org/10.1007/s12265-016-9673-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767849PMC
February 2016

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

Authors:
Timothy H T Cheng Deborah Thompson Jodie Painter Tracy O'Mara Maggie Gorman Lynn Martin Claire Palles Angela Jones Daniel D Buchanan Aung Ko Win John Hopper Mark Jenkins Noralane M Lindor Polly A Newcomb Steve Gallinger David Conti Fred Schumacher Graham Casey Graham G Giles Paul Pharoah Julian Peto Angela Cox Anthony Swerdlow Fergus Couch Julie M Cunningham Ellen L Goode Stacey J Winham Diether Lambrechts Peter Fasching Barbara Burwinkel Hermann Brenner Hiltrud Brauch Jenny Chang-Claude Helga B Salvesen Vessela Kristensen Hatef Darabi Jingmei Li Tao Liu Annika Lindblom Per Hall Magdalena Echeverry de Polanco Monica Sans Angel Carracedo Sergi Castellvi-Bel Augusto Rojas-Martinez Samuel Aguiar Jnr Manuel R Teixeira Alison M Dunning Joe Dennis Geoffrey Otton Tony Proietto Elizabeth Holliday John Attia Katie Ashton Rodney J Scott Mark McEvoy Sean C Dowdy Brooke L Fridley Henrica M J Werner Jone Trovik Tormund S Njolstad Emma Tham Miriam Mints Ingo Runnebaum Peter Hillemanns Thilo Dörk Frederic Amant Stefanie Schrauwen Alexander Hein Matthias W Beckmann Arif Ekici Kamila Czene Alfons Meindl Manjeet K Bolla Kyriaki Michailidou Jonathan P Tyrer Qin Wang Shahana Ahmed Catherine S Healey Mitul Shah Daniela Annibali Jeroen Depreeuw Nada A Al-Tassan Rebecca Harris Brian F Meyer Nicola Whiffin Fay J Hosking Ben Kinnersley Susan M Farrington Maria Timofeeva Albert Tenesa Harry Campbell Robert W Haile Shirley Hodgson Luis Carvajal-Carmona Jeremy P Cheadle Douglas Easton Malcolm Dunlop Richard Houlston Amanda Spurdle Ian Tomlinson

Sci Rep 2015 12 1;5:17369. Epub 2015 Dec 1.

Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/srep17369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664893PMC
December 2015

A retrospective observational study of the relationship between single nucleotide polymorphisms associated with the risk of developing colorectal cancer and survival.

Authors:
Eva J A Morris Steve Penegar Nicola Whiffin Peter Broderick D Timothy Bishop Emma Northwood Philip Quirke Paul Finan Richard S Houlston

PLoS One 2015 24;10(2):e0117816. Epub 2015 Feb 24.

Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117816PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339731PMC
November 2015

Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer.

Authors:
Maria N Timofeeva Ben Kinnersley Susan M Farrington Nicola Whiffin Claire Palles Victoria Svinti Amy Lloyd Maggie Gorman Li-Yin Ooi Fay Hosking Ella Barclay Lina Zgaga Sara Dobbins Lynn Martin Evropi Theodoratou Peter Broderick Albert Tenesa Claire Smillie Graeme Grimes Caroline Hayward Archie Campbell David Porteous Ian J Deary Sarah E Harris Emma L Northwood Jennifer H Barrett Gillian Smith Roland Wolf David Forman Hans Morreau Dina Ruano Carli Tops Juul Wijnen Melanie Schrumpf Arnoud Boot Hans F A Vasen Frederik J Hes Tom van Wezel Andre Franke Wolgang Lieb Clemens Schafmayer Jochen Hampe Stephan Buch Peter Propping Kari Hemminki Asta Försti Helga Westers Robert Hofstra Manuela Pinheiro Carla Pinto Manuel Teixeira Clara Ruiz-Ponte Ceres Fernández-Rozadilla Angel Carracedo Antoni Castells Sergi Castellví-Bel Harry Campbell D Timothy Bishop Ian P M Tomlinson Malcolm G Dunlop Richard S Houlston

Sci Rep 2015 Nov 10;5:16286. Epub 2015 Nov 10.

Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom.

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http://dx.doi.org/10.1038/srep16286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639776PMC
November 2015

Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

Authors:
Nada A Al-Tassan Nicola Whiffin Fay J Hosking Claire Palles Susan M Farrington Sara E Dobbins Rebecca Harris Maggie Gorman Albert Tenesa Brian F Meyer Salma M Wakil Ben Kinnersley Harry Campbell Lynn Martin Christopher G Smith Shelley Idziaszczyk Ella Barclay Timothy S Maughan Richard Kaplan Rachel Kerr David Kerr Daniel D Buchanan Aung Ko Win John Hopper Mark Jenkins Noralane M Lindor Polly A Newcomb Steve Gallinger David Conti Fred Schumacher Graham Casey Malcolm G Dunlop Ian P Tomlinson Jeremy P Cheadle Richard S Houlston

Sci Rep 2015 Aug 3;5:12372. Epub 2015 Aug 3.

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http://dx.doi.org/10.1038/srep12372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523102PMC
August 2015

A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

Authors:
Nada A Al-Tassan Nicola Whiffin Fay J Hosking Claire Palles Susan M Farrington Sara E Dobbins Rebecca Harris Maggie Gorman Albert Tenesa Brian F Meyer Salma M Wakil Ben Kinnersley Harry Campbell Lynn Martin Christopher G Smith Shelley Idziaszczyk Ella Barclay Timothy S Maughan Richard Kaplan Rachel Kerr David Kerr Daniel D Buchanan Daniel D Buchannan Aung Ko Win John Hopper Mark Jenkins Noralane M Lindor Polly A Newcomb Steve Gallinger David Conti Fred Schumacher Graham Casey Malcolm G Dunlop Ian P Tomlinson Jeremy P Cheadle Richard S Houlston

Sci Rep 2015 May 20;5:10442. Epub 2015 May 20.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/srep10442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438486PMC
May 2015

Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.

Authors:
Roland Jäger Gabriele Migliorini Marc Henrion Radhika Kandaswamy Helen E Speedy Andreas Heindl Nicola Whiffin Maria J Carnicer Laura Broome Nicola Dryden Takashi Nagano Stefan Schoenfelder Martin Enge Yinyin Yuan Jussi Taipale Peter Fraser Olivia Fletcher Richard S Houlston

Nat Commun 2015 Feb 19;6:6178. Epub 2015 Feb 19.

Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.1038/ncomms7178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346635PMC
February 2015

Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

Authors:
Nicola Whiffin Fay J Hosking Susan M Farrington Claire Palles Sara E Dobbins Lina Zgaga Amy Lloyd Ben Kinnersley Maggie Gorman Albert Tenesa Peter Broderick Yufei Wang Ella Barclay Caroline Hayward Lynn Martin Daniel D Buchanan Aung Ko Win John Hopper Mark Jenkins Noralane M Lindor Polly A Newcomb Steve Gallinger David Conti Fred Schumacher Graham Casey Tao Liu Harry Campbell Annika Lindblom Richard S Houlston Ian P Tomlinson Malcolm G Dunlop

Hum Mol Genet 2014 Sep 15;23(17):4729-37. Epub 2014 Apr 15.

Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK

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http://dx.doi.org/10.1093/hmg/ddu177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133584PMC
September 2014

Putative cis-regulatory drivers in colorectal cancer.

Authors:
Halit Ongen Claus L Andersen Jesper B Bramsen Bodil Oster Mads H Rasmussen Pedro G Ferreira Juan Sandoval Enrique Vidal Nicola Whiffin Alexandra Planchon Ismael Padioleau Deborah Bielser Luciana Romano Ian Tomlinson Richard S Houlston Manel Esteller Torben F Orntoft Emmanouil T Dermitzakis

Nature 2014 Aug 23;512(7512):87-90. Epub 2014 Jul 23.

1] Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland [2] Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland [3] Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1038/nature13602DOI Listing
August 2014

Architecture of inherited susceptibility to colorectal cancer: a voyage of discovery.

Authors:
Nicola Whiffin Richard S Houlston

Genes (Basel) 2014 Mar 27;5(2):270-84. Epub 2014 Mar 27.

Molecular and Population Genetics Team, Genetics and Epidemiology, The Institute of Cancer Research, Sutton, SM2 5NG, UK.

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http://www.mdpi.com/2073-4425/5/2/270
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http://dx.doi.org/10.3390/genes5020270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094933PMC
March 2014

Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer.

Authors:
Nicola Whiffin Sara E Dobbins Fay J Hosking Claire Palles Albert Tenesa Yufei Wang Susan M Farrington Angela M Jones Peter Broderick Harry Campbell Polly A Newcomb Graham Casey David V Conti Fred Schumacher Steve Gallinger Noralane M Lindor John Hopper Mark Jenkins Malcolm G Dunlop Ian P Tomlinson Richard S Houlston

Hum Mol Genet 2013 Dec 30;22(24):5075-82. Epub 2013 Jul 30.

Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.1093/hmg/ddt357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836483PMC
December 2013

Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.

Authors:
Suzanne Floyd Nicola Whiffin Maria P Gavilan Stefan Kutscheidt Maria De Luca Chiara Marcozzi Mingwei Min Johnathan Watkins Kathryn Chung Oliver T Fackler Catherine Lindon

J Cell Sci 2013 Jul 23;126(Pt 13):2845-56. Epub 2013 Apr 23.

University of Cambridge Department of Genetics, Downing Street, Cambridge CB2 3EH, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.123232
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http://dx.doi.org/10.1242/jcs.123232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699108PMC
July 2013

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

Authors:
Malcolm G Dunlop Sara E Dobbins Susan Mary Farrington Angela M Jones Claire Palles Nicola Whiffin Albert Tenesa Sarah Spain Peter Broderick Li-Yin Ooi Enric Domingo Claire Smillie Marc Henrion Matthew Frampton Lynn Martin Graeme Grimes Maggie Gorman Colin Semple Yusanne P Ma Ella Barclay James Prendergast Jean-Baptiste Cazier Bianca Olver Steven Penegar Steven Lubbe Ian Chander Luis G Carvajal-Carmona Stephane Ballereau Amy Lloyd Jayaram Vijayakrishnan Lina Zgaga Igor Rudan Evropi Theodoratou John M Starr Ian Deary Iva Kirac Dujo Kovacević Lauri A Aaltonen Laura Renkonen-Sinisalo Jukka-Pekka Mecklin Koichi Matsuda Yusuke Nakamura Yukinori Okada Steven Gallinger David J Duggan David Conti Polly Newcomb John Hopper Mark A Jenkins Fredrick Schumacher Graham Casey Douglas Easton Mitul Shah Paul Pharoah Annika Lindblom Tao Liu Christopher G Smith Hannah West Jeremy P Cheadle Rachel Midgley David J Kerr Harry Campbell Ian P Tomlinson Richard S Houlston

Nat Genet 2012 May 27;44(7):770-6. Epub 2012 May 27.

Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council (MRC) Human Genetics Unit, Edinburgh, UK.

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http://dx.doi.org/10.1038/ng.2293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747430PMC
May 2012

Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.

Authors:
Steven J Lubbe Nicola Whiffin Ian Chandler Peter Broderick Richard S Houlston

Carcinogenesis 2012 Jan 31;33(1):108-12. Epub 2011 Oct 31.

Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.1093/carcin/bgr243DOI Listing
January 2012

MLH1-93G > A is a risk factor for MSI colorectal cancer.

Authors:
Nicola Whiffin Peter Broderick Steven J Lubbe Alan M Pittman Steven Penegar Ian Chandler Richard S Houlston

Carcinogenesis 2011 Aug 11;32(8):1157-61. Epub 2011 May 11.

Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK.

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http://dx.doi.org/10.1093/carcin/bgr089DOI Listing
August 2011

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.

Authors:
Ian P M Tomlinson Luis G Carvajal-Carmona Sara E Dobbins Albert Tenesa Angela M Jones Kimberley Howarth Claire Palles Peter Broderick Emma E M Jaeger Susan Farrington Annabelle Lewis James G D Prendergast Alan M Pittman Evropi Theodoratou Bianca Olver Marion Walker Steven Penegar Ella Barclay Nicola Whiffin Lynn Martin Stephane Ballereau Amy Lloyd Maggie Gorman Steven Lubbe Bryan Howie Jonathan Marchini Clara Ruiz-Ponte Ceres Fernandez-Rozadilla Antoni Castells Angel Carracedo Sergi Castellvi-Bel David Duggan David Conti Jean-Baptiste Cazier Harry Campbell Oliver Sieber Lara Lipton Peter Gibbs Nicholas G Martin Grant W Montgomery Joanne Young Paul N Baird Steven Gallinger Polly Newcomb John Hopper Mark A Jenkins Lauri A Aaltonen David J Kerr Jeremy Cheadle Paul Pharoah Graham Casey Richard S Houlston Malcolm G Dunlop

PLoS Genet 2011 Jun 2;7(6):e1002105. Epub 2011 Jun 2.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1002105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107194PMC
June 2011