Nicola Normanno

Nicola Normanno

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Nicola Normanno

Nicola Normanno

Publications by authors named "Nicola Normanno"

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Application of the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) to patients conservatively treated: Outcomes from an institutional series.

Eur J Obstet Gynecol Reprod Biol 2019 Sep 13;240:220-225. Epub 2019 Jul 13.

Department of Gynecologic Oncology Surgery, Istituto Nazionale Tumori, IRCSS, "Fondazione G. Pascale", Naples, Italy.

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http://dx.doi.org/10.1016/j.ejogrb.2019.07.013DOI Listing
September 2019

The potential of monitoring treatment response in non-small cell lung cancer using circulating tumour cells.

Expert Rev Mol Diagn 2019 Aug 15;19(8):683-694. Epub 2019 Jul 15.

Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori-IRCCS-"Fondazione G. Pascale" , Naples , Italy.

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http://dx.doi.org/10.1080/14737159.2019.1640606DOI Listing
August 2019

Extracellular matrix proteins as circulating biomarkers for the diagnosis of non-small cell lung cancer patients.

J Thorac Dis 2019 May;11(Suppl 9):S1252-S1256

Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G.Pascale, Naples, Italy.

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http://dx.doi.org/10.21037/jtd.2019.02.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560566PMC
May 2019

The role of circulating free DNA in the management of NSCLC.

Expert Rev Anticancer Ther 2019 01 29;19(1):19-28. Epub 2018 Nov 29.

a Cell Biology and Biotherapy Unit , Istituto Nazionale Tumori, IRCSS, Fondazione G. Pascale , Napoli , Italy.

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http://dx.doi.org/10.1080/14737140.2019.1548938DOI Listing
January 2019

Measuring tumor mutation burden in non-small cell lung cancer: tissue versus liquid biopsy.

Transl Lung Cancer Res 2018 Dec;7(6):668-677

Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori, IRCSS, Fondazione G. Pascale, Napoli, Italy.

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http://tlcr.amegroups.com/article/view/24600/18845
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http://dx.doi.org/10.21037/tlcr.2018.09.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249618PMC
December 2018

The liquid biopsy in the management of colorectal cancer patients: Current applications and future scenarios.

Cancer Treat Rev 2018 Nov 18;70:1-8. Epub 2018 Jul 18.

Medical Oncology, S. Maria Nuova Hospital - IRCCS, Reggio Emilia, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S03057372183012
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http://dx.doi.org/10.1016/j.ctrv.2018.07.007DOI Listing
November 2018

Pharmacokinetic drug evaluation of palbociclib for the treatment of breast cancer.

Expert Opin Drug Metab Toxicol 2018 Sep 3;14(9):891-900. Epub 2018 Sep 3.

a Cell Biology and Biotherapy Unit , Istituto Nazionale Tumori-IRCCS-"Fondazione G. Pascale" , Naples , Italy.

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http://dx.doi.org/10.1080/17425255.2018.1514720DOI Listing
September 2018

International pilot external quality assessment scheme for analysis and reporting of circulating tumour DNA.

BMC Cancer 2018 Aug 9;18(1):804. Epub 2018 Aug 9.

UK NEQAS for Molecular Genetics, Department of Laboratory Medicine, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh, EH16 4SA, UK.

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http://dx.doi.org/10.1186/s12885-018-4694-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085634PMC
August 2018

RANTES and IL-6 cooperate in inducing a more aggressive phenotype in breast cancer cells.

Oncotarget 2018 Apr 3;9(25):17543-17553. Epub 2018 Apr 3.

Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori-IRCCS-"Fondazione G. Pascale", Naples, Italy.

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http://dx.doi.org/10.18632/oncotarget.24784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915136PMC
April 2018

Gene methylation in liquid biopsy and risk of recurrence in lung cancer.

J Thorac Dis 2018 Mar;10(3):1286-1289

Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS, Naples, Italy.

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http://dx.doi.org/10.21037/jtd.2018.02.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906327PMC
March 2018

Review of the implementation of plasma ctDNA testing on behalf of IQN Path ASBL: a perspective from an EQA providers' survey.

Virchows Arch 2017 12 25;471(6):809-813. Epub 2017 Aug 25.

International Quality Network for Pathology (IQN Path ASBL), 3A Sentier de l'Esperance, L-1474, Luxembourg, Luxembourg.

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http://dx.doi.org/10.1007/s00428-017-2222-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711978PMC
December 2017

EGFR mutation prevalence in Asia-Pacific and Russian patients with advanced NSCLC of adenocarcinoma and non-adenocarcinoma histology: The IGNITE study.

Lung Cancer 2017 11 1;113:37-44. Epub 2017 Sep 1.

Department of Thoracic Oncology, LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Centre for Lung Research (DZL), Wöhrendamm 80, Grosshansdorf, 22927, Germany.

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http://dx.doi.org/10.1016/j.lungcan.2017.08.021DOI Listing
November 2017

VEGF as a potential target in lung cancer.

Expert Opin Ther Targets 2017 10 30;21(10):959-966. Epub 2017 Aug 30.

a Cell Biology and Biotherapy Unit , Istituto Nazionale Tumori - IRCCS - 'Fondazione G. Pascale' , Naples , Italy.

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http://dx.doi.org/10.1080/14728222.2017.1371137DOI Listing
October 2017

Angiogenesis Inhibitors in NSCLC.

Int J Mol Sci 2017 Sep 21;18(10). Epub 2017 Sep 21.

Thoracic Medical Oncology, Istituto Nazionale Tumori, "Fondazione G.Pascale"-IRCCS, 80131 Napoli, Italy.

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http://dx.doi.org/10.3390/ijms18102021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666703PMC
September 2017

FGFR-targeted therapeutics for the treatment of breast cancer.

Expert Opin Investig Drugs 2017 Mar 6;26(3):303-311. Epub 2017 Feb 6.

a Cell Biology and Biotherapy Unit , Istituto Nazionale Tumori 'Fondazione G. Pascale'-IRCCS , Naples , Italy.

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http://dx.doi.org/10.1080/13543784.2017.1287173DOI Listing
March 2017

Guide to detecting epidermal growth factor receptor (EGFR) mutations in ctDNA of patients with advanced non-small-cell lung cancer.

Oncotarget 2017 Feb;8(7):12501-12516

Department of Thoracic Oncology, LungenClinic Grosshansdorf, Grosshansdorf, Airway Research Center North (ARCN), Member of the German Centre for Lung Research (DZL), Germany.

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http://dx.doi.org/10.18632/oncotarget.13915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355360PMC
February 2017

Targeting the EGFR T790M mutation in non-small-cell lung cancer.

Expert Opin Ther Targets 2017 Feb 23;21(2):159-165. Epub 2016 Dec 23.

a Cell Biology and Biotherapy Unit , Istituto Nazionale Tumori 'Fondazione G. Pascale'-IRCCS , Naples , Italy.

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http://dx.doi.org/10.1080/14728222.2017.1272582DOI Listing
February 2017

ctDNA Determination of EGFR Mutation Status in European and Japanese Patients with Advanced NSCLC: The ASSESS Study.

J Thorac Oncol 2016 Oct 25;11(10):1682-9. Epub 2016 Jul 25.

Cell Biology and Biotherapy Unit, National Cancer Institute "Pascale Foundation," Institute of Hospitalization and Scientific Care (IRCCS), Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.05.036DOI Listing
October 2016

Efficacy and safety of rechallenge treatment with gefitinib in patients with advanced non-small cell lung cancer.

Lung Cancer 2016 09 14;99:31-7. Epub 2016 Jun 14.

Thoracic Oncology Division, Istituto Europeo di Oncologia (IEO), Via Ripamonti 435, 20141 Milan, Italy, Italy; Formerly Department of Thoracic Oncology, 1st Pulmonary Oncological Unit, Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2016.06.008DOI Listing
September 2016

The prognostic role of circulating tumor cells in lung cancer.

Expert Rev Anticancer Ther 2016 Aug 30;16(8):859-67. Epub 2016 Jun 30.

b Division of Medical Oncology , 'S.G. Moscati' Hospital , Avellino , Italy.

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http://dx.doi.org/10.1080/14737140.2016.1202767DOI Listing
August 2016

Vascular Endothelial Growth Factor A Regulates the Secretion of Different Angiogenic Factors in Lung Cancer Cells.

J Cell Physiol 2016 Jul 24;231(7):1514-21. Epub 2015 Nov 24.

Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS, Naples, Italy.

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http://dx.doi.org/10.1002/jcp.25243DOI Listing
July 2016

Survival After Surgical Treatment of Lung Cancer Arising in the Population Exposed to Illegal Dumping of Toxic Waste in the Land of Fires ('Terra dei Fuochi') of Southern Italy.

Anticancer Res 2016 May;36(5):2119-24

Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, U.S.A. Department of Medicine, Surgery & Neuroscience, University of Siena, Siena, Italy.

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May 2016

RAS testing in metastatic colorectal cancer: advances in Europe.

Virchows Arch 2016 Apr 16;468(4):383-96. Epub 2015 Nov 16.

Institute of Pathology, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1007/s00428-015-1876-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830882PMC
April 2016

EGFR mutations in lung cancer: from tissue testing to liquid biopsy.

Future Oncol 2015 ;11(11):1611-23

1Laboratory of Pharmacogenomics, Centro di Ricerche Oncologiche di Mercogliano (CROM)-Istituto Nazionale Tumori 'Fondazione G. Pascale'-IRCCS, Mercogliano (AV), Italy.

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https://www.futuremedicine.com/doi/10.2217/fon.15.23
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http://dx.doi.org/10.2217/fon.15.23DOI Listing
February 2016

Afatinib: An overview of its clinical development in non-small-cell lung cancer and other tumors.

Crit Rev Oncol Hematol 2016 Jan 12;97:143-51. Epub 2015 Aug 12.

Medical Oncology Unit, Thoracic Department, Istituto Nazionale Tumori, "Fondazione G. Pascale" - IRCCS, Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2015.08.016DOI Listing
January 2016

EGFR and MEK Blockade in Triple Negative Breast Cancer Cells.

J Cell Biochem 2015 Dec;116(12):2778-85

Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS, Naples, Italy.

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http://dx.doi.org/10.1002/jcb.25220DOI Listing
December 2015

[Precision medicine from experimental to clinical applications in oncology].

Authors:
Nicola Normanno

Recenti Prog Med 2015 Dec;106(12):597-600

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http://dx.doi.org/10.1701/2094.22646DOI Listing
December 2015

Evaluation of the pharmacokinetics of ixabepilone for the treatment of breast cancer.

Expert Opin Drug Metab Toxicol 2015 Jul;11(7):1177-85

Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS, Cell Biology and Biotherapy Unit , Naples , Italy +39 081 5903826 ; +39 081 5903826 ; ;

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http://dx.doi.org/10.1517/17425255.2015.1057497DOI Listing
July 2015

Structure-fluctuation-function relationships of seven pro-angiogenic isoforms of VEGFA, important mediators of tumorigenesis.

Biochim Biophys Acta 2015 May 21;1854(5):410-25. Epub 2015 Jan 21.

Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2015.01.005DOI Listing
May 2015

EGFR mutation testing practices within the Asia Pacific region: results of a multicenter diagnostic survey.

J Thorac Oncol 2015 Mar;10(3):438-45

*Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan; †Department of Pathology, Aberdeen University Medical School, Aberdeen, United Kingdom; ‡KalGen Laboratory, Stem-cell and Cancer Institute (SCI), Jakarta, Indonesia; §School of Medicine, Monash University Malaysia & Sime Darby Medical Center, Kuala Lumpur, Malaysia; ‖Center for Gene and Protein Research, Hanoi Medical University, Hanoi, Vietnam; ¶Department of Pathology, Fudan University Shanghai Cancer Center; Institute of Pathology, Fudan University, Shanghai, China; #Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; **Research and Biotechnology Division, St. Luke's Medical Center, Quezon City & COS-CENSER, De La Salle University, Manila, Philippines; ††Department of Pathology, National Cancer Center, Goyang-si, Gyeonggi-do, Korea; ‡‡Department of Pathology, Singapore General Hospital, Singapore, Singapore; §§Chulalongkorn GenePRO Center, Chulalongkorn Hospital, Bangkok, Thailand; ‖‖Seoul National University Bundang Hospital, Seoul, Korea; ¶¶Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; ##Peking Union Medical College Hospital, Beijing, China; ***Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale" - IRCCS, Naples, Italy; †††Division of Hematology/Oncology, Innovative Cancer Medicine Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; ‡‡‡Clinical Genomic Medicine/Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; §§§Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; ‖‖‖University of Melbourne, Melbourne, VIC, Australia; ¶¶¶Sun Yat-Sen University Cancer Center, Guangzhou, China; ###Personalised Healthcare, AstraZeneca, Macclesfield, United Kingdom; ****Clinical Science Division, Astr

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http://dx.doi.org/10.1097/JTO.0000000000000422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342317PMC
March 2015

External quality assessment unravels interlaboratory differences in quality of RAS testing for anti-EGFR therapy in colorectal cancer.

Oncologist 2015 Mar 5;20(3):257-62. Epub 2015 Feb 5.

Biomedical Quality Assurance Research Unit, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands; Cell Biology and Biotherapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale" - IRCCS, Naples, Italy; Department of Pathology, UZ Leuven, Leuven, Belgium

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http://dx.doi.org/10.1634/theoncologist.2014-0382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350801PMC
March 2015

Genomics driven-oncology: challenges and perspectives.

BMC Cancer 2015 Mar 23;15:141. Epub 2015 Mar 23.

Department of Pathology, University Hospital Coventry and Warwickshire, Coventry, CV2 2DX, UK.

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http://dx.doi.org/10.1186/s12885-015-1147-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381449PMC
March 2015

RNA-seq analysis reveals significant effects of EGFR signalling on the secretome of mesenchymal stem cells.

Oncotarget 2014 Nov;5(21):10518-28

Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS, Naples, Italy. Centro di Ricerche Oncologiche di Mercogliano (CROM)-Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS, Mercogliano (AV), Italy.

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http://www.oncotarget.com/fulltext/2420
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279390PMC
http://dx.doi.org/10.18632/oncotarget.2420DOI Listing
November 2014

ALK rearrangement testing by FISH analysis in non-small-cell lung cancer patients: results of the first italian external quality assurance scheme.

J Thorac Oncol 2014 Oct;9(10):1470-6

*Center of Predictive Molecular Medicine, Center of Excellence on Aging, University-Foundation, Chieti, Italy; †Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy; ‡Division of Anatomic Pathology, San Luigi Hospital and University of Turin, Orbassano, Italy; §Pathology Department, Policlinico di Modena, Modena, Italy; ‖Diagnostic and Laboratory Medicine, INT-Fondazione "G.Pascale", Naples, Italy; ¶Medical Oncology Unit, University Hospital, Parma, Italy; #Department of Medical Oncology, Perugia Hospital, Perugia, Italy; **Division of Medical Oncology, S.G. Moscati Hospital, Avellino, Italy; ††Department of Human Pathology and Oncology, University of Florence, Florence, Italy; ‡‡Pathology Department, Casa di Cura San Pio X and I.R.C.C.S. Policlinico San Donato, Milano, Italy; §§Thoracic Oncology Unit, University of Torino, San Luigi Hospital, Torino, Italy; ‖‖Cell Biology and Biotherapy Unit, INT-Fondazione "G.Pascale", Naples, Italy; and ¶¶Medical Oncology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy.

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http://dx.doi.org/10.1097/JTO.0000000000000280DOI Listing
October 2014

Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib.

Cell Cycle 2014 29;13(1):148-56. Epub 2013 Oct 29.

Cell Biology and Biotherapy Unit; Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"; IRCCS; Naples, Italy.

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http://dx.doi.org/10.4161/cc.26899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925726PMC
September 2014

Treatment of small cell lung cancer.

Crit Rev Oncol Hematol 2014 Sep 2;91(3):257-70. Epub 2014 Apr 2.

Clinical Trials Unit, Istituto Nazionale Tumori, "Fondazione G. Pascale" - IRCCS, Napoli, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S10408428140005
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http://dx.doi.org/10.1016/j.critrevonc.2014.03.003DOI Listing
September 2014

Vandetanib as a potential treatment for breast cancer.

Expert Opin Investig Drugs 2014 Sep 4;23(9):1295-303. Epub 2014 Aug 4.

Istituto Nazionale Tumori "Fondazione G. Pascale" - IRCCS, Cell Biology and Biotherapy Unit , Via Mariano Semmola 80131, Naples , Italy +39 081 5903826 ; ,

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http://dx.doi.org/10.1517/13543784.2014.942034DOI Listing
September 2014

Detection of EGFR mutations by TaqMan mutation detection assays powered by competitive allele-specific TaqMan PCR technology.

Biomed Res Int 2013 1;2013:385087. Epub 2013 Dec 1.

Laboratory of Pharmacogenomics, Centro di Ricerche Oncologiche di Mercogliano (CROM), Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"(IRCCS), 83013 Mercogliano, Italy ; Cell Biology and Biotherapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"(IRCCS), 80131 Naples, Italy.

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http://dx.doi.org/10.1155/2013/385087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864078PMC
July 2014

Higher quality of molecular testing, an unfulfilled priority: Results from external quality assessment for KRAS mutation testing in colorectal cancer.

J Mol Diagn 2014 May 14;16(3):371-7. Epub 2014 Mar 14.

Biomedical Quality Assurance Research Unit, Department of Public Health and Primary Care, KU Leuven-University of Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2014.01.003DOI Listing
May 2014

Results of the First Italian External Quality Assurance Scheme for somatic EGFR mutation testing in non-small-cell lung cancer.

J Thorac Oncol 2013 Jun;8(6):773-8

Research Department, Cell Biology and Biotherapy Unit, INT Fondazione G.Pascale, Via M. Semmola, Naples, Italy.

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http://dx.doi.org/10.1097/JTO.0b013e31828c2b08DOI Listing
June 2013

The significance of a Cripto-1 positive subpopulation of human melanoma cells exhibiting stem cell-like characteristics.

Cell Cycle 2013 May 10;12(9):1450-6. Epub 2013 Apr 10.

Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.4161/cc.24601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674072PMC
May 2013

Anaplastic lymphoma kinase: a glimmer of hope in lung cancer treatment?

Expert Rev Anticancer Ther 2013 Apr;13(4):407-20

Pathology Unit, National Cancer Institute, Pascale Hospital, Naples, Italy.

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http://dx.doi.org/10.1586/era.13.18DOI Listing
April 2013

Pharmacokinetic evaluation of capecitabine in breast cancer.

Expert Opin Drug Metab Toxicol 2013 Feb 10;9(2):225-35. Epub 2013 Jan 10.

Clinical Trials Unit, INT-Fondazione Pascale, Naples, Italy.

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http://dx.doi.org/10.1517/17425255.2013.759939DOI Listing
February 2013