Nicola J Stonehouse

Nicola J Stonehouse

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Nicola J Stonehouse

Nicola J Stonehouse

Publications by authors named "Nicola J Stonehouse"

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Structure-function analysis of the equine hepacivirus 5' untranslated region highlights the conservation of translational mechanisms across the hepaciviruses.

J Gen Virol 2019 Nov;100(11):1501-1514

School of Molecular and Cellular Biology, Faculty of Biological Sciences, and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1099/jgv.0.001316DOI Listing
November 2019

The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication.

J Gen Virol 2019 Sep 4;100(9):1293-1302. Epub 2019 Jun 4.

Department of Global Health, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1099/jgv.0.001283DOI Listing
September 2019

Structural and phenotypic analysis of Chikungunya virus RNA replication elements.

Nucleic Acids Res 2019 09;47(17):9296-9312

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1093/nar/gkz640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753490PMC
September 2019

Antimicrobial Peptide LL-37 Facilitates Intracellular Uptake of RNA Aptamer Apt 21-2 Without Inducing an Inflammatory or Interferon Response.

Front Immunol 2019 24;10:857. Epub 2019 Apr 24.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.00857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491520PMC
April 2019

Involvement of a Nonstructural Protein in Poliovirus Capsid Assembly.

J Virol 2019 03 19;93(5). Epub 2019 Feb 19.

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom

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http://dx.doi.org/10.1128/JVI.01447-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384072PMC
March 2019

Recombinant Expression of Tandem-HBc Virus-Like Particles (VLPs).

Methods Mol Biol 2018 ;1776:97-123

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1007/978-1-4939-7808-3_7DOI Listing
February 2019

An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells.

Nat Microbiol 2019 02 26;4(2):280-292. Epub 2018 Nov 26.

Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41564-018-0297-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443042PMC
February 2019

The Oxysterol 25-Hydroxycholesterol Inhibits Replication of Murine Norovirus.

Viruses 2019 01 24;11(2). Epub 2019 Jan 24.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.3390/v11020097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409565PMC
January 2019

Photodynamic inactivation of non-enveloped RNA viruses.

J Photochem Photobiol B 2018 Dec 9;189:87-94. Epub 2018 Oct 9.

School of Biomedical Sciences, University of Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jphotobiol.2018.10.009DOI Listing
December 2018

Photodynamic inactivation of bacteriophage MS2: The A-protein is the target of virus inactivation.

J Photochem Photobiol B 2018 Jan 26;178:404-411. Epub 2017 Nov 26.

School of Biomedical Sciences, University of Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jphotobiol.2017.11.032DOI Listing
January 2018

Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research.

Sci Rep 2017 11 7;7(1):14641. Epub 2017 Nov 7.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1038/s41598-017-15269-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677012PMC
November 2017

Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways.

PLoS Pathog 2017 Oct 2;13(10):e1006666. Epub 2017 Oct 2.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1006666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638621PMC
October 2017

Increasing Type 1 Poliovirus Capsid Stability by Thermal Selection.

J Virol 2017 02 31;91(4). Epub 2017 Jan 31.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom

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http://dx.doi.org/10.1128/JVI.01586-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286869PMC
February 2017

Foot-and-mouth disease virus genome replication is unaffected by inhibition of type III phosphatidylinositol-4-kinases.

J Gen Virol 2016 09 20;97(9):2221-2230. Epub 2016 Jun 20.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1099/jgv.0.000527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042127PMC
September 2016

Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.

J Virol 2016 08 11;90(15):6864-6883. Epub 2016 Jul 11.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom

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http://dx.doi.org/10.1128/JVI.00469-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944275PMC
August 2016

Assembly Pathway of Hepatitis B Core Virus-like Particles from Genetically Fused Dimers.

J Biol Chem 2015 Jun 7;290(26):16238-45. Epub 2015 May 7.

From the School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom and

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http://dx.doi.org/10.1074/jbc.M114.622035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481223PMC
June 2015

The Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in Cervical Cancer Cells and Its Perturbation by RNA Aptamers.

Viruses 2015 Jun 26;7(7):3443-61. Epub 2015 Jun 26.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.3390/v7072780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517109PMC
June 2015

Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers.

J Gen Virol 2014 Dec 5;95(Pt 12):2649-57. Epub 2014 Aug 5.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK

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http://dx.doi.org/10.1099/vir.0.067751-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233629PMC
December 2014

An RNA Aptamer Targets the PDZ-Binding Motif of the HPV16 E6 Oncoprotein.

Cancers (Basel) 2014 Jul 24;6(3):1553-69. Epub 2014 Jul 24.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.3390/cancers6031553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190555PMC
July 2014

Probing bunyavirus N protein oligomerisation using mass spectrometry.

Rapid Commun Mass Spectrom 2014 Apr;28(7):793-800

Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1002/rcm.6841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377080PMC
April 2014

IL-17A RNA aptamer: possible therapeutic potential in some cells, more than we bargained for in others?

J Invest Dermatol 2014 Mar 20;134(3):852-855. Epub 2013 Sep 20.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Centre for Skin Sciences, School of Life Sciences, University of Bradford, Bradford, UK; Department of Dermatology, St Luke's Hospital, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK; Chapel Allerton Hospital, Leeds Musculoskeletal Biomedical Research Unit, National Institute for Health Research, Leeds, UK. Electronic address:

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http://dx.doi.org/10.1038/jid.2013.399DOI Listing
March 2014

An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein.

PLoS One 2013 30;8(5):e64781. Epub 2013 May 30.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064781PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667794PMC
January 2014

Formation of higher-order foot-and-mouth disease virus 3D(pol) complexes is dependent on elongation activity.

J Virol 2012 Feb 7;86(4):2371-4. Epub 2011 Dec 7.

Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1128/JVI.05696-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302376PMC
February 2012

Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner.

J Virol 2011 Jul 18;85(14):7460-4. Epub 2011 May 18.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Mount Preston Street, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1128/JVI.00393-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126559PMC
July 2011

Effects of single nucleotide changes on the binding and activity of RNA aptamers to human papillomavirus 16 E7 oncoprotein.

Biochem Biophys Res Commun 2011 Feb 14;405(3):417-21. Epub 2011 Jan 14.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1016/j.bbrc.2011.01.044DOI Listing
February 2011

RNA-induced conformational changes in a viral coat protein studied by hydrogen/deuterium exchange mass spectrometry.

Phys Chem Chem Phys 2010 Nov 28;12(41):13468-75. Epub 2010 Sep 28.

Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UKLS2 9JT.

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http://dx.doi.org/10.1039/c0cp00817fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782220PMC
November 2010

Determining the topology of virus assembly intermediates using ion mobility spectrometry-mass spectrometry.

Rapid Commun Mass Spectrom 2010 Oct;24(20):3033-3042

Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1002/rcm.4732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789508PMC
October 2010

All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding.

J Virol 2010 Sep 30;84(18):9267-77. Epub 2010 Jun 30.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1128/JVI.00616-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937630PMC
September 2010

The impact of viral RNA on assembly pathway selection.

J Mol Biol 2010 Aug 1;401(2):298-308. Epub 2010 Jun 1.

Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1016/j.jmb.2010.05.059DOI Listing
August 2010

Viral genomic single-stranded RNA directs the pathway toward a T=3 capsid.

J Mol Biol 2010 Feb 12;395(5):924-36. Epub 2009 Nov 12.

Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1016/j.jmb.2009.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785722PMC
February 2010

Insights into virus capsid assembly from non-covalent mass spectrometry.

Mass Spectrom Rev 2008 Nov-Dec;27(6):575-95

Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1002/mas.20176DOI Listing
February 2009

A simple, RNA-mediated allosteric switch controls the pathway to formation of a T=3 viral capsid.

J Mol Biol 2007 Jun 15;369(2):541-52. Epub 2007 Mar 15.

Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1016/j.jmb.2007.03.020DOI Listing
June 2007

Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus.

RNA 2006 Nov 3;12(11):1970-9. Epub 2006 Oct 3.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1261/rna.161006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1624902PMC
November 2006

Affinity of molecular interactions in the bacteriophage phi29 DNA packaging motor.

Nucleic Acids Res 2006 19;34(9):2698-709. Epub 2006 May 19.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1093/nar/gkl318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464111PMC
May 2006

Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2.

Structure 2006 Mar;14(3):487-95

Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1016/j.str.2005.12.006DOI Listing
March 2006

Engineering thermal stability in RNA phage capsids via disulphide bonds.

J Nanosci Nanotechnol 2005 Dec;5(12):2034-41

Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1166/jnn.2005.507DOI Listing
December 2005