Publications by authors named "Nicola Hughes"

37Publications

2020 White Paper on Recent Issues in Bioanalysis: BMV of Hybrid Assays, Acoustic MS, HRMS, Data Integrity, Endogenous Compounds, Microsampling and Microbiome ( - Recommendations on Industry/Regulators Consensus on BMV of Biotherapeutics by LCMS, Advanced Application in Hybrid Assays, Regulatory Challenges in Mass Spec, Innovation in Small Molecules, Peptides and Oligos).

Authors:
Hendrik Neubert Stephen C Alley Anita Lee Wenying Jian Michael Buonarati Anna Edmison Fabio Garofolo Boris Gorovits Sam Haidar Bill Mylott Parya Nouri Mark Qian Stephen Vinter Troy Voelker Jan Welink Jiang Wu Eric Yang Hongbin Yu Chris Evans Scott Summerfield Jian Wang Kevin Bateman Jason Boer Brian Dean Lieve Dillen Patrick Faustino Luca Ferrari Nicola Hughes Lina Luo Timothy Olah Noah Post Daniel S Spellman Jens Sydor Hui Zhang Jenny Zhang Jinhui Zhang Christine Fandozzi Amanda Wilson Daniela Fraier Christopher J Beaver Suman Dandamudi Arindam Dasgupta Rebecca Elliott Allena Ji Wenkui Li Michael McGuinness Gustavo Mendes Lima Santos Tahseen Mirza Natasha Savoie Diaa Shakleya Sune Sporring Susan Stojdl Phillip Sundman Nilufer Tampal Eric Woolf

Bioanalysis 2021 Jan 20. Epub 2021 Jan 20.

Merck, West Point, PA, USA.

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January 2021

Risk stratification of young adult survivors of cancer to estimate hospital morbidity burden: applicability of a pediatric therapy-based approach.

Authors:
Christopher Clements Kirsten J Cromie Lesley Smith Richard G Feltbower Nicola Hughes Adam W Glaser

J Cancer Surviv 2020 Sep 16. Epub 2020 Sep 16.

Leeds Teaching Hospitals NHS Trust, Beckett Street, Leeds, LS9 7TF, UK.

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September 2020

Subperiosteal hematoma of the iliac wing presenting with leg weakness in a young adult footballer.

Authors:
John P Hynes Richard E Downey Nicola Hughes Conor J O'Keane Eoin Kavanagh

Radiol Case Rep 2020 Apr 12;15(4):424-426. Epub 2020 Feb 12.

Department of Radiology, Mater Misericordiae University Hospital, Dublin, Ireland.

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April 2020

12th GCC Closed Forum: critical reagents; oligonucleotides; CoA; method transfer; HRMS; flow cytometry; regulatory findings; stability and immunogenicity.

Authors:
Chad Briscoe Nicola Hughes Roger Hayes Rafiq Islam Patrick Bennett Bruce Stouffer Stephanie Cape Paul Rhyne Chris Beaver Jessica St Charles Vellalore Kakkanaiah Allan Xu Maria Cruz Caturla Franklin Spriggs Rabab Tayyem Colin Barry Anahita Keyhani Jennifer Zimmer Philippe Couerbe Mark Warren Ardeshir Khadang James Bourdage Kathie Lindley Dave Williams Curtis Sheldon Christina Satterwhite Jenifer Vija Mathilde Yu Iohann Boulay John Stamatopoulos Jenny Lin Sian Estdale Eric Thomas Andrew Dinan Robert MacNeill Yi Qun Xiao Luca Matassa Wei Garofolo Natasha Savoie George Hristopoulos Arron Xu Lawrence Goodwin Kayode Awaiye Hanna Ritzén Mohammed Bouhajib Chantal Di Marco Simona Rizea Savu Corey Nehls Edward Tabler Amanda Hays Shane Karnik Michael Brown Steve Lowes Ira DuBey Nadia Kulagina John Lindsay Clark Williard Hao Wang Michele Malone Edward Wells Xinping Fang Marc Moussallie

Bioanalysis 2019 Jun 19;11(12):1129-1138. Epub 2019 Jul 19.

WuXi Apptec, Plainsboro, NJ 08536, USA.

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June 2019

Combining structural and textural assessments of volumetric FDG-PET uptake in NSCLC.

Authors:
Eric Wolsztynski Janet O'Sullivan Nicola M Hughes Tian Mou Peter Murphy Finbarr O'Sullivan Kevin O'Regan

IEEE Trans Radiat Plasma Med Sci 2019 Jul 24;3(4):421-433. Epub 2019 Apr 24.

Department of Radiology, Cork University Hospital, Cork, Ireland.

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July 2019

Whole-body MRI of bone marrow: A review.

Authors:
John P Hynes Nicola Hughes Patricia Cunningham Eoin C Kavanagh Stephen J Eustace

J Magn Reson Imaging 2019 12 23;50(6):1687-1701. Epub 2019 Apr 23.

Mater Misericordiae University Hospital, Dublin, Republic of Ireland.

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December 2019

Recommendations for classification of commercial LBA kits for biomarkers in drug development from the GCC for bioanalysis.

Authors:
Rafiq Islam Sumit Kar Hanna Ritzén Amanda Hays Rabab Tayyem Colin Barry Anahita Keyhani Jennifer Zimmer Maria Cruz Caturla Philippe Couerbe Mark Warren Ardeshir Khadang James Bourdage Kathie Lindley Dave Williams Nicola Hughes Curtis Sheldon Christina Satterwhite Jenifer Vija Mathilde Yu Iohann Boulay John Stamatopoulos Jenny Lin Stephanie Cape Sian Estdale Eric Thomas Andrew Dinan Robert MacNeill Yi Qun Xiao Wei Garofolo Natasha Savoie Michael Brown Paul Rhyne George Hristopoulos Arron Xu Lawrence Goodwin Franklin Spriggs Allan Xu Kayode Awaiye Roger Hayes Jessica St Charles Mohammed Bouhajib Chantal DiMarco Luigi DiMarco Simona Rizea Savu Patrick Bennett Vellalore Kakkanaiah Corey Nehls Bruce Stouffer Edward Tabler Chad Briscoe Shane Karnik Ira DuBey Nadia Kulagina John Lindsay Chris Beaver Clark Williard Hao Wang Hao Feng Michele Malone Edward Wells Xinping Fang Marc Moussallie

Bioanalysis 2019 Apr 17;11(7):645-653. Epub 2019 Apr 17.

WuXi Apptec, Plainsboro, NJ, USA.

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April 2019

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

Authors:
Anna Schubart Karen Anderson Nello Mainolfi Holger Sellner Takeru Ehara Christopher M Adams Aengus Mac Sweeney Sha-Mei Liao Maura Crowley Amanda Littlewood-Evans Sophie Sarret Grazyna Wieczorek Ludovic Perrot Valérie Dubost Thierry Flandre Yuzhou Zhang Richard J H Smith Antonio M Risitano Rajeshri G Karki Chun Zhang Eric Valeur Finton Sirockin Bernd Gerhartz Paulus Erbel Nicola Hughes Thomas M Smith Frederic Cumin Upendra A Argikar Börje Haraldsson Muneto Mogi Richard Sedrani Christian Wiesmann Bruce Jaffee Jürgen Maibaum Stefanie Flohr Richard Harrison Jörg Eder

Proc Natl Acad Sci U S A 2019 04 29;116(16):7926-7931. Epub 2019 Mar 29.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland;

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April 2019

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.

Authors:
Jean Quancard Theo Klein Shan-Yu Fung Martin Renatus Nicola Hughes Laura Israël John J Priatel Sohyeong Kang Michael A Blank Rosa I Viner Jutta Blank Achim Schlapbach Paul Erbel Jayachandran Kizhakkedathu Frédéric Villard René Hersperger Stuart E Turvey Joerg Eder Frédéric Bornancin Christopher M Overall

Nat Chem Biol 2019 03 28;15(3):304-313. Epub 2019 Jan 28.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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March 2019

2018 White Paper on Recent Issues in Bioanalysis: 'A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)' (Part 1 - small molecule regulated bioanalysis, small molecule biomarkers, peptides & oligonucleotide bioanalysis).

Authors:
Jan Welink Yuanxin Xu Eric Yang Amanda Wilson Neil Henderson Lina Luo Stephanie Fraser Uma Kavita Adrien Musuku Christopher James Daniela Fraier Yan Zhang Dina Goykhman Scott Summerfield Eric Woolf Tom Verhaeghe Nicola Hughes Alexander Behling Kirk Brown Alex Bulychev Michael Buonarati Elana Cherry Seongeun Julia Cho Isabelle Cludts Lieve Dillen Robert Dodge Anna Edmison Fabio Garofolo Rachel Green Sam Haidar Charles Hottenstein Akiko Ishii-Watabe Hyun Gyung Jang Allena Ji Barry Jones Sean Kassim Mark Ma Gustavo Mendes Lima Santos Daniel A Norris Tate Owen Steven Piccoli Ragu Ramanathan Ingo Röhl Anton I Rosenbaum Yoshiro Saito Timothy Sangster Natasha Savoie Christopher Stebbins Jens Sydor Nico van de Merbel Daniela Verthelyi Stephen Vinter Emma Whale

Bioanalysis 2018 Nov 29;10(22):1781-1801. Epub 2018 Nov 29.

UK MHRA, London, UK.

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November 2018

Therapeutic Intervention in Musculoskeletal Radiology: Current Practice and Future Directions.

Authors:
John P Walsh Terence P Farrell John Hynes Nicola Hughes Ciara O'Byrne Stephen J Eustace

Semin Musculoskelet Radiol 2018 Nov 6;22(5):546-563. Epub 2018 Nov 6.

Cappagh National Orthopedic Hospital, Dublin, Ireland.

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November 2018

A Case of Recurrent Painful Ophthalmoplegic Neuropathy with Associated Oculomotor Nerve Tumour.

Authors:
Patrick Moloney Nicola M Hughes Ronan P Killeen Sean O' Riordan

Neuroophthalmology 2020 Feb 26;44(1):28-33. Epub 2018 Oct 26.

Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland.

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February 2020

The management of adolescents and young adults with cancer.

Authors:
Nicola Hughes Dan Stark

Cancer Treat Rev 2018 Jun 7;67:45-53. Epub 2018 May 7.

Leeds Institute of Cancer and Pathology, St James's Institute of Oncology, Beckett Street, Leeds, UK.

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June 2018

11th GCC Closed Forum: cumulative stability; matrix stability; immunogenicity assays; laboratory manuals; biosimilars; chiral methods; hybrid LBA/LCMS assays; fit-for-purpose validation; China Food and Drug Administration bioanalytical method validation.

Authors:
Rafiq Islam Chad Briscoe Joseph Bower Stephanie Cape Mark Arnold Roger Hayes Mark Warren Shane Karnik Bruce Stouffer Yi Qun Xiao Barry van der Strate Daniel Sikkema Xinping Fang Ariana Tudoroniu Rabab Tayyem Ashley Brant Franklin Spriggs Colin Barry Masood Khan Anahita Keyhani Jennifer Zimmer Maria Cruz Caturla Philippe Couerbe Ardeshir Khadang James Bourdage Jim Datin Jennifer Zemo Nicola Hughes Saadya Fatmi Curtis Sheldon Scott Fountain Christina Satterwhite Kelly Colletti Jenifer Vija Mathilde Yu John Stamatopoulos Jenny Lin Jim Wilfahrt Andrew Dinan Susan Ohorodnik James Hulse Vimal Patel Wei Garofolo Natasha Savoie Michael Brown Damon Papac Mike Buonarati George Hristopoulos Chris Beaver Nadine Boudreau Clark Williard Yansheng Liu Gene Ray Dominic Warrino Allan Xu Rachel Green Joanne Hayward-Sewell John Marcelletti Christina Sanchez Michael Kennedy Jessica St Charles Mohammed Bouhajib Corey Nehls Edward Tabler Jing Tu Philip Joyce Adriana Iordachescu Ira DuBey John Lindsay Jim Yamashita Edward Wells

Bioanalysis 2018 Apr 27;10(7):433-444. Epub 2018 Apr 27.

Worldwide Clinical Trials, Austin, TX, USA.

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April 2018

2017 White Paper on recent issues in bioanalysis: aren't BMV guidance/guidelines 'Scientific'? (Part 1 - LCMS: small molecules, peptides and small molecule biomarkers).

Authors:
Jan Welink Eric Yang Nicola Hughes Brian Rago Eric Woolf Jens Sydor Laura Coppola Brad Ackermann Wenkui Li Stephen C Alley Mark Arnold Isabella Berger Chad Briscoe Michael Buonarati Mark Bustard Mark Cancilla Seongeun Julia Cho Jeff Duggan Daniela Fraier Fabio Garofolo Rachel Green Sam Haidar Lucinda Hittle Akiko Ishii-Watabe Rafiq Islam Rand Jenkins Barry Jones John Kadavil Sean Kassim Olga Kavetska Olivier Le Blaye Anita Lee Hanlan Liu John Mehl Gustavo Mendes Lima Santos Adrien Musuku Ragu Ramanathan Yoshiro Saito Natasha Savoie Scott Summerfield Sekhar Surapaneni Matthew Szapacs Nilufer Tampal Tom Verhaeghe Stephen Vinter Emma Whale

Bioanalysis 2017 Nov 17;9(22):1807-1825. Epub 2017 Nov 17.

UK MHRA, London, UK.

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November 2017

Sonographic differences between conventional and follicular variant papillary thyroid carcinoma.

Authors:
Nicola M Hughes Andreea Nae Josephine Barry Brendan Fitzgerald Linda Feeley Patrick Sheahan

Eur Arch Otorhinolaryngol 2017 Jul 10;274(7):2907-2913. Epub 2017 Apr 10.

Department of Otolaryngology, Head and Neck Surgery, South Infirmary Victoria University Hospital, Cork, Ireland.

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July 2017

The 10th GCC Closed Forum: rejected data, GCP in bioanalysis, extract stability, BAV, processed batch acceptance, matrix stability, critical reagents, ELN and data integrity and counteracting fraud.

Authors:
Stephanie Cape Rafiq Islam Corey Nehls John Allinson Afshin Safavi Patrick Bennett James Hulse Chris Beaver Masood Khan Shane Karnik Maria Cruz Caturla Steve Lowes Adriana Iordachescu Luigi Silvestro Rabab Tayyem Ron Shoup Stephanie Mowery Anahita Keyhani Andrea Wakefield Yinghe Li Jennifer Zimmer Javier Torres Philippe Couerbe Ardeshir Khadang James Bourdage Nicola Hughes Kayode Awaiye Brent Matthews Saadya Fatmi Rhonda Johnson Christina Satterwhite Mathilde Yu Jenny Lin Laura Cojocaru Michele Fiscella Eric Thomas Kai Kurylak John Kamerud Zhongping John Lin Wei Garofolo Natasha Savoie Mike Buonarati Nadine Boudreau Clark Williard Yansheng Liu Dominic Warrino Prashant Kale Neil Adcock Radha Shekar Edward O'Connor Hanna Ritzen Christina Sanchez Roger Hayes Mohammed Bouhajib Simona Rizea Savu Bruce Stouffer Edward Tabler Jing Tu Chad Briscoe Barry van der Strate Paul Rhyne Phyllis Conliffe Ira DuBey Jim Yamashita Daniel Tang Elizabeth Groeber Jenifer Vija Michele Malone Mohamed Osman

Bioanalysis 2017 Apr 24;9(7):505-516. Epub 2017 Mar 24.

WuXi Apptec, Plainsboro, NJ, USA.

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April 2017

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV): (Part 2 - Hybrid LBA/LCMS and input from regulatory agencies).

Authors:
An Song Anita Lee Fabio Garofolo Surinder Kaur Jeff Duggan Christopher Evans Joe Palandra Lorella Di Donato Keyang Xu Ronald Bauer Mark Bustard Linzhi Chen Laurent Cocea Stephanie Croft Fabrizio Galliccia Sam Haidar Nicola Hughes Akiko Ishii-Watabe Rafiqul Islam Barry Jones John Kadavil Carsten Krantz Gustavo Mendes Lima Santos Timothy Olah João Pedras-Vasconcelos Ludovicus Staelens Yoshiro Saito Natasha Savoie Kara Scheibner Susan Spitz Nilufer Tampal Eric Thomas Stephen Vinter Jason Wakelin-Smith Jan Welink Jianing Zeng Shaolian Zhou

Bioanalysis 2016 Dec;8(23):2457-2474

Roche Pharma Research and Early Development, Roche Innovation Center, Basel, Switzerland.

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December 2016

Small-molecule factor D inhibitors targeting the alternative complement pathway.

Authors:
Jürgen Maibaum Sha-Mei Liao Anna Vulpetti Nils Ostermann Stefan Randl Simon Rüdisser Edwige Lorthiois Paul Erbel Bernd Kinzel Fabrice A Kolb Samuel Barbieri Julia Wagner Corinne Durand Kamal Fettis Solene Dussauge Nicola Hughes Omar Delgado Ulrich Hommel Ty Gould Aengus Mac Sweeney Bernd Gerhartz Frederic Cumin Stefanie Flohr Anna Schubart Bruce Jaffee Richard Harrison Antonio Maria Risitano Jörg Eder Karen Anderson

Nat Chem Biol 2016 Dec 24;12(12):1105-1110. Epub 2016 Oct 24.

Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.

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December 2016

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV) (Part 1 - small molecules, peptides and small molecule biomarkers by LCMS).

Authors:
Eric Yang Jan Welink Stephanie Cape Eric Woolf Jens Sydor Christopher James Dina Goykhman Mark Arnold Neil Addock Ronald Bauer Michael Buonarati Eugene Ciccimaro Raj Dodda Christopher Evans Fabio Garofolo Nicola Hughes Rafiq Islam Corey Nehls Amanda Wilson Chad Briscoe Mark Bustard Laura Coppola Stephanie Croft Dieter Drexler Luca Ferrari Daniela Fraier Rand Jenkins John Kadavil Lloyd King Wenkui Li Gustavo Mendes Lima Santos Adrien Musuku Ragu Ramanathan Yoshiro Saito Natasha Savoie Scott Summerfield Rachel Sun Nilufer Tampal Steve Vinter Jason Wakelin-Smith Qin Yue

Bioanalysis 2016 Nov 7;8(22):2363-2378. Epub 2016 Oct 7.

Novartis, Emeryville, CA, USA.

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November 2016