Nicola De Stefano

Nicola De Stefano

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Nicola De Stefano

Nicola De Stefano

Publications by authors named "Nicola De Stefano"

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MRI quality control for the Italian Neuroimaging Network Initiative: moving towards big data in multiple sclerosis.

J Neurol 2019 Aug 17. Epub 2019 Aug 17.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.

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http://dx.doi.org/10.1007/s00415-019-09509-4DOI Listing
August 2019

Exploring the role of music therapy in multiple sclerosis: brief updates from research to clinical practice.

Neurol Sci 2019 Jul 12. Epub 2019 Jul 12.

Department of Medicine, Surgery and Neurosciences, University of Siena, Viale Bracci 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1007/s10072-019-04007-xDOI Listing
July 2019

Automated lesion segmentation with BIANCA: Impact of population-level features, classification algorithm and locally adaptive thresholding.

Neuroimage 2019 Jul 31;202:116056. Epub 2019 Jul 31.

Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2019.116056DOI Listing
July 2019

Pathological cut-offs of global and regional brain volume loss in multiple sclerosis.

Mult Scler 2019 04 16;25(4):541-553. Epub 2017 Nov 16.

Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.

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http://dx.doi.org/10.1177/1352458517742739DOI Listing
April 2019

How much do periventricular lesions assist in distinguishing migraine with aura from CIS?

Neurology 2019 Apr 8;92(15):e1739-e1744. Epub 2019 Mar 8.

From the Departments of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health (C.L., G.B., M.P., L.B., G.L.M., M.I.), University of Genoa; Departments of Neuroradiology (L.S., L.R.), Health Sciences (M.P.S., L.R.), and Neurology (M.P., G.L.M., M.I.), Ospedale Policlinico San Martino IRCCS, Genoa; Department of Neurosciences (C.G.), S. Camillo-Forlanini Hospital, Rome; and Departments of Medicine, Surgery, and Neuroscience (A.G., N.D.S.), University of Siena, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000007266DOI Listing
April 2019

Reduced dynamics of functional connectivity and cognitive impairment in multiple sclerosis.

Mult Scler 2019 Mar 19:1352458519837707. Epub 2019 Mar 19.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1177/1352458519837707DOI Listing
March 2019

Validating the use of brain volume cutoffs to identify clinically relevant atrophy in RRMS.

Mult Scler 2019 02 20;25(2):217-223. Epub 2017 Nov 20.

Biostatistics Unit, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.1177/1352458517743804DOI Listing
February 2019

Changes in grey matter volume and functional connectivity in cluster headache versus migraine.

Brain Imaging Behav 2019 Feb 14. Epub 2019 Feb 14.

Headache Centre, Careggi University Hospital, Department of Health Sciences, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1007/s11682-019-00046-2DOI Listing
February 2019

Unraveling treatment response in multiple sclerosis: A clinical and MRI challenge.

Neurology 2019 01 26;92(4):180-192. Epub 2018 Dec 26.

From the Department of Neurosciences (C.G., L.P.), San Camillo-Forlanini Hospital, Rome, Italy; Centre d'Esclerosi Multiple de Catalunya (Cemcat), Department of Neurology/Neuroimmunology (M.T., J.R., J.S.-G., X.M.), and Magnetic Resonance Unit, Department of Radiology (A.R.), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Biostatistics Unit (M.P.S.), Department of Health Sciences, University of Genoa; Neuroimaging Research Unit (M.F., M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Nuffield Department of Clinical Neurosciences (J.P.), West Wing, John Radcliffe Hospital, Oxford; Institutes of Neurology & Healthcare Engineering (O.C., F.B.), University College London (O.C.), UK; Amsterdam Neuroscience and Department of Radiology and Nuclear Medicine (F.B., H.V.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (J.L.F.), Rigshospitalet Glostrup and University of Copenhagen, Denmark; Neuroradiological Academic Unit (T.A.Y.), Institute of Neurology, London, UK; Department of Neurology (C.E.), Medical University of Graz, Austria; Neurologic Clinic and Policlinic, Department of Medicine (L.K.), Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, University of Basel, Switzerland; Department of Neurology and Psychiatry (C.P.), Sapienza University, Rome; and Neurology and Neurometabolic Unit, Department of Neurological and Behavioral Sciences (N.D.S.), University of Siena, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000006810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345120PMC
January 2019

The dilemma of benign multiple sclerosis: Can we predict the risk of losing the "benign status"? A 12-year follow-up study.

Mult Scler Relat Disord 2018 Nov 18;26:71-73. Epub 2018 Aug 18.

NEUROFARBA Department, Neuroscience Section, Florence University, Viale Piareccini 16, 50139 Florence, Italy; IRCCS Don Carlo Gnocchi, Don Gnocchi Foundation, Via di Scandicci, 269, 50143, Florence, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183028
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http://dx.doi.org/10.1016/j.msard.2018.08.011DOI Listing
November 2018

Response to 'Does cladribine have an impact on brain atrophy in people with relapsing remitting multiple sclerosis?' by Schiffmann et al.

Mult Scler 2018 09 8;24(10):1388-1389. Epub 2018 Jan 8.

Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1177/1352458517748476DOI Listing
September 2018

Measurement of Whole-Brain and Gray Matter Atrophy in Multiple Sclerosis: Assessment with MR Imaging.

Radiology 2018 08 1;288(2):554-564. Epub 2018 May 1.

From the Neuroimaging Research Unit (L.S., M.A.R., E.P., M.F.) and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience (M.A.R., M.F.), San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy; Department of Research and Development, Icometrix, Leuven, Belgium (W.V.H., D. Sima, D. Smeets); Xinapse Systems, Colchester, England (M.A.H.); Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy (N.D.S.); Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain (A.R.); Unit of Clinical Neuroimmunology, CEM-Cat, Hospital Universitari Vall d'Hebron, Barcelona, Spain (J.S.G.); and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England (J.P.).

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http://dx.doi.org/10.1148/radiol.2018172468DOI Listing
August 2018

Estimates of age-dependent cutoffs for pathological brain volume loss using SIENA/FSL-a longitudinal brain volumetry study in healthy adults.

Neurobiol Aging 2018 05 30;65:1-6. Epub 2017 Dec 30.

Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S01974580173042
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http://dx.doi.org/10.1016/j.neurobiolaging.2017.12.024DOI Listing
May 2018

Within-patient fluctuation of brain volume estimates from short-term repeated MRI measurements using SIENA/FSL.

J Neurol 2018 May 16;265(5):1158-1165. Epub 2018 Mar 16.

Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

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http://link.springer.com/10.1007/s00415-018-8825-8
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http://dx.doi.org/10.1007/s00415-018-8825-8DOI Listing
May 2018

SIENA-XL for improving the assessment of gray and white matter volume changes on brain MRI.

Hum Brain Mapp 2018 03 8;39(3):1063-1077. Epub 2017 Dec 8.

Department of Medicine, Surgery and Neuroscience, University of Siena, Italy.

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http://dx.doi.org/10.1002/hbm.23828DOI Listing
March 2018

Effective Utilization of MRI in the Diagnosis and Management of Multiple Sclerosis.

Neurol Clin 2018 Feb;36(1):27-34

Department of Medicine, Surgery and Neuroscience, University of Siena, Viale Bracci 2, Siena 53100, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ncl.2017.08.013DOI Listing
February 2018

Diffuse brain damage in normal tension glaucoma.

Hum Brain Mapp 2018 01 24;39(1):532-541. Epub 2017 Oct 24.

Department of Medicine, Surgery and Neuroscience, University of Siena, Italy.

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http://dx.doi.org/10.1002/hbm.23862DOI Listing
January 2018

Relationship of white and gray matter abnormalities to clinical and genetic features in myotonic dystrophy type 1.

Neuroimage Clin 2016 3;11:678-685. Epub 2016 May 3.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, via Ugo Foscolo 7, 40123 Bologna, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna, via Altura 3, 40139 Bologna, Italy.

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http://dx.doi.org/10.1016/j.nicl.2016.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900512PMC
October 2017

Advanced MRI measures like DTI or fMRI should be outcome measures in future clinical trials - Commentary.

Mult Scler 2017 10 30;23(11):1458-1460. Epub 2017 Jun 30.

Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1177/1352458517717812DOI Listing
October 2017

Imaging outcome measures for progressive multiple sclerosis trials.

Mult Scler 2017 10;23(12):1614-1626

NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, University College London, London, UK; Translational Imaging Group, UCL Institute of Healthcare Engineering, University College London, London, UK; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458517729456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650056PMC
October 2017

Predicting long-term disability outcomes in patients with MS treated with teriflunomide in TEMSO.

Neurol Neuroimmunol Neuroinflamm 2017 Sep 28;4(5):e379. Epub 2017 Jun 28.

Biostatistics Unit (M.P.S.), University of Genoa, Italy; Sanofi Genzyme (P.T., P.R.), Chilly-Mazarin, France; Sanofi Genzyme (K.T.), Cambridge, MA; Fishawack Communications Ltd (C.S.), Abingdon, Oxfordshire, UK; and Department of Medicine, Surgery, and Neurosciences (N.D.S.), University of Siena, Italy.

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http://dx.doi.org/10.1212/NXI.0000000000000379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489388PMC
September 2017

Vitamin D levels in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Neurol Sci 2017 Jul 4;38(7):1333-1336. Epub 2017 Apr 4.

Unit of Neurology and Neurometabolic Disorders, Department of Medical, Surgical and Neurological Sciences, University of Siena, Viale Bracci 1, 53100, Siena, Italy.

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http://dx.doi.org/10.1007/s10072-017-2900-2DOI Listing
July 2017

The role of dentate nuclei in human oculomotor control: insights from cerebrotendinous xanthomatosis.

J Physiol 2017 06 14;595(11):3607-3620. Epub 2017 Mar 14.

Eye tracking and Visual Application Lab (EVA Lab) - Neurology and Neurometabolic Unit, Department of Medical and Surgical Sciences and Neurosciences, University of Siena, Italy.

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http://dx.doi.org/10.1113/JP273670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451708PMC
June 2017

The spectrum of magnetic resonance findings in cerebrotendinous xanthomatosis: redefinition and evidence of new markers of disease progression.

J Neurol 2017 May 21;264(5):862-874. Epub 2017 Mar 21.

Unit of Diagnostic and Therapeutic Neuroradiology, Azienda Ospedaliera Siena, Siena, Italy.

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http://dx.doi.org/10.1007/s00415-017-8440-0DOI Listing
May 2017

Subcutaneous interferon β-1a in the treatment of clinically isolated syndromes: 3-year and 5-year results of the phase III dosing frequency-blind multicentre REFLEXION study.

J Neurol Neurosurg Psychiatry 2017 Apr 30;88(4):285-294. Epub 2016 Dec 30.

Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1136/jnnp-2016-314843DOI Listing
April 2017

Effect of Fingolimod on Brain Volume Loss in Patients with Multiple Sclerosis.

CNS Drugs 2017 Apr;31(4):289-305

Brain and Mind Research Institute, Sydney, NSW, Australia.

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http://dx.doi.org/10.1007/s40263-017-0415-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374177PMC
April 2017

Functional Evaluation of Awareness in Vegetative and Minimally Conscious State.

Open Neuroimag J 2017 27;11:17-25. Epub 2017 Apr 27.

UOSA Experimental Neurology, Dept. of Medicine, Surgery & Neuroscience, University of Siena, Italy.

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http://dx.doi.org/10.2174/1874440001711010017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427708PMC
April 2017

Resting state fMRI regional homogeneity correlates with cognition measures in subcortical vascular cognitive impairment.

J Neurol Sci 2017 Feb 6;373:1-6. Epub 2016 Dec 6.

"Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; Quantitative and Functional Neuroradiology Research Program at Meyer Children Hospital and Careggi General Hospital, Florence, Italy.

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http://dx.doi.org/10.1016/j.jns.2016.12.003DOI Listing
February 2017

Brain MRI atrophy quantification in MS: From methods to clinical application.

Neurology 2017 01 16;88(4):403-413. Epub 2016 Dec 16.

From the Neuroimaging Research Unit (M.A.R., E.P., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan; Department of Medicine, Surgery and Neuroscience (M.B., N.D.S.), University of Siena, Italy; Department of Neurology (R.H.B.B.), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York; Department of Anatomy and Neuroscience (J.J.G.G.), Section of Clinical Neuroscience, VUmc MS Center Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (R.G.H.), University of California, San Francisco; Xinapse Systems Ltd. (M.A.H.), Colchester, Essex, UK; and FMRIB Centre (M.J.), Nuffield Department of Clinical Neurosciences, University of Oxford, UK.

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http://dx.doi.org/10.1212/WNL.0000000000003542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272969PMC
January 2017

Early changes of brain connectivity in primary open angle glaucoma.

Hum Brain Mapp 2016 12 9;37(12):4581-4596. Epub 2016 Aug 9.

Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1002/hbm.23330DOI Listing
December 2016

A practical review of the neuropathology and neuroimaging of multiple sclerosis.

Pract Neurol 2016 Aug 23;16(4):279-87. Epub 2016 Mar 23.

Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1136/practneurol-2016-001381DOI Listing
August 2016

MRI monitoring of spinal cord changes in patients with multiple sclerosis.

Curr Opin Neurol 2016 Aug;29(4):445-52

aSection of Neuroradiology, Department of Radiology (IDI), Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain bDepartment of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1097/WCO.0000000000000343DOI Listing
August 2016

Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis.

PLoS One 2016 5;11(1):e0145906. Epub 2016 Jan 5.

Department of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145906PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701472PMC
July 2016

Assessing response to interferon-β in a multicenter dataset of patients with MS.

Neurology 2016 Jul 15;87(2):134-40. Epub 2016 Jun 15.

From the University of Genoa (M.P.S.); Hospital San Camillo Forlanini (C.G.) and Department of Neurology and Psychiatry (L.P., C.P.), Sapienza University, Rome; Department of Neurology (M.R., V.M., G.C.) and Neuroimaging Research Unit (M.A.R., M.F.), San Raffaele Scientific Institute, Milan, Italy; Hospital Universitario Vall d'Hebron (J.R., M. Tintorè, A.R., X.M.), Barcelona, Spain; University of Verona (M.C.); Department of Public Health, Clinical and Molecular Medicine (E.C.), and Department of Medical Sciences (M.G.M., E.C.), University of Cagliari, Italy; Department of Neurology (C.E., F.F.), Medical University of Graz, Austria; Dip. to di Scienze Mediche, Chirurgiche, Neurologiche, Metaboliche e dell'Invecchiamento (A.G., G.T.), Seconda Universita' di Napoli, MRI Research Center "SUN-FISM," Hermitage-Capodimonte Clinic, Naples, Italy; Neurology (L.K., T.S.), Departments of Medicine, Clinical Research, and Biomedical Engineering, University Hospital Basel, Switzerland; DKD Helios Klinik Wiesbaden (T.S.), Germany; University of Siena (M.L.S., N.D.S.); and Department of Medical Sciences, Neurosciences and Sense Organs (M. Trojano, C.T.), University of Bari, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000002830DOI Listing
July 2016

Optimizing treatment success in multiple sclerosis.

J Neurol 2016 Jun 24;263(6):1053-65. Epub 2015 Dec 24.

Department of Neurology, Neuroimmunology and Multiple Sclerosis Research, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00415-015-7986-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893374PMC
June 2016

Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI-Tuscany Study.

Alzheimers Dement 2016 Apr 13;12(4):407-18. Epub 2015 Jun 13.

NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy; Stroke Unit and Neurology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.02.010DOI Listing
April 2016

Structural MRI correlates of cognitive impairment in patients with multiple sclerosis: A Multicenter Study.

Hum Brain Mapp 2016 Apr 2;37(4):1627-44. Epub 2016 Feb 2.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1002/hbm.23125DOI Listing
April 2016

Advanced Structural and Functional Brain MRI in Multiple Sclerosis.

Semin Neurol 2016 Apr 26;36(2):163-76. Epub 2016 Apr 26.

Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1055/s-0036-1579737DOI Listing
April 2016

Primary Progressive Multiple Sclerosis Evolving From Radiologically Isolated Syndrome.

Ann Neurol 2016 Feb 29;79(2):288-94. Epub 2015 Dec 29.

Department of Neurology & Neurotherapeutics, Clinical Center for Multiple Sclerosis, Multiple Sclerosis and NeuroImmunology Imaging ProgramUniversity of Texas Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1002/ana.24564DOI Listing
February 2016

Long-term assessment of no evidence of disease activity in relapsing-remitting MS.

Neurology 2015 Nov 14;85(19):1722-3. Epub 2015 Oct 14.

From the University of Siena (N.D., M.L.S., A.G., M.B.); the Hospital of Empoli (M.L.B.); the University of Florence (M.P.A.); and the University of Genoa (M.P.S.), Italy.

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http://dx.doi.org/10.1212/WNL.0000000000002105DOI Listing
November 2015

GABA: a new imaging biomarker of neurodegeneration in multiple sclerosis?

Brain 2015 Sep;138(Pt 9):2467-8

Department of Medicine, Surgery and Neuroscience, University of Siena, Italy.

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http://dx.doi.org/10.1093/brain/awv213DOI Listing
September 2015

Optimizing therapy early in multiple sclerosis: An evidence-based view.

Mult Scler Relat Disord 2015 Sep 17;4(5):460-469. Epub 2015 Jul 17.

Department of Neurology, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2015.07.007DOI Listing
September 2015

Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process.

Nat Rev Neurol 2015 08 7;11(8):471-82. Epub 2015 Jul 7.

Magnetic Resonance Unit, Cemcat, Hospital Vall d'Hebron, Autonomous University of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.

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http://dx.doi.org/10.1038/nrneurol.2015.106DOI Listing
August 2015

Connectivity-based parcellation of the thalamus in multiple sclerosis and its implications for cognitive impairment: A multicenter study.

Hum Brain Mapp 2015 Jul 14;36(7):2809-25. Epub 2015 Apr 14.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://doi.wiley.com/10.1002/hbm.22809
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http://dx.doi.org/10.1002/hbm.22809DOI Listing
July 2015

Towards a better understanding of pseudoatrophy in the brain of multiple sclerosis patients.

Mult Scler 2015 May 26;21(6):675-6. Epub 2015 Jan 26.

Montreal Neurological Institute, McGill University, Canada.

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http://dx.doi.org/10.1177/1352458514564494DOI Listing
May 2015

Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis.

Lancet Neurol 2015 Mar 4;14(3):302-17. Epub 2015 Feb 4.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. Electronic address:

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http://www.thelancet.com/pdfs/journals/laneur/PIIS1474-4422(
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http://linkinghub.elsevier.com/retrieve/pii/S147444221470250
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http://dx.doi.org/10.1016/S1474-4422(14)70250-9DOI Listing
March 2015

Spinal cord imaging in multiple sclerosis: filling the gap with the brain.

Neurology 2014 Oct 3;83(15):1306-7. Epub 2014 Sep 3.

From the Department of Medicine Surgery and Neuroscience (N.D.S.), University of Siena, Italy; Department of Radiology (S.A.S.), Vanderbilt University, Nashville; and Vanderbilt University Institute of Imaging Science (S.A.S.), Nashville, TN.

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http://dx.doi.org/10.1212/WNL.0000000000000873DOI Listing
October 2014

Placebo-controlled trial of oral laquinimod in multiple sclerosis: MRI evidence of an effect on brain tissue damage.

J Neurol Neurosurg Psychiatry 2014 Aug 12;85(8):851-8. Epub 2013 Sep 12.

Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Ospedale San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1136/jnnp-2013-306132DOI Listing
August 2014

Twelve-year monitoring of a patient with megalencephalic leukoencephalopathy with subcortical cysts.

Neurol Sci 2014 Aug 2;35(8):1249-53. Epub 2014 Mar 2.

Department of Medicine, Surgery and Neuroscience, University of Siena, Policlinico "S. Maria alle Scotte", Viale Bracci, 2, 53100, Siena, Italy,

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http://dx.doi.org/10.1007/s10072-014-1691-yDOI Listing
August 2014

Automated identification of brain new lesions in multiple sclerosis using subtraction images.

J Magn Reson Imaging 2014 Jun;39(6):1543-9

Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1002/jmri.24293DOI Listing
June 2014

Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL.

Stroke 2014 Apr 27;45(4):968-72. Epub 2014 Feb 27.

From Institute for Stroke and Dementia Research (C.O., M.G., M. Duering, R.M., M. Dichgans), and Department of Neurology (C.O.), Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany; Department of Neurology, DHU NeuroVasc, Hopital Lariboisiere, APHP, Paris, France (E.J., H.C.); Université Paris Diderot, Sorbonne Paris Cité, Génétique des Maladies Vasculaires, INSERM UMR-S740, Paris, France (D.H., E.T.-L.); Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom (P.A.-S., S.B.); Neurology Division and Molecular Medicine Section, Mazzoni Hospital, Ascoli Piceno, Italy (L.P., S.S., M.R.); Department of Medicine, Surgery and Neurosciences, University of Siena, Italy (M.T.D., N.D.S., A.F.); Departments of Radiology (M.L.) and Clinical Genetics (E.M.J.B., S.L.O.), Leiden University Medical Center, Leiden, the Netherlands; Stroke Unit and Neurology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy (F.P., L.P.); BioClinica Inc, Lyon, France (C.P., L.B.); Max-Planck Institute of Psychiatry, Munich, Germany (B.M.-M.); Institute of Human Genetics, Helmholtz Center, Munich, Germany (T.M.); Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Boston, MA (N.R., J.R.); Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (H.S.M.); Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (J.R.); and Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M. Dichgans).

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http://stroke.ahajournals.org/cgi/doi/10.1161/STROKEAHA.113.
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http://dx.doi.org/10.1161/STROKEAHA.113.004461DOI Listing
April 2014

Natalizumab discontinuation in the increasing complexity of multiple sclerosis therapy.

Neurology 2014 Apr 28;82(17):1484-5. Epub 2014 Mar 28.

From the Department of Health Sciences (M.P.S.), University of Genova; and the Department of Medicine Surgery and Neuroscience (N.D.S.), University of Siena, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000000369DOI Listing
April 2014

Cortical lesion counts by double inversion recovery should be part of the MRI monitoring process for all MS patients: yes.

Mult Scler 2014 Apr;20(5):537-8

Neurology Section, Department Of Neurological and Movement Sciences, University Hospital of Verona, Italy.

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http://dx.doi.org/10.1177/1352458514526084DOI Listing
April 2014

Reply: To PMID 24006277.

Ann Neurol 2014 Mar 7;75(3):463-4. Epub 2014 Mar 7.

Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.1002/ana.24111DOI Listing
March 2014

MRI measures should be a primary outcome endpoint in Phase III randomized, controlled trials in multiple sclerosis: yes.

Mult Scler 2014 Mar;20(3):280-1

Biostatistics Unit, Department of Health Sciences, University of Genoa, Italy.

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March 2014

Moving toward earlier treatment of multiple sclerosis: Findings from a decade of clinical trials and implications for clinical practice.

Mult Scler Relat Disord 2014 Mar 31;3(2):147-55. Epub 2013 Jul 31.

Departments of Neurology and Biomedicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.msard.2013.07.001DOI Listing
March 2014

A novel approach with "skeletonised MTR" measures tract-specific microstructural changes in early primary-progressive MS.

Hum Brain Mapp 2014 Feb 24;35(2):723-33. Epub 2013 Apr 24.

Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1002/hbm.22196DOI Listing
February 2014

Clinical relevance of brain volume measures in multiple sclerosis.

CNS Drugs 2014 Feb;28(2):147-56

Department of Medicine, Surgery and Neuroscience, University of Siena, Viale Bracci 2, Siena, 53100, Italy,

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http://link.springer.com/10.1007/s40263-014-0140-z
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February 2014

Treatment effect on brain atrophy correlates with treatment effect on disability in multiple sclerosis.

Ann Neurol 2014 Jan 2;75(1):43-9. Epub 2014 Jan 2.

Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy.

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January 2014

Defining and scoring response to IFN-β in multiple sclerosis.

Nat Rev Neurol 2013 09 30;9(9):504-12. Epub 2013 Jul 30.

Department of Health Sciences (DISSAL), University of Genoa, Via Pastore 1, Genoa 16132, Italy. mariapia.sormani@ unige.it

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September 2013