SimpleXMLElement Object ( [PubmedArticle] => Array ( [0] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33094322 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 10 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1460-2385 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => Oct [Day] => 23 ) ) [Title] => Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [ISOAbbreviation] => Nephrol Dial Transplant ) [ArticleTitle] => Routine serum biomarkers, but not dual-energy X-ray absorptiometry, correlate with cortical bone mineral density in children and young adults with chronic kidney disease. [ELocationID] => Array ( [0] => gfaa199 [1] => 10.1093/ndt/gfaa199 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Biomarkers and dual-energy X-ray absorptiometry (DXA) are thought to be poor predictors of bone mineral density (BMD). The Kidney Disease: Improving Global Outcomes guidelines suggest using DXA if the results will affect patient management, but this has not been studied in children or young adults in whom bone mineral accretion continues to 30 years of age. We studied the clinical utility of DXA and serum biomarkers against tibial cortical BMD (CortBMD) measured by peripheral quantitative computed tomography, expressed as Z-score CortBMD, which predicts fracture risk. [1] => This was a cross-sectional multicentre study in 26 patients with CKD4 and 5 and 77 on dialysis. [2] => Significant bone pain that hindered activities of daily living was present in 58%, and 10% had at least one low-trauma fracture. CortBMD and cortical mineral content Z-scores were lower in dialysis compared with CKD patients (P = 0.004 and P = 0.02). DXA BMD hip and lumbar spine Z-scores did not correlate with CortBMD or biomarkers. CortBMD was negatively associated with parathyroid hormone (PTH; r = -0.44, P < 0.0001) and alkaline phosphatase (ALP; r = -0.22, P = 0.03) and positively with calcium (Ca; r = 0.33, P = 0.001). At PTH <3 times upper limit of normal, none of the patients had a CortBMD below -2 SD (odds ratio 95% confidence interval 7.331 to infinity). On multivariable linear regression PTH (β = -0.43 , P < 0.0001), ALP (β = -0.36, P < 0.0001) and Ca (β = 0.21, P = 0.005) together predicted 57% of variability in CortBMD. DXA measures did not improve this model. [3] => Taken together, routinely used biomarkers, PTH, ALP and Ca, but not DXA, are moderate predictors of cortical BMD. DXA is not clinically useful and should not be routinely performed in children and young adults with CKD 4-5D. ) [CopyrightInformation] => © The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Lalayiannis [ForeName] => Alexander D [Initials] => AD [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Great Ormond St Hospital for Children NHS Foundation Trust, University College London Institute of Child Health, London, UK. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola J [Initials] => NJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ferro [ForeName] => Charles J [Initials] => CJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Askiti [ForeName] => Varvara [Initials] => V [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => "P. & A. Kyriakou" Childrens' Hospital, Athens, Greece. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mitsioni [ForeName] => Andromachi [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => "P. & A. Kyriakou" Childrens' Hospital, Athens, Greece. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Biassoni [ForeName] => Lorenzo [Initials] => L [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Great Ormond St Hospital for Children NHS Foundation Trust, University College London Institute of Child Health, London, UK. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kaur [ForeName] => Amrit [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Manchester University NHS Foundation Trust, Manchester, UK. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sinha [ForeName] => Manish D [Initials] => MD [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Evelina Children's Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Wheeler [ForeName] => David C [Initials] => DC [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Renal Medicine, University College London, London, UK. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Duncan [ForeName] => Neill D [Initials] => ND [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, UK. ) ) [10] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Popoola [ForeName] => Joyce [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Nephrology and Transplantation, George's University Hospital NHS Foundation Trust, London, UK. ) ) [11] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Milford [ForeName] => David V [Initials] => DV [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. ) ) [12] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Long [ForeName] => Jin [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Stanford University, Palo Alto, CA, USA. ) ) [13] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Leonard [ForeName] => Mary Beth [Initials] => MB [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Stanford University, Palo Alto, CA, USA. ) ) [14] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Fewtrell [ForeName] => Mary [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Great Ormond St Hospital for Children NHS Foundation Trust, University College London Institute of Child Health, London, UK. ) ) [15] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shroff [ForeName] => Rukshana [Initials] => R [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Great Ormond St Hospital for Children NHS Foundation Trust, University College London Institute of Child Health, London, UK. ) ) ) ) [Language] => eng [GrantList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Grant] => SimpleXMLElement Object ( [GrantID] => CDF-2016-09-038 [Acronym] => DH_ [Agency] => Department of Health [Country] => United Kingdom ) ) [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 10 [Day] => 23 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Nephrol Dial Transplant [NlmUniqueID] => 8706402 [ISSNLinking] => 0931-0509 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => bone mineralization [1] => chronic kidney disease [2] => dual-energy X-ray absorptiometry [3] => mineral bone disorder [4] => peripheral quantitative computed tomography ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 03 [Day] => 23 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 10 [Day] => 23 [Hour] => 5 [Minute] => 59 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 10 [Day] => 24 [Hour] => 6 [Minute] => 0 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 10 [Day] => 24 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33094322 [1] => 5936064 [2] => 10.1093/ndt/gfaa199 ) ) ) ) [1] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 32972858 [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 09 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1094-6950 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => Aug [Day] => 29 ) ) [Title] => Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry [ISOAbbreviation] => J Clin Densitom ) [ArticleTitle] => Assessment of Bone Density by DXA in Poorly Controlled Children With β-Thalassemia: Correction for Hepatic Iron Overload by Manual Analysis. [ELocationID] => Array ( [0] => S1094-6950(20)30114-1 [1] => 10.1016/j.jocd.2020.08.001 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Beta thalassemia major (BTM) is characterized by anemia and iron overload, especially with inadequate chelation therapy. Dual energy x-ray absorptiometry software (DXA) may misanalyse bone measurements due to iron deposition in organs such as the liver. Our objective was to study difference between the posterior-anterior spine measurements of bone mineral content (BMC), area (BA) and density (BMD) in poorly chelated beta thalassemia patients with and without inclusion of the liver in the DXA analysis. [1] => We studied hemoglobin and serum ferritin concentrations in 208 patients with BTM (children n = 177, young adults n = 31). Posteroanterior spine measurements BMC, BA and areal BMD were performed using a GE iDXA. Using the tissue point typing feature (EnCore software, version 16), analysis was carried out including and excluding (manually) the iron overloaded liver. Machine generated Z-scores of L1-L4 BMD were used for analysis. [2] => The mean age of the study group was 12.9 ± 5.4 yr. Mean hemoglobin and serum ferritin concentrations were 8.0 ± 1.7 g/dl and 2256.9 ± 1978.0 ng/ml, respectively. The mean BMC, BA, and aBMD at the lumbar spine were 23.2 ± 11.4 g, 29.9 ± 8.5 cm and 0.736 ± 0.173 g/cm respectively with inclusion of liver that is standard machine analysis. After the liver was excluded from the analysis, the mean BMC, BA, and aBMD were 23.9 ± 11.6 g, 30.0 ± 8.6 cm and 0.757 ±0.173 g/cm respectively and the BMC and aBMD were significantly greater (p < 0.05). Mean BMD Z-score was -1.5 ± 1.2, which significantly (p < 0.05) improved to -1.3 ± 1.2 after exclusion of the liver from the analysis. [3] => In poorly chelated patients with thalassemia, inclusion of the iron-overloaded liver in the tissue analysis may exaggerate the deficit in bone parameters. Iron overloaded tissues need to be manually excluded during analysis of the PA spine. ) [CopyrightInformation] => Copyright © 2020 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ekbote [ForeName] => Veena [Initials] => V [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Growth and Pediatric Endocrine Department, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Khadilkar [ForeName] => Anuradha [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Growth and Pediatric Endocrine Department, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India; School of Health Sciences, Savitribai Phule Pune University, Pune, Maharashtra, India. Electronic address: anuradhavkhadilkar@gmail.com. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Chauthmal [ForeName] => Sujata [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Growth and Pediatric Endocrine Department, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Padidela [ForeName] => Raja [Initials] => R [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Khadilkar [ForeName] => Shachi [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Growth and Pediatric Endocrine Department, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mughal [ForeName] => Zulf [Initials] => Z [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 08 [Day] => 29 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => J Clin Densitom [NlmUniqueID] => 9808212 [ISSNLinking] => 1094-6950 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => DXA manual analysis [1] => DXA software [2] => PA Spine [3] => misanalysis [4] => thalassemia ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 06 [Day] => 27 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 08 [Day] => 26 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 08 [Day] => 27 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 9 [Day] => 25 [Hour] => 5 [Minute] => 41 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 9 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 9 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32972858 [1] => S1094-6950(20)30114-1 [2] => 10.1016/j.jocd.2020.08.001 ) ) ) ) [2] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => In-Data-Review [Owner] => NLM ) [PMID] => 32950700 [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 12 [Day] => 29 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1873-2763 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 143 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb ) ) [Title] => Bone [ISOAbbreviation] => Bone ) [ArticleTitle] => Increased prevalence of fractures in inadequately transfused and chelated Indian children and young adults with beta thalassemia major. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 115649 ) [ELocationID] => Array ( [0] => S8756-3282(20)30429-4 [1] => 10.1016/j.bone.2020.115649 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => In patients with beta thalassemia major, inadequate transfusion and chelation may compromise bone health and increase risk of fractures. The objective of this study was to describe the prevalence of fractures in Indian inadequately transfused and chelated children, adolescents and young adults with beta thalassemia major. [1] => We studied 179 patients with beta thalassemia (3.6-28.3 years; 105 boys). Medical, transfusion, chelation and fracture history were recorded. Vertebral fracture assessment (VFA) was performed using lateral spine images acquired using the GE Lunar iDXA (Wisconsin, MD). Fractures were classified according to an adapted semi-quantitative method. [2] => History of non-traumatic long bone fractures was observed in 21% patients (n = 37); there were significantly greater (p < 0.05) number of males (n = 30) than females (n = 15). The 21% fracture prevalence in the present study is higher than the reported fractures of 9% in healthy Indian children and adolescents. The prevalence of vertebral fractures was 4.5% (n = 8) in the study group. Of those with fractures, four patients had both long bone and vertebral fractures, and (any, long bone or vertebral fractures) sixteen patients had more than 1 fracture; eleven patients had 2 fractures, four patients had 3 fractures and one patient had 5 fractures. Thus, in 179 patients, there were a total of 68 single fractures which translates to 307 fractures per 10,000 patient years. [3] => This study found increased prevalence of non-traumatic long bone and vertebral fractures in children and adolescents with thalassemia major. ) [CopyrightInformation] => Copyright © 2020 Elsevier Inc. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ekbote [ForeName] => Veena [Initials] => V [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Growth and Pediatric Endocrine Department, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra 411 001, India. Electronic address: ekbote.veena@gmail.com. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Padidela [ForeName] => Raja [Initials] => R [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Electronic address: Raja.Padidela@mft.nhs.uk. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Khadilkar [ForeName] => Vaman [Initials] => V [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Growth and Pediatric Endocrine Department, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra 411 001, India; School of Health Sciences, Savitribai Phule Pune University, Ganeshkhind Rd, Ganeshkhind, Pune, Maharashtra 411007, India. Electronic address: vamankhadilkar@gmail.com. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ramanan [ForeName] => Vijay [Initials] => V [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Clinical Hematology and Transplant, Yashoda Hematology Clinic, Pune, Maharashtra, India. Electronic address: mvijayr@gmail.com. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Maheshwari [ForeName] => Ankita [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Pediatric and Adolescent Endocrinology, Sir Aurobindo Institute of Medical Science, Indore, Madhya Pradesh 453555, India. Electronic address: ankitamaheshwari23@gmail.com. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mughal [ForeName] => Zulf [Initials] => Z [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Electronic address: Zulf.Mughal@mft.nhs.uk. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kariki [ForeName] => Eleni P [Initials] => EP [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Clinical Radiology, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address: Eleni.Kariki@mft.nhs.uk. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. Electronic address: nicola.crabtree@nhs.net. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Khadilkar [ForeName] => Anuradha [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Growth and Pediatric Endocrine Department, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra 411 001, India; School of Health Sciences, Savitribai Phule Pune University, Ganeshkhind Rd, Ganeshkhind, Pune, Maharashtra 411007, India. Electronic address: anuradhavkhadilkar@gmail.com. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 09 [Day] => 18 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Bone [NlmUniqueID] => 8504048 [ISSNLinking] => 1873-2763 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Beta thalassemia major [1] => Inadequate transfusion [2] => India [3] => Long bone fractures [4] => Vertebral fractures ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 05 [Day] => 29 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 08 [Day] => 12 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 09 [Day] => 12 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 9 [Day] => 21 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 9 [Day] => 21 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 9 [Day] => 20 [Hour] => 20 [Minute] => 28 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 32950700 [1] => S8756-3282(20)30429-4 [2] => 10.1016/j.bone.2020.115649 ) ) ) ) [3] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 32457287 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 08 [Day] => 18 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 17 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 2041-1723 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 11 [Issue] => 1 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 05 [Day] => 26 ) ) [Title] => Nature communications [ISOAbbreviation] => Nat Commun ) [ArticleTitle] => The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 2624 ) [ELocationID] => 10.1038/s41467-020-15948-9 [Abstract] => SimpleXMLElement Object ( [AbstractText] => UK Biobank is a population-based cohort of half a million participants aged 40-69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Littlejohns [ForeName] => Thomas J [Initials] => TJ [Identifier] => 0000-0003-1177-6923 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Nuffield Department of Population Health, University of Oxford, Oxford, UK. thomas.littlejohns@ndph.ox.ac.uk. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Holliday [ForeName] => Jo [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Nuffield Department of Population Health, University of Oxford, Oxford, UK. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gibson 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 115249 ) [ELocationID] => Array ( [0] => S8756-3282(20)30029-6 [1] => 10.1016/j.bone.2020.115249 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => There is significant inter and intraobserver variability in diagnosing vertebral fractures in children. [1] => We aimed to evaluate the diagnostic accuracy of morphometric vertebral fracture analysis (MXA) using a 33-point software program designed for adults, on dual-energy x-ray absorptiometry (DXA) images of children. [2] => Lateral spine DXA images of 420 children aged between 5 and 18 years were retrospectively reviewed. Vertebral fracture assessment (VFA) by an expert pediatric radiologist using Genant's semiquantitative scoring system served as the gold standard. All 420 DXA scans were analyzed by a trained radiographer, using semi-automated software (33-point morphometry). VFA of a random sample of 100 DXA was performed by an experienced pediatric clinical scientist. MXA of a random sample of 30 DXA images were analyzed by three pediatric radiologists and the pediatric clinical scientist. Diagnostic accuracy and inter and intraobserver agreement (kappa statistics) were calculated. [3] => Overall sensitivity, specificity, false positive (FP) and false negative (FN) rates for the radiographer using the MXA software were 80%, 90%, 10%, and 20% respectively and for mild fractures alone were 46%, 92%, 8%, and 54% respectively. Overall sensitivity, specificity, FP, and FN rates for the four additional observers using MXA were 89%, 79%, 21%, and 11% respectively and for mild fractures alone were 36%, 86%, 14%, and 64% respectively. Agreement between two expert observers was fair to good for VFA and MXA [kappa = 0·29 to 0·76 (95% CI: 0·17-0·88) and 0·29 to 0·69 (95% CI: 0·17-0·83)] respectively. [4] => MXA using a 33-point technique developed for adults is not a reliable method for the identification of mild vertebral fractures in children. A pediatric standard is required which not only incorporates specific vertebral body height ratios but also the age-related physiological changes in vertebral shape that occur throughout childhood. ) [CopyrightInformation] => Copyright © 2020 Elsevier Inc. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Alqahtani [ForeName] => Fawaz F [Initials] => FF [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Academic Unit of Child Health, University of Sheffield, Sheffield, UK. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola J [Initials] => NJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Bromiley [ForeName] => Paul A [Initials] => PA [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Cootes [ForeName] => Timothy [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Broadley [ForeName] => Penny [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Radiology Department, Sheffield Children's NHS Foundation Trust, Sheffield, UK. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Lang [ForeName] => Isla [Initials] => I [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Radiology Department, Sheffield Children's NHS Foundation Trust, Sheffield, UK. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Offiah [ForeName] => Amaka C [Initials] => AC [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Academic Unit of Child Health, University of Sheffield, Sheffield, UK; Radiology Department, Sheffield Children's NHS Foundation Trust, Sheffield, UK. Electronic address: a.offiah@sheffield.ac.uk. ) ) ) ) [Language] => eng [GrantList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Grant] => SimpleXMLElement Object ( [GrantID] => PB-PG-0110-21240 [Acronym] => DH_ [Agency] => Department of Health [Country] => United Kingdom ) ) [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Research Support, Non-U.S. Gov't ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2020 [Month] => 01 [Day] => 21 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Bone [NlmUniqueID] => 8504048 [ISSNLinking] => 1873-2763 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => DXA [1] => Fracture [2] => Morphometric vertebral fracture analysis [3] => Pediatric [4] => Vertebral fracture assessment ) ) [CoiStatement] => Declaration of competing interest None. ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2019 [Month] => 09 [Day] => 18 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 01 [Day] => 14 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 01 [Day] => 19 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2020 [Month] => 1 [Day] => 25 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 1 [Day] => 25 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2020 [Month] => 1 [Day] => 25 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 31978618 [1] => S8756-3282(20)30029-6 [2] => 10.1016/j.bone.2020.115249 ) ) ) ) [5] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 31082498 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 07 [Day] => 27 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 09 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1873-2763 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 125 [PubDate] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 08 ) ) [Title] => Bone [ISOAbbreviation] => Bone ) [ArticleTitle] => Older age at initiation of antiretroviral therapy predicts low bone mineral density in children with perinatally-infected HIV in Zimbabwe. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 96-102 ) [ELocationID] => Array ( [0] => S8756-3282(19)30176-0 [1] => 10.1016/j.bone.2019.05.012 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Perinatally-acquired HIV infection commonly causes stunting in children; how this affects bone and muscle development is unclear. We investigated differences in bone and muscle mass and muscle function between children with HIV (CWH) and uninfected children. [1] => Cross-sectional study of CWH (6-16 years) receiving antiretroviral therapy (ART) for >6 months and similar aged children testing HIV-negative at primary health clinics in Zimbabwe. [2] => From Dual-energy X-ray Absorptiometry (DXA) we calculated total-body less-head (TBLH) Bone Mineral Content (BMC) for lean mass adjusted-for-height (TBLH-BMC) Z-scores, and lumbar spine (LS) Bone Mineral Apparent Density (BMAD) Z-scores. [3] => The 97 CWH were older (mean age 12.7 vs. 10.0 years) and taller (mean height 142 cm vs. 134 cm) than 77 uninfected. However, stunting (height-for-age Z-score ≤ -2) was more prevalent in CWH (35% vs. 5%, p < 0.001). Among CWH, 15% had low LS-BMAD (Z-score ≤ -2) and 13% low TBLH-BMC, vs. 1% and 3% respectively in those uninfected (both p ≤ 0.02). After age, sex, height and puberty adjustment, LS-BMAD was 0.33 SDs (95%CI -0.01, 0.67; p = 0.06) lower in CWH, with no differences by HIV status in TBLH-BMC, lean mass (0.11 [-0.03, 0.24], p = 0.11) or grip strength (0.05 [-0.16, 0.27], p = 0.62). However, age at ART initiation was correlated with both LS-BMAD Z-score (r = -0.33, p = 0.001) and TBLH-BMC Z-score (r = -0.23, p = 0.027); for each year ART initiation was delayed a 0.13 SD reduction in LS-BMAD was seen. [4] => Size-adjusted low bone density is common in CWH. Delay in initiating ART adversely affects bone density. Findings support immediate ART initiation at HIV diagnosis. ) [CopyrightInformation] => Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gregson [ForeName] => Celia L [Initials] => CL [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => The Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address: celia.gregson@bristol.ac.uk. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hartley [ForeName] => April [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => The Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Majonga [ForeName] => Edith [Initials] => E [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Biomedical Research and Training Institute (BRTI), Harare, Zimbabwe; Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), London, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => McHugh [ForeName] => Grace [Initials] => G [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Biomedical Research and Training Institute (BRTI), Harare, Zimbabwe. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology, Birmingham Women's and Children's NHS Foundation Trust, UK. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rukuni [ForeName] => Ruramayi [Initials] => R [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Biomedical Research and Training Institute (BRTI), Harare, Zimbabwe; Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), London, UK. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Bandason [ForeName] => Tsitsi [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Biomedical Research and Training Institute (BRTI), Harare, Zimbabwe. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mukwasi-Kahari [ForeName] => Cynthia [Initials] => C [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Radiology, University of Zimbabwe, Harare, Zimbabwe. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ward [ForeName] => Kate A [Initials] => KA [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mujuru [ForeName] => Hilda [Initials] => H [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Paediatrics, University of Zimbabwe, Harare, Zimbabwe. ) ) [10] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ferrand [ForeName] => Rashida A [Initials] => RA [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Biomedical Research and Training Institute (BRTI), Harare, Zimbabwe; Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), London, UK. ) ) ) ) [Language] => eng [GrantList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Grant] => Array ( [0] => SimpleXMLElement Object ( [GrantID] => 20378/Z/16/Z [Acronym] => WT_ [Agency] => Wellcome Trust [Country] => United Kingdom ) [1] => SimpleXMLElement Object ( [GrantID] => 206764/Z/17/Z [Acronym] => WT_ [Agency] => Wellcome Trust [Country] => United Kingdom ) [2] => SimpleXMLElement Object ( [GrantID] => 095878/Z/11Z [Acronym] => WT_ [Agency] => Wellcome Trust [Country] => United Kingdom ) [3] => SimpleXMLElement Object ( [GrantID] => 20000 [Acronym] => VAC_ [Agency] => Versus Arthritis [Country] => United Kingdom ) [4] => SimpleXMLElement Object ( [Acronym] => WT_ [Agency] => Wellcome Trust [Country] => United Kingdom ) ) ) [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Research Support, Non-U.S. Gov't ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2019 [Month] => 05 [Day] => 10 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Bone [NlmUniqueID] => 8504048 [ISSNLinking] => 1873-2763 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Anti-Retroviral Agents ) ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Absorptiometry, Photon [QualifierName] => trends ) 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[Month] => 03 [Day] => 31 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1468-2044 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 104 [Issue] => 11 [PubDate] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 11 ) ) [Title] => Archives of disease in childhood [ISOAbbreviation] => Arch Dis Child ) [ArticleTitle] => Bone density in children: what are we measuring? [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 1108-1111 ) [ELocationID] => 10.1136/archdischild-2019-316940 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The measurement of bone density is a frequent request in the assessment of children with concerns about bone health due to chronic disease or recurrent fractures. Dual energy X-ray absorptiometry (DXA) remains the recommended modality and is widely available. However, the interpretation and reporting of results in growing individuals needs to be undertaken by individuals who are familiar with scanning children and the potential pitfalls. [CopyrightInformation] => © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shaw [ForeName] => Nick [Initials] => N [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology & Diabetes, Birmingham Children's Hospital, Birmingham, West Midlands, UK. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology & Diabetes, Birmingham Children's Hospital, Birmingham, West Midlands, UK. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Review ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2019 [Month] => 04 [Day] => 25 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Arch Dis Child [NlmUniqueID] => 0372434 [ISSNLinking] => 0003-9888 ) [CitationSubset] => Array ( [0] => AIM [1] => IM ) [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Absorptiometry, Photon ) [1] => SimpleXMLElement Object ( [DescriptorName] => Bone Density [QualifierName] => physiology ) [2] => SimpleXMLElement Object ( [DescriptorName] => Bone Diseases [QualifierName] => diagnostic imaging ) [3] => SimpleXMLElement Object ( [DescriptorName] => Child ) [4] => SimpleXMLElement Object ( [DescriptorName] => Clinical Competence [QualifierName] => standards ) [5] => SimpleXMLElement Object ( [DescriptorName] => Fractures, Bone [QualifierName] => diagnostic imaging ) [6] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [7] => SimpleXMLElement Object ( [DescriptorName] => Reproducibility of Results ) [8] => SimpleXMLElement Object ( [DescriptorName] => Tomography, X-Ray Computed ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => bone disease [1] => endocrinology ) ) [CoiStatement] => Competing interests: None declared. ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2019 [Month] => 01 [Day] => 29 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2019 [Month] => 03 [Day] => 12 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2019 [Month] => 03 [Day] => 22 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2019 [Month] => 4 [Day] => 27 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 4 [Day] => 1 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2019 [Month] => 4 [Day] => 27 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 31023705 [1] => archdischild-2019-316940 [2] => 10.1136/archdischild-2019-316940 ) ) ) ) [7] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 30667079 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 08 [Day] => 24 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 09 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1365-2265 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 91 [Issue] => 1 [PubDate] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 07 ) ) [Title] => Clinical endocrinology [ISOAbbreviation] => Clin Endocrinol (Oxf) ) [ArticleTitle] => Increased central adiposity and decreased subcutaneous adipose tissue 11β-hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance-A longitudinal cohort study. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 72-81 ) [ELocationID] => 10.1111/cen.13939 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Increasing adiposity, ageing and tissue-specific regeneration of cortisol through the activity of 11β-hydroxysteroid dehydrogenase type 1 have been associated with deterioration in glucose tolerance. We undertook a longitudinal, prospective clinical study to determine if alterations in local glucocorticoid metabolism track with changes in glucose tolerance. [1] => Sixty-five overweight/obese individuals (mean age 50.3 ± 7.3 years) underwent oral glucose tolerance testing, body composition assessment, subcutaneous adipose tissue biopsy and urinary steroid metabolite analysis annually for up to 5 years. Participants were categorized into those in whom glucose tolerance deteriorated ("deteriorators") or improved ("improvers"). [2] => Deteriorating glucose tolerance was associated with increasing total and trunk fat mass and increased subcutaneous adipose tissue expression of lipogenic genes. Subcutaneous adipose tissue 11β-HSD1 gene expression decreased in deteriorators, and at study completion, it was highest in the improvers. There was a significant negative correlation between change in area under the curve glucose and 11β-HSD1 expression. Global 11β-HSD1 activity did not change and was not different between deteriorators and improvers at baseline or follow-up. [3] => Longitudinal deterioration in metabolic phenotype is not associated with increased 11β-HSD1 activity, but decreased subcutaneous adipose tissue gene expression. These changes may represent a compensatory mechanism to decrease local glucocorticoid exposure in the face of an adverse metabolic phenotype. ) [CopyrightInformation] => © 2019 John Wiley & Sons Ltd. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crowley [ForeName] => Rachel K [Initials] => RK [Identifier] => 0000-0003-1472-4117 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology, St Vincent's University Hospital, Dublin, Ireland. ) [1] => SimpleXMLElement Object ( [Affiliation] => School of Medicine & Medical Sciences, University College Dublin, Dublin, Ireland. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Woods [ForeName] => Conor P [Initials] => CP [Identifier] => 0000-0003-0358-4745 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology, Naas General Hospital, Kildare, Ireland. ) [1] => SimpleXMLElement Object ( [Affiliation] => Tallaght Hospital, Dublin, Ireland. ) ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hughes [ForeName] => Beverly A [Initials] => BA [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gray [ForeName] => Joanna [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => NIHR/Wellcome Trust Clinical Research Facility, Queen Elizabeth Hospital, Birmingham, UK. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => McCarthy [ForeName] => Theresa [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => NIHR/Wellcome Trust Clinical Research Facility, Queen Elizabeth Hospital, Birmingham, UK. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Taylor [ForeName] => Angela E [Initials] => AE [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gathercole [ForeName] => Laura L [Initials] => LL [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shackleton [ForeName] => Cedric H L [Initials] => CHL [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => NIHR/Wellcome Trust Clinical Research Facility, Queen Elizabeth Hospital, Birmingham, UK. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Arlt [ForeName] => Wiebke [Initials] => W [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK. ) ) [10] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Stewart [ForeName] => Paul M [Initials] => PM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Medical School, University of Leeds, Leeds, UK. ) ) [11] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tomlinson [ForeName] => Jeremy W [Initials] => JW [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Oxford Centre for Diabetes Endocrinology & Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK. ) ) ) ) [Language] => eng [GrantList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Grant] => Array ( [0] => SimpleXMLElement Object ( [GrantID] => G0802765 [Acronym] => MRC_ [Agency] => Medical Research Council [Country] => United Kingdom ) [1] => SimpleXMLElement Object ( [GrantID] => MR/N024591/1 [Acronym] => MRC_ [Agency] => Medical Research Council [Country] => United Kingdom ) [2] => SimpleXMLElement Object ( [GrantID] => MR/P011462/1 [Acronym] => MRC_ [Agency] => Medical Research Council [Country] => United Kingdom ) [3] => SimpleXMLElement Object ( [Acronym] => DH_ [Agency] => Department of Health [Country] => United Kingdom ) ) ) [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Research Support, Non-U.S. Gov't ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2019 [Month] => 04 [Day] => 17 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Clin Endocrinol (Oxf) [NlmUniqueID] => 0346653 [ISSNLinking] => 0300-0664 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => Array ( [0] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Adrenal Cortex Hormones ) [1] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Glucocorticoids ) [2] => SimpleXMLElement Object ( [RegistryNumber] => EC 1.1.1.146 [NameOfSubstance] => 11-beta-Hydroxysteroid Dehydrogenase Type 1 ) ) ) [CitationSubset] => IM [CommentsCorrectionsList] => SimpleXMLElement Object ( [CommentsCorrections] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [RefType] => CommentIn ) [RefSource] => Clin Endocrinol (Oxf). 2019 Jun;90(6):849 [PMID] => 30768800 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [RefType] => CommentIn ) [RefSource] => Clin Endocrinol (Oxf). 2019 Jun;90(6):849-850 [PMID] => 30828849 ) ) ) [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => 11-beta-Hydroxysteroid Dehydrogenase Type 1 [QualifierName] => metabolism ) [1] => SimpleXMLElement Object ( [DescriptorName] => Adiposity [QualifierName] => Array ( [0] => genetics [1] => physiology ) ) [2] => SimpleXMLElement Object ( [DescriptorName] => Adrenal Cortex Hormones [QualifierName] => Array ( [0] => metabolism [1] => urine ) ) [3] => SimpleXMLElement Object ( [DescriptorName] => Adult ) [4] => SimpleXMLElement Object ( [DescriptorName] => Female ) [5] => SimpleXMLElement Object ( [DescriptorName] => Glucocorticoids [QualifierName] => Array ( [0] => metabolism [1] => urine ) ) [6] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [7] => SimpleXMLElement Object ( [DescriptorName] => Longitudinal Studies ) [8] => SimpleXMLElement Object ( [DescriptorName] => Male ) [9] => SimpleXMLElement Object ( [DescriptorName] => Middle Aged ) [10] => SimpleXMLElement Object ( [DescriptorName] => Prospective Studies ) [11] => SimpleXMLElement Object ( [DescriptorName] => Real-Time Polymerase Chain Reaction ) [12] => SimpleXMLElement Object ( [DescriptorName] => Subcutaneous Fat [QualifierName] => metabolism ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => 11β-HSD1 [1] => cortisol [2] => gene expression [3] => glucose tolerance [4] => metabolic function [5] => subcutaneous adipose tissue ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2018 [Month] => 10 [Day] => 11 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2019 [Month] => 01 [Day] => 10 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2019 [Month] => 01 [Day] => 16 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2019 [Month] => 1 [Day] => 23 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2020 [Month] => 8 [Day] => 25 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2019 [Month] => 1 [Day] => 23 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 30667079 [1] => 10.1111/cen.13939 ) ) ) ) [8] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 29960081 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 07 [Day] => 22 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 07 [Day] => 22 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1873-2763 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 114 [PubDate] => SimpleXMLElement Object ( [Year] => 2018 [Month] => 09 ) ) [Title] => Bone [ISOAbbreviation] => Bone ) [ArticleTitle] => Cumulative radiation exposure from medical imaging and associated lifetime cancer risk in children with osteogenesis imperfecta. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 252-256 ) [ELocationID] => Array ( [0] => S8756-3282(18)30253-9 [1] => 10.1016/j.bone.2018.06.021 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => To estimate the cumulative effective dose of radiation (E) and additional lifetime attributable risk (LAR) of cancer from ionizing radiation in children with osteogenesis imperfecta (OI), who require frequent imaging for fractures and bone densitometry (DXA) surveillance. Also, to evaluate the pattern of long bone fractures. [1] => We reviewed all imaging (x-rays, DXA and computed tomography [CT]) conducted in a cohort of children with OI with a minimum observation period of 5 years. For each image, E was estimated using age-dependent local data, and LAR of cancer was extrapolated. LAR and fracture data were compared among children with mild, moderate and severe OI. LAR was allocated to cancer risk categories, and the moderate risk group (1 in 1000 to 1 in 100) was evaluated further. [2] => Results from 106 children with OI (50% females, 5747 images) are presented, with a median (range) observation period of 11.7 (5.2-15.6) years. CT accounted for 0.8% of total imaging procedures but contributed to 66% of total E. The overall LAR of cancer was minimal, averaging an additional 8.8 cases per 100,000 exposed patients (0.8-403). LAR was significantly lower in children with mild OI compared to those with moderate (p = 0.006) and severe OI (p = 0.001). All patients with a moderate LAR of cancer (n = 8) had undergone CT scans and 88% had scoliosis or vertebral fractures. The cohort experienced 412 long bone fractures, with the most common site being the femur (26.5%). OI severity correlated positively with long bone fracture rates (p < 0.001). [3] => When compared to baseline LAR of cancer (50%) the additional cancer risk from ionizing radiation imaging in our paediatric OI cohort was small (0.0088%). To reduce additional cancer risk, we recommend replacing spinal x-rays with vertebral fracture assessments on DXA and exercising caution with CT imaging. ) [CopyrightInformation] => Copyright © 2018 Elsevier Inc. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Thorby-Lister [ForeName] => Amy [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Women's and Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Högler [ForeName] => Wolfgang [Initials] => W [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Women's and Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK; Institute of Metabolism and Systems Research, University of Birmingham, IBR Tower, Level 2, College of Medical and Dental Sciences, Edgbaston, Birmingham B15 2TT, UK. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hodgson [ForeName] => Kirsten [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Radiation Physics and Protection Services, University Hospitals Birmingham NHS Foundation Trust, 63 Melchett Road, Kings Norton Business Centre, Birmingham B30 3HP, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Women's and Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Nightingale [ForeName] => Peter [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Institute of Translational Medicine, Heritage Building, Mindelsohn Way, Edgbaston, Birmingham B15 2TH, UK. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shaw [ForeName] => Nick [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Women's and Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK; Institute of Metabolism and Systems Research, University of Birmingham, IBR Tower, Level 2, College of Medical and Dental Sciences, Edgbaston, Birmingham B15 2TT, UK. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Saraff [ForeName] => Vrinda [Initials] => V [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Women's and Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. Electronic address: vrinda.saraff@nhs.net. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Observational Study ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2018 [Month] => 06 [Day] => 27 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Bone [NlmUniqueID] => 8504048 [ISSNLinking] => 1873-2763 ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Adolescent ) [1] => SimpleXMLElement Object ( [DescriptorName] => Child ) [2] => SimpleXMLElement Object ( [DescriptorName] => Child, Preschool ) [3] => SimpleXMLElement Object ( [DescriptorName] => Cohort Studies ) [4] => SimpleXMLElement Object ( [DescriptorName] => Diagnostic Imaging [QualifierName] => Array ( [0] => adverse effects [1] => trends ) ) [5] => SimpleXMLElement Object ( [DescriptorName] => Female ) [6] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [7] => SimpleXMLElement Object ( [DescriptorName] => Infant ) [8] => SimpleXMLElement Object ( [DescriptorName] => Infant, Newborn ) [9] => SimpleXMLElement Object ( [DescriptorName] => Longevity [QualifierName] => radiation effects ) [10] => SimpleXMLElement Object ( [DescriptorName] => Male ) [11] => SimpleXMLElement Object ( [DescriptorName] => Neoplasms, Radiation-Induced [QualifierName] => Array ( [0] => diagnosis [1] => epidemiology ) ) [12] => SimpleXMLElement Object ( [DescriptorName] => Osteogenesis Imperfecta [QualifierName] => Array ( [0] => diagnostic imaging [1] => epidemiology ) ) [13] => SimpleXMLElement Object ( [DescriptorName] => Radiation Exposure [QualifierName] => adverse effects ) [14] => SimpleXMLElement Object ( [DescriptorName] => Retrospective Studies ) [15] => SimpleXMLElement Object ( [DescriptorName] => Risk Factors ) [16] => SimpleXMLElement Object ( [DescriptorName] => Tomography, X-Ray Computed [QualifierName] => Array ( [0] => adverse effects [1] => trends ) ) [17] => SimpleXMLElement Object ( [DescriptorName] => United Kingdom [QualifierName] => epidemiology ) [18] => SimpleXMLElement Object ( [DescriptorName] => Young Adult ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Cumulative radiation exposure [1] => Fractures [2] => Lifetime cancer risk [3] => Osteogenesis imperfecta [4] => x-rays ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2018 [Month] => 02 [Day] => 20 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2018 [Month] => 06 [Day] => 26 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2018 [Month] => 06 [Day] => 26 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2018 [Month] => 7 [Day] => 1 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2019 [Month] => 7 [Day] => 23 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2018 [Month] => 7 [Day] => 1 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 29960081 [1] => S8756-3282(18)30253-9 [2] => 10.1016/j.bone.2018.06.021 ) ) ) ) [9] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 29804121 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2018 [Month] => 10 [Day] => 18 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2018 [Month] => 10 [Day] => 18 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1663-2826 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 89 [Issue] => 4 [PubDate] => SimpleXMLElement Object ( [Year] => 2018 ) ) [Title] => Hormone research in paediatrics [ISOAbbreviation] => Horm Res Paediatr ) [ArticleTitle] => Bone Mineral Density Corrected for Size in Childhood Leukaemia Survivors Treated with Haematopoietic Stem Cell Transplantation and Total Body Irradiation. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 246-254 ) [ELocationID] => 10.1159/000487996 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Childhood leukaemia survivors treated with haematopoietic stem cell transplantation and total body irradiation (HSCT-TBI) have multiple risk factors for reduced bone mineral density (BMD) and growth failure; hence, BMD assessment must take body size into consideration. This study aimed to evaluate size-corrected BMD in leukaemia survivors treated with and without HSCT-TBI. [1] => Childhood leukaemia survivors treated with HSCT-TBI (n = 35), aged 17.3 (10.5-20.9) years, were compared with those treated with chemotherapy only, (n = 16) aged 18.5 (16.1-20.9) years, and population references. Outcome measures included anthropometric measurements and BMD by dual-energy X-ray absorptiometry. BMD was corrected for size as bone mineral apparent density (BMAD). Statistical analysis was performed by 1- and 2-sample t tests as well as regression analysis (5% significance). [2] => HSCT-TBI survivors were lighter and shorter with reduced spinal heights compared with chemotherapy-only subjects and population references. Compared with population references, HSCT-TBI survivors showed lower BMD standard deviation scores (SDS) (p = 0.008), but no difference in BMAD-SDS, and chemotherapy-only survivors showed no differences in neither BMD-SDS nor BMAD-SDS. All HSCT-TBI participants with BMD-SDS <-2 had BMAD-SDS >-2. BMAD-SDS was negatively associated with age (r = -0.38, p = 0.029) in HSCT-TBI survivors. [3] => Size-corrected BMD are normal in HSCT-TBI survivors in young adulthood, but may reduce overtime. BMD measurements should be corrected for size in these patients to be clinically meaningful. ) [CopyrightInformation] => © 2018 S. Karger AG, Basel. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Wei [ForeName] => Christina [Initials] => C [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom. ) [1] => SimpleXMLElement Object ( [Affiliation] => University of Bristol, Bristol, United Kingdom. ) [2] => SimpleXMLElement Object ( [Affiliation] => St George's University, NHS Foundation Trust, Bristol, United Kingdom. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Candler [ForeName] => Toby [Initials] => T [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom. ) [1] => SimpleXMLElement Object ( [Affiliation] => University of Bristol, Bristol, United Kingdom. ) ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Davis [ForeName] => Nikki [Initials] => N [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom. ) [1] => SimpleXMLElement Object ( [Affiliation] => University of Bristol, Bristol, United Kingdom. ) [2] => SimpleXMLElement Object ( [Affiliation] => University Hospital Southampton, NHS Foundation Trust, Southampton, United Kingdom. ) ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Elson [ForeName] => Ruth [Initials] => R [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Birmingham Women's and Children's Hospital, Birmingham, United Kingdom. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Stevens [ForeName] => Michael [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => University of Bristol, Bristol, United Kingdom. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crowne [ForeName] => Elizabeth [Initials] => E [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom. ) [1] => SimpleXMLElement Object ( [Affiliation] => University of Bristol, Bristol, United Kingdom. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Clinical Trial [1] => Comparative Study [2] => Journal Article ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2018 [Month] => 05 [Day] => 25 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Switzerland [MedlineTA] => Horm Res Paediatr [NlmUniqueID] => 101525157 [ISSNLinking] => 1663-2818 ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Absorptiometry, Photon ) [1] => SimpleXMLElement Object ( [DescriptorName] => Adolescent ) [2] => SimpleXMLElement Object ( [DescriptorName] => Adult ) [3] => SimpleXMLElement Object ( [DescriptorName] => Allografts ) [4] => SimpleXMLElement Object ( [DescriptorName] => Bone Density ) [5] => SimpleXMLElement Object ( [DescriptorName] => Cancer Survivors ) [6] => SimpleXMLElement Object ( [DescriptorName] => Child ) [7] => SimpleXMLElement Object ( [DescriptorName] => Hematopoietic Stem Cell Transplantation ) [8] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [9] => SimpleXMLElement Object ( [DescriptorName] => Leukemia [QualifierName] => therapy ) [10] => SimpleXMLElement Object ( [DescriptorName] => Male ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Bone mineral density [1] => Haematopoietic stem cell transplantation [2] => Leukaemia [3] => Long-term survivors [4] => Total body irradiation ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2017 [Month] => 12 [Day] => 05 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2018 [Month] => 02 [Day] => 26 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( 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[Journal] => SimpleXMLElement Object ( [ISSN] => 1468-2044 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 103 [Issue] => 1 [PubDate] => SimpleXMLElement Object ( [Year] => 2018 [Month] => 01 ) ) [Title] => Archives of disease in childhood [ISOAbbreviation] => Arch Dis Child ) [ArticleTitle] => Efficacy and treatment costs of zoledronate versus pamidronate in paediatric osteoporosis. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 92-94 ) [ELocationID] => 10.1136/archdischild-2017-313234 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Intravenous pamidronate has been used in the treatment of osteogenesis imperfecta (OI) in children for over 20 years. The more potent zoledronate is an attractive alternative as it is administered less frequently. This study compares the clinical efficacy of intravenous pamidronate (1.5 mg/kg/day over 2 days, every 3 months) versus zoledronate (0.05 mg/kg/dose every 6 months) in 40 children (20 per group) with mild to moderate OI and the treatment costs of the two drugs in a tertiary centre for children with osteoporosis. Lumbar spine bone mineral density and fracture rate did not differ between drug groups following 1 and 2 years of treatment, respectively. Total cost per treatment course per patient was £1157 for pamidronate and £498 for zoledronate. Therefore, zoledronate is a considerably cheaper alternative to pamidronate with comparable efficacy, resulting in substantial annual savings for healthcare providers and a more convenient option for patients due to fewer hospital visits. [CopyrightInformation] => © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Saraff [ForeName] => Vrinda [Initials] => V [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Children's Hospital, Birmingham, UK. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sahota [ForeName] => Jaskiran [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Children's Hospital, Birmingham, UK. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Children's Hospital, Birmingham, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sakka [ForeName] => Sophia [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Children's Hospital, Birmingham, UK. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shaw [ForeName] => Nicholas J [Initials] => NJ [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Children's Hospital, Birmingham, UK. ) [1] => SimpleXMLElement Object ( [Affiliation] => Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK. ) ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Högler [ForeName] => Wolfgang [Initials] => W [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Children's Hospital, Birmingham, UK. ) [1] => SimpleXMLElement Object ( [Affiliation] => Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2017 [Month] => 10 [Day] => 07 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Arch Dis Child [NlmUniqueID] => 0372434 [ISSNLinking] => 0003-9888 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => Array ( [0] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Bone Density Conservation Agents ) [1] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Diphosphonates ) [2] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Imidazoles ) [3] => SimpleXMLElement Object ( [RegistryNumber] => 6XC1PAD3KF [NameOfSubstance] => Zoledronic Acid ) [4] => SimpleXMLElement Object ( [RegistryNumber] => OYY3447OMC [NameOfSubstance] => Pamidronate ) ) ) [SupplMeshList] => SimpleXMLElement Object ( [SupplMeshName] => Juvenile osteoporosis ) [CitationSubset] => Array ( [0] => AIM [1] => IM ) [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Administration, Intravenous ) [1] => SimpleXMLElement Object ( [DescriptorName] => Bone Density ) [2] => SimpleXMLElement Object ( [DescriptorName] => Bone Density Conservation Agents [QualifierName] => Array ( [0] => economics [1] => therapeutic use ) ) [3] => SimpleXMLElement Object ( [DescriptorName] => Child ) [4] => SimpleXMLElement Object ( [DescriptorName] => Diphosphonates [QualifierName] => Array ( [0] => economics [1] => therapeutic use ) ) [5] => SimpleXMLElement Object ( 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Response to Letter to the Editor: "The Effect of Whole Body Vibration Training on Bone and Muscle Function in Children With Osteogenesis Imperfecta". 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[2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Nightingale [ForeName] => Peter [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Wellcome Trust Clinical Research Facility, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shaw [ForeName] => Nick [Initials] => N [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology & Diabetes, Birmingham Children's Hospital, Birmingham B4 6NH, United Kingdom. ) [1] => SimpleXMLElement Object ( [Affiliation] => Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, United Kingdom. ) ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Padidela [ForeName] => Raja [Initials] => R [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology, Royal Manchester Children's Hospital, Manchester M13 9WL, United Kingdom. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology & Diabetes, Birmingham Children's Hospital, Birmingham B4 6NH, United Kingdom. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Letter [1] => Comment ) ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => J Clin Endocrinol Metab [NlmUniqueID] => 0375362 [ISSNLinking] => 0021-972X ) [CitationSubset] => Array ( [0] => AIM [1] => IM ) [CommentsCorrectionsList] => SimpleXMLElement Object ( [CommentsCorrections] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [RefType] => CommentOn ) [RefSource] => J Clin Endocrinol Metab. 2017 Aug 1;102(8):2734-2743 [PMID] => 28472303 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [RefType] => CommentOn ) [RefSource] => J Clin Endocrinol Metab. 2017 Nov 1;102(11):4260-4261 [PMID] => 28938436 ) ) ) [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Bone Density ) [1] => SimpleXMLElement Object ( [DescriptorName] => Bone and Bones ) [2] => SimpleXMLElement Object ( [DescriptorName] => Child ) [3] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [4] => SimpleXMLElement Object ( [DescriptorName] => Muscular Diseases ) [5] => SimpleXMLElement Object ( [DescriptorName] => Osteogenesis Imperfecta ) [6] => SimpleXMLElement Object ( [DescriptorName] => Vibration ) ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2017 [Month] => 07 [Day] => 28 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2017 [Month] => 08 [Day] => 24 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2017 [Month] => 9 [Day] => 25 [Hour] => 6 [Minute] => 0 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2018 [Month] => 5 [Day] => 22 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2017 [Month] => 9 [Day] => 23 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 28938474 [1] => 4096787 [2] => 10.1210/jc.2017-01682 ) ) ) ) [12] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 28472303 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2017 [Month] => 09 [Day] => 20 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 06 [Day] => 21 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1945-7197 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 102 [Issue] => 8 [PubDate] => SimpleXMLElement Object ( [Year] => 2017 [Month] => 08 [Day] => 01 ) ) [Title] => The Journal of clinical endocrinology and metabolism [ISOAbbreviation] => J Clin Endocrinol Metab ) [ArticleTitle] => The Effect of Whole Body Vibration Training on Bone and Muscle Function in Children With Osteogenesis Imperfecta. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 2734-2743 ) [ELocationID] => 10.1210/jc.2017-00275 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Osteogenesis imperfecta (OI) is associated with reduced muscle size, dynamic muscle function, and mobility. [1] => To assess the effect of whole body vibration (WBV) on bone density and geometry, muscle size and function, mobility, and balance in children with OI. [2] => Randomized controlled pilot trial. [3] => Tertiary pediatric research center. [4] => Twenty-four children (5 to 16 years) with OI types 1, 4, and limited mobility [Child Health Assessment Questionnaire (CHAQ) score ≥ 0.13] recruited in sex- and pubertal stage-matched pairs. Incident fractures in two boys (WBV arm) led to exclusion of two prepubertal pairs. [5] => Five months of WBV training (3 × 3 minutes twice daily) or regular care. [6] => Bone and muscle variables measured by dual-energy X-ray absorptiometry (spine, hip, total body) and peripheral quantitative computed tomography (tibia). Mobility assessed by 6-minute walk tests and CHAQ; dynamic muscle function by mechanography. [7] => All participants had reduced walking distances and muscle function (P < 0.001). Body mass index z score was associated with higher CHAQ scores (ρ + 0.552; P = 0.005) and lower walking and two-leg jumping performance (ρ - 0.405 to -0.654, P < 0.05). The WBV and control groups did not differ in the 5-month changes in bone. Total lean mass increased more in the WBV group [+1119 g (+224 to +1744)] compared with controls [+635 g (-951 to +1006)], P = 0.01, without improving mobility, muscle function, or balance. [8] => The increase in lean mass without changes in muscle function or bone mass suggests reduced biomechanical responsiveness of the muscle-bone unit in children with OI. ) [CopyrightInformation] => Copyright © 2017 Endocrine Society ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Högler [ForeName] => Wolfgang [Initials] => W [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology & Diabetes, Birmingham Children's Hospital, Birmingham B4 6NH, United Kingdom. ) [1] => SimpleXMLElement Object ( [Affiliation] => Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, United Kingdom. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Scott [ForeName] => Janis [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology & Diabetes, Birmingham Children's Hospital, Birmingham B4 6NH, United Kingdom. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Bishop [ForeName] => Nick [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Academic Unit of Child Health, Sheffield Children's Hospital, Sheffield S10 2TH, United Kingdom. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Arundel [ForeName] => Paul [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Academic Unit of Child Health, Sheffield Children's Hospital, Sheffield S10 2TH, United Kingdom. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Nightingale [ForeName] => Peter [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Wellcome Trust Clinical Research Facility, Queen Elizabeth Hospital, 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[@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 102 [Issue] => 6 [PubDate] => SimpleXMLElement Object ( [Year] => 2017 [Month] => 06 [Day] => 01 ) ) [Title] => The Journal of clinical endocrinology and metabolism [ISOAbbreviation] => J Clin Endocrinol Metab ) [ArticleTitle] => Phenotypic Spectrum in Osteogenesis Imperfecta Due to Mutations in TMEM38B: Unraveling a Complex Cellular Defect. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 2019-2028 ) [ELocationID] => 10.1210/jc.2016-3766 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Recessive mutations in TMEM38B cause type XIV osteogenesis imperfecta (OI) by dysregulating intracellular calcium flux. [1] => Clinical and bone material phenotype description and osteoblast differentiation studies. [2] => Natural history study in pediatric research centers. [3] => Eight patients with type XIV OI. [4] => Clinical examinations included bone mineral density, radiographs, echocardiography, and muscle biopsy. Bone biopsy samples (n = 3) were analyzed using histomorphometry, quantitative backscattered electron microscopy, and Raman microspectroscopy. Cellular differentiation studies were performed on proband and control osteoblasts and normal murine osteoclasts. [5] => Type XIV OI clinical phenotype ranges from asymptomatic to severe. Previously unreported features include vertebral fractures, periosteal cloaking, coxa vara, and extraskeletal features (muscular hypotonia, cardiac abnormalities). Proband lumbar spine bone density z score was reduced [median -3.3 (range -4.77 to +0.1; n = 7)] and increased by +1.7 (1.17 to 3.0; n = 3) following bisphosphonate therapy. TMEM38B mutant bone has reduced trabecular bone volume, osteoblast, and particularly osteoclast numbers, with >80% reduction in bone resorption. Bone matrix mineralization is normal and nanoporosity low. We demonstrate a complex osteoblast differentiation defect with decreased expression of early markers and increased expression of late and mineralization-related markers. Predominance of trimeric intracellular cation channel type B over type A expression in murine osteoclasts supports an intrinsic osteoclast defect underlying low bone turnover. [6] => OI type XIV has a bone histology, matrix mineralization, and osteoblast differentiation pattern that is distinct from OI with collagen defects. 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Active serum 1,25-dihydroxyvitamin D3 (1α,25(OH)2D3), but not inactive 25-hydroxyvitamin D3 (25OHD3), correlated positively with measures of lower limb strength including power (rho = 0.42, p = 0.02), velocity (Vmax, rho = 0.40, p = 0.02) and jump height (rho = 0.36, p = 0.04). Lean mass correlated positively with 1α,25(OH)2D3 (rho = 0.47, p = 0.02), in women. Serum 25OHD3 and inactive 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) had an inverse relationship with body fat (rho = -0.30, p = 0.02 and rho = -0.33, p = 0.01, respectively). Serum 25OHD3 and 24,25(OH)2D3 were also correlated with urinary steroid metabolites, suggesting a link with glucocorticoid metabolism. PCR array analysis of 92 muscle genes identified vitamin D receptor (VDR) mRNA in all muscle biopsies, with this expression being negatively correlated with serum 25OHD3, and Vmax, and positively correlated with fat mass. Of the other 91 muscle genes analysed by PCR array, 24 were positively correlated with 25OHD3, but only 4 were correlated with active 1α,25(OH)2D3. These data show that although 25OHD3 has potent actions on muscle gene expression, the circulating concentrations of this metabolite are more closely linked to body fat mass, suggesting that 25OHD3 can influence muscle function via indirect effects on adipose tissue. By contrast, serum 1α,25(OH)2D3 has limited effects on muscle gene expression, but is associated with increased muscle strength and lean mass in women. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 514-527 ) [ELocationID] => 10.1007/s00223-016-0233-4 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The prevalence of obesity in children has reached epidemic proportions. Concern about bone health in obese children, in part, derives from the potentially increased fracture risk associated with obesity. Additional risk factors that affect bone mineral accretion, may also contribute to obesity, such as low physical activity and nutritional factors. Consequences of obesity, such as inflammation, insulin resistance, and non-alcoholic fatty liver disease, may also affect bone mineral acquisition, especially during the adolescent years when rapid increases in bone contribute to attaining peak bone mass. Further, numerous pediatric health conditions are associated with excess adiposity, altered body composition, or endocrine disturbances that can affect bone accretion. Thus, there is a multitude of reasons for considering clinical assessment of bone health in an obese child. Multiple diagnostic challenges affect the measurement of bone density and its interpretation. These include greater precision error, difficulty in positioning, and the effects of increased lean and fat tissue on bone health outcomes. 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Miner Res ) [ArticleTitle] => Amalgamated Reference Data for Size-Adjusted Bone Densitometry Measurements in 3598 Children and Young Adults-the ALPHABET Study. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 172-180 ) [ELocationID] => 10.1002/jbmr.2935 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The increasing use of dual-energy X-ray absorptiometry (DXA) in children has led to the need for robust reference data for interpretation of scans in daily clinical practice. Such data need to be representative of the population being studied and be "future-proofed" to software and hardware upgrades. The aim was to combine all available pediatric DXA reference data from seven UK centers to create reference curves adjusted for age, sex, ethnicity, and body size to enable clinical application, using in vivo cross-calibration and making data back and forward compatible. Seven UK sites collected data on GE Lunar or Hologic Scanners between 1996 and 2012. Males and females aged 4 to 20 years were recruited (n = 3598). The split by ethnic group was white 2887; South Asian 385; black Afro-Caribbean 286; and mixed heritage 40. Scans of the total body and lumbar spine (L to L ) were obtained. The European Spine Phantom was used to cross-calibrate the 7 centers and 11 scanners. Reference curves were produced for L to L bone mineral apparent density (BMAD) and total body less head (TBLH) and L to L areal bone mineral density (aBMD) for GE Lunar Prodigy and iDXA (sex- and ethnic-specific) and for Hologic (sex-specific). Regression equations for TBLH BMC were produced using stepwise linear regression. Scans of 100 children were randomly selected to test backward and forward compatibility of software versions, up to version 15.0 for GE Lunar and Apex 4.1 for Hologic. For the first time, sex- and ethnic-specific reference curves for lumbar spine BMAD, aBMD, and TBLH aBMD are provided for both GE Lunar and Hologic scanners. These curves will facilitate interpretation of DXA data in children using methods recommended in ISCD guidelines. The databases have been created to allow future updates and analysis when more definitive evidence for the best method of fracture prediction in children is agreed. © 2016 American Society for Bone and Mineral Research. [CopyrightInformation] => © 2016 American Society for Bone and Mineral Research. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola J [Initials] => NJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Children's Hospital, Birmingham, UK. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shaw [ForeName] => Nicholas J [Initials] => NJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology and Diabetes, Birmingham Children's Hospital, Birmingham, UK. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Bishop [ForeName] => Nicholas J [Initials] => NJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Academic Unit of Child Health, University of Sheffield, Sheffield, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Adams [ForeName] => Judith E [Initials] => JE [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Radiology and Manchester Academic Health Science Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, Manchester, UK. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mughal [ForeName] => M Zulf [Initials] => MZ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Endocrinology, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, Manchester, UK. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Arundel [ForeName] => Paul [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Academic Unit 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Groups were compared for neutrophil migration, phagocytosis, oxidative burst, cell surface receptor expression, metabolic health parameters and systemic inflammation. Groups were also compared against ten young participants (23±4years). [2] => The most active group completed over twice as many steps/day as the least active group (p<0.001), had lower BMI's (p=0.007) and body fat percentages (p=0.029). Neutrophils migrated towards IL-8 better in the most active group compared to the least active (p<0.05) and was comparable to that of the young (p>0.05). These differences remained after adjusting for BMI, body fat and plasma metabolic markers which were different between groups. Correlations revealed that steps/day, higher adiponectin and lower insulin were positively associated with migratory ability (p<0.05). There was no difference in expression of the chemokine receptors CXCR1 or CXCR2 (p>0.05 for both). CD11b was higher in the most active group compared to the least active (p=0.048). No differences between activity groups or young controls were observed for neutrophil phagocytosis or oxidative burst in response to Escherichia coli (p>0.05). The young group had lower concentrations of IL-6, IL-8, MCP-1, CRP, IL-10 and IL-13 (p<0.05 for all) with no differences between the two older groups. [3] => These data suggest that impaired neutrophil migration, but not bactericidal function, in older adults may be, in part, the result of reduced physical activity. A 2-fold difference in physical activity is associated with better preserved neutrophil migratory dynamics in healthy older people. As a consequence increasing habitual physical activity may be beneficial for neutrophil mediated immunity. ) [CopyrightInformation] => Copyright © 2016 The Authors. Published by Elsevier Inc. 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[PubDate] => SimpleXMLElement Object ( [Year] => 2016 [Month] => Mar ) ) [Title] => Transplant international : official journal of the European Society for Organ Transplantation [ISOAbbreviation] => Transpl Int ) [ArticleTitle] => Cardiovascular, muscular and perceptual contributions to physical fatigue in prevalent kidney transplant recipients. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 338-51 ) [ELocationID] => 10.1111/tri.12727 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Physical fatigue is debilitating and common among kidney transplant recipients (KTRs). This study investigated the mechanistic aetiology of physical fatigue in this setting through examinations of muscle mass, muscular and cardiovascular function, and perceived exertion. The incidence of physical fatigue, its association with quality of life (QoL), and the predictors of perceived exertion, were evaluated. This single-centre observational cross-sectional study enrolled 55 KTRs. Muscle mass was quantified using dual-energy x-ray absorptiometry. Muscular function was assessed by jumping mechanography. Cardiovascular function (maximal oxygen consumption and oxygen pulse) was estimated during submaximal exercise testing, with perceived exertion determined using age-adjusted Borg scale-ratings. Physical fatigue was measured using Multi-Dimensional Fatigue Inventory-20. QoL was assessed using Medical Outcomes Study Short Form-36. Demographic, clinical, nutritional, psychosocial and behavioural predictors of perceived exertion were assessed. Of clinical importance, increased perceived exertion was the only independent predictor of physical fatigue (P = 0.001), with no association found between physical fatigue and muscular or cardiovascular parameters. Physical fatigue occurred in 22% of KTRs, and negatively impacted on QoL (P < 0.001). Predictors of heightened perception included anxiety (P < 0.05) and mental fatigue (P < 0.05). Perception is a key determinant of physical fatigue in KTRs, paving the way for future interventions. [CopyrightInformation] => © 2015 Steunstichting ESOT. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Chan [ForeName] => Winnie [Initials] => W [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Nephrology & Kidney Transplantation, Queen Elizabeth Hospital Birmingham, Birmingham, UK. ) [1] => SimpleXMLElement Object ( [Affiliation] => School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. ) [2] => SimpleXMLElement Object ( [Affiliation] => Department of Nutrition & Dietetics, Queen Elizabeth Hospital Birmingham, Birmingham, UK. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Jones [ForeName] => David [Initials] => D [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Healthcare Science, Manchester Metropolitan University, Manchester, UK. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Bosch [ForeName] => Jos A [Initials] => JA [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands. ) ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => McPhee [ForeName] => Jamie [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Healthcare Science, Manchester Metropolitan University, Manchester, UK. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Nuclear Medicine, Queen Elizabeth Hospital Birmingham, Birmingham, UK. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => McTernan [ForeName] => Philip G [Initials] => PG [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Metabolic and Vascular Health, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kaur [ForeName] => Okdeep [Initials] => O [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Nephrology & Kidney Transplantation, Queen Elizabeth Hospital Birmingham, Birmingham, UK. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Inston [ForeName] => Nicholas [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Nephrology & Kidney Transplantation, Queen 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[@attributes] => Array ( [ValidYN] => Y ) [LastName] => Phillips [ForeName] => Anna C [Initials] => AC [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. ) ) [12] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Borrows [ForeName] => Richard [Initials] => R [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Nephrology & Kidney Transplantation, Queen Elizabeth Hospital Birmingham, Birmingham, UK. ) [1] => SimpleXMLElement Object ( [Affiliation] => Translational Inflammation Research, University of Birmingham, Birmingham, UK. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Observational Study [2] => Research Support, Non-U.S. Gov't ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2016 [Month] => 01 [Day] => 06 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Transpl Int [NlmUniqueID] => 8908516 [ISSNLinking] => 0934-0874 ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Adult ) [1] => SimpleXMLElement Object ( [DescriptorName] => Cross-Sectional Studies ) [2] => SimpleXMLElement Object ( [DescriptorName] => Fatigue [QualifierName] => Array ( [0] => epidemiology [1] => etiology [2] => psychology ) ) [3] => SimpleXMLElement Object ( [DescriptorName] => Female ) [4] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [5] => SimpleXMLElement Object ( [DescriptorName] => Kidney Transplantation ) [6] => SimpleXMLElement Object ( [DescriptorName] => Male ) [7] => SimpleXMLElement Object ( [DescriptorName] => Middle Aged ) [8] => SimpleXMLElement Object ( [DescriptorName] => Muscle, Skeletal [QualifierName] => physiology ) [9] => SimpleXMLElement Object ( [DescriptorName] => Oxygen Consumption ) [10] => SimpleXMLElement Object ( [DescriptorName] => Postoperative Complications [QualifierName] => Array ( [0] => epidemiology [1] => etiology [2] => psychology ) ) [11] => SimpleXMLElement Object ( [DescriptorName] => Quality of Life ) [12] => SimpleXMLElement Object ( [DescriptorName] => United Kingdom [QualifierName] => epidemiology ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => cardiovascular [1] => fatigue [2] => kidney [3] => muscular [4] => perception [5] => transplant ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2015 [Month] => 07 [Day] => 23 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2015 [Month] => 08 [Day] => 18 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2015 [Month] => 11 [Day] => 24 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2015 [Month] => 11 [Day] => 29 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2015 [Month] => 11 [Day] => 29 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2016 [Month] => 12 [Day] => 15 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 26614985 [1] => 10.1111/tri.12727 ) ) ) ) [19] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 26264718 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2016 [Month] => 01 [Day] => 12 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 10 [Day] => 08 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1479-683X [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 173 [Issue] => 5 [PubDate] => SimpleXMLElement Object ( [Year] => 2015 [Month] => Nov ) ) [Title] => European journal of endocrinology [ISOAbbreviation] => Eur J Endocrinol ) [ArticleTitle] => The modulation of corticosteroid metabolism by hydrocortisone therapy in patients with hypopituitarism increases tissue glucocorticoid exposure. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 583-93 ) [ELocationID] => 10.1530/EJE-15-0490 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Patients with hypopituitarism have increased morbidity and mortality. There is ongoing debate about the optimum glucocorticoid (GC) replacement therapy. [1] => To assess the effect of GC replacement in hypopituitarism on corticosteroid metabolism and its impact on body composition. [2] => We assessed the urinary corticosteroid metabolite profile (using gas chromatography/mass spectrometry) and body composition (clinical parameters and full body DXA) of 53 patients (19 female, median age 46 years) with hypopituitarism (33 ACTH-deficient/20 ACTH-replete) (study A). The corticosteroid metabolite profile of ten patients with ACTH deficiency was then assessed prospectively in a cross over study using three hydrocortisone (HC) dosing regimens (20/10 mg, 10/10 mg and 10/5 mg) (study B) each for 6 weeks. 11 beta-hydroxysteroid dehydrogenase 1 (11β-HSD1) activity was assessed by urinary THF+5α-THF/THE. [3] => Endocrine Centres within University Teaching Hospitals in the UK and Ireland. [4] => Urinary corticosteroid metabolite profile and body composition assessment. [5] => In study A, when patients were divided into three groups - patients not receiving HC and patients receiving HC≤20 mg/day or HC>20 mg/day - patients in the group receiving the highest daily dose of HC had significantly higher waist-to-hip ratio (WHR) than the ACTH replete group. They also had significantly elevated THF+5α-THF/THE (P=0.0002) and total cortisol metabolites (P=0.015). In study B, patients on the highest HC dose had significantly elevated total cortisol metabolites and all patients on HC had elevated THF+5α-THF/THE ratios when compared to controls. [6] => In ACTH-deficient patients daily HC doses of >20 mg/day have increased WHR, THF+5α-THF/THE ratios and total cortisol metabolites. GC metabolism and induction of 11β-HSD1 may play a pivitol role in the development of the metabolically adverse hypopituitary phenotype. ) [CopyrightInformation] => © 2015 European Society of Endocrinology. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sherlock [ForeName] => Mark [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UKDepartment of Nuclear MedicineQueen Elizabeth Hospital, Birmingham, UKDepartment of Medicine and EndocrinologyUniversity of Leeds, Leeds, UK Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UKDepartment of Nuclear MedicineQueen Elizabeth Hospital, Birmingham, UKDepartment of Medicine and EndocrinologyUniversity of Leeds, Leeds, UK sherloma@tcd.ie. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Behan [ForeName] => Lucy Ann [Initials] => LA [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UKDepartment of Nuclear MedicineQueen Elizabeth Hospital, Birmingham, UKDepartment of Medicine and EndocrinologyUniversity of Leeds, Leeds, UK Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UKDepartment of Nuclear MedicineQueen Elizabeth Hospital, Birmingham, UKDepartment of Medicine and EndocrinologyUniversity of Leeds, Leeds, UK. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hannon [ForeName] => Mark J [Initials] => MJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UKDepartment of Nuclear MedicineQueen Elizabeth Hospital, Birmingham, UKDepartment of Medicine and EndocrinologyUniversity of Leeds, Leeds, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Alonso [ForeName] => Aurora Aragon [Initials] => AA [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UKDepartment of Nuclear MedicineQueen Elizabeth Hospital, Birmingham, UKDepartment of Medicine and EndocrinologyUniversity of Leeds, Leeds, UK. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Thompson [ForeName] => Christopher J [Initials] => CJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UKDepartment of Nuclear MedicineQueen Elizabeth Hospital, Birmingham, UKDepartment of Medicine and EndocrinologyUniversity of Leeds, Leeds, UK. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Murray [ForeName] => Robert D [Initials] => RD [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UKDepartment of Nuclear MedicineQueen Elizabeth Hospital, Birmingham, UKDepartment of Medicine and EndocrinologyUniversity of Leeds, Leeds, UK. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Crabtree [ForeName] => Nicola [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UKDepartment of Nuclear MedicineQueen Elizabeth Hospital, Birmingham, UKDepartment of Medicine and EndocrinologyUniversity of Leeds, Leeds, UK. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hughes [ForeName] => Beverly A [Initials] => BA [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals 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Publications by authors named "Nicola Crabtree"

38Publications

Assessment of Bone Density by DXA in Poorly Controlled Children With β-Thalassemia: Correction for Hepatic Iron Overload by Manual Analysis.

J Clin Densitom 2020 Aug 29. Epub 2020 Aug 29.

Department of Endocrinology and Diabetes, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

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August 2020

Increased prevalence of fractures in inadequately transfused and chelated Indian children and young adults with beta thalassemia major.

Bone 2021 Feb 18;143:115649. Epub 2020 Sep 18.

Growth and Pediatric Endocrine Department, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra 411 001, India; School of Health Sciences, Savitribai Phule Pune University, Ganeshkhind Rd, Ganeshkhind, Pune, Maharashtra 411007, India. Electronic address:

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February 2021

Diagnostic performance of morphometric vertebral fracture analysis (MXA) in children using a 33-point software program.

Bone 2020 04 21;133:115249. Epub 2020 Jan 21.

Academic Unit of Child Health, University of Sheffield, Sheffield, UK; Radiology Department, Sheffield Children's NHS Foundation Trust, Sheffield, UK. Electronic address:

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April 2020

Older age at initiation of antiretroviral therapy predicts low bone mineral density in children with perinatally-infected HIV in Zimbabwe.

Bone 2019 08 10;125:96-102. Epub 2019 May 10.

Biomedical Research and Training Institute (BRTI), Harare, Zimbabwe; Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), London, UK.

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August 2019

Bone density in children: what are we measuring?

Arch Dis Child 2019 11 25;104(11):1108-1111. Epub 2019 Apr 25.

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

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November 2019

Cumulative radiation exposure from medical imaging and associated lifetime cancer risk in children with osteogenesis imperfecta.

Bone 2018 09 27;114:252-256. Epub 2018 Jun 27.

Department of Endocrinology and Diabetes, Birmingham Women's and Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. Electronic address:

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September 2018

Bone Mineral Density Corrected for Size in Childhood Leukaemia Survivors Treated with Haematopoietic Stem Cell Transplantation and Total Body Irradiation.

Horm Res Paediatr 2018 25;89(4):246-254. Epub 2018 May 25.

Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.

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October 2018

Efficacy and treatment costs of zoledronate versus pamidronate in paediatric osteoporosis.

Arch Dis Child 2018 01 7;103(1):92-94. Epub 2017 Oct 7.

Department of Endocrinology and Diabetes, Birmingham Children's Hospital, Birmingham, UK.

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January 2018

Response to Letter to the Editor: "The Effect of Whole Body Vibration Training on Bone and Muscle Function in Children With Osteogenesis Imperfecta".

J Clin Endocrinol Metab 2017 11;102(11):4262-4263

Department of Endocrinology & Diabetes, Birmingham Children's Hospital, Birmingham B4 6NH, United Kingdom.

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November 2017

The Effect of Whole Body Vibration Training on Bone and Muscle Function in Children With Osteogenesis Imperfecta.

J Clin Endocrinol Metab 2017 08;102(8):2734-2743

Department of Endocrinology & Diabetes, Birmingham Children's Hospital, Birmingham B4 6NH, United Kingdom.

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August 2017

Bone Density in the Obese Child: Clinical Considerations and Diagnostic Challenges.

Calcif Tissue Int 2017 05 20;100(5):514-527. Epub 2017 Jan 20.

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Room 1560, Philadelphia, PA, 19104, USA.

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May 2017

Habitual physical activity is associated with the maintenance of neutrophil migratory dynamics in healthy older adults.

Brain Behav Immun 2016 Aug 27;56:12-20. Epub 2016 Feb 27.

MRC-ARUK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, United Kingdom.

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August 2016

The modulation of corticosteroid metabolism by hydrocortisone therapy in patients with hypopituitarism increases tissue glucocorticoid exposure.

Eur J Endocrinol 2015 Nov 11;173(5):583-93. Epub 2015 Aug 11.

Centre for EndocrinologyDiabetes and Metabolism, University of Birmingham, Birmingham, UKDepartment of Endocrinology and DiabetesAdelaide and Meath Hospitals, Incorporating the National Children's Hospital and Trinity College, Tallaght Hospital, Dublin 24, IrelandDepartment of EndocrinologyDiabetes and Metabolism, Beaumont Hospital and RCSI Medical School, Dublin, IrelandDepartment of EndocrinologyLeeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UKDepartment of Nuclear MedicineQueen Elizabeth Hospital, Birmingham, UKDepartment of Medicine and EndocrinologyUniversity of Leeds, Leeds, UK.

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November 2015