Publications by authors named "Nico M Wulffraat"

100Publications

Treating juvenile idiopathic arthritis to target: what is the optimal target definition to reach all goals?

Pediatr Rheumatol Online J 2020 Apr 16;18(1):34. Epub 2020 Apr 16.

Department of Pediatric Rheumatology and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KC.03.063.0, P.O. box 85090, 3508, AB, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s12969-020-00428-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164231PMC
April 2020

The Patient and Parent Perspective on Methotrexate in Recent Juvenile Idiopathic Arthritis Guidelines: Comment on the Article by Ringold et al.

Arthritis Rheumatol 2020 06 16;72(6):1039-1040. Epub 2020 Apr 16.

Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/art.41234DOI Listing
June 2020

Fatigue in childhood chronic disease.

Arch Dis Child 2019 11 7;104(11):1090-1095. Epub 2019 Jun 7.

Department of Paediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/archdischild-2019-316782DOI Listing
November 2019

Barbara Ansell: a person ahead of her time.

Ann Rheum Dis 2019 06 24;78(6):725-728. Epub 2019 Apr 24.

Department of Rheumatology, Basel University, Basel, Swaziland.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21510
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http://dx.doi.org/10.1136/annrheumdis-2019-215106DOI Listing
June 2019

Children and young people get rheumatic disease too.

Lancet Child Adolesc Health 2019 01 23;3(1):8-9. Epub 2018 Nov 23.

Department of Paediatric Rheumatology, University Medical Center Utrecht, Utrecht 3508AB, Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23524642183037
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http://dx.doi.org/10.1016/S2352-4642(18)30374-2DOI Listing
January 2019

Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus.

J Rheumatol 2019 02 1;46(2):190-197. Epub 2018 Oct 1.

From Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Direzione Scientifica; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, Pediatric Rheumatology International Trials Organization (PRINTO), and Università degli Studi di Genova; IRCCS Istituto Giannina Gaslini, Servizio di Epidemiologia e Biostatistica, Genoa, Italy; University Children's Hospital, University Medical Center Ljubljana, Department of Allergology, Rheumatology and Clinical Immunology, Ljubljana, Slovenia; Department of Paediatric Rheumatology, Alder Hey Children's National Health Service (NHS) Foundation Trust; Institute of Translational Medicine, University of Liverpool, Liverpool, UK; Hospital General de Mexico, Departamento de Reumatología, Mexico City, Mexico; Hospital Pedro de Elizalde, Rheumatology Section, Buenos Aires, Argentina; Children's Hospital at Montefiore, Albert Einstein College of Medicine, Pediatrics, New Hyde Park, New York; Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, Ohio; Seattle Children's Hospital, Seattle, Washington, USA; Jaslok Hospital and Research Centre, Department of Paediatrics, Mumbai, India; The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, Ontario; British Columbia Children's Hospital, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Wilhelmina Children's Hospital, Department of Pediatric Immunology and Rheumatology, Utrecht, the Netherlands.

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http://dx.doi.org/10.3899/jrheum.180168DOI Listing
February 2019

The role of placebo effects in immune-related conditions: mechanisms and clinical considerations.

Expert Rev Clin Immunol 2018 09 10;14(9):761-770. Epub 2018 Sep 10.

a Faculty of Social and Behavioural Sciences , Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University , Leiden , The Netherlands.

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http://dx.doi.org/10.1080/1744666X.2018.1516144DOI Listing
September 2018

The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey.

Pediatr Rheumatol Online J 2018 Mar 21;16(1):19. Epub 2018 Mar 21.

Department of General Pediatrics, University Medical Center Utrecht, Room KE 04 133 1, PO-Box 85090, 3508, AB Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s12969-018-0235-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863478PMC
March 2018

Disease activity and dropout in young persons with juvenile idiopathic arthritis in transition of care: a longitudinal observational study.

Clin Exp Rheumatol 2018 Jan-Feb;36(1):163-168. Epub 2018 Jan 31.

Department of Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands.

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April 2018

Patient's experiences with the care for juvenile idiopathic arthritis across Europe.

Pediatr Rheumatol Online J 2018 Feb 8;16(1):10. Epub 2018 Feb 8.

Paediatric Rheumatology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Room KC.03.063.0, P.O. box 85090, 3508, AB, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s12969-018-0226-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806356PMC
February 2018

Evolution, trends, outcomes, and economics of hematopoietic stem cell transplantation in severe autoimmune diseases.

Blood Adv 2017 12 20;1(27):2742-2755. Epub 2017 Dec 20.

Unité Clinique de Médecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, Unité Fonctionnelle 04, Hôpital Saint-Louis, AP-HP, INSERM Unité Mixte de Recherche Scientifique 1160, Paris Denis Diderot University, Paris, France; and.

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http://dx.doi.org/10.1182/bloodadvances.2017010041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745133PMC
December 2017

Clinical Juvenile Arthritis Disease Activity Score proves to be a useful tool in treat-to-target therapy in juvenile idiopathic arthritis.

Ann Rheum Dis 2018 03 14;77(3):336-342. Epub 2017 Nov 14.

Department of Pediatric Rheumatology and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2017-212104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867401PMC
March 2018

Haematopoietic stem cell transplantation for autoimmune diseases.

Nat Rev Rheumatol 2017 Apr 23;13(4):244-256. Epub 2017 Feb 23.

Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3508 AB Utrecht, Netherlands.

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http://dx.doi.org/10.1038/nrrheum.2017.7DOI Listing
April 2017

Pneumococcal Vaccination Strategies in the Real World of Chronically Ill Patients.

J Rheumatol 2016 Feb;43(2):255-7

Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.3899/jrheum.151289DOI Listing
February 2016

A safety evaluation of canakinumab for the treatment of systemic onset juvenile idiopathic arthritis.

Authors:
Nico M Wulffraat

Expert Opin Drug Saf 2015 14;14(12):1961-7. Epub 2015 Nov 14.

a Department of Pediatrics, Section Pediatric Rheumatology , Wilhelmina Children's Hospital, University Medical Centrum Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1517/14740338.2016.1112377DOI Listing
September 2016

Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells.

Blood 2016 Jan 19;127(1):91-101. Epub 2015 Oct 19.

Laboratory of Translational Immunology, Department of Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands;

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http://dx.doi.org/10.1182/blood-2015-06-649145DOI Listing
January 2016

Prevalence of Severe Fatigue Among Adolescents With Pediatric Rheumatic Diseases.

Arthritis Care Res (Hoboken) 2016 Jan;68(1):108-14

Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/acr.22710DOI Listing
January 2016

Vaccinations in paediatric rheumatology: an update on current developments.

Curr Rheumatol Rep 2015 Jul;17(7):46

Department of Pediatrics, Wilhemina Children's Hospital/University Medical Centre Utrecht (UMCU), PO-box 85090, 3508 AB, Utrecht, The Netherlands,

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http://dx.doi.org/10.1007/s11926-015-0519-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449376PMC
July 2015

Use and perceived relevance of health-related Internet sites and online contact with peers among young people with juvenile idiopathic arthritis.

Rheumatology (Oxford) 2015 Oct 20;54(10):1833-41. Epub 2015 May 20.

Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht.

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http://dx.doi.org/10.1093/rheumatology/kev193DOI Listing
October 2015

Methotrexate treatment affects effector but not regulatory T cells in juvenile idiopathic arthritis.

Rheumatology (Oxford) 2015 Sep 14;54(9):1724-34. Epub 2015 Apr 14.

Center for Molecular and Cellular Intervention, Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kev101DOI Listing
September 2015

Prediction of methotrexate intolerance in juvenile idiopathic arthritis: a prospective, observational cohort study.

Pediatr Rheumatol Online J 2015 18;13. Epub 2015 Feb 18.

Department of Paediatric Immunology, University Medical Centre Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s12969-015-0002-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349799PMC
September 2015

Prediction of methotrexate efficacy and adverse events in patients with juvenile idiopathic arthritis: a systematic literature review.

Pediatr Rheumatol Online J 2014 11;12:51. Epub 2014 Dec 11.

Department of Paediatric Immunology, University Medical Centre Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/1546-0096-12-51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269851PMC
May 2015

Erythrocyte sedimentation rate as baseline predictor for the development of uveitis in children with juvenile idiopathic arthritis.

Am J Ophthalmol 2015 Feb 7;159(2):372-7.e1. Epub 2014 Nov 7.

Department of Ophthalmology, Utrecht University Medical Center, Utrecht, Netherlands.

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http://dx.doi.org/10.1016/j.ajo.2014.11.007DOI Listing
February 2015

Pathogenesis of juvenile idiopathic arthritis associated uveitis: the known and unknown.

Surv Ophthalmol 2014 Sep-Oct;59(5):517-31. Epub 2014 Mar 29.

Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.survophthal.2014.03.002DOI Listing
March 2015

Early predictors of prognosis in juvenile idiopathic arthritis: a systematic literature review.

Ann Rheum Dis 2015 Nov 24;74(11):1996-2005. Epub 2014 Jun 24.

Department of Paediatric Immunology, University Medical Centre Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands.

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http://ard.bmj.com/content/early/2014/06/24/annrheumdis-2014
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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2014-20526
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http://dx.doi.org/10.1136/annrheumdis-2014-205265DOI Listing
November 2015

Methotrexate in juvenile idiopathic arthritis: towards tailor-made treatment.

Expert Rev Clin Immunol 2014 Jul 26;10(7):843-54. Epub 2014 May 26.

Department of Pediatric Rheumatology and Immunology, University Medical Centre Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands.

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http://dx.doi.org/10.1586/1744666X.2014.916617DOI Listing
July 2014

Assessment of disease activity by patients with juvenile idiopathic arthritis and the parents compared to the assessment by pediatric rheumatologists.

Pediatr Rheumatol Online J 2013 Dec 24;11(1):48. Epub 2013 Dec 24.

Department of Pediatric Rheumatology, University Medical Center Groningen, Beatrix Children's Hospital, University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1186/1546-0096-11-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879656PMC
December 2013

Biologic treatment of pediatric rheumatic diseases: are we spoilt for choice?

Immunotherapy 2014 ;6(1):1-3

Department of Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.2217/imt.13.153DOI Listing
August 2014

Methotrexate polyglutamates in erythrocytes are associated with lower disease activity in juvenile idiopathic arthritis patients.

Ann Rheum Dis 2015 Feb 28;74(2):402-7. Epub 2013 Nov 28.

Department of Paediatric Immunology, University Medical Centre Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2013-203723DOI Listing
February 2015

Effects of the live attenuated measles-mumps-rubella booster vaccination on disease activity in patients with juvenile idiopathic arthritis: a randomized trial.

JAMA 2013 Jun;309(23):2449-56

Department of Pediatric Immunology, University Medical Center Utrecht, Wilhelmina Children's Hospital, Room KC03.063.0, PO Box 85090, 3508 AB, Utrecht, The Netherlands.

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http://dx.doi.org/10.1001/jama.2013.6768DOI Listing
June 2013

Immunogenicity and safety of the bivalent HPV vaccine in female patients with juvenile idiopathic arthritis: a prospective controlled observational cohort study.

Ann Rheum Dis 2014 Aug 30;73(8):1500-7. Epub 2013 May 30.

Department of Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2013-203429DOI Listing
August 2014

Kinetics of the long-term antibody response after meningococcal C vaccination in patients with juvenile idiopathic arthritis: a retrospective cohort study.

Ann Rheum Dis 2014 Apr 16;73(4):728-34. Epub 2013 Mar 16.

Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control Netherlands, National Institute of Public Health and the Environment (RIVM), , Bilthoven, The Netherlands.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2012-20256
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http://dx.doi.org/10.1136/annrheumdis-2012-202561DOI Listing
April 2014

Canakinumab in pediatric rheumatic diseases.

Expert Opin Biol Ther 2013 Apr 4;13(4):615-22. Epub 2013 Mar 4.

University medical Center Utrecht, Department Pediatric Rheumatology, Utrecht, Netherlands.

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http://dx.doi.org/10.1517/14712598.2013.778239DOI Listing
April 2013

Time to share.

Pediatr Rheumatol Online J 2013 Feb 15;11(1). Epub 2013 Feb 15.

Department of Pediatric Rheumatology, UMCU, Utrecht, Netherlands.

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http://dx.doi.org/10.1186/1546-0096-11-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583675PMC
February 2013

Aerobic capacity and disease activity in children, adolescents and young adults with juvenile idiopathic arthritis (JIA).

Pediatr Rheumatol Online J 2012 Aug 27;10(1):27. Epub 2012 Aug 27.

Department of Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.1186/1546-0096-10-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551670PMC
August 2012

Aerobic capacity and disease activity in children, adolescents and young adults with juvenile idiopathic arthritis (JIA).

Pediatr Rheumatol Online J 2012 Aug 20;10(1):25. Epub 2012 Aug 20.

Department of Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.1186/1546-0096-10-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511878PMC
August 2012

ABCB1 and ABCC3 gene polymorphisms are associated with first-year response to methotrexate in juvenile idiopathic arthritis.

J Rheumatol 2012 Oct 1;39(10):2032-40. Epub 2012 Aug 1.

Department of Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.3899/jrheum.111593DOI Listing
October 2012

Prediction of clinical non-response to methotrexate treatment in juvenile idiopathic arthritis.

Ann Rheum Dis 2012 Sep 3;71(9):1484-9. Epub 2012 Apr 3.

University Medical Center Utrecht, Wilhelmina Children's Hospital, Department of Pediatric Immunology, 3508AB Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2011-200942DOI Listing
September 2012

Differences in persistence of measles, mumps, rubella, diphtheria and tetanus antibodies between children with rheumatic disease and healthy controls: a retrospective cross-sectional study.

Ann Rheum Dis 2012 Jun 15;71(6):948-54. Epub 2011 Dec 15.

Department of Paediatric Immunology, Wilhelmina Children’s Hospital, University Medical Centre, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2011-200637DOI Listing
June 2012

Factors associated with treatment response to etanercept in juvenile idiopathic arthritis.

JAMA 2011 Dec 6;306(21):2340-7. Epub 2011 Nov 6.

Department of Pediatrics, Sp 1546, Erasmus Medical Center Sophia Children's Hospital, PO Box 2060, 3000 CB Rotterdam, The Netherlands.

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http://dx.doi.org/10.1001/jama.2011.1671DOI Listing
December 2011

Vaccination leads to an aberrant FOXP3 T-cell response in non-remitting juvenile idiopathic arthritis.

Ann Rheum Dis 2011 Nov 22;70(11):2037-43. Epub 2011 Aug 22.

Department of Pediatrics, Center for Cellular and Molecular Intervention, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/ard.2010.145151DOI Listing
November 2011

The efficacy and safety of interleukin-1-receptor antagonist anakinra in the treatment of systemic juvenile idiopathic arthritis.

Expert Opin Biol Ther 2010 Dec 28;10(12):1743-52. Epub 2010 Oct 28.

VU University Medical Center, Department of Pediatric Infectious diseases, Immunology and Rheumatology, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1517/14712598.2010.532785DOI Listing
December 2010

Awareness of Fabry disease among rheumatologists--current status and perspectives.

Clin Rheumatol 2011 Apr;30(4):467-75

Department of Pediatric Rheumatology, Meyer Hospital, Viale Pieraccini 24, 50139 Florence, Italy.

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http://link.springer.com/10.1007/s10067-010-1445-z
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http://dx.doi.org/10.1007/s10067-010-1445-zDOI Listing
April 2011

Delayed clinical response in patients with juvenile idiopathic arthritis treated with etanercept.

J Rheumatol 2010 Mar 15;37(3):665-7. Epub 2010 Jan 15.

Department of Paediatrics, Sp 1547, Erasmus MC Sophia Children's Hospital, PO Box 2060, 3000 CB Rotterdam, The Netherlands.

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http://dx.doi.org/10.3899/jrheum.090550DOI Listing
March 2010

Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis.

Rheumatology (Oxford) 2010 Mar 17;49(3):441-9. Epub 2009 Dec 17.

Department of Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kep418DOI Listing
March 2010

Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis.

Arthritis Rheum 2009 Sep;60(9):2782-93

Department of Pediatrics, Centre for Cellular and Molecular Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/art.24750DOI Listing
September 2009

Survival in a recent cohort of mechanically ventilated pediatric allogeneic hematopoietic stem cell transplantation recipients.

Biol Blood Marrow Transplant 2008 Dec;14(12):1385-93

Department of Pediatrics, Pediatric Intensive Care Unit, Subdivision of Pediatric Hematology, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.bbmt.2008.09.020DOI Listing
December 2008

Diagnostic workup for mixed connective tissue disease in childhood.

Isr Med Assoc J 2008 Aug-Sep;10(8-9):650-2

VU University Medical Center, Amsterdam, The Netherlands.

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November 2008