Nickolas Papadopoulos

Nickolas Papadopoulos

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Nickolas Papadopoulos

Publications by authors named "Nickolas Papadopoulos"

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Direct Detection and Quantification of Neo-antigens.

Cancer Immunol Res 2019 Sep 16. Epub 2019 Sep 16.

Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center

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http://dx.doi.org/10.1158/2326-6066.CIR-19-0107DOI Listing
September 2019

Applications of liquid biopsies for cancer.

Sci Transl Med 2019 Aug;11(507)

Ludwig Center and the Howard Hughes Medical Institute at the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans St., CRB1, Room 520, Baltimore, MD 21128, USA.

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http://dx.doi.org/10.1126/scitranslmed.aay1984DOI Listing
August 2019

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome.

Nature 2018 12 12;564(7735):273-277. Epub 2018 Dec 12.

Ludwig Center and the Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41586-018-0774-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512810PMC
December 2018

Selected reaction monitoring approach for validating peptide biomarkers.

Proc Natl Acad Sci U S A 2017 12 4;114(51):13519-13524. Epub 2017 Dec 4.

Ludwig Center, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287;

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http://dx.doi.org/10.1073/pnas.1712731114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754789PMC
December 2017

Bisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations.

Proc Natl Acad Sci U S A 2017 05 17;114(18):4733-4738. Epub 2017 Apr 17.

Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21128;

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http://dx.doi.org/10.1073/pnas.1701382114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422780PMC
May 2017

Cancer-Associated Mutations in Endometriosis without Cancer.

N Engl J Med 2017 05;376(19):1835-1848

From the Departments of Obstetrics and Gynaecology (M.S.A., C.A., C.W., P.J.Y., D.G.H.) and Pathology and Laboratory Medicine (M.S.A., T.M.N., J. Senz, B.T.-C., C.B.G., D.G.H.), University of British Columbia, the Department of Anatomical Pathology, Vancouver General Hospital (T.M.N., H.M.H., J.H., V.L., B.T.-C., A.W., C.B.G., D.G.H.), the Department of Molecular Oncology, British Columbia Cancer Agency (H.M.H., A.L., V.L., N.B., D.G.H.), and the BC Women's Centre for Pelvic Pain and Endometriosis, BC Women's Hospital and Health Centre (F.W., N.O., C.A., C.W., P.J.Y.) - all in Vancouver, BC, Canada; the Department of Oncology (N.P., C.T., K.W.K., L.D., T.-L.W., B.V., I.-M.S.) and Ludwig Center (N.P., Y.W., J.D.C., M.Z., M.P., W.M., A.M., K.W.K., L.D., B.V.), Sidney Kimmel Comprehensive Cancer Center, the Departments of Pathology (N.P., A.A., M.N., L.D.W., T.-L.W., B.V., I.-M.S.) and Gynecology and Obstetrics (J. Segars, I.-M.S.), Johns Hopkins Medical Institutions, Personal Genome Diagnostics (S.J.), and Johns Hopkins University Howard Hughes Medical Institute (B.V.) - all in Baltimore; the Department of Pathology, Seirei Mikatahara Hospital (A.A., H.O.), and the Department of Tumor Pathology, Hamamatsu University School of Medicine (A.A.), Hamamatsu, and the Department of Molecular Pathology, Hiroshima University School of Medicine, Hiroshima (A.A.) - all in Japan; the Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands (M.N.); the Departments of Obstetrics and Gynecology (T.S.) and Pathology (R.A., A.H.), Lenox Hill Hospital-Northwell Health (Hofstra University), New York; and the Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Tao-Yuan City, Taiwan (R.-C.W.).

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http://dx.doi.org/10.1056/NEJMoa1614814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555376PMC
May 2017

Evaluating the evaluation of cancer driver genes.

Proc Natl Acad Sci U S A 2016 12 22;113(50):14330-14335. Epub 2016 Nov 22.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218;

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http://dx.doi.org/10.1073/pnas.1616440113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167163PMC
December 2016

Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing.

Proc Natl Acad Sci U S A 2016 08 15;113(35):9846-51. Epub 2016 Aug 15.

Ludwig Center for Cancer Genetics and Therapeutics, Department of Oncology, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231.

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http://dx.doi.org/10.1073/pnas.1607794113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024639PMC
August 2016

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer.

Sci Transl Med 2016 07;8(346):346ra92

Division of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia. Department of Medical Oncology, Western Health, St Albans, Victoria 3021, Australia. Department of Medical Oncology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria 3010, Australia. Ludwig Institute for Cancer Research, New York, NY 10017, USA.

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http://stm.sciencemag.org/content/8/346/346ra92.full.pdf
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http://dx.doi.org/10.1126/scitranslmed.aaf6219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346159PMC
July 2016

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.

Gastroenterology 2016 Apr 5;150(4):931-43. Epub 2016 Jan 5.

Ludwig Center at Johns Hopkins, Baltimore, Maryland; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.12.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270616PMC
April 2016

Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma.

Cancer Prev Res (Phila) 2016 04 9;9(4):265-74. Epub 2016 Feb 9.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Surgery, Section of Otolaryngology-Head and Neck Surgery, The University of Chicago, Chicago, Illinois States.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818686PMC
April 2016

Identification of novel noncoding transcripts in telomerase-negative yeast using RNA-seq.

Sci Rep 2016 Jan 20;6:19376. Epub 2016 Jan 20.

Department of Biology, Johns Hopkins University, Baltimore, MD, 21218 USA.

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http://dx.doi.org/10.1038/srep19376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726298PMC
January 2016

Intraductal papillary mucinous neoplasm in a neonate with congenital hyperinsulinism and a de novo germline SKIL gene mutation.

Pancreatology 2015 Mar-Apr;15(2):194-6. Epub 2014 Oct 27.

Division of Pediatric Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.pan.2014.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387019PMC
December 2015

Lavage of the Uterine Cavity for Molecular Detection of Müllerian Duct Carcinomas: A Proof-of-Concept Study.

J Clin Oncol 2015 Dec 9;33(36):4293-300. Epub 2015 Nov 9.

Elisabeth Maritschnegg, Nina Pecha, Reinhard Horvat, Paul Speiser, and Robert Zeillinger, Medical University of Vienna, Vienna, Austria; Yuxuan Wang, Isaac Kinde, Luis A. Diaz Jr, Nickolas Papadopoulos, Kenneth W. Kinzler, and Bert Vogelstein, Johns Hopkins University, Baltimore, MD; Els Van Nieuwenhuysen and Ignace Vergote, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium; Florian Heitz, Kliniken Essen Mitte, Essen; and Jalid Sehouli, Charité Medical University, Berlin, Germany.

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http://dx.doi.org/10.1200/JCO.2015.61.3083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678180PMC
December 2015

A combination of molecular markers and clinical features improve the classification of pancreatic cysts.

Gastroenterology 2015 Nov 4;149(6):1501-10. Epub 2015 Aug 4.

The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, Maryland; Department of Surgery, The Johns Hopkins University, Baltimore, Maryland; Department of Medicine, The Johns Hopkins University, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782782PMC
November 2015

Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.

Genes Dev 2015 Nov 29;29(21):2219-24. Epub 2015 Oct 29.

Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA; Howard Hughes Medical Institute, University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA; University of Colorado Comprehensive Cancer Center, Aurora, Colorado 80045, USA;

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http://dx.doi.org/10.1101/gad.269498.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647555PMC
November 2015

Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes.

Proc Natl Acad Sci U S A 2015 Aug 27;112(32):9967-72. Epub 2015 Jul 27.

Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287;

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http://dx.doi.org/10.1073/pnas.1511996112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538619PMC
August 2015

Genetic Classification of Gliomas: Refining Histopathology.

Cancer Cell 2015 Jul;28(1):9-11

The Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA; The Ludwig Center for Cancer Genetics and Therapeutic at Johns Hopkins, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.06.014DOI Listing
July 2015

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.

N Engl J Med 2015 Jun 30;372(26):2509-20. Epub 2015 May 30.

From the Swim Across America Laboratory (D.T.L., J.N.U., B.R.B., L.A.D.), Sidney Kimmel Comprehensive Cancer Center (D.T.L., J.N.U., H.W., H.K., A.D.E., A.D.S., B.S.L., N.S.A., D.L., B.B., R.C.D., D.M.P., N.P., K.W.K., S.Z., B.V., L.A.D.), Ludwig Center and Howard Hughes Medical Institute (B.R.B., A.D.S., N.P., K.W.K., S.Z., B.V., L.A.D.), and the Departments of Radiology (A.Z.) and Pathology (F.B., T.H., R.H.H., L.D.W., N.C., T.C.C., J.M.T., R.A.A., J.R.E.), Johns Hopkins University School of Medicine, Baltimore; Department of Medicine, Stanford University School of Medicine, Stanford, CA (G.A.F.); Providence Cancer Center at Providence Health and Services, Portland, OR (T.S.C.); Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh (J.J.L.); Bon Secours Cancer Institute, Richmond, VA (S.M.D.); Division of Medical Oncology, Ohio State University Comprehensive Cancer Center-James Cancer Center and Solove Research Institute, and Human Cancer Genetics Program, Ohio State University Comprehensive Cancer Center, Columbus (R.M.G., A.C.); and Merck, Kenilworth, NJ, and North Wales, PA (M.K.).

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http://dx.doi.org/10.1056/NEJMoa1500596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481136PMC
June 2015

Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas.

Sci Transl Med 2015 Jun;7(293):293ra104

Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa8507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587492PMC
June 2015

Familial and sporadic pancreatic cancer share the same molecular pathogenesis.

Fam Cancer 2015 Mar;14(1):95-103

Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins University School of Medicine, Room 344, Cancer Research Building-II, 1550 Orleans Street, Baltimore, MD, 21231, USA.

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http://link.springer.com/content/pdf/10.1007/s10689-014-9755
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http://link.springer.com/10.1007/s10689-014-9755-y
Publisher Site
http://dx.doi.org/10.1007/s10689-014-9755-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357548PMC
March 2015

Epigenetic remodelling and dysregulation of DLGAP4 is linked with early-onset cerebellar ataxia.

Hum Mol Genet 2014 Dec 1;23(23):6163-76. Epub 2014 Jul 1.

Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark,

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http://dx.doi.org/10.1093/hmg/ddu337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222360PMC
December 2014

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors.

Nat Genet 2014 Nov 12;46(11):1170-2. Epub 2014 Oct 12.

1] Ludwig Center for Cancer Genetics, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA. [2] Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [3] Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/ng.3116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383254PMC
November 2014

Detection of somatic TP53 mutations in tampons of patients with high-grade serous ovarian cancer.

Obstet Gynecol 2014 Nov;124(5):881-5

Departments of Obstetrics and Gynecology and Pathology, University of Alabama at Birmingham, Birmingham, Alabama; the Ludwig Center of Cancer Genetics and Therapeutics and the Swim Across America Laboratory at Johns Hopkins University, Baltimore, Maryland; and the Departments of Obstetrics and Gynecology and Pathology, University of Virginia, Charlottesville, Virginia.

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http://dx.doi.org/10.1097/AOG.0000000000000484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316672PMC
November 2014

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.

Proc Natl Acad Sci U S A 2014 Aug 28;111(32):11774-9. Epub 2014 Jul 28.

Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center,

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http://dx.doi.org/10.1073/pnas.1410626111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136565PMC
August 2014

Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas.

Genes Chromosomes Cancer 2014 Jan 5;53(1):15-24. Epub 2013 Nov 5.

Ludwig Center, the Howard Hughes Medical Institutions, and the Departmentof Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.

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http://dx.doi.org/10.1002/gcc.22114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007004PMC
January 2014

Association of the autoimmune disease scleroderma with an immunologic response to cancer.

Science 2014 Jan 5;343(6167):152-7. Epub 2013 Dec 5.

Ludwig Center, the Howard Hughes Medical Institutions, and the Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1126/science.1246886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038033PMC
January 2014

TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine.

Cancer Res 2013 Dec 11;73(24):7162-7. Epub 2013 Oct 11.

Authors' Affiliations: The Ludwig Center for Cancer Genetics and Therapeutics, The Swim Across America Laboratory at Johns Hopkins, and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center; Departments of Pathology, Oncology, and Urology, The Johns Hopkins Medical Institutes, Baltimore, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966102PMC
December 2013

Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphoma.

J Neurooncol 2013 Sep 5;114(3):275-9. Epub 2013 Jul 5.

Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s11060-013-1182-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133769PMC
September 2013

Cancer genome landscapes.

Science 2013 Mar;339(6127):1546-58

The Ludwig Center and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1126/science.1235122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749880PMC
March 2013

FAST-SeqS: a simple and efficient method for the detection of aneuploidy by massively parallel sequencing.

PLoS One 2012 18;7(7):e41162. Epub 2012 Jul 18.

The Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041162PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399813PMC
January 2013

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.

Nat Genet 2013 Jan 2;45(1):12-7. Epub 2012 Dec 2.

Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/ng.2493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557959PMC
January 2013

Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.

Cancer Discov 2012 Oct 9;2(10):899-905. Epub 2012 Aug 9.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institutions, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473124PMC
October 2012

Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.

Proc Natl Acad Sci U S A 2012 Oct 8;109(43):17603-8. Epub 2012 Oct 8.

The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, cDepartment of Pathology, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.1208807109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491484PMC
October 2012

Sequence and expression analysis of gaps in human chromosome 20.

Nucleic Acids Res 2012 Aug 17;40(14):6660-72. Epub 2012 Apr 17.

Wilhelm Johannsen Centre for Functional Genome Research, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1093/nar/gks302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413113PMC
August 2012

Low-grade serous carcinomas of the ovary contain very few point mutations.

J Pathol 2012 Feb 20;226(3):413-20. Epub 2011 Dec 20.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1002/path.3967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503448PMC
February 2012

Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia.

Blood 2011 Nov 11;118(22):5914-7. Epub 2011 Oct 11.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins University Kimmel Cancer Center, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1182/blood-2011-05-356204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228503PMC
November 2011

IgH gene rearrangements as plasma biomarkers in Non- Hodgkin's lymphoma patients.

Oncotarget 2011 Mar;2(3):178-85

The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260819PMC
http://dx.doi.org/10.18632/oncotarget.235DOI Listing
March 2011

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.

Science 2010 Oct 8;330(6001):228-31. Epub 2010 Sep 8.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1126/science.1196333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076894PMC
October 2010

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.

Nature 2010 Mar 3;464(7288):610-4. Epub 2010 Mar 3.

The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1038/nature08802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176451PMC
March 2010

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.

Proc Natl Acad Sci U S A 2010 Feb 20;107(6):2598-603. Epub 2010 Jan 20.

The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1073/pnas.0914018107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823889PMC
February 2010

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.

Science 2009 Sep 6;325(5947):1555-9. Epub 2009 Aug 6.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1126/science.1174229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820374PMC
September 2009

Sensitive digital quantification of DNA methylation in clinical samples.

Nat Biotechnol 2009 Sep 16;27(9):858-63. Epub 2009 Aug 16.

The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nbt.1559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847606PMC
September 2009

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.

Proc Natl Acad Sci U S A 2009 Mar 18;106(10):3964-9. Epub 2009 Feb 18.

The Howard Hughes Medical Institute and The Ludwig Center for Cancer Genetics and Therapeutics, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1073/pnas.0813333106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656188PMC
March 2009

The antisense transcriptomes of human cells.

Science 2008 Dec 4;322(5909):1855-7. Epub 2008 Dec 4.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1126/science.1163853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824178PMC
December 2008