Nicki Tiffin

Nicki Tiffin

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Nicki Tiffin

Publications by authors named "Nicki Tiffin"

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A framework for tiered informed consent for health genomic research in Africa.

Nat Genet 2019 11;51(11):1566-1571

Department of Integrative Biomedical Sciences, Computational Biology Division, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1038/s41588-019-0520-xDOI Listing
November 2019

Potential risks and solutions for sharing genome summary data from African populations.

Authors:
Nicki Tiffin

BMC Med Genomics 2019 11 4;12(1):152. Epub 2019 Nov 4.

Computational Biology Division, Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1186/s12920-019-0604-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830006PMC
November 2019

Use of Big Data and Machine Learning Methods in the Monitoring and Evaluation of Digital Health Programs in India: An Exploratory Protocol.

JMIR Res Protoc 2019 May 24;8(5):e11456. Epub 2019 May 24.

Department of International Health, Global Disease Epidemiology & Control Program, Johns Hopkins Bloomberg School Public Health, Baltimore, MD, United States.

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http://dx.doi.org/10.2196/11456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555122PMC
May 2019

How to use relevant data for maximal benefit with minimal risk: digital health data governance to protect vulnerable populations in low-income and middle-income countries.

BMJ Glob Health 2019 11;4(2):e001395. Epub 2019 Apr 11.

Division of Epidemiology and Biostatistics, Public Health and Family Medicine, University of Cape Town, Rondebosch, South Africa.

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http://dx.doi.org/10.1136/bmjgh-2019-001395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509603PMC
April 2019

Tiered informed consent: respecting autonomy, agency and individuality in Africa.

Authors:
Nicki Tiffin

BMJ Glob Health 2018 17;3(6):e001249. Epub 2018 Dec 17.

Wellcome Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1136/bmjgh-2018-001249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304098PMC
December 2018

Delineation of the HPV11E6 and HPV18E6 Pathways in Initiating Cellular Transformation.

Front Oncol 2017 1;7:258. Epub 2017 Nov 1.

Faculty of Health Sciences, Division of Medical Biochemistry and Structural Biology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fonc.2017.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672010PMC
November 2017

A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those without.

BMC Med Genomics 2016 11 15;9(1):66. Epub 2016 Nov 15.

South African National Bioinformatics Institute/Medical Research Council of South Africa Bioinformatics Capacity Development Unit, University of the Western Cape, Cape Town, South Africa.

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http://dx.doi.org/10.1186/s12920-016-0227-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111272PMC
November 2016

NetCapDB: measuring bioinformatics capacity development in Africa.

BMC Res Notes 2016 Mar 5;9:144. Epub 2016 Mar 5.

South African National Bioinformatics Institute/Medical Research Council of South Africa Bioinformatics Unit, University of the Western Cape, Cape Town, South Africa.

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http://dx.doi.org/10.1186/s13104-016-1950-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779554PMC
March 2016

The Development of Computational Biology in South Africa: Successes Achieved and Lessons Learnt.

PLoS Comput Biol 2016 Feb 4;12(2):e1004395. Epub 2016 Feb 4.

South African National Bioinformatics Institute/Medical Research Council of South Africa Bioinformatics Unit, University of the Western Cape, Bellville, South Africa.

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http://dx.doi.org/10.1371/journal.pcbi.1004395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742231PMC
February 2016

Human Heredity and Health (H3) in Africa Kidney Disease Research Network: A Focus on Methods in Sub-Saharan Africa.

Clin J Am Soc Nephrol 2015 Dec 2;10(12):2279-87. Epub 2015 Jul 2.

Departments of Pediatrics and Medicine, Hospital for Sick Children, University of Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2215/CJN.11951214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670777PMC
December 2015

Informed consent and ethical re-use of African genomic data.

Hum Genomics 2014 Oct 22;8:18. Epub 2014 Oct 22.

South African National Bioinformatics Institute/Medical Research Council of South Africa Bioinformatics Unit, University of the Western Cape, Private Bag X17, Bellville, 7535, South Africa.

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http://dx.doi.org/10.1186/s40246-014-0018-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445680PMC
October 2014

Research capacity. Enabling the genomic revolution in Africa.

Authors:
Charles Rotimi Akin Abayomi Alash'le Abimiku Victoria May Adabayeri Clement Adebamowo Ezekiel Adebiyi Adebowale D Ademola Adebowale Adeyemo Dwomoa Adu Dissou Affolabi Godfred Agongo Samuel Ajayi Sally Akarolo-Anthony Rufus Akinyemi Albert Akpalu Marianne Alberts Orlando Alonso Betancourt Ahmed Mansour Alzohairy Gobena Ameni Olukemi Amodu Gabriel Anabwani Kristian Andersen Fatiu Arogundade Oyedunni Arulogun Danny Asogun Rasheed Bakare Naby Balde Mary Lynn Baniecki Christine Beiswanger Alia Benkahla Lara Bethke Micheal Boehnke Vincent Boima James Brandful Andrew I Brooks Frank C Brosius Chester Brown Bruno Bucheton David T Burke Barrington G Burnett Stacy Carrington-Lawrence Nadia Carstens John Chisi Alan Christoffels Richard Cooper Heather Cordell Nigel Crowther Talishiea Croxton Jantina de Vries Leslie Derr Peter Donkor Seydou Doumbia Audrey Duncanson Ivy Ekem Ahmed El Sayed Mark E Engel John C K Enyaru Dean Everett Faisal M Fadlelmola Eyitayo Fakunle Kenneth H Fischbeck Anne Fischer Onikepe Folarin Junaid Gamieldien Robert F Garry Simani Gaseitsiwe Rasheed Gbadegesin Anita Ghansah Maria Giovanni Parham Goesbeck F Xavier Gomez-Olive Donald S Grant Ravnit Grewal Mark Guyer Neil A Hanchard Christian T Happi Scott Hazelhurst Branwen J Hennig Christiane Hertz- Fowler Winston Hide Friedhelm Hilderbrandt Christopher Hugo-Hamman Muntaser E Ibrahim Regina James Yasmina Jaufeerally-Fakim Carolyn Jenkins Ute Jentsch Pan-Pan Jiang Moses Joloba Victor Jongeneel Fourie Joubert Mukthar Kader Kathleen Kahn Pontiano Kaleebu Saidi H Kapiga Samar Kamal Kassim Ishmael Kasvosve Jonathan Kayondo Bernard Keavney Adeodata Kekitiinwa Sheik Humarr Khan Paul Kimmel Mary-Claire King Robert Kleta Mathurin Koffi Jeffrey Kopp Matthias Kretzler Judit Kumuthini Samuel Kyobe Catherine Kyobutungi Daniel T Lackland Karen A Lacourciere Guida Landouré Rita Lawlor Thomas Lehner Maia Lesosky Naomi Levitt Katherine Littler Zane Lombard Jeanne F Loring Sylvester Lyantagaye Annette Macleod Ebony B Madden Chengetai R Mahomva Julie Makani Manmak Mamven Marape Marape Graeme Mardon Patricia Marshall Darren P Martin Daniel Masiga Robin Mason Michael Mate-Kole Enock Matovu Mary Mayige Bongani M Mayosi Jean Claude Mbanya Sheryl A McCurdy Mark I McCarthy Helen McIlleron S O Mc'Ligeyo Corrine Merle Ana Olga Mocumbi Charles Mondo John V Moran Ayesha Motala Marva Moxey-Mims Wata Sununguko Mpoloka Chisomo L Msefula Thuli Mthiyane Nicola Mulder Gebregziab her Mulugeta Dieuodonne Mumba John Musuku Mo Nagdee Oyekanmi Nash Daouda Ndiaye Anh Quynh Nguyen Mark Nicol Oathokwa Nkomazana Shane Norris Betty Nsangi Alexander Nyarko Moffat Nyirenda Eileen Obe Reginald Obiakor Abraham Oduro Solomon F Ofori-Acquah Okechukwu Ogah Stephen Ogendo Kwaku Ohene-Frempong Akinlolu Ojo Timothy Olanrewaju John Oli Charlotte Osafo Odile Ouwe Missi Oukem-Boyer Bruce Ovbiagele Andrew Owen Mayowa Ojo Owolabi Lukman Owolabi Ellis Owusu-Dabo Guillaume Pare Rulan Parekh Hugh G Patterton Margaret B Penno Jane Peterson Rembert Pieper Jacob Plange-Rhule Martin Pollak Julia Puzak Rajkumar S Ramesar Michele Ramsay Rebekah Rasooly Shiksha Reddy Pardis C Sabeti Kwamena Sagoe Tunde Salako Oumar Samassékou Manjinder S Sandhu Osman Sankoh Fred Stephen Sarfo Marie Sarr Gasnat Shaboodien Issa Sidibe Gustave Simo Martin Simuunza Liam Smeeth Eugene Sobngwi Himla Soodyall Hermann Sorgho Oumou Sow Bah Sudha Srinivasan Dan J Stein Ezra S Susser Carmen Swanepoel Godfred Tangwa Andrew Tareila Ozlem Tastan Bishop Bamidele Tayo Nicki Tiffin Halidou Tinto Ekaete Tobin Stephen Meir Tollman Mahamadou Traoré Marsha J Treadwell Jennifer Troyer Masego Tsimako-Johnstone Vincent Tukei Ifeoma Ulasi Nzovu Ulenga Beverley van Rooyen Ablo Prudence Wachinou Salina P Waddy Alisha Wade Misaki Wayengera James Whitworth Louise Wideroff Cheryl A Winkler Sarah Winnicki Ambroise Wonkam Mengistu Yewondwos Tadase sen Nathan Yozwiak Heather Zar

Science 2014 Jun;344(6190):1346-8

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http://dx.doi.org/10.1126/science.1251546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491PMC
June 2014

Unique considerations for advancing genomic medicine in African populations.

Authors:
Nicki Tiffin

Per Med 2014 Mar;11(2):187-196

South African National Bioinformatics Institute/SA Medical Research Council Bioinformatics Unit, University of the Western Cape, Cape Town, Western Cape, South Africa.

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http://dx.doi.org/10.2217/pme.13.105DOI Listing
March 2014

Ethical and legal implications of whole genome and whole exome sequencing in African populations.

BMC Med Ethics 2013 May 28;14:21. Epub 2013 May 28.

South African National Bioinformatics Institute, University of the Western Cape, Bellville, South Africa.

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http://dx.doi.org/10.1186/1472-6939-14-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668248PMC
May 2013

A diverse array of genetic factors contribute to the pathogenesis of systemic lupus erythematosus.

Orphanet J Rare Dis 2013 Jan 7;8. Epub 2013 Jan 7.

South African National Bioinformatics Institute/MRC Unit for Bioinformatics Capacity Development, University of the Western Cape, Private Bag X17, Bellville, Cape Town 7535, South Africa.

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http://dx.doi.org/10.1186/1750-1172-8-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551738PMC
January 2013

Conceptual thinking for in silico prioritization of candidate disease genes.

Authors:
Nicki Tiffin

Methods Mol Biol 2011 ;760:175-87

The South African National Bioinformatics Institute, University of the Western Cape, 7925, Belville, Cape Town, South Africa.

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http://dx.doi.org/10.1007/978-1-61779-176-5_11DOI Listing
November 2011

Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.

PLoS One 2010 Sep 27;5(9):e12989. Epub 2010 Sep 27.

Division of Nephrology and Hypertension, University of Cape Town/Groote Schuur Hospital, Cape Town, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012989PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946338PMC
September 2010

Linking genes to diseases: it's all in the data.

Genome Med 2009 Aug 7;1(8):77. Epub 2009 Aug 7.

MRC/UWC/SANBI Bioinformatics Capacity Development Unit, South African National Bioinformatics Institute, University of the Western Cape, Bellville 7535, South Africa.

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http://dx.doi.org/10.1186/gm77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768963PMC
August 2009

Prioritization of candidate disease genes for metabolic syndrome by computational analysis of its defining phenotypes.

Physiol Genomics 2008 Sep 8;35(1):55-64. Epub 2008 Jul 8.

Division of Human Genetics, MRC Human Genetics Research Unit, Institute for Infectious Diseases and Molecular Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1152/physiolgenomics.90247.2008DOI Listing
September 2008

Computational selection and prioritization of candidate genes for fetal alcohol syndrome.

BMC Genomics 2007 Oct 25;8:389. Epub 2007 Oct 25.

Division of Human Genetics, National Health Laboratory Service & School of Pathology, University of the Witwatersrand, Johannesburg, 2001, South Africa.

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http://dx.doi.org/10.1186/1471-2164-8-389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194724PMC
October 2007

Integration of text- and data-mining using ontologies successfully selects disease gene candidates.

Nucleic Acids Res 2005 14;33(5):1544-52. Epub 2005 Mar 14.

South African National Bioinformatics Institute, University of the Western Cape Belville 7535, South Africa.

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http://dx.doi.org/10.1093/nar/gki296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065256PMC
March 2005

Akt phosphorylation is not sufficient for insulin-like growth factor-stimulated myogenin expression but must be accompanied by down-regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylation.

Endocrinology 2004 Nov 22;145(11):4991-6. Epub 2004 Jul 22.

Department of Pediatrics, Box 0434, University of California San Francisco, San Francisco, California 94143-0434, USA.

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http://dx.doi.org/10.1210/en.2004-0101DOI Listing
November 2004

WT1 expression does not disrupt myogenic differentiation in C2C12 murine myoblasts or in human rhabdomyosarcoma.

Exp Cell Res 2003 Jul;287(1):155-65

Section of Paediatric Oncology, Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, SM2 5NG, Surrey, UK.

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http://dx.doi.org/10.1016/s0014-4827(03)00131-9DOI Listing
July 2003