Nick J Spencer

Nick J Spencer

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Nick J Spencer

Nick J Spencer

Publications by authors named "Nick J Spencer"

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73Publications

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Visceral pain - Novel approaches for optogenetic control of spinal afferents.

Brain Res 2018 Aug 7;1693(Pt B):159-164. Epub 2018 Feb 7.

S A Biomedical Engineering, SA Health, Government of South Australia, Adelaide, Australia.

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August 2018

Optogenetic Induction of Colonic Motility in Mice.

Gastroenterology 2018 08 18;155(2):514-528.e6. Epub 2018 May 18.

College of Medicine and Public Health and Centre for Neuroscience, Flinders University, Adelaide, Australia. Electronic address:

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August 2018

Morphological evidence for novel enteric neuronal circuitry in guinea pig distal colon.

J Comp Neurol 2018 Jul 15;526(10):1662-1672. Epub 2018 Apr 15.

College of Medicine and Public Health & Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia.

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July 2018

Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle.

J Neurosci 2018 Jun 28;38(24):5507-5522. Epub 2018 May 28.

Cyber Sensing and Shaping, Cyber and Electronic Warfare Division, Defence, Science and Technology Group, Edinburgh, South Australia 5111, Australia.

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June 2018

What is the role of endogenous gut serotonin in the control of gastrointestinal motility?

Pharmacol Res 2018 Jun 21. Epub 2018 Jun 21.

College of Medicine and Public Health and Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia. Electronic address:

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June 2018

Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice.

J Comp Neurol 2018 Mar 15;526(4):707-720. Epub 2017 Dec 15.

College of Medicine and Public Health, Centre for Neuroscience, School of Medicine, Flinders University of South Australia, Adelaide, South Australia, Australia.

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March 2018

CGRPα within the Trpv1-Cre population contributes to visceral nociception.

Am J Physiol Gastrointest Liver Physiol 2018 02 28;314(2):G188-G200. Epub 2017 Sep 28.

Department of Neuroscience, Uppsala University , Uppsala , Sweden.

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February 2018

Synaptic activation of putative sensory neurons by hexamethonium-sensitive nerve pathways in mouse colon.

Am J Physiol Gastrointest Liver Physiol 2018 01 21;314(1):G53-G64. Epub 2017 Sep 21.

Discipline of Human Physiology and Centre for Neuroscience, Flinders University , Adelaide South Australia.

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January 2018

Extrinsic Sensory Innervation of the Gut: Structure and Function.

Adv Exp Med Biol 2016;891:63-9

Department of Human Physiology, School of Medicine, Flinders University, Adelaide, SA, Australia.

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June 2017

Is There a Role for Endogenous 5-HT in Gastrointestinal Motility? How Recent Studies Have Changed Our Understanding.

Adv Exp Med Biol 2016 ;891:113-22

Department of Human Physiology and Centre for Neuroscience, School of Medicine, Flinders University of South Australia, Adelaide, SA, Australia.

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June 2017

The Diverse Metabolic Roles of Peripheral Serotonin.

Endocrinology 2017 05;158(5):1049-1063

Discipline of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, Adelaide 5042, Australia.

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May 2017

Techniques to identify and temporally correlate calcium transients between multiple regions of interest in vertebrate neural circuits.

J Neurophysiol 2017 Mar 30;117(3):885-902. Epub 2016 Nov 30.

Discipline of Human Physiology and Centre for Neuroscience, School of Medicine, Flinders University of South Australia, Adelaide, Australia

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March 2017

Regional differences in nutrient-induced secretion of gut serotonin.

Physiol Rep 2017 Mar;5(6)

Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, Australia

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March 2017

Promotility Action of the Probiotic HN019 Extract Compared with Prucalopride in Isolated Rat Large Intestine.

Front Neurosci 2017 26;11:20. Epub 2017 Jan 26.

Food Nutrition and Health Team, Food and Bio-based Products Group, AgResearchPalmerston North, New Zealand; Riddet Institute, Massey UniversityPalmerston North, New Zealand.

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January 2017

Spinal afferent nerve endings in visceral organs: recent advances.

Am J Physiol Gastrointest Liver Physiol 2016 12 17;311(6):G1056-G1063. Epub 2016 Nov 17.

Discipline of Human Physiology and Centre for Neuroscience, School of Medicine, Flinders University of South Australia, Adelaide, Australia.

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December 2016

Imaging activation of peptidergic spinal afferent varicosities within visceral organs using novel CGRPα-mCherry reporter mice.

Am J Physiol Gastrointest Liver Physiol 2016 11 22;311(5):G880-G894. Epub 2016 Sep 22.

Discipline of Human Physiology and Centre for Neuroscience, School of Medicine, Flinders University of South Australia, Adelaide, South Australia, Australia.

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November 2016

Switching off pain at the source: is this the end for opioid pain relief?

Authors:
Nick J Spencer

Pain Manag 2016 17;6(1):39-47. Epub 2015 Dec 17.

Department of Human Physiology & Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia.

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October 2016

Different types of spinal afferent nerve endings in stomach and esophagus identified by anterograde tracing from dorsal root ganglia.

J Comp Neurol 2016 10 14;524(15):3064-83. Epub 2016 Apr 14.

Discipline of Human Physiology and Centre for Neuroscience, School of Medicine, Flinders University, Adelaide, 5001, South Australia, Australia.

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October 2016

Insights into the mechanisms underlying colonic motor patterns.

J Physiol 2016 08 9;594(15):4099-116. Epub 2016 Jun 9.

Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia.

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August 2016

Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPα transgenic reporter mouse.

Am J Physiol Gastrointest Liver Physiol 2016 04 28;310(8):G561-73. Epub 2016 Jan 28.

Discipline of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia; and

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April 2016

A composite fibre optic catheter for monitoring peristaltic transit of an intra-luminal bead.

J Biophotonics 2016 Mar 30;9(3):305-10. Epub 2015 Nov 30.

Human Physiology and Centre for Neuroscience, Flinders University, SA 5001, Australia.

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March 2016

Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?

Authors:
Nick J Spencer

Front Cell Neurosci 2015 18;9:487. Epub 2015 Dec 18.

Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia Adelaide, SA, Australia.

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January 2016

Identification of different types of spinal afferent nerve endings that encode noxious and innocuous stimuli in the large intestine using a novel anterograde tracing technique.

PLoS One 2014 10;9(11):e112466. Epub 2014 Nov 10.

Discipline of Human Physiology and Centre for Neuroscience, School of Medicine, Flinders University of South Australia, Adelaide, Australia.

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December 2015

Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability.

Nutr Metab (Lond) 2015 15;12:55. Epub 2015 Dec 15.

Department of Human Physiology and Centre for Neuroscience, Flinders University, Sturt Rd, Adelaide, SA 5042 Australia ; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, 5001 Australia.

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December 2015

CrossTalk opposing view: 5-HT is not necessary for peristalsis.

J Physiol 2015 Aug;593(15):3229-31

Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia.

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August 2015

Rebuttal from Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating.

J Physiol 2015 Aug;593(15):3235

Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia.

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August 2015

Can colonic migrating motor complexes occur in mice lacking the endothelin-3 gene?

Clin Exp Pharmacol Physiol 2015 May;42(5):485-95

Discipline of Human Physiology, Center for Neuroscience, School of Medicine, Flinders University of South Australia, Adelaide, SA, Australia.

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May 2015

Neurally mediated propagating discrete clustered contractions superimposed on myogenic ripples in ex vivo segments of human ileum.

Am J Physiol Gastrointest Liver Physiol 2015 Jan 13;308(1):G1-G11. Epub 2014 Nov 13.

Discipline of Human Physiology, Flinders University, Adelaide, South Australia, Australia;

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January 2015

Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro.

Front Physiol 2014 22;5:319. Epub 2014 Aug 22.

Discipline of Surgery and Centre for Neuroscience, Flinders University Adelaide, SA, Australia.

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September 2014

Characterization of primary afferent spinal innervation of mouse uterus.

Front Neurosci 2014 28;8:202. Epub 2014 Jul 28.

Discipline of Human Physiology and Centre for Neuroscience, Flinders University Adelaide, SA, Australia.

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August 2014

Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis.

Front Neurosci 2014 16;8:75. Epub 2014 Apr 16.

Department of Human Physiology, School of Medicine, Flinders University Bedford Park, SA, Australia.

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May 2014

Control of intrinsic pacemaker frequency and velocity of colonic migrating motor complexes in mouse.

Front Neurosci 2014 8;8:96. Epub 2014 May 8.

Discipline of Human Physiology, Center for Neuroscience, School of Medicine, Flinders University of South Australia Adelaide, SA, Australia.

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May 2014

Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells.

J Physiol 2013 Dec 7;591(23):5959-75. Epub 2013 Oct 7.

D. Keating: Department of Human Physiology and Centre for Neuroscience, Flinders University, Sturt Road, Adelaide, 5001, Australia.

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December 2013

Imaging stretch-activated firing of spinal afferent nerve endings in mouse colon.

Front Neurosci 2013 7;7:179. Epub 2013 Oct 7.

Discipline of Human Physiology, Center for Neuroscience, School of Medicine, Flinders University Bedford Park, SA, Australia.

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October 2013

Characteristics of colonic migrating motor complexes in neuronal NOS (nNOS) knockout mice.

Authors:
Nick J Spencer

Front Neurosci 2013 14;7:184. Epub 2013 Oct 14.

Discipline of Human Physiology, Center for Neuroscience, School of Medicine, Flinders University Adelaide, SA, Australia ; Department of Physiology & Cell Biology, University of Nevada School of Medicine Reno, NV, USA.

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October 2013

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT.

Front Neurosci 2013 5;7:136. Epub 2013 Aug 5.

Discipline of Human Physiology and Center for Neuroscience, Flinders University Adelaide, SA, Australia.

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August 2013

Extrinsic primary afferent signalling in the gut.

Nat Rev Gastroenterol Hepatol 2013 May 26;10(5):286-96. Epub 2013 Feb 26.

Centre for Neuroscience and Discipline of Human Physiology, Flinders Medical Science and Technology, Flinders University, Sturt Road, Bedford Park, SA 5042, Australia.

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May 2013

Localization of the sensory neurons and mechanoreceptors required for stretch-evoked colonic migrating motor complexes in mouse colon.

Front Physiol 2011 21;2:98. Epub 2011 Dec 21.

Department of Human Physiology and Centre for Neuroscience, Flinders University Adelaide, SA, Australia.

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October 2012

Firing patterns and functional roles of different classes of spinal afferents in rectal nerves during colonic migrating motor complexes in mouse colon.

Am J Physiol Gastrointest Liver Physiol 2012 Aug 24;303(3):G404-11. Epub 2012 May 24.

Discipline of Human Physiology and Centre for Neuroscience, Flinders Medical Science and Technology Cluster, Flinders University, South Australia, Australia.

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August 2012

Loss of responsiveness of circular smooth muscle cells from the guinea pig ileum is associated with changes in gap junction coupling.

Am J Physiol Gastrointest Liver Physiol 2012 Jun 29;302(12):G1434-44. Epub 2012 Mar 29.

Discipline of Human Physiology and Centre for Neuroscience, Flinders Medical Science and Technology, Flinders University, Adelaide, South Australia, Australia.

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June 2012

Characterization of motor patterns in isolated human colon: are there differences in patients with slow-transit constipation?

Am J Physiol Gastrointest Liver Physiol 2012 Jan 29;302(1):G34-43. Epub 2011 Sep 29.

Dept. of Human Physiology, School of Medicine, Flinders Univ., South Australia, Australia.

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January 2012

Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?

Am J Physiol Gastrointest Liver Physiol 2011 Sep 23;301(3):G519-27. Epub 2011 Jun 23.

Discipline of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, Australia.

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September 2011

Regulatory barriers to equity in a health system in transition: a qualitative study in Bulgaria.

BMC Health Serv Res 2011 Sep 17;11:219. Epub 2011 Sep 17.

Norwich Medical School, University of East Anglia, Norwich, UK.

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September 2011

Identification of the visceral pain pathway activated by noxious colorectal distension in mice.

Front Neurosci 2011 22;5:16. Epub 2011 Feb 22.

Department of Human Physiology, Flinders Medical Science and Technology Cluster, Flinders University Adelaide, SA, Australia.

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July 2011

Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung's disease.

J Physiol 2011 Apr 14;589(Pt 7):1691-706. Epub 2011 Feb 14.

Discipline of Human Physiology, Flinders Medical Science and Technology Cluster, Flinders University, 5001, South Australia, Australia.

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April 2011

Chronic constipation: lessons from animal studies.

Best Pract Res Clin Gastroenterol 2011 Feb;25(1):59-71

Centre for Academic Surgery, GI Physiology Unit, Barts and The London Queen Mary's School of Medicine and Dentistry, London, UK.

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February 2011

Peristalsis and fecal pellet propulsion do not require nicotinic, purinergic, 5-HT3, or NK3 receptors in isolated guinea pig distal colon.

Am J Physiol Gastrointest Liver Physiol 2010 Jun 1;298(6):G952-61. Epub 2010 Apr 1.

Department of Human Physiology, Flinders University, Adelaide, South Australia, Australia.

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June 2010

Prevalence of childhood disability and the characteristics and circumstances of disabled children in the UK: secondary analysis of the Family Resources Survey.

BMC Pediatr 2010 Apr 16;10:21. Epub 2010 Apr 16.

School of Health and Social Studies, University of Warwick, Coventry CV4 7AL, UK.

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April 2010

Structure-function relationship of sensory endings in the gut and bladder.

Auton Neurosci 2010 Feb 14;153(1-2):3-11. Epub 2009 Aug 14.

Department of Human Physiology & Centre for Neuroscience, Flinders University of South Australia, GPO Box 2100, Adelaide, South Australia, Australia.

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February 2010

Release of 5-hydroxytryptamine from the mucosa is not required for the generation or propagation of colonic migrating motor complexes.

Gastroenterology 2010 Feb 24;138(2):659-70 670.e1-2. Epub 2009 Sep 24.

Department of Human Physiology, Flinders University, School of Medicine, South Australia, Australia.

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February 2010

Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium.

J Physiol 2009 Jul 26;587(Pt 14):3523-38. Epub 2009 May 26.

Department of Human Physiology, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia.

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July 2009

Access to health care for Roma children in Central and Eastern Europe: findings from a qualitative study in Bulgaria.

Int J Equity Health 2009 Jun 30;8:24. Epub 2009 Jun 30.

School of Medicine, Health Policy and Practice, University of East Anglia, UK.

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June 2009

Overproduction, purification and preliminary X-ray diffraction analysis of YncE, an iron-regulated Sec-dependent periplasmic protein from Escherichia coli.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 Oct 30;64(Pt 10):966-9. Epub 2008 Sep 30.

School of Biological Sciences, University of Reading, Whiteknights Campus, Reading, Berkshire RG6 6AS, England.

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October 2008

Polarized intrinsic neural reflexes in response to colonic elongation.

J Physiol 2008 Sep 17;586(17):4225-40. Epub 2008 Jul 17.

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.

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September 2008

Identification of functional intramuscular rectal mechanoreceptors in aganglionic rectal smooth muscle from piebald lethal mice.

Am J Physiol Gastrointest Liver Physiol 2008 Apr 24;294(4):G855-67. Epub 2008 Jan 24.

Dept. of Human Physiology, School of Medicine, Flinders Univ., South Australia, Australia.

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April 2008

Septal interstitial cells of Cajal conduct pacemaker activity to excite muscle bundles in human jejunum.

Gastroenterology 2007 Sep 20;133(3):907-17. Epub 2007 Jun 20.

Department of Physiology & Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA.

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September 2007

The mechanism and spread of pacemaker activity through myenteric interstitial cells of Cajal in human small intestine.

Gastroenterology 2007 May 23;132(5):1852-65. Epub 2007 Feb 23.

Department of Physiology & Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89577, USA.

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May 2007

An enteric occult reflex underlies accommodation and slow transit in the distal large bowel.

Gastroenterology 2007 May 23;132(5):1912-24. Epub 2007 Feb 23.

Department of Physiology & Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA.

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May 2007

Activation of neural circuitry and Ca2+ waves in longitudinal and circular muscle during CMMCs and the consequences of rectal aganglionosis in mice.

Am J Physiol Gastrointest Liver Physiol 2007 Feb 5;292(2):G546-55. Epub 2006 Oct 5.

Dept of Physiology and Cell Biology, Univ of Nevada School of Medicine, Reno, NV 89557, USA.

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February 2007

Sensory elements within the circular muscle are essential for mechanotransduction of ongoing peristaltic reflex activity in guinea-pig distal colon.

J Physiol 2006 Oct 3;576(Pt 2):519-31. Epub 2006 Aug 3.

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.

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October 2006

Social equalization in youth: evidence from a cross-sectional British survey.

Authors:
Nick J Spencer

Eur J Public Health 2006 Aug 23;16(4):368-75. Epub 2006 Jan 23.

School of Health and Social Studies and Warwick Medical School, University of Warwick, UK.

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August 2006

Spatial and temporal mapping of pacemaker activity in interstitial cells of Cajal in mouse ileum in situ.

Am J Physiol Cell Physiol 2006 May 28;290(5):C1411-27. Epub 2005 Dec 28.

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.

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May 2006

Anatomic modifications in the enteric nervous system of piebald mice and physiological consequences to colonic motor activity.

Am J Physiol Gastrointest Liver Physiol 2006 Apr 8;290(4):G710-8. Epub 2005 Dec 8.

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, 89557, USA.

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April 2006

Synchronization of enteric neuronal firing during the murine colonic MMC.

J Physiol 2005 May 24;564(Pt 3):829-47. Epub 2005 Feb 24.

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.

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May 2005

Mechanosensory S-neurons rather than AH-neurons appear to generate a rhythmic motor pattern in guinea-pig distal colon.

J Physiol 2004 Jul 14;558(Pt 2):577-96. Epub 2004 May 14.

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.

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July 2004

Migrating motor complexes do not require electrical slow waves in the mouse small intestine.

J Physiol 2003 Dec 26;553(Pt 3):881-93. Epub 2003 Sep 26.

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.

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December 2003

A smooth muscle tone-dependent stretch-activated migrating motor pattern in isolated guinea-pig distal colon.

J Physiol 2003 Sep 7;551(Pt 3):955-69. Epub 2003 Jul 7.

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.

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September 2003

Characterization of properties underlying rhythmicity in mouse portal vein.

Auton Neurosci 2003 Mar;104(2):73-82

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.

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March 2003

Stretch-activated neuronal pathways to longitudinal and circular muscle in guinea pig distal colon.

Am J Physiol Gastrointest Liver Physiol 2003 Feb 16;284(2):G231-41. Epub 2002 Oct 16.

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA.

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February 2003

A rhythmic motor pattern activated by circumferential stretch in guinea-pig distal colon.

J Physiol 2002 Dec;545(Pt 2):629-48

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA.

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December 2002

Electrical rhythmicity and spread of action potentials in longitudinal muscle of guinea pig distal colon.

Am J Physiol Gastrointest Liver Physiol 2002 May;282(5):G904-17

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA.

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May 2002