Nick J Reynolds

Nick J Reynolds

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Nick J Reynolds

Publications by authors named "Nick J Reynolds"

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IL-17 May Be a Key Cytokine Linking Psoriasis and Hyperglycemia.

J Invest Dermatol 2019 Jun;139(6):1214-1216

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.02.038DOI Listing
June 2019

A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.

J Invest Dermatol 2019 Jan 17;139(1):100-107. Epub 2018 Jul 17.

Centre for Translational Bioinformatics, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK.

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http://dx.doi.org/10.1016/j.jid.2018.04.041DOI Listing
January 2019

Defining the Therapeutic Range for Adalimumab and Predicting Response in Psoriasis: A Multicenter Prospective Observational Cohort Study.

J Invest Dermatol 2019 Jan 18;139(1):115-123. Epub 2018 Aug 18.

St John's Institute of Dermatology, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; St. John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300405PMC
January 2019

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council.

J Allergy Clin Immunol 2019 Jan 7;143(1):36-45. Epub 2018 Nov 7.

Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183157
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http://dx.doi.org/10.1016/j.jaci.2018.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626639PMC
January 2019

The devil is in the data: differences in drug persistence between SNIIRAM, the French national health insurance database, and psoriasis biologics intervention registers.

Br J Dermatol 2019 01;180(1):8-10

Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, U.K.

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http://doi.wiley.com/10.1111/bjd.17275
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http://dx.doi.org/10.1111/bjd.17275DOI Listing
January 2019

Response to "Comment on: 'When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council'".

J Am Acad Dermatol 2018 08;79(2):e25-e26

Trinity College Dublin, National Children's Research Centre, Paediatric Dermatology, Our Lady's Children's Hospital, Dublin, Republic of Ireland.

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http://dx.doi.org/10.1016/j.jaad.2018.03.048DOI Listing
August 2018

Differential Drug Survival of Second-Line Biologic Therapies in Patients with Psoriasis: Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR).

J Invest Dermatol 2018 04 6;138(4):775-784. Epub 2017 Dec 6.

Dermatology Centre, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences and NIHR Manchester Biomedical Research Centre, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.09.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869053PMC
April 2018

Risk of Serious Infection in Patients with Psoriasis Receiving Biologic Therapies: A Prospective Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR).

J Invest Dermatol 2018 03 17;138(3):534-541. Epub 2017 Oct 17.

Dermatology Centre, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832757PMC
March 2018

Proteomic analysis of filaggrin deficiency identifies molecular signatures characteristic of atopic eczema.

J Allergy Clin Immunol 2017 Nov 4;140(5):1299-1309. Epub 2017 May 4.

Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.01.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667587PMC
November 2017

When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.

J Am Acad Dermatol 2017 Oct 10;77(4):623-633. Epub 2017 Aug 10.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2017.06.042DOI Listing
October 2017

Doxycycline: a first-line treatment for bullous pemphigoid?

Lancet 2017 04 6;389(10079):1586-1588. Epub 2017 Mar 6.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK; Newcastle Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01406736173054
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http://dx.doi.org/10.1016/S0140-6736(17)30549-4DOI Listing
April 2017

Differential Drug Survival of Biologic Therapies for the Treatment of Psoriasis: A Prospective Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR).

J Invest Dermatol 2015 Nov 8;135(11):2632-2640. Epub 2015 Jun 8.

Dermatology Centre, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.208DOI Listing
November 2015

Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down.

J Dermatol Sci 2014 Jan 11;73(1):10-22. Epub 2013 Sep 11.

Dermatological Sciences, 2nd Floor Leech Building, Medical Science, Institute of Cellular Medicine, Newcastle University, NE2 4HH, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2013.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885976PMC
January 2014

Lysophosphatidic acid promotes cell migration through STIM1- and Orai1-mediated Ca2+(i) mobilization and NFAT2 activation.

J Invest Dermatol 2013 Mar 25;133(3):793-802. Epub 2012 Oct 25.

Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. Electronic address:

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http://dx.doi.org/10.1038/jid.2012.370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572452PMC
March 2013

Lithium regulates keratinocyte proliferation via glycogen synthase kinase 3 and NFAT2 (nuclear factor of activated T cells 2).

J Cell Physiol 2012 Apr;227(4):1529-37

Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/jcp.22872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150531PMC
April 2012

Keratinocyte apoptosis in epidermal remodeling and clearance of psoriasis induced by UV radiation.

J Invest Dermatol 2011 Sep 26;131(9):1916-26. Epub 2011 May 26.

Dermatological Sciences, Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X153538
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http://dx.doi.org/10.1038/jid.2011.134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160491PMC
September 2011

Keratinocyte secretion of cyclophilin B via the constitutive pathway is regulated through its cyclosporin-binding site.

J Invest Dermatol 2011 May 27;131(5):1085-94. Epub 2011 Jan 27.

Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1038/jid.2010.415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182837PMC
May 2011

Filaggrin null mutations and childhood atopic eczema: a population-based case-control study.

J Allergy Clin Immunol 2008 Apr 4;121(4):940-46.e3. Epub 2008 Mar 4.

Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2008.01.013DOI Listing
April 2008

Eczema in pregnancy.

BMJ 2007 Jul;335(7611):152-4

Dermatological Sciences, Institute of Cellular Medicine, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne.

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http://dx.doi.org/10.1136/bmj.39227.671227.AEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925231PMC
July 2007

Agonist-induced calcium entry correlates with STIM1 translocation.

J Cell Physiol 2007 Jun;211(3):569-76

Dermatological Sciences, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/jcp.20993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737609PMC
June 2007

Management of psoriasis in pregnancy.

BMJ 2007 Jun;334(7605):1218-20

Dermatological Sciences, Institute of Cellular Medicine, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH.

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http://dx.doi.org/10.1136/bmj.39202.518484.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1889937PMC
June 2007

An ancient malady.

Am J Med 2006 Dec;119(12):1039-42

Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.amjmed.2006.09.016DOI Listing
December 2006

Use of topical glycopyrrolate in Ross syndrome.

J Am Acad Dermatol 2006 Nov;55(5 Suppl):S111-2

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http://dx.doi.org/10.1016/j.jaad.2005.08.058DOI Listing
November 2006

Atopic and non-atopic eczema.

BMJ 2006 Mar;332(7541):584-8

Department of Dermatology, Royal Victoria Infirmary, and Dermatological Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH.

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http://dx.doi.org/10.1136/bmj.332.7541.584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1397720PMC
March 2006

Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial.

Lancet 2006 Mar;367(9513):839-46

School of Clinical and Laboratory Sciences (Dermatological Sciences), University of Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/S0140-6736(06)68340-2DOI Listing
March 2006

The anti-psoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, and induces apoptosis through a pathway dependent on respiratory competent mitochondria.

FASEB J 2005 Jun 31;19(8):1012-4. Epub 2005 Mar 31.

Skin and Environmental Interactions Research Group, School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1096/fj.04-2664fjeDOI Listing
June 2005

Phototherapy and systemic treatments.

Hosp Med 2002 Nov;63(11):657-61

Department of Dermatology, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH.

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November 2002

Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A.

J Invest Dermatol 2002 May;118(5):779-88

Department of Dermatology, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1046/j.1523-1747.2002.01709.xDOI Listing
May 2002