Publications



7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial.
Trials 2018 Feb 17;19(1):111. Epub 2018 Feb 17.
Departments of Medicine and Critical Care Medicine, Sunnybrook Health Sciences Center, Adjunct Scientist, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

A decade of outpatient antimicrobial use in older adults in Ontario: a descriptive study.
CMAJ Open 2017 Dec;5(4):E878-E885
Affiliations: Sunnybrook Research Institute (Tan, Daneman) and Division of Infectious Diseases (Daneman), Sunnybrook Health Sciences Centre; Institute for Clinical Evaluative Sciences (Graves, Lu, Chen, Li, Schwartz, Daneman); Public Health Ontario (Schwartz, Daneman); Dalla Lana School of Public Health (Schwartz), University of Toronto, Toronto, Ont.


Time required to initiate outbreak and pandemic observational research.
J Crit Care 2017 Aug 1;40:7-10. Epub 2017 Mar 1.
Departments of Medicine and Critical Care Medicine, Sunnybrook Health Sciences Center, Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada M4N 3M5. Electronic address:

Predictive utility of swab screening for vancomycin-resistant Enterococcus in selection of empiric antibiotics for Enterococcus sterile-site infections: a retrospective cohort study.
CMAJ Open 2017 Aug;5(3):E632-E637
Affiliations: Department of Medicine (Brasg), Division of Infectious Diseases (MacFadden, Daneman) and Division of Clinical Epidemiology (Daneman), University of Toronto; Department of Pharmacy (Elligsen), Sunnybrook Health Sciences Centre, Toronto, Ont.

Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis.
Crit Care Med 2017 Jul;45(7):1121-1129
1Department of Medicine, McMaster University, Hamilton, ON, Canada.2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.3Department of Critical Care, University of Dammam, Dammam, Saudi Arabia.4Discipline of Acute Care Medicine, University of Adelaide, Adelaide, SA, Australia.5Department of Surgery and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.6Departments of Anesthesia, Pain Management and Perioperative Medicine and Critical Care Medicine, Dalhousie University, Halifax, NS, Canada.7Department of Critical Care, Queens University, Kingston, ON, Canada.8Department of Medicine (Critical Care), University of Ottawa, Ottawa, ON, Canada.9Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.10Departments of Medicine, Anesthesiology and Critical Care, Université Laval, Quebec City, QC, Canada.11Biostatistics Unit, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.12Intensive Care Department, King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.13The George Institute for Global Health and Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.14Department of Medicine, University of Toronto, Toronto, ON, Canada.15Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.

Influences on the start, selection and duration of treatment with antibiotics in long-term care facilities.
CMAJ 2017 Jun;189(25):E851-E860
Institute for Clinical Evaluative Sciences (Daneman, Campitelli, Giannakeas, Bell, Maxwell, Austin, Bronskill), Toronto, Ont.; Sunnybrook Research Institute and Division of Infectious Diseases (Daneman), Sunnybrook Health Sciences Centre; Department of Medicine (Daneman, Morris, Bell); Institute of Health Policy, Management and Evaluation (Daneman, Bell, Austin, Bronskill); Sinai Health System (Morris, Bell); St. Michael's Hospital (Jeffs), University of Toronto, Toronto, Ont.; University of Waterloo (Maxwell), Waterloo, Ont.

Accuracy of administrative data for identification of patients with infective endocarditis.
Int J Cardiol 2016 Dec 17;224:162-164. Epub 2016 Sep 17.
Sunnybrook Research Institute, Toronto, Canada; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada.

Effectiveness of pertussis vaccination and duration of immunity.
CMAJ 2016 Nov 26;188(16):E399-E406. Epub 2016 Sep 26.
Institute for Clinical Evaluative Sciences (Schwartz, Kwong, Campitelli, Stukel, Daneman); Institute of Health Policy, Management, and Evaluation (Schwartz, Stukel, Rosella, Daneman), University of Toronto; The Hospital for Sick Children (Schwartz); Public Health Ontario (Kwong, Deeks, Rosella, Rilkoff, Crowcroft); Dalla Lana School of Public Health (Kwong, Deeks, Bolotin, Crowcroft), University of Toronto; Department of Family and Community Medicine (Kwong), University of Toronto; University Health Network (Kwong); Department of Laboratory Medicine and Pathobiology (Jamieson, Marchand-Austin, Crowcroft), University of Toronto; Public Health Ontario Laboratory Services (Jamieson, Marchand-Austin); Toronto, Ont.; ProvLab Alberta, University of Alberta Hospital (Drews); Department of Pathology and Laboratory Medicine (Drews), University of Alberta, Edmonton, Alta.

Influenza A (H1N1pdm09)-Related Critical Illness and Mortality in Mexico and Canada, 2014.
Crit Care Med 2016 Oct;44(10):1861-70
1Department of Critical Care Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.2Escuela de Medicina, Tecnologico de Monterrey, Monterrey, Mexico.3Department of Hospital Epidemiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.4Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.5Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.6Department of Critical Care Medicine, Instituto Nacional de Cancerología, Mexico City, Mexico.7Department of Infectious Diseases, Hospital universitario Dr. José Eleuterio González, Monterrey, Nuevo León, Mexico.8Department of Critical Care Medicine and Emergency, Instituto de Salud del Estado de México, Toluca, Mexico.9Department of Critical Care Medicine, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.10Department of Critical Care Medicine, Hospital General de Tijuana, Tijuana, Baja California, Mexico.11Department of Critical Care Medicine, Hospital Central Ignacio Morones Prieto, San Luis Potosi, Mexico.12Department of Critical Care Medicine, Hospital General de Uruapan, Uruapan, Michoacan, Mexico.13Department of Infectious Diseases, Hospital General Regional de León, León, Guanajuato, Mexico.14Department of Infectious Diseases, Hospital Regional de Alta Especialidad de Oaxaca, Oaxaca, Mexico.15Department of Critical Care Medicine, Hospital General "Dr. Manuel Gea González," Mexico City, Mexico.16Department of Disasters Response, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.17Department of Critical Care Medicine, Hospital San José Monterrey, Monterrey, Nuevo León, Mexico.18Faculty of Medicine, Universidad de Guanajuato, León, Guanajuato, Mexico.19Department of Critical Care Medicine, Hospital Regional de Alta Especialidad de Oaxaca,

The authors reply.
Crit Care Med 2016 Aug;44(8):e776
Division of Infectious Diseases, Department of Medicine & Clinical Epidemiology, Sunnybrook Health Sciences Centre, University of Toronto and Adjunct Scientist, Toronto, ON, Canada, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Medicine and Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

A passage from India: Association between air traffic and reported cases of New Delhi Metallo-beta-lactamase 1 from 2007 to 2012.
Travel Med Infect Dis 2015 Jul-Aug;13(4):295-9. Epub 2015 Jun 24.
Division of Infectious Diseases, University of Toronto, Toronto, Ontario, Canada; Centre for Research on Inner City Health, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada.

Outcomes in Documented Pseudomonas aeruginosa Bacteremia Treated with Intermittent IV Infusion of Ceftazidime, Meropenem, or Piperacillin-Tazobactam: A Retrospective Study.
Can J Hosp Pharm 2015 Sep-Oct;68(5):386-94
MD, MSc, FRCPC, is with the Division of Infectious Diseases, Sunnybrook Health Sciences Centre, and the Faculty of Medicine, University of Toronto, Toronto, Ontario.

Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients.
Crit Care Med 2016 Feb;44(2):256-64
1Division of Infectious Diseases, Department of Medicine and Clinical Epidemiology, Sunnybrook Health Sciences Centre, University of Toronto and Adjunct Scientist, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 2Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 3Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada. 4Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul's Hospital and University of British Columbia, Vancouver, BC, Canada. 5Department of Critical Care Medicine, Dalhousie University and the Capital District, Health Authority, Halifax, NS, Canada. 6Sections of Critical Care Medicine and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada. 7Department of Medicine, Centre de recherche du CHU de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada. 8Centre de recherche du CHU de Québec, Axe santé des populations et pratiques optimales en santé, Division de soins intensifs adultes, départements de médecine et d'anesthésiologie, Université Laval, Quebec, QC, Canada. 9Departments of Surgery and Critical Care Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. 10Department of Medicine, University of Western Ontario, London, ON, Canada. 11Division of Critical Care, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada. 12Department of Medicine, Queen's University, Kingston, ON, Canada. 13Department of Medicine, University of British Columbia, Vancouver, BC, Canada. 14Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada. 15Departments of Medicine, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. 16Department of Medicine and Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

A National Survey of Critical Care Physicians' Knowledge, Attitudes, and Perceptions of Antimicrobial Stewardship Programs.
J Intensive Care Med 2016 Jan 8;31(1):61-5. Epub 2014 Jul 8.
Mount Sinai Hospital, Toronto, Canada University Health Network, Toronto, Canada Division of Infectious Diseases, University of Toronto, Toronto, Canada Department of Medicine, University of Toronto, Toronto, Canada.

Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study.
BMJ Open 2015 Nov 18;5(11):e010077. Epub 2015 Nov 18.
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada Division of General Internal Medicine, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Variability in Antibiotic Use Across Nursing Homes and the Risk of Antibiotic-Related Adverse Outcomes for Individual Residents.
JAMA Intern Med 2015 Aug;175(8):1331-9
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada3Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada6Division of General Internal Medicine, Mount Sinai Hospital, University of Toronto.

Point prevalence survey of antimicrobial utilization in a Canadian tertiary-care teaching hospital.
J Epidemiol Glob Health 2015 Jun 8;5(2):143-50. Epub 2014 Aug 8.
Department of Microbiology and Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Sunnybrook Research Institute, Toronto, Ontario, Canada; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

The economic impact of Clostridium difficile infection: a systematic review.
Am J Gastroenterol 2015 Apr 7;110(4):511-9. Epub 2015 Apr 7.
1] Toronto Health Economics and Technology Assessment Collaborative, Toronto, Ontario, Canada [2] Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada [3] Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada [4] Public Health Ontario, Toronto, Ontario, Canada.


Hospital-wide rollout of antimicrobial stewardship: a stepped-wedge randomized trial.
Clin Infect Dis 2014 Sep 13;59(6):867-74. Epub 2014 Jun 13.
Department of Microbiology and Division of Infectious Diseases, Sunnybrook Health Sciences Centre Faculty of Medicine, University of Toronto Sunnybrook Research Institute Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.


Determination of tobramycin pharmacokinetics in burn patients to evaluate the potential utility of once-daily dosing in this population.
J Burn Care Res 2014 Jul-Aug;35(4):e240-9
From the *Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; †Leslie L. Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada; ‡Department of Microbiology and Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; and §Faculty of Medicine, University of Toronto, Ontario, Canada.

Duration of antibiotic therapy for critically ill patients with bloodstream infections: A retrospective cohort study.
Can J Infect Dis Med Microbiol 2013 ;24(3):129-37
Department of Medicine, University of Toronto, Toronto, Ontario ; Trauma, Emergency and Critical Care Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario ; Division of Infectious Diseases, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario.


Patient Characteristics and Outcomes of Outpatient Parenteral Antimicrobial Therapy: A Retrospective Study.
Can J Infect Dis Med Microbiol 2016 22;2016:8435257. Epub 2016 Feb 22.
Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, Canada M5S 1A8; Division of Infectious Diseases, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5; Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5.

Re-evaluating the Inhibition of Stress Erosions (REVISE): a protocol for pilot randomized controlled trial.
Ann Saudi Med 2016 Nov-Dec;36(6):427-433
Dr. Waleed Alhazzani, Critical Care Medicine, McMaster University,, 50 Charlton Avenue East,, Hamilton, Ontario,, L8N 4A6, Canada, T: +1905-522-1155 ext 32800, F: +1905-521-6068 ORCID: http://orcid.org/0000-0001-8076-9626.

Pathogens and antimicrobial susceptibility profiles in critically ill patients with bloodstream infections: a descriptive study.
CMAJ Open 2016 Oct-Dec;4(4):E569-E577. Epub 2016 Oct 13.
Dalla Lana School of Public Health (Savage), University of Toronto; Sunnybrook Health Sciences Centre (Savage, Fowler, Rishu, Daneman), Toronto, Ont.; Division of Critical Care Medicine (Fowler), Department of Medicine; Institute of Health Policy, Management and Evaluation (Fowler, Daneman), University of Toronto, Toronto, Ont.; Division of Critical Care Medicine (Bagshaw), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta.; Departments of Medicine and Clinical Epidemiology & Biostatistics (Cook), McMaster University, Hamilton, Ont.; Division of Critical Care Medicine (Dodek, Reynolds), Department of Medicine, University of British Columbia; Center for Health Evaluation and Outcome Sciences (Dodek), St. Paul's Hospital, Vancouver, BC; Department of Critical Care Medicine (Hall), Faculty of Medicine, Dalhousie University; Nova Scotia Health Authority (Hall), Halifax, NS; Section of Critical Care Medicine (Kumar), Department of Medicine; Departments of Medical Microbiology and of Pharmacology and Therapeutics (Kumar), University of Manitoba, Winnipeg, Man.; Centre de recherche du Centre hospitalier universitaire de Sherbrooke (Lamontagne), Sherbrooke, Que.; Service de médecine interne (Lamontagne), Département de médecine, Université de Sherbrooke, Sherbrooke, Que.; Axe Santé des populations et pratiques optimales en santé (Lauzier), Centre de recherche du Centre hospitalier universitaire de Québec-Université Laval, Québec, Que.; Départements de medicine et d'anesthésiologie et de soins intensifs (Lauzier), Université Laval, Québec, Que.; St. Michael's Hospital (Marshall), Toronto, Ont.; Department of Surgery (Marshall), University of Toronto, Toronto, Ont.; Department of Medicine (Martin), Western University; Critical Care Medicine (Martin), Schulich School of Medicine & Dentistry, London Health Sciences Centre, London, Ont.; Division of Critical Care (McIntyre), Department of Medicine, The Ottawa Hospital, Ottawa, Ont.; Department of Medicine (Muscedere), Queen's University, Kingston, Ont.; Department of Critical Care Medicine (Muscedere), Kingston General Hospital, Kingston, Ont.; Department of Critical Care Medicine (Stelfox), University of Calgary, Calgary, Alta.; Division of Infectious Diseases (Daneman), Department of Medicine, University of Toronto; Institute for Clinical Evaluative Sciences (Daneman), Toronto, Ont.

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